Peptide Profile
Ipamorelin
A uniquely selective growth hormone booster that tells your pituitary to release more GH without messing with your cortisol or other hormones—making it the 'clean' choice among growth hormone peptides.
Dose Range
100-300mcg
Frequency
Multiple times daily
Route
Subcutaneous injection
Cycle Length
8-12 weeks
Onset
Moderate (1-2 weeks)
Evidence
Moderate
Compound Profile
Scientific & Efficacy Data
C38H49N9O5
Molecular Formula
711.85 g/mol
Molecular Weight
Developed By · 1998
Novo Nordisk Research Team
Novo Nordisk A/S (Denmark)
Primary Benefits
Unmatched selectivity—releases growth hormone without affecting cortisol, ACTH, or other hormones even at very high doses
Enhances workout recovery, sleep quality, and tissue repair through optimized natural GH release patterns
Well-tolerated in clinical trials with minimal side effects, making it suitable for longer-term use
Amino Acid Sequence
Aib-His-D-2-Nal-D-Phe-Lys-NH2Dosing
How much
do I take?
Starting Dose
100 mcg
Start low to assess your body's response. Inject on an empty stomach for best absorption. Many people start with just twice daily (morning and before bed) to keep things simple.
Standard Dose
200 mcg
The sweet spot for most users. Injecting 200 mcg three times daily (morning, post-workout, and bedtime) maximizes GH pulses throughout the day while staying well-tolerated.
Advanced Dose
300 mcg
Higher doses for those who've established tolerance. Some research used up to 1mg/kg, but most users find diminishing returns above 300 mcg per dose. Always combine with proper nutrition and training.
Timing
Best time to take
Inject on an empty stomach—ideally first thing in the morning, post-workout, and before bed. The bedtime dose aligns with your natural overnight GH surge. Wait at least 30 minutes before eating after injection.
With food?
Food, especially carbs and fats, can blunt the GH response. Always inject at least 30-60 minutes before meals or 2-3 hours after eating for best results.
If stacking
When pairing with CJC-1295, inject them together at the same time—they work synergistically. If using BPC-157 or TB-500 for healing, you can inject those at different sites or times.
Adjusting Your Dose
Increase if
- +You've used the starting dose for 2+ weeks with zero side effects
- +You're not noticing any changes in sleep, recovery, or body composition
- +You're stacking with a GHRH and want amplified effects
Decrease if
- -You experience persistent headaches that don't resolve
- -Water retention becomes uncomfortable
- -You notice tingling in hands that worsens (carpal tunnel signs)
- -Blood sugar becomes harder to control
Signs of right dose
- ✓Improved sleep quality—waking up more refreshed
- ✓Faster recovery between workouts
- ✓Gradual improvements in body composition (less fat, more muscle tone)
- ✓Better skin quality and overall sense of vitality
Dosing Calculator
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Suitability
Is this
right for me?
Best For
Clean GH Boost Seekers
If you want the benefits of increased growth hormone without spiking cortisol or other stress hormones, Ipamorelin is uniquely selective. Unlike GHRP-2 or GHRP-6, it won't raise your cortisol levels even at doses 200 times higher than needed for GH release.
Recovery-Focused Athletes
Ipamorelin shines for athletes who want better recovery between training sessions. The GH boost helps repair muscle tissue faster, and since it doesn't mess with other hormones, you can use it consistently without the rollercoaster effects.
Anti-Aging Enthusiasts
Growth hormone naturally declines as we age, contributing to muscle loss, fat gain, and reduced vitality. Ipamorelin offers a gentle way to restore more youthful GH levels without the risks of actual HGH therapy.
Those Recovering from Steroid Use
Research shows Ipamorelin can help counteract the muscle and bone-weakening effects of glucocorticoid medications. If you've been on steroids for medical reasons, this peptide may help you rebuild what you've lost.
