Pralmorelin (GHRP-2)

50-100 mcg

Begin conservatively to assess individual responsiveness and side effect tolerance. Administer subcutaneously in abdomen or thigh.

100-200 mcg

Most individuals find optimal response and tolerability in this range. Typical use case for GH axis stimulation and recovery support.

200-300 mcg

Higher doses used in intensive research or competitive athletic settings. Requires previous GHRP experience and close monitoring. Risk-benefit ratio increases.

Pralmorelin (GHRP-2) has been safely used in diagnostic settings in Japan for decades and is well-tolerated in most individuals when used at appropriate doses. The peptide is synthetic and chemically stable, with low immunogenicity risk. However, it is NOT FDA approved and should only be used under medical supervision or within research protocols. Long-term safety data in healthy humans is limited.

Most safety evidence comes from short-term diagnostic studies (single or few-dose protocols) and animal research. Long-term use in therapeutic dosing is not extensively studied in humans. Users should be aware they are using a research compound with limited long-term safety profiling.

Experienced by some users

• •Carpal tunnel-like sensations
• •Joint or muscle aches
• •Sleep quality changes

These typically resolve with continued use or dose adjustment.

Common reasons

• •{"problem":"No observable flush or GH response after injection","possible_causes":["Improper injection technique (too shallow, into muscle instead of fat)","Peptide degradation or poor quality formulation","Injection within 2 hours of eating (fed state blunts response)","Individual GH axis insensitivity (rare but possible—some people have naturally blunted GHRP responsiveness)","Inadequate reconstitution (incorrect mixing ratio leading to wrong concentration)"],"solutions":["Verify injection technique: Pinch skin fold, inject at 45-90° angle into fatty layer","Confirm peptide quality and proper storage conditions","Always inject on fasted stomach (2+ hours after eating)","Increase dose gradually (start at 100 mcg, move to 150-200 mcg if no response)","If still non-responsive after 1-2 weeks at higher doses, consider GHRH (CJC-1295) as alternative stimulus"]}
• •{"problem":"Excessive headaches or dizziness after each injection","possible_causes":["Dose too high for individual tolerance","Dehydration amplifying symptoms","Injection timing (too close to sleep or meals affects metabolism)","Blood pressure spike (check BP if available)","Anxiety or anticipatory response to injection"],"solutions":["Reduce dose by 25-50 mcg and reassess tolerance","Drink 16 oz water before injection and 16 oz after","Inject in early morning on empty stomach to minimize timing issues","If available, monitor blood pressure at baseline and post-injection","Practice calm injection technique; some side effects are psychosomatic"]}
• •{"problem":"Injection site becomes red, swollen, or painful (beyond minor soreness)","possible_causes":["Contaminated needle or peptide solution (bacterial infection)","Allergic reaction to peptide or bacteriostatic water","Injection into muscle instead of fat (causes inflammation)","Repeated injections into same area (tissue irritation buildup)","Poor injection technique (tissue trauma)"],"solutions":["STOP injections immediately if signs of infection (warmth, spreading redness, drainage)","Contact physician—infection risk is serious","Rotate injection sites: abdomen one day, thigh next day, arm day after (24-48 hour minimum between same site)","Use fresh alcohol swab for each injection; ensure clean technique","Switch to new batch of peptide if contamination suspected"]}
• •{"problem":"Little to no visible results after 4-6 weeks despite consistent dosing","possible_causes":["Inadequate training stimulus (GH amplifies effect of training, doesn't create it alone)","Poor nutrition (insufficient protein or calories to support muscle growth)","Insufficient sleep (GH is secreted during deep sleep; 7-9 hours needed)","Very low baseline GH axis responsiveness","Peptide concentration error during reconstitution (lower actual dose than intended)"],"solutions":["Verify training program is progressive resistance-based (peptide needs stimulus to work)","Audit nutrition: Minimum 0.8-1g protein per lb body weight daily","Prioritize sleep: 7-9 hours nightly, consistent bed times","Verify reconstitution math and concentration accuracy","Increase dose to 150-200 mcg if not already; if still no response, consider adding CJC-1295"]}
• •{"problem":"Appetite becomes unmanageably strong and interferes with diet","possible_causes":["GHRP-2 stimulates appetite (less than GHRP-6 but still significant for some)","Injection timing relative to meals (injecting before hunger window amplifies effect)","Individual is particularly sensitive to ghrelin (hunger hormone) stimulation","High dose is excessive for individual tolerance"],"solutions":["Inject immediately after finishing a meal (reduces hunger window impact)","Eat protein-rich snacks post-injection (prevents excessive hunger)","Reduce dose by 25-50 mcg","Switch to Ipamorelin if appetite control is critical priority","Plan meals ahead to maintain diet discipline despite increased appetite"]}
• •{"problem":"Inconsistent results—some injections produce obvious flush, others minimal response","possible_causes":["Variations in injection depth (fat layer depth differs by site)","Variations in stomach fullness at injection time (fed state blunts response)","Reconstituted solution degrading over weeks (older dilutions less potent)","Natural variation in GH axis responsiveness (body responds differently some days)"],"solutions":["Standardize injection sites and depth for consistency","Always inject on truly empty stomach (3+ hours since food)","Prepare fresh reconstituted batches weekly if possible (improves consistency)","Recognize some natural variation is normal; focus on overall trend not individual injections","If inconsistency is severe, verify peptide quality"]}