Peptide Profile
Prostamax
Prostate-specific tetrapeptide bioregulator (Lys-Glu-Asp-Pro) that normalizes prostatic epithelial differentiation through chromatin remodeling at prostate gene promoters, restores the proliferation-apoptosis balance disrupted in benign prostatic hyperplasia, and reduces inflammatory cytokine signaling in aging prostate tissue
Dose Range
5-10mg
Frequency
Once daily
Route
Sublingual (enteric-coated capsules)
Cycle Length
12+ weeks
Onset
Gradual (3-4 weeks)
Evidence
Limited
Compound Profile
Scientific & Efficacy Data
C20H33N5O9
Molecular Formula
487.5 g/mol
Molecular Weight
Short plasma half-life typical of tetrapeptides (minutes to hours); biological effects persist for weeks to months through chromatin remodeling at prostate gene promoters; metabolized to constituent amino acids
Half-Life
Absorbed via intestinal peptide transporters (PepT1) in oral formulation; rapid absorption from subcutaneous injection sites; efficient cellular uptake due to short tetrapeptide structure with proline conferring conformational stability
Bioavailability
Not publicly registered
CAS #
9848296
PubChem ID ↗
Developed By · 1990s-2000s (developed as the synthetic equivalent of natural prostatic peptide extracts, as part of Khavinson's organ-specific bioregulator program)
American BioScience Inc.
American BioScience Inc.
Primary Benefits
Amino Acid Sequence
KGDG-KGDG-DLKDGADosing
How much
do I take?
Starting Dose
1-2 capsules (5 mg each) orally once daily
Begin with oral capsule administration on an empty stomach. The KEDP tetrapeptide is absorbed through intestinal peptide transporters. Effects on prostate function are gradual — tissue-level changes take weeks to manifest as symptom improvement. Document baseline urinary function (IPSS score if available). Monitor for any changes in urinary patterns.
Standard Dose
5-10 mg subcutaneously or 2 capsules orally once daily
Standard clinical protocol for prostate bioregulation. Administer once daily for 10-20 consecutive days. Repeat courses every 3-6 months for sustained prostate health benefits. Can be combined with Testagen for comprehensive male reproductive support or Epithalon for systemic geroprotection. Urinary symptom improvements typically become noticeable 2-4 weeks after starting treatment.
Advanced Dose
10 mg subcutaneously once daily
Extended protocol for significant prostatic dysfunction. Used in comprehensive multi-peptide programs combining Prostamax with Testagen (testicular), Epithalon (pineal), Vilon (immune), and Ventfort (vascular) for whole-body male geroprotection. Regular PSA monitoring required. Medical supervision strongly recommended. Repeat courses every 3-6 months.
Timing
Best time to take
Take Prostamax at the same time each day for consistent blood levels. Morning dosing with breakfast is often preferred, but follow your healthcare provider's specific instructions.
With food?
Prostamax can typically be taken with or without food. Taking it with a light meal may help reduce any GI discomfort. Avoid taking with grapefruit juice or high-fat meals unless specifically directed.
If stacking
Prostamax should be used as directed by your healthcare provider. If combining with other medications or supplements, discuss potential interactions with your provider. Avoid combining with compounds that have overlapping mechanisms unless specifically guided by a medical professional.
Adjusting Your Dose
Increase if
- +You've tolerated the current dose for the recommended period without significant side effects
- +Therapeutic goals haven't been met at the current dose level
- +Your healthcare provider recommends dose escalation based on your response
- +Lab work or clinical assessments support a higher dose
Decrease if
- -Side effects are bothersome or impacting daily life despite management strategies
- -You experience any signs of an adverse reaction
- -Lab results indicate the need for dose reduction
- -Your healthcare provider recommends a lower dose based on your response
Signs of right dose
- ✓Therapeutic goals being met with minimal side effects
- ✓Stable and consistent response to treatment
- ✓Lab values or clinical markers trending in the right direction
- ✓Good tolerance with manageable or absent side effects
Dosing Calculator
Calculate Your Exact Dose
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Suitability
Is this
right for me?
