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Peptide Database

Goals
Fat LossMuscle BuildingInjury HealingAnti-AgingCognitive EnhancementSleep OptimizationImmune SupportGut HealingSkin RejuvenationSexual Health
Peptides
5-Amino-1MQ
Weight Management
Abarelix
Hormone Support
Acetyl Hexapeptide-3 (Argireline)
Cosmetic
Adipotide
Weight Management
Adrenomedullin
Healing & Recovery
Alexamorelin
Growth Hormone
Angiotensin (1-7)
Healing & Recovery
AOD-9604
Weight Management
Apelin-13
Healing & Recovery
ARA-290 (Cibinetide)
Healing & Recovery
Bestatin (Ubenimex)
Immune
BPC-157
Healing & Recovery
Buserelin
Hormone Support
Cagrilintide
Weight Management
CagriSema
Weight Management
Capromorelin
Growth Hormone
Cartalax
Anti-Aging
Cathelicidin (hCAP-18 / Synthetic Derivatives)
Immune
Cerebrolysin
Cognitive
Cerluten
Cognitive
Cetrorelix
Hormone Support
Chonluten
Immune
CJC-1295 (No DAC)
Growth Hormone
CJC-1295 with DAC
Growth Hormone
Cortexin
Cognitive
Crystagen
Immune
Daptomycin
Immune
Defensin (HBD-2)
Immune
Defensin (HBD-3)
Immune
Degarelix
Hormone Support
Dihexa
Cognitive
DSIP (Delta Sleep-Inducing Peptide)
Sleep & Recovery
Dulaglutide
Weight Management
Enalapril
Healing & Recovery
Epithalon
Anti-Aging
Exenatide
Weight Management
Fertirelin
Hormone Support
FOXO4-DRI
Anti-Aging
Ganirelix
Hormone Support
GHK-Cu (Copper Peptide)
Cosmetic
GHRH (1-29)
Growth Hormone
GHRP-2
Growth Hormone
GHRP-6 (Growth Hormone Releasing Peptide-6)
Growth Hormone
Glutathione
Anti-Aging
Gonadorelin (GnRH)
Hormone Support
Gramicidin
Immune
Hexarelin
Growth Hormone
Human Chorionic Gonadotropin (HCG)
Hormone Support
Human Growth Hormone (HGH)
Growth Hormone
IGF-1 LR3
Growth Hormone
Immunoxel (Dzherelo)
Immune
Imunofan
Immune
Intermedin (Adrenomedullin-2)
Healing & Recovery
Ipamorelin
Growth Hormone
Kisspeptin-10
Sexual Health
KPV (Alpha-MSH Fragment)
Healing & Recovery
Lactoferricin B
Immune
Larazotide
Healing & Recovery
Lentinan
Immune
Leuphasyl
Cosmetic
Leuprolide
Hormone Support
Liraglutide
Weight Management
Livagen
Anti-Aging
Lixisenatide
Weight Management
LL-37
Immune
Macimorelin
Growth Hormone
Magainin-2
Immune
Mazdutide
Weight Management
Melanotan-2
Cosmetic
MK-677 (Ibutamoren)
Growth Hormone
MOTS-c
Metabolic
Myristoyl Pentapeptide-17
Cosmetic
N-Acetyl Selank
Cognitive
N-Acetyl Semax Amidate
Cognitive
NAD+
Mitochondrial
Nafarelin
Hormone Support
Natriuretic Peptide (ANP)
Healing & Recovery
Nesiritide (BNP)
Healing & Recovery
Nisin
Immune
Noopept (Omberacetam)
Cognitive
Orforglipron
Weight Management
Ovagen
Anti-Aging
Oxytocin Acetate
Hormone Support
P21 (P021)
Cognitive
PACAP-38
Healing & Recovery
Palmitoyl Oligopeptide
Cosmetic
Palmitoyl Pentapeptide-4 (Matrixyl)
Cosmetic
Palmitoyl Tetrapeptide-7
Cosmetic
Palmitoyl Tripeptide-1
Cosmetic
Pancragen
Metabolic
PEG-MGF
Healing & Recovery
Pemvidutide
Weight Management
Pentadecapeptide (BPC Analog)
Healing & Recovery
Pidotimod
Immune
Pinealon
Cognitive
PNC-27
Immune
Polymyxin B
Immune
Pralmorelin (GHRP-2)
Growth Hormone
Pramlintide
Weight Management
Prostamax
Hormone Support
PT-141 (Bremelanotide)
Sexual Health
Relaxin-2 (Serelaxin)
Healing & Recovery
Retatrutide
Weight Management
Selank
Cognitive
Semaglutide
Weight Management
Semax
Cognitive
Sermorelin
Growth Hormone
Setmelanotide
Weight Management
SLU-PP-332
Metabolic
SM-130686
Growth Hormone
Snap-8
Cosmetic
SS-31 (Elamipretide)
Mitochondrial
Substance P Antagonists
Healing & Recovery
Survodutide
Weight Management
SYN-AKE
Cosmetic
Tabimorelin
Growth Hormone
TB-500
Healing & Recovery
Tesamorelin
Growth Hormone
Testagen
Hormone Support
Thymalin
Immune
Thymopentin (TP-5)
Immune
Thymopoietin
Immune
Thymosin Alpha-1
Immune
Thymosin Beta-4
Healing & Recovery
Thymulin (FTS)
Immune
Thymulin Analog (PAT)
Healing & Recovery
Tirzepatide
Weight Management
Tripeptide-29
Cosmetic
Triptorelin
Hormone Support
Ularitide
Healing & Recovery
Urocortin
Healing & Recovery
Ventfort
Anti-Aging
Vesilute
Hormone Support
Vilon
Immune
VIP (Vasoactive Intestinal Peptide)
Healing & Recovery
Xenin-25
Metabolic
Ziconotide (Prialt)
Healing & Recovery
Total Peptides: 137
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Condition Spotlight

