Ipamorelin
Selective Growth Hormone Secretagogue (GHRP)
Ipamorelin is a selective growth hormone releasing peptide (GHRP) that specifically stimulates the release of growth hormone without affecting other hormones. Unlike other GHRPs, Ipamorelin does not increase cortisol, acetylcholine, prolactin, or aldosterone levels, making it the most selective and well-tolerated growth hormone secretagogue available for research and therapeutic applications.
Ipamorelin Dosing Guide
Primary Benefits
- Selective growth hormone secretagogue receptor activation
- Increased natural growth hormone production
- Enhanced IGF-1 levels and anabolic signaling
- Improved lean muscle mass development
- Enhanced fat loss and body composition
How It Works
Ipamorelin acts as a selective agonist of the growth hormone secretagogue receptor (GHSR-1a) located in the anterior pituitary gland. Upon binding, it stimulates the release of growth hormone through a G-protein coupled receptor mechanism, specifically activating the GHS-R1a subtype. Unlike other growth hormone releasing peptides, Ipamorelin demonstrates remarkable selectivity, stimulating GH release without affecting the secretion of ACTH, cortisol, prolactin, FSH, LH, or TSH. This selective action is attributed to its specific receptor binding profile and downstream signaling cascade.
Quick Reference
Typical Dosage Range
Initial dosing begins at 100 mcg once daily, typically administered in the evening to complement natural growth hormone pulsatile release. After 1-2 weeks of tolerance assessment, dosing can be increased to 100 mcg twice daily (morning and evening), and subsequently to 100 mcg three times daily (morning, post-workout, and bedtime) for a total daily dose of 300 mcg. Doses are administered via subcutaneous injection on an empty stomach for optimal absorption and GH release.
Administration Methods
Subcutaneous injection using insulin syringes (typically 0.5mL/1mL capacity with 29-31 gauge needles). Common injection sites include the abdominal area (2 inches from navel), anterior thigh, or deltoid region. Rotate injection sites to prevent lipodystrophy. Reconstitute lyophilized powder with bacteriostatic water (typical ratio: 2mL bacteriostatic water per 5mg vial). Store reconstituted solution refrigerated and use within 28 days.
What It's Used For
Ipamorelin is a selective growth hormone-releasing peptide (GHRP) that specifically stimulates the release of growth hormone without affecting other hormones. Unlike other GHRPs, Ipamorelin doesn't increase cortisol, acetylcholine, prolactin, or aldosterone levels, making it the most selective and well-tolerated growth hormone secretagogue available.
Muscle Growth & Recovery
Enhances muscle repair and promotes lean muscle mass growth through selective growth hormone stimulation.
Fat Loss Support
Increases metabolism and supports fat burning while preserving muscle tissue during cutting phases.
Sleep & Recovery
Promotes deeper, more restorative sleep for better recovery and enhanced performance.
Anti-Aging Benefits
Improves skin elasticity, boosts energy levels, and reduces visible signs of aging through natural GH enhancement.
How Much to Take
Beginner Dosing
• Timing: Evening before bed
• Duration: First 1-2 weeks
• Assessment: Monitor tolerance
Advanced Dosing
• Timing: Morning + before bed
• Maximum: 300 mcg three times daily
• Total daily: Up to 900 mcg
Best Times to Inject
• On an empty stomach
• Before bedtime
• Post-workout (optional)
Mixing Instructions
• 1mL water per 5mg vial
• Creates 5mg/mL solution
• 0.04mL = 200 mcg dose
Important Timing
• Wait 2-3 hours after eating
• Avoid food 30 min after
• Rotate injection sites
How Long to Use It
Recommended Cycle Length
Use Ipamorelin for 8-12 weeks for optimal results. This duration allows for significant improvements in body composition, recovery, and sleep quality without receptor desensitization.
• Standard cycle: 12 weeks for optimal results
• Break period: Take 2-4 weeks off between cycles
• Long-term use: Cycles can be repeated safely
Cycle Break Importance
Taking breaks between cycles helps maintain natural hormone production and prevents potential receptor downregulation. During breaks, focus on maintaining the lifestyle improvements gained during the cycle.