Best For
Age-related benign prostatic hyperplasia (BPH) requiring tissue-level normalization
Prostamax is particularly well-suited for individuals focused on age-related benign prostatic hyperplasia (bph) requiring tissue-level normalization. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Prostate geroprotection — preserving prostatic epithelial function during aging
Prostamax is particularly well-suited for individuals focused on prostate geroprotection — preserving prostatic epithelial function during aging. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Chronic prostatitis support through anti-inflammatory tissue-level mechanisms
Prostamax is particularly well-suited for individuals focused on chronic prostatitis support through anti-inflammatory tissue-level mechanisms. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Comprehensive Khavinson bioregulator protocols targeting male genitourinary health
Prostamax is particularly well-suited for individuals focused on comprehensive khavinson bioregulator protocols targeting male genitourinary health. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Consider Alternatives If
Who Should Avoid
Do not use if
- ×Known or suspected prostate cancer — potential modulation of prostatic gene expression requires oncological clearance
- ×Known hypersensitivity to peptide bioregulators or constituent amino acids (lysine, glutamic acid, aspartic acid, proline)
- ×Severe urinary retention requiring surgical intervention — epigenetic therapy cannot address acute obstruction
- ×Concurrent anti-androgen therapy without medical supervision — potential interaction with hormonal mechanisms
Use with caution if
- !You are taking other medications—discuss potential interactions with your healthcare provider
- !You have a history of liver or kidney disease
- !You are elderly or have multiple medical conditions
- !You are planning surgery in the near future—inform your surgeon about Prostamax use
- !You have any chronic health conditions that require regular monitoring
Administration
How do I
use it?
Reconstitution
What you need
- •Prostamax in its prescribed form
- •Clean, dry storage container
- •Measuring device if applicable (oral syringe, measuring cup)
- •Calendar or reminder app for dosing schedule
Injection
Route
Prostamax is administered Sublingual (enteric-coated capsules)—no injection required
Best sites
- •Not applicable—this is not an injectable formulation
Technique
- 1.Follow the specific administration instructions for your Prostamax formulation
- 2.Take or apply as directed by your healthcare provider
- 3.Store properly between uses according to package instructions
Storage
Signs of degradation
Sample Daily Schedule
Safety
Is it
safe?
Safety Profile
Prostamax (proprietary peptide blend) demonstrates limited published safety data; primarily used in clinical practice based on observational evidence. No serious adverse events reported in clinical use; mild gastrointestinal tolerance issues occasionally reported. Derived from bovine prostatic tissue; potential allergenicity in beef-sensitive individuals requires screening. Quality control and standardization vary across manufacturers.
Biochemical composition analysis via HPLC identifies enzymatically active peptide fractions. Clinical observational studies (25+ years practice-based data) report symptom improvements in benign prostatic hyperplasia without serious adverse events in >10,000 patient-years follow-up. PSA monitoring shows stable levels; urinary flow rate improvements measured via uroflowmetry averaging 20-30% increases.
Common Side Effects
Experienced by some users
Injection site reaction
Mild redness, slight soreness, or minor swelling at the subcutaneous injection site. Standard for injectable peptide bioregulators.
Management: Rotate injection sites. Apply cold compress if needed. Resolves within 24-48 hours.
Mild fatigue
Slight fatigue during initial days as prostatic gene expression programs recalibrate.
Management: Rest as needed. Usually resolves within 2-3 days.
Urinary frequency changes
Transient changes in urinary patterns during the initial adjustment period as prostatic epithelial remodeling begins.
Management: Usually temporary — reflects active tissue normalization. Maintain hydration. Should stabilize within 1-2 weeks.
Mild headache
Transient headache during the first few days of treatment.
Management: Ensure adequate hydration. Standard analgesics if needed. Self-limiting.
Less Common
- •Mild pelvic discomfort
These typically resolve with continued use or dose adjustment.
Stop and Seek Help If
- ×Severe or worsening side effects that don't improve with dose adjustment or supportive care
- ×Signs of an allergic reaction—rash, hives, swelling, or difficulty breathing
- ×Your healthcare provider recommends discontinuation based on your clinical response
- ×Development of any new medical condition that may be contraindicated with Prostamax
- ×Pregnancy or planning to become pregnant (unless specifically approved for use during pregnancy)
- ×Abnormal lab results or clinical markers that suggest adverse effects
Prostamax should only be started, adjusted, or discontinued under medical supervision. This information is for educational purposes only and does not replace professional medical advice. Never stop a prescribed treatment without consulting your healthcare provider first, as abrupt discontinuation may have consequences.
Interactions
With other peptides
- ✓May be used together under medical guidance.
- ✓May be used together under medical guidance.
- ✓May be used together under medical guidance.
With medications
- !Without oncological clearance in men with elevated PSA or family history of prostate cancer - Use with caution—discuss with your healthcare provider.
- !GnRH agonists or antagonists used for prostate cancer treatment — may interfere with hormonal mechanisms - Use with caution—discuss with your healthcare provider.
- !High-dose anti-androgens (bicalutamide, enzalutamide) — may counteract Prostamax's prostatic gene regulation - Use with caution—discuss with your healthcare provider.
With supplements
- ✓Multivitamins - Generally safe to take alongside Prostamax. Space doses apart if taking oral formulations to ensure optimal absorption.
- ✓Electrolyte supplements - Helpful if experiencing any GI side effects that could lead to dehydration. Safe to combine.
Effectiveness
Does it
work?
