Peptide Profile
Alexamorelin
A next-generation growth hormone releaser that converts to hexarelin in your body for enhanced GH, cortisol, and unique aldosterone stimulation.
Dose Range
100-300mcg
Frequency
Multiple times daily
Route
Subcutaneous injection
Cycle Length
4-6 weeks
Onset
Moderate (1-2 weeks)
Evidence
Limited
Compound Profile
Scientific & Efficacy Data
C50H63N13O7
Molecular Formula
958.1 g/mol
Molecular Weight
Estimated 1-3 hours (rapidly metabolized to hexarelin)
Half-Life
Active IV and orally; subcutaneous bioavailability expected moderate to good
Bioavailability
196808-85-2
CAS #
10011122
PubChem ID ↗
Developed By · 1998
Romano Deghenghi
Europeptides / University of Turin
Primary Benefits
Alexamorelin ranks among the most potent GHS compounds for stimulating growth hormone secretion, matching hexarelin's proven efficacy while potentially offering faster initial response due to unique ACTH pathway activation.
Beyond GH, alexamorelin's stronger ACTH release and unique aldosterone elevation provide comprehensive endocrine system stimulation, though this requires careful monitoring of cortisol and sodium balance.
As a cutting-edge GHS with demonstrated prodrug metabolism and novel receptor selectivity, alexamorelin appeals to peptide researchers and advanced users exploring next-generation growth hormone secretagogues.
Amino Acid Sequence
Ala-His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2Dosing
How much
do I take?
Timing
Best time to take
Morning injection on empty stomach 30-60 minutes before food maximizes GH response; second dose in late afternoon if dosing twice daily
With food?
Separate from large meals by at least 30-60 minutes; food delays or blunts response. Light snack acceptable 2+ hours after injection
If stacking
If stacking with GHRH, inject GHRH 5-10 minutes after alexamorelin for synergistic effect. Avoid other GHS compounds on same day
Adjusting Your Dose
Increase if
- +No noticeable GH response after 5-7 days at starting dose
- +Already using similar compounds and tolerated well
- +Aiming for aggressive muscle-building phase with recovery capacity
Decrease if
- -Excessive hunger interferes with daily life
- -ACTH-related side effects (anxiety, mood changes) emerge
- -Water retention becomes problematic
Signs of right dose
- ✓Increased appetite 1-2 hours post-injection
- ✓Noticeable energy lift and improved sleep quality
- ✓Visible muscle pump and recovery improvement within 1-2 weeks
Dosing Calculator
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Suitability
Is this
right for me?
Best For
Muscle Builders and Athletes
Alexamorelin's potent GH release makes it ideal for those serious about muscle gains. Its stronger ACTH response compared to hexarelin provides additional recovery benefits, though the cortisol elevation requires monitoring. The oral option is convenient for athletes avoiding injections, though subcutaneous injection remains most practical.
Research-Focused Peptide Users
If you're exploring next-generation GHS compounds, alexamorelin offers a fascinating case study: it's a prodrug that becomes hexarelin in your body, offering a unique window into peptide metabolism. This makes it valuable for understanding how compound modifications affect potency and half-life.
Synergistic Stack Enthusiasts
Alexamorelin shines when stacked with GHRH, creating synergistic GH release that exceeds either alone. It also pairs well with recovery-focused peptides like BPC-157, making it the centerpiece of comprehensive growth protocols.
Consider Alternatives If
Who Should Avoid
Do not use if
- ×You have active cancer or recent malignancy history
- ×Uncontrolled high blood pressure or cardiovascular disease
- ×Severe diabetes or glucose control issues
- ×You're pregnant, nursing, or attempting to conceive
- ×You have cortisol-sensitive conditions (some mood disorders, immune issues)
- ×Allergic to any peptide or amino acid component
Use with caution if
- !History of anxiety or mood disorders (ACTH elevation may amplify)
- !Hypertension or cardiovascular risk factors
- !Diabetes or metabolic syndrome (increases cortisol and blood sugar)
- !Sleep apnea (GH stimulation may worsen)
- !Water retention issues (aldosterone elevation)
- !On medications affecting cortisol or sodium balance
Administration
How do I
use it?