Consider Alternatives If
Who Should Avoid
Do not use if
- ×You have active cancer or a history of cancer—GH can potentially fuel tumor growth
- ×You are pregnant or might become pregnant—effects on fetal development are unknown
- ×You are breastfeeding—peptide could potentially pass into breast milk
- ×You have a pituitary tumor or disorder—could worsen the condition
- ×You have uncontrolled diabetes—GH can affect blood sugar regulation
- ×You're under 18—growth plates are still active and shouldn't be manipulated
Use with caution if
- !You have diabetes or prediabetes—monitor blood sugar closely as GH affects glucose
- !You're on blood pressure medications—some users experience changes
- !You have carpal tunnel syndrome—GH can worsen symptoms temporarily
- !You take thyroid medications—GH may affect thyroid hormone conversion
- !You have a history of joint problems—GH can initially cause joint discomfort
- !You're over 65—start with lower doses and monitor carefully
Administration
How do I
use it?
Reconstitution
What you need
- •Bacteriostatic water (BAC water)—the preservative allows multiple uses
- •Insulin syringes (29-31 gauge, 0.5mL or 1mL)
- •Alcohol swabs for cleaning vial tops and injection sites
- •Your Ipamorelin powder vial (typically 2mg or 5mg)
Injection
Route
Subcutaneous injection (just under the skin)—quick, easy, and most effective for peptides like Ipamorelin
Best sites
- •Belly fat area (about 2 inches from your belly button)
- •Front or outer thigh (middle section)
- •Back of the upper arm (pinch the skin if needed)
Technique
- 1.Wash your hands thoroughly with soap and water
- 2.Clean the injection site with an alcohol swab and let it air dry
- 3.Pinch about an inch of skin to create a fold
- 4.Insert the needle at a 45-90 degree angle (45 for lean individuals, 90 if you have more tissue)
- 5.Push the plunger slowly and steadily over 5-10 seconds
- 6.Wait 5 seconds before removing the needle to ensure full delivery
- 7.Apply light pressure with a cotton ball if needed—don't rub the site
Storage
Signs of degradation
Sample Daily Schedule
Safety
Is it
safe?
Safety Profile
Ipamorelin has shown a favorable safety profile in both animal and human studies. What makes it stand out is its remarkable selectivity—it releases growth hormone without significantly affecting cortisol, ACTH, or other hormones. In clinical trials, it was well-tolerated with mostly mild, temporary side effects. Phase 2 trials in patients recovering from surgery showed no significant safety concerns compared to placebo.
Ipamorelin has been studied in multiple Phase 1 and Phase 2 human trials, giving it more clinical data than many peptides. The key 1998 study by Novo Nordisk demonstrated its unique selectivity, and subsequent trials in postoperative patients confirmed its safety profile. However, it remains a research compound without FDA approval.
Common Side Effects
Experienced by some users
Mild headache
Some users experience headaches in the first few days to weeks. This usually relates to your body adjusting to increased GH pulses.
Management: Stay well-hydrated, start with lower doses, and it typically resolves within the first 1-2 weeks.
Injection site reactions
Redness, minor swelling, or itching at the injection site is normal and harmless.
Management: Rotate injection sites between belly, thigh, and arm. A cool compress can help. Usually fades within hours.
Water retention
Mild bloating or puffiness, especially in the first few weeks. This is a known GH effect that usually stabilizes.
Management: Reduce sodium intake, stay hydrated, and give your body 2-3 weeks to adjust. Consider slightly lower doses if significant.
Increased appetite
Ipamorelin activates the ghrelin receptor, which can stimulate hunger—the same receptor that makes your stomach growl.
Management: Plan your meals around injection times. This effect can actually be useful if you're trying to gain muscle and need to eat more.
Less Common
- •Tingling in hands or feet
- •Joint stiffness
These typically resolve with continued use or dose adjustment.
