Peptide Profile
BPC-157
The "Wolverine peptide" known for its remarkable healing properties across tendons, ligaments, muscles, and the gut.
Dose Range
250-500mcg
Frequency
Once daily
Route
Subcutaneous injection
Cycle Length
4-6 weeks
Onset
Moderate (1-2 weeks)
Evidence
Strong
Compound Profile
Scientific & Efficacy Data
C62H98N16O22
Molecular Formula
1419.53 g/mol
Molecular Weight
Developed By · 1992
Predrag Sikirić
University of Zagreb
Primary Benefits
Amino Acid Sequence
Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-ValDosing
How much
do I take?
Starting Dose
250 mcg
Start here to assess tolerance. Can split into AM/PM if preferred.
Standard Dose
250-500 mcg
Most common protocol. Split doses morning and evening for best results.
Advanced Dose
500 mcg
For experienced users or severe injuries. Higher doses not shown to improve outcomes significantly.
Timing
Best time to take
Morning and evening, consistent times each day
With food?
Can be taken with or without food
If stacking
Can be taken same time as TB-500 or other peptides
Adjusting Your Dose
Increase if
- +No response after 2 weeks
- +Tolerating well but minimal improvement
Decrease if
- -Experiencing side effects
- -Rapid improvement (maintenance)
Signs of right dose
- ✓Steady improvement
- ✓No significant side effects
- ✓Sustainable long-term
Dosing Calculator
Calculate Your Exact Dose
Amount to Draw
10
units
Suitability
Is this
right for me?
Best For
Tendon and ligament injuries
Sprains, strains, tears, tendinitis - BPC-157 accelerates collagen synthesis and tissue repair
Gut healing
IBS, leaky gut, ulcers, inflammatory bowel conditions - derived from gastric juice, it has a natural affinity for digestive tissue
Muscle injuries
Strains, post-workout recovery, chronic muscle issues - promotes angiogenesis and growth factor expression
Joint problems
Arthritis support, joint pain, cartilage issues - anti-inflammatory and regenerative properties
Post-surgical recovery
Accelerating healing after procedures - works systemically to enhance the body's repair mechanisms
Consider Alternatives If
Who Should Avoid
Do not use if
- ×Pregnant or breastfeeding
- ×Active cancer or history of cancer (promotes blood vessel growth)
- ×Allergy to peptides
Use with caution if
- !Taking blood thinners
- !Scheduled for surgery
- !Under 18 years old
Administration
How do I
use it?
Reconstitution
What you need
- •Bacteriostatic water (BAC)
- •Insulin syringe (29-31 gauge)
- •Alcohol swabs
Injection
Route
Subcutaneous (under the skin)
Best sites
- •Near injury (for localized healing)
- •Abdomen (for gut issues or systemic use)
- •Thigh or upper arm (alternative)
Technique
- 1.Clean site with alcohol
- 2.Pinch skin, insert at 45°
- 3.Inject slowly
- 4.Rotate sites to prevent irritation
Storage
Signs of degradation
Sample Daily Schedule
Safety
Is it
safe?
Safety Profile
BPC-157 has an excellent safety profile in research. Most users experience no side effects. When side effects occur, they're typically mild and resolve on their own.
Evidence: 100+ preclinical studies with no significant toxicity findings at therapeutic doses.
Common Side Effects
Experienced by some users
Injection site redness
Usually resolves in 30-60 minutes
Management: Rotate sites, ice if needed
Mild nausea
Typically only first few doses
Management: Take with food, reduce dose temporarily
Dizziness
Rare, usually with higher doses
Management: Reduce dose, stay hydrated
Less Common
- •Headache
- •Fatigue
- •Hot/cold sensations
These typically resolve with continued use or dose adjustment.
Stop and Seek Help If
- ×Severe allergic reaction (swelling, difficulty breathing)
- ×Persistent nausea or vomiting that doesn't improve
- ×Unusual pain at injection site (signs of infection)
- ×Any symptom that concerns you
When in doubt, stop and consult a healthcare provider.
Interactions
With other peptides
- ✓Safe to combine - synergistic healing effects
- ✓Safe to combine
- ✓No known conflicts
With medications
- !Blood thinners - Caution - may enhance effects
- !NSAIDs - May reduce effectiveness (avoid ibuprofen, aspirin when possible)
With supplements
- ✓Collagen - Pairs well for healing support
- ✓Zinc - Pairs well for healing support
- ✓Vitamin C - Pairs well for healing support
Effectiveness
Does it
work?
Evidence Level
Strong preclinical
What to Expect
Week 1-2
What you might notice
- •Reduced inflammation
- •Less pain at injury site
- •Improved gut comfort (if used for digestive issues)
What's normal
- •Subtle changes—don't expect dramatic results yet
- •Some users feel nothing this early
What's next
- →Continue protocol
- →Maintain consistent timing
Week 3-4
What you might notice
- •Noticeable improvement in injury healing
- •Increased mobility
- •Better function in affected area
- •Significant gut symptom relief
What's normal
- •This is when most users see clear benefits
- •Progress may be gradual, not sudden
What's next
- →Assess if dose adjustment needed
- →Continue if seeing progress
Week 5-6+
What you might notice
- •Substantial or complete healing
- •Return to normal activity
- •Lasting improvements
What's normal
- •Healing timeline varies by injury severity
- •Some chronic conditions need longer
What's next
- →Consider stopping if healed
- →Take 2-4 week break
- →Can restart if needed
Signs It's Working
For injuries
- ✓Less pain at rest
- ✓Less pain with movement
- ✓Improved range of motion
- ✓Faster recovery between workouts
- ✓Reduced swelling
For gut issues
- ✓Less bloating
- ✓Reduced pain after eating
- ✓More regular digestion
- ✓Decreased symptoms overall
Not Seeing Results?
Common reasons
- •Dose too low—try increasing
- •Not enough time—give it 4 weeks minimum
- •Product quality issues—ensure reputable source
- •Injury may require additional treatment beyond peptides
Key Research
"BPC 157 and its role in healing"
Sikiric et al., 2018
Finding: Demonstrated healing across multiple tissue types including tendon, ligament, muscle, and gut lining with no observed toxicity.
View Study"Gastric pentadecapeptide BPC 157 and wound healing"
Seiwerth et al., 2014
Finding: Accelerated wound closure and tissue regeneration in multiple animal models.
View Study"Effect of BPC 157 on tendon healing"
Chang et al., 2011
Finding: Significantly improved tendon-to-bone healing in rat rotator cuff model.
View StudyFrequently Asked Questions