Reconstitution
What you need
- •Bacteriostatic water or normal saline (typically 1-2 mL per vial)
- •Sterile syringe and needle (25-27 gauge preferred)
- •Alcohol swabs for vial sterilization
- •Sterile vial for storage
Injection
Route
Subcutaneous injection preferred for consistent GH response; intravenous only in clinical/research settings
Best sites
- •Lower abdomen (2 inches from navel, avoiding surrounding area)
- •Upper thigh or lateral thigh
- •Lateral chest wall above waist
- •Upper arm outer tricep area
Technique
- 1.Clean injection site with alcohol swab and let dry 10-15 seconds
- 2.Pinch skin at injection site to create small fold
- 3.Insert needle at 45-90 degree angle (steeper = more subcutaneous, shallower = easier)
- 4.Push plunger slowly to minimize discomfort and ensure proper dispersion
- 5.Withdraw needle, release skin, and apply gentle pressure for 5 seconds
Storage
Signs of degradation
Sample Daily Schedule
Safety
Is it
safe?
Safety Profile
Alexamorelin is a research compound with only one small human study (6 subjects), making it much less proven than hexarelin. While it shows promise as a potent GH releaser, the limited human evidence means we don't fully understand long-term effects, optimal dosing in different populations, or rare side effects. Its unique stronger ACTH and aldosterone effects require careful monitoring. Always start low and monitor how your body responds.
This compound has NOT been approved by the FDA and is not available as a pharmaceutical medication. All use is research-based. The single human study was published in 2000 (Eur J Endocrinol), providing our only direct human efficacy data.
Common Side Effects
Experienced by some users
Increased Hunger
Ghrelin receptor activation stimulates appetite, typically 1-3 hours post-injection. Most users report mild to moderate increase.
Management: Time injections around normal meal times or plan snacks accordingly. This side effect usually decreases after 1-2 weeks as your body adapts.
Water Retention
Aldosterone elevation causes sodium and water retention, usually mild to moderate. Can manifest as slight bloating or puffy face.
Management: Maintain hydration and moderate sodium intake. If severe, reduce dose or frequency. Usually resolves within days of stopping.
Injection Site Reactions
Mild redness, itching, or small lumps at injection site. Normal immune response to foreign peptide.
Management: Rotate injection sites to prevent irritation. Use proper sterile technique. Reactions typically fade within hours to days.
Less Common
- •Cortisol-Related Mood Changes
- •Joint or Muscle Aches
These typically resolve with continued use or dose adjustment.
Stop and Seek Help If
- ×Severe mood changes or anxiety that don't improve with dose adjustment
- ×Signs of cardiovascular stress (chest pain, irregular heartbeat, severe headaches)
- ×Uncontrolled blood sugar elevation or worsening of diabetes
- ×Persistent allergic reactions or injection site infections
- ×Completion of planned 4-6 week cycle (take break before restarting)
- ×New or worsening joint problems that limit training
This is research compound information, not medical advice. Consult a healthcare provider before starting, especially if you have existing health conditions. Stop immediately if you experience serious side effects and seek medical attention.
Interactions
With other peptides
- ✓Synergistic GH release; inject GHRH 5-10 minutes after alexamorelin for maximum effect
- !Redundant since alexamorelin metabolizes to hexarelin; combining offers no additional benefit and increases side effects
- ✓Complementary for recovery; IGF-1 amplifies growth signaling without competing with alexamorelin's GHS mechanism
- ✓Synergistic for tissue repair; alexamorelin provides systemic GH while BPC-157 targets local healing
With medications
- !Corticosteroids (prednisone, dexamethasone, etc.) - Alexamorelin already elevates cortisol through ACTH; combining risks excessive cortisol with serious metabolic effects
- !Dopamine antagonists (antipsychotics like haloperidol) - May reduce GH response; dopamine pathways influence GHS effectiveness
- !Somatostatin analogs (octreotide) - Directly block GH secretion, completely negating alexamorelin's mechanism
- !Blood pressure medications - Monitor closely; aldosterone elevation may reduce antihypertensive effectiveness
With supplements
- ✓GHRH-boosting supplements (arginine, ornithine) - Synergistic but additive ACTH response; monitor cortisol effects carefully
- ✓High-dose electrolyte supplements (sodium, potassium) - Aldosterone elevation already increases sodium retention; excess supplementation risks dangerous electrolyte imbalance
- ✓Sleep aids or melatonin - Compatible; actually beneficial since quality sleep amplifies GH response
Effectiveness
Does it
work?