Stop and Seek Help If
- ×Any signs of allergic reaction—stop immediately and seek medical help
- ×Persistent carpal tunnel symptoms that worsen despite dose reduction
- ×Significant joint pain that interferes with daily activities
- ×Blood sugar control becomes significantly harder to manage
- ×Unusual swelling that doesn't resolve with lower doses
- ×Any side effect that feels serious or really concerns you
Ipamorelin is a research compound, not an FDA-approved medication. Never start, stop, or change your dosing without guidance from a qualified healthcare provider. This information is for educational purposes only—not medical advice.
Interactions
With other peptides
- ✓Excellent synergistic pairing. CJC-1295 provides the GHRH signal while Ipamorelin amplifies it through the ghrelin receptor. Inject together for best results.
- ✓Another great pairing. Both stimulate GH but through different mechanisms, creating a more robust natural GH pulse.
- ✓Safe to combine for enhanced recovery. BPC-157 handles tissue repair while Ipamorelin boosts overall GH for systemic recovery.
- ✓Complementary for healing. Inject at different sites but can use on the same day.
- ✓Usually redundant since both hit the ghrelin receptor. Ipamorelin is preferred for its selectivity. Using both together is unnecessary.
With medications
- !Insulin - GH can affect insulin sensitivity. Diabetics need to monitor blood sugar closely and may need insulin adjustments. Consult your doctor.
- !Diabetes medications (metformin, etc.) - GH affects glucose metabolism. Monitor blood sugar more frequently and inform your doctor.
- ✓Thyroid medications - GH can affect T4 to T3 conversion. May need thyroid level monitoring if on thyroid replacement.
- ✓Glucocorticoids (prednisone, etc.) - Actually potentially beneficial—research shows Ipamorelin can help counter steroid-induced muscle and bone loss. Discuss with your doctor.
- ✓Blood pressure medications - Some users experience BP changes with GH peptides. Monitor blood pressure regularly.
With supplements
- ✓Arginine - Can enhance GH release when taken separately. Some people take arginine at different times to compound effects.
- ✓GABA - Safe to combine—GABA may support additional GH release, especially when taken before bed.
- ✓Melatonin - Safe and potentially synergistic for sleep quality and nighttime GH release.
- ✓High-dose glucose or carbs - Blood sugar spikes blunt GH release. Avoid carbs around injection times for best results.
Effectiveness
Does it
work?
Evidence Level
Moderate human trials
What to Expect
Week 1-2
What you might notice
- •Possibly better sleep quality, especially with the bedtime dose
- •Mild headache or injection site reactions (normal)
- •Slight increase in appetite
- •Some temporary water retention or bloating
What's normal
- •Adjusting to the injection routine
- •Minor side effects that resolve on their own
- •No dramatic visible changes yet
What's next
- →Continue consistent dosing timing
- →Track any effects in a simple log
- →Side effects typically improve by end of week 2
Week 3-4
What you might notice
- •More consistent, deeper sleep
- •Improved workout recovery—less soreness, faster bounce-back
- •Side effects usually stabilize or resolve
- •Possible subtle improvements in skin quality
What's normal
- •Starting to feel the benefits
- •Water retention typically stabilizes
- •Getting into a comfortable routine
What's next
- →Consider increasing dose if on starting protocol with no issues
- →Continue tracking progress
- →Focus on nutrition and training to maximize benefits
Week 5-8
What you might notice
- •Noticeable improvements in body composition with proper diet/training
- •Enhanced recovery becoming clearly apparent
- •Better energy and vitality
- •Improved skin elasticity and quality
- •Potential fat loss, especially with caloric deficit
What's normal
- •Steady, gradual improvements rather than dramatic changes
- •Benefits compound with consistent use
- •Most side effects resolved by now
What's next
- →Continue through 8-12 week cycle
- →Consider blood work to monitor IGF-1 and health markers
- →Plan your next cycle or maintenance approach
Week 9-12+
What you might notice
- •Peak benefits typically experienced
- •Significant improvements in lean mass and fat loss with proper training
- •Sustained energy and recovery improvements
- •Possible plateau as your body adapts
What's normal
- •Benefits stabilizing at their new baseline
- •Some people cycle off for 4-8 weeks, others continue
- •Considering whether to maintain, cycle off, or adjust
What's next
- →Evaluate results and decide on next steps
- →Some users take a 4-8 week break then resume
- →Others continue with maintenance dosing
Signs It's Working
Sleep and Recovery
- ✓Falling asleep more easily at night
- ✓Waking up feeling more refreshed and rested
- ✓Deeper, more restorative sleep
- ✓Faster recovery between workouts
- ✓Less muscle soreness after training
Body Composition
- ✓Gradual reduction in body fat, especially around the midsection
- ✓Improved muscle tone and definition
- ✓Better muscle pumps during workouts
- ✓Clothes fitting differently (tighter in good places, looser around waist)
Skin and Appearance
- ✓Improved skin elasticity and hydration
- ✓Reduction in fine lines over time
- ✓Healthier hair quality
- ✓Overall more youthful appearance
Lab Markers (if tested)
- ✓Elevated IGF-1 levels on blood work
- ✓Stable or improved lipid profiles
- ✓Maintained healthy blood sugar levels
Not Seeing Results?
