BPC-157 vs Intermedin (Adrenomedullin-2)
The "Wolverine peptide" known for its remarkable healing properties across tendons, ligaments, muscles, and the gut.
A powerful peptide hormone that protects your heart and blood vessels while managing stress and inflammation naturally.
Written by Michael Carroll — Owner, Director of Research · Reviewed by the Peptide Initiative Research Team · Editorial standards
Quick comparison
Dose range
BPC-157
250–500 mcg
Intermedin (Adrenomedullin-2)
As prescribed–As prescribed mg
Frequency
BPC-157
Once daily
Intermedin (Adrenomedullin-2)
Once daily
Administration
BPC-157
Subcutaneous injection
Intermedin (Adrenomedullin-2)
As directed by healthcare provider
Cycle length
BPC-157
4-6 weeks
Intermedin (Adrenomedullin-2)
Ongoing/indefinite
Onset speed
BPC-157
Moderate (1-2 weeks)
Intermedin (Adrenomedullin-2)
Moderate (1-2 weeks)
Evidence level
BPC-157
Strong preclinical (extensive animal studies)
Intermedin (Adrenomedullin-2)
Limited human trials
Benefit ratings
Primary Benefit
Secondary Benefit
Additional Benefit
Cardiovascular Health & Protection
Stress & Anxiety Management
Anti-Inflammatory & Antioxidant Support
Compound specifications
BPC-157
Molecular formula
C62H98N16O22
Molecular weight
1419.53 g/mol
Half-life
4-6 hours
Bioavailability
~100% (subcutaneous)
CAS number
137525-51-0
Intermedin (Adrenomedullin-2)
Molecular formula
C15H25NO5 (precursor compound)
Molecular weight
299.36 g/mol (precursor)
Half-life
Approximately 2-6 hours (varies by route of administration)
Bioavailability
Varies by route of administration
CAS number
148498-78-6
Dosing compared
BPC-157
Subcutaneous
250 mcg
Once daily · 1-2 weeks
A common starting amount in research practice, often injected near the injured area. BPC-157 has no human dose-finding trials, so doses come from animal studies and documented practice [1][2].
250-500 mcg
Twice daily · 4-6 weeks
Commonly used range for tissue and tendon recovery in research practice [1][3].
500 mcg
Twice daily · 6-8 weeks
Upper end used in practice for more demanding acute injuries [1][3].
Intermedin (Adrenomedullin-2)
Best suited for
BPC-157
Tendon and ligament injuries
Sprains, strains, tears, tendinitis - BPC-157 accelerates collagen synthesis and tissue repair [1][7]
Gut healing
IBS, leaky gut, ulcers, inflammatory bowel conditions [1][11] - derived from gastric juice, it has a natural affinity for digestive tissue [3][5]
Muscle injuries
Strains, post-workout recovery, chronic muscle issues - promotes angiogenesis and growth factor expression [8]
Joint problems
Arthritis support, joint pain, cartilage issues - anti-inflammatory and regenerative properties [9][10]
Post-surgical recovery
Accelerating healing after procedures - works systemically to enhance the body's repair mechanisms [2]
Intermedin (Adrenomedullin-2)
Supporting cardiovascular health and heart function
Intermedin (Adrenomedullin-2) is particularly well-suited for individuals focused on supporting cardiovascular health and heart function. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Managing inflammation and oxidative stress
Intermedin (Adrenomedullin-2) is particularly well-suited for individuals focused on managing inflammation and oxidative stress. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Improving overall vascular health and circulation
Intermedin (Adrenomedullin-2) is particularly well-suited for individuals focused on improving overall vascular health and circulation. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Side effects
BPC-157
Common
- Injection site redness
- Mild nausea
- Dizziness
Uncommon
- Headache
- Fatigue
- Hot/cold sensations
Serious
- Allergic reaction
Intermedin (Adrenomedullin-2)
Common
- Mild discomfort at treatment site
- Flushing and mild facial redness
- Dizziness or lightheadedness
- Mild headache
- Injection site reactions (redness, itching, swelling)
- Nausea or mild gastrointestinal discomfort
- Fatigue or mild energy changes
- Transient hypotension (temporary low blood pressure)
- Mild palpitations (in some individuals)
Serious
- Severe allergic reaction
Safety & evidence
BPC-157
Evidence level
Strong preclinical (extensive animal studies)
FDA status
Research compound
Safety overview
BPC-157 is a gastric pentadecapeptide with strong preclinical evidence from extensive animal studies spanning over 25 years of research. Critical limitation: BPC-157 has NOT completed Phase 3 human clinical trials. [5] No FDA approval exists. [4][6] Safety data comes primarily from rat and mouse studies, with only limited Phase 1-2 human data. [4][5] Animal studies show no toxicity at therapeutic doses, but human data is insufficient for regulatory approval. [2][4] The peptide is unregulated, and no standardized manufacturing or quality control requirements exist for research compounds. [6][7] Individual responses may vary significantly, and serious medical supervision is essential before use, particularly if you have gastrointestinal conditions, take medications, or have pre-existing medical conditions.
Contraindications
- Pregnancy
- Breastfeeding
- Active cancer
- History of cancer
Intermedin (Adrenomedullin-2)
Evidence level
Limited human trials
FDA status
Not FDA approved
Safety overview
Intermedin (Adrenomedullin-2) is an endogenous peptide hormone with systemic vascular and renal effects that warrant cautious use. As a vasodilator acting through CGRP and other peptide receptors, it can significantly lower blood pressure—a key safety consideration for hypotensive or cardiovascular-compromised individuals. Preclinical studies show dose-dependent hypotensive effects and tachycardia, limiting clinical translation. The compound remains largely experimental with limited safety data in humans outside specific research contexts.
Contraindications
- Pregnancy and breastfeeding - insufficient safety data
- Active cardiovascular events (heart attack, stroke)
- Severe renal (kidney) impairment
- Hypersensitivity to calcitonin family peptides
- Uncontrolled endocrine disorders
Which is right for you?
Choose BPC-157 if...
- Injury recovery
- Post-surgery healing
- Chronic pain management
- Gut health
Choose Intermedin (Adrenomedullin-2) if...
- Supporting cardiovascular health and heart function
- Managing inflammation and oxidative stress
- Improving overall vascular health and circulation