Evidence Level
Limited human trials
What to Expect
Week 1
What you might notice
- •Increased appetite starting within hours of first injection
- •Mild energy boost or slight euphoria
- •Possible sleep improvement quality
What's normal
- •Slight injection site redness
- •Mild water retention starting day 2-3
- •No dramatic strength gains yet (GH takes time)
What's next
- →Assess tolerance and adjust dose if needed
- →Expect GH response to solidify by day 5-7
- →Monitor mood for any ACTH-related effects
Week 2-3
What you might notice
- •Noticeable strength and endurance improvements in training
- •Better sleep quality and faster recovery from workouts
- •Increased hunger remains consistent
- •Possible subtle changes in body composition
What's normal
- •Continued mild appetite increase
- •Slight water retention (usually manageable)
- •Increased energy and focus
What's next
- →Body adapting well; continue current dose unless issues emerge
- →Notice baseline improvements in recovery before dramatic changes
- →Strength gains accelerate as GH accumulates
Week 4-6
What you might notice
- •Visible improvement in muscle definition and recovery
- •Significant strength increases compared to baseline
- •Noticeably improved body composition
- •Better joint health and reduced injury risk
What's normal
- •Appetite elevation remains stable or slightly decreases
- •Water retention may decrease as body adapts
- •Energy remains high throughout day
What's next
- →As cycle ends (4-6 weeks), plan 4-week break before restarting
- →Document progress to track long-term changes
- →Consider stacking with other compounds for next cycle if desired
Signs It's Working
Performance
- ✓Increased bench press, squat, or deadlift maxes by 10-15 lbs within 3-4 weeks
- ✓Ability to perform extra reps at same weight
- ✓Improved workout endurance and reduced mid-set fatigue
Recovery
- ✓Reduced muscle soreness 24-48 hours after training
- ✓Faster recovery between intense sessions
- ✓Ability to train hard 6-7 days weekly without overtraining
Body Composition
- ✓Leaner appearance despite no diet change
- ✓Increased muscle definition, especially in abs and shoulders
- ✓Visual circumference increase in arms, legs, or chest
Not Seeing Results?
Common reasons
- •No GH response or weak response: Check injection technique (may not be truly subcutaneous), verify reconstitution accuracy, ensure adequate sleep and nutrition to support response, or consider dose too low
- •Excessive side effects early: Dose likely too high for your sensitivity; reduce to 50-100 mcg and titrate up slowly over 1-2 weeks
- •Cortisol-related anxiety or mood: Unique stronger ACTH effect of alexamorelin vs hexarelin; lower dose, reduce frequency, or switch to hexarelin if side effect persists
- •Minimal strength gains despite good GH response: Often training or nutrition limitation, not compound failure; increase protein to 0.8-1g per lb bodyweight and ensure progressive overload in workouts
- •Water retention too severe: Usually from combined effect of GH (sodium retention) and aldosterone (enhanced by alexamorelin); reduce sodium intake and ensure adequate potassium, or lower dose
- •Injection site swelling or inflammation: Poor sterile technique or sensitivity to peptide; improve injection hygiene, rotate sites more frequently, or apply ice after injection
Key Research
"Endocrine activities of alexamorelin (Ala-His-d-2-methyl-Trp-Ala-Trp-d-Phe-Lys-NH2), a synthetic GH secretagogue, in humans"
Broglio F, Benso A, Gottero C, et al., 2000
Finding: In 6 young healthy subjects, alexamorelin showed identical GH-releasing potency to hexarelin at both IV doses (1.0 and 2.0 mcg/kg). Remarkably, alexamorelin demonstrated stronger ACTH-releasing activity than hexarelin and uniquely elevated aldosterone levels that hexarelin did not trigger. At oral 20mg dose, alexamorelin produced GH release comparable to or exceeding the same oral hexarelin dose.
View Study"Identification of alexamorelin consumption biomarkers using human hepatocyte incubations and high-resolution mass spectrometry"
Pobee E, Daziani G, Gameli PS, 2025
Finding: Alexamorelin undergoes rapid hepatic metabolism with approximately 150-fold signal decrease after just 3 hours in human hepatocyte studies. The primary metabolite formed is examorelin (hexarelin), created through C-terminal cleavage of the alanine amino acid by carboxypeptidase enzyme. This demonstrates alexamorelin functions as a prodrug that effectively converts to hexarelin within the body.
View Study"Orally active growth hormone secretagogues: state of the art and clinical perspectives"
Ghigo E, Arvat E, Camanni F, 1998
Finding: Comprehensive review of GHS compounds including alexamorelin's class showing potent, dose-dependent, and reproducible GH-releasing effects across IV, subcutaneous, intranasal, and oral administration routes. GHS molecules activate the GHS receptor (ghrelin receptor) and synergize with GHRH for enhanced effects. Prolonged intermittent oral administration increases IGF-1 levels. The class shows clinical promise for GH deficiency, aging-related issues, critical illness, and muscle wasting conditions.
View StudyFrequently Asked Questions