Common reasons
- •Eating too close to injection—food, especially carbs, blunts GH release. Always inject fasted.
- •Inconsistent dosing schedule—GH peptides work best with consistent timing to establish rhythmic release
- •Poor quality peptide from unreliable source—always verify third-party testing certificates (COAs)
- •Improper storage degraded the peptide—check that solution is crystal clear before using
- •Unrealistic expectations—Ipamorelin provides gradual, natural improvements, not overnight transformations
- •Not supporting with proper nutrition and exercise—peptides enhance your lifestyle, they don't replace it
- •Blood sugar too high at injection time—insulin spikes inhibit GH release
Key Research
"Ipamorelin, the first selective growth hormone secretagogue"
Raun K, Hansen BS, Johansen NL, et al., 1998
Finding: This landmark study established Ipamorelin as uniquely selective among growth hormone peptides. Unlike GHRP-2 and GHRP-6, Ipamorelin released GH without raising cortisol or ACTH, even at doses over 200 times higher than needed for GH release. This selectivity makes it the 'cleanest' option for GH stimulation.
View Study"Pharmacokinetic-pharmacodynamic modeling of ipamorelin, a growth hormone releasing peptide, in human volunteers"
Gobburu JV, Agersø H, Jusko WJ, Ynddal L, 1999
Finding: This human clinical trial established Ipamorelin's pharmacokinetics—showing a 2-hour half-life, dose-proportional responses, and consistent GH release across all dose levels tested. The study provided the foundation for understanding proper human dosing.
View Study"Prospective, randomized, controlled, proof-of-concept study of the Ghrelin mimetic ipamorelin for the management of postoperative ileus in bowel resection patients"
Beck DE, Sweeney WB, McCarter MD, et al., 2014
Finding: This Phase 2 randomized controlled trial in 117 surgery patients showed Ipamorelin was well-tolerated with no significant safety concerns compared to placebo. Patients receiving Ipamorelin showed trends toward faster recovery, demonstrating its potential for post-surgical healing.
View Study"The growth hormone secretagogue ipamorelin counteracts glucocorticoid-induced decrease in bone formation of adult rats"
Andersen NB, Malmlöf K, Johansen PB, et al., 2001
Finding: This study showed Ipamorelin can counteract the muscle and bone damage caused by glucocorticoid (steroid) medications. Rats on steroids plus Ipamorelin had significantly increased muscle strength and four times greater bone formation compared to steroids alone.
View Study"Efficacy of ipamorelin, a novel ghrelin mimetic, in a rodent model of postoperative ileus"
Venkova K, Mann W, Nelson R, Greenwood-Van Meerveld B, 2009
Finding: Repeated Ipamorelin dosing significantly improved gut motility, food intake, and body weight recovery after surgery in rats. This supports its potential use for post-surgical recovery beyond just GH benefits.
View StudyFrequently Asked Questions