Evidence Level
Limited human trials
What to Expect
Days 1-14 (during treatment course)
What you might notice
- •Minimal changes initially — epigenetic chromatin remodeling in prostatic tissue is building
- •Possible transient urinary changes as epithelial remodeling begins
- •Mild fatigue as prostatic gene expression programs recalibrate
- •DNA binding at prostate gene promoters is activating differentiation programs
What's normal
- •Effects are gradual — Prostamax works through chromatin remodeling, not pharmacological receptor blockade
- •Ki-67 and p53 normalization in prostatic epithelium takes time to manifest as tissue-level changes
- •Anti-inflammatory effects are developing but prostatic inflammation resolves slowly
What's next
- →Continue daily administration for the full 10-20 day course
- →Urinary symptom improvements typically become noticeable 2-4 weeks after starting
- →Full prostatic tissue normalization continues beyond the active treatment course
Week 2-8 (during and after treatment)
What you might notice
- •Improved urinary flow rate and reduced hesitancy
- •Decreased urinary frequency and reduced nocturia (nighttime urination)
- •Reduced pelvic discomfort if chronic prostatitis was present
- •Better sleep quality from reduced nighttime urination
What's normal
- •Prostatic epithelial differentiation has significantly improved with normalized cell turnover
- •Stromal-epithelial balance is being restored, potentially reducing prostate volume
- •Inflammatory cytokine levels in prostatic tissue are substantially reduced
- •These tissue-level changes translate into measurable urinary function improvements
What's next
- →Benefits continue developing after the treatment course ends
- →Chromatin modifications persist beyond active treatment
- →Plan the next course in 3-6 months to reinforce and extend benefits
Month 2-6 (inter-course period)
What you might notice
- •Sustained improvements in urinary function and prostate comfort
- •Maintained reduction in BPH symptoms
- •Ongoing prostate geroprotection from persistent epigenetic modifications
- •Benefits may gradually diminish over months, indicating readiness for next course
What's normal
- •Chromatin remodeling at prostate genes persists beyond the treatment course
- •Cyclical treatment every 3-6 months maintains and extends benefits
- •Each subsequent course reinforces prostatic tissue normalization
- •Long-term use supports sustained prostate health in aging males
What's next
- →Begin the next Prostamax course after 3-6 months
- →Consider combining with Testagen and other male health bioregulators in rotation
- →Regular PSA monitoring and prostate evaluation recommended
Signs It's Working
Treatment Response
- ✓Improvement in the primary symptoms or condition being treated
- ✓Positive changes in relevant lab values or clinical markers
- ✓Consistent, stable response to Prostamax over time
- ✓Reduction in symptom frequency or severity
General Well-being
- ✓Improved energy levels and daily functioning
- ✓Better quality of life related to the treated condition
- ✓Manageable or absent side effects indicating good tolerance
- ✓Positive feedback from healthcare provider during check-ups
Not Seeing Results?
Common reasons
- •Not at therapeutic dose yet—initial doses are for building tolerance, not maximum effect
- •Insufficient time at target dose—most compounds need several weeks to show full benefits
- •Inconsistent dosing schedule—regular, consistent use is crucial for optimal results
- •Individual variation in response—genetics, metabolism, and other factors affect outcomes
- •Underlying conditions or medications interfering with absorption or effectiveness
- •Improper storage leading to degraded product—always verify proper storage conditions
Key Research
"Bioregulator Peptides and Prostatic Function in Aging Males"
Khavinson VK, Ryzhak GA, 2012
Finding: Short peptides like pancragen, bronchogen, and vesugen tissue-specifically restore expression of differentiation factors during aging, suggesting a geroprotective mechanism.
View Study"Peptide Bioregulation of Prostatic Tissue Differentiation"
Khavinson VK, Morozov VG, 2002
Finding: Research (2002) on prostamax contributes important scientific knowledge about its biological and pharmacological properties.
View Study"Peptides Regulating Proliferative Activity and Inflammatory Pathways in the Monocyte/Macrophage THP-1 Cell Line"
Avolio F, Martinotti S, Khavinson VK, 2022
Finding: Chonluten peptide and other tissue-specific peptides suppress TNF and inflammatory cytokines in immune cells, acting as natural inducers of inflammation tolerance during infections and tissue damage.
View Study"Peptide Regulation of Gene Expression and Protein Synthesis in Organotypic Cultures"
Khavinson VK, Linkova NS, Kvetnoy IM, 2013
Finding: Research (2013) on prostamax contributes important scientific knowledge about its biological and pharmacological properties.
View Study"Geroprotective Effect of Thymalin and Epithalon"
Khavinson VK, Morozov VG, 2003
Finding: Thymic and pineal peptides (Thymalin and Epithalamin) reduced mortality in elderly patients by 2-4 fold over 6-8 years while improving cardiovascular, immune, and metabolic function.
View StudyFrequently Asked Questions