Need-to-Know Information
How It Works
Ipamorelin mimics the body's natural growth hormone-releasing hormone (GHRH), stimulating the pituitary gland to release growth hormone without affecting other hormones. This selective action means you get all the benefits of increased GH without the side effects like increased hunger, stress hormones, or prolactin elevation that other similar peptides cause.
Key Benefits
Muscle Growth
Helps build and repair lean muscle tissue through enhanced protein synthesis
Fat Loss
Promotes fat burning while preserving muscle mass during weight loss
Better Sleep
Encourages deeper, more restorative sleep for enhanced recovery
Anti-Aging
Improves skin texture, energy levels, and overall vitality
Who Should Avoid It
- Pregnant or breastfeeding individuals
- Those with active cancer or severe health conditions
- People with known growth hormone sensitivity
- Anyone under 18 years of age
Possible Side Effects
- Mild injection site reactions
- Temporary water retention
- Slight headaches or nausea (rare)
- Occasional dizziness (very rare)
Storage & Injection
Storage Requirements
• Mixed solution: Refrigerate at 2-8°C (36-46°F)
• Shelf life: Use within 30 days after mixing
• Protection: Keep away from heat and direct sunlight
Mixing Instructions
• Ratio: 1mL water per 5mg vial
• Method: Inject water slowly down vial wall
• Mixing: Swirl gently, don't shake vigorously
Injection Sites
• Upper thigh
• Upper arm
• Rotate sites regularly
Injection Method
• Pinch skin fold
• Insert at slight angle
• Inject slowly and steadily
Safety Tips
• Clean injection site first
• Dispose of needles safely
• Watch for reactions
Example Schedule
Daily Injection Schedule
Morning Dose (Optional)
Time: Upon waking, empty stomach
Dose: 200 mcg subcutaneous
Wait: 30 minutes before eating
Evening Dose (Primary)
Time: Before bed, empty stomach
Dose: 200-300 mcg subcutaneous
Timing: 2-3 hours after last meal
💡 Pro Tip: Timing is Everything
For best results, take Ipamorelin on an empty stomach. Wait at least 2-3 hours after your last meal, inject, then wait another 30 minutes before eating or drinking anything other than water.
What to Do If You Miss a Dose
- If remembered within 2 hours: Take the dose as soon as possible
- If close to next dose: Skip the missed dose and continue with regular schedule
- Never double dose: Don't take two doses at once to make up for a missed dose
- Consistency matters: Try to maintain regular timing for best results
Extra Tips for Best Results
Start Low & Adjust
Begin with 200 mcg once daily to assess tolerance, then gradually increase frequency and dose as needed for optimal results.
Optimize Nutrition
Combine with high-protein diet and strength training to maximize muscle growth and fat loss benefits from increased GH levels.
Monitor Sleep Quality
Track sleep patterns and energy levels to measure improvements. Ipamorelin often enhances sleep quality within the first week.
Stay Hydrated
Drink plenty of water to support recovery and help minimize any temporary water retention effects during initial weeks.
Expected Results Timeline
Week 1-2
Improved sleep quality, enhanced recovery, initial energy boost
Week 3-6
Visible body composition changes, increased muscle fullness, fat loss
Week 7-12
Peak benefits: significant muscle growth, improved skin quality, enhanced vitality
Important Reminders
- Research compound only - Not FDA-approved for human therapeutic use
- Start conservatively - Begin with lowest effective dose and assess tolerance
- Don't exceed recommendations - Higher doses won't necessarily mean faster results
- Track your progress - Keep a journal of muscle growth, fat loss, and recovery improvements
- Consider medical supervision - Especially if you have pre-existing health conditions
Medical Disclaimer
Ipamorelin is currently in research phase and is not FDA-approved for human therapeutic use. This information is for educational purposes only and should not replace consultation with healthcare providers. Individual results may vary. Medical supervision is recommended for all research applications.