Cognitive Decline
Mild Cognitive Impairment

Losing your keys. Forgetting a name. Walking into a room and having no idea why. It starts small, but cognitive decline is relentless if left unchecked. We're talking about the kind of memory loss that threatens your independence and quality of life - not just normal aging.

Written by Michael Carroll — Owner, Director of Research · Reviewed by the Peptide Initiative Research Team · Editorial standards

The Problem

Your Brain Is Losing Its
Network Connections

Memory Loss

Difficulty recalling recent events and familiar information

Lost Words

Knowing what you want to say but can't find the words

Concentration Issues

Trouble staying focused on complex tasks

Understanding Neurological Aging

Why Cognitive Decline Happens

Your brain is made of roughly 86 billion neurons, each connecting to thousands of others through structures called synapses. When you learn something, remember something, or think through a problem, information travels across these connections at lightning speed. With age - especially after 60 - several things start going wrong simultaneously. The connections weaken. The protective coating around nerve fibers (myelin) deteriorates. Inflammation increases. Toxic proteins like amyloid beta and tau accumulate. Blood flow to the brain decreases. Growth factors that keep neurons healthy decline. Your mitochondria - the energy factories inside brain cells - start functioning less efficiently.

"Your brain isn't failing - it's becoming less efficient at maintaining its network."

This is where peptide therapy becomes powerful. Different peptides address different aspects of cognitive decline: some enhance neural growth, some reduce inflammation, some improve blood flow, some protect mitochondria. The result? You can potentially slow, halt, or even reverse some forms of cognitive decline.

The Solutions

6 Peptides
6 Angles of Attack

1970s (Russian Research)

Semax

The Neural Growth Stimulator

An ACTH(4-7) analog originally developed in Russia for cognitive enhancement and nootropic effects. Acts as a growth factor for nerve cells.

Role

Fertilizer for your neurons, helping them grow new connections

1990s

Selank

The Immune-Cognitive Bridge

A Tuftsin analog developed in Russia that enhances immune function while simultaneously improving cognitive performance and mood.

Role

Training your brain's defense squad to be smarter fighters

2015 Research

Dihexa

The Connection Multiplier

An Angiotensin IV analog developed for research purposes. One of the most potent activators of nerve growth factor and brain-derived neurotrophic factor (BDNF) discovered to date.

Role

Supercharging the cables connecting your neurons

1991

BPC-157

The Neuroprotector

A peptide naturally found in gastric juice with remarkable neuroprotective and neuroregenerative properties. Originally studied for gut healing, later recognized for powerful cognitive effects.

Role

Protective scaffolding for brain cells under stress

1980s (European Research)

Cerebrolysin

The Brain Cell Nutrient Complex

A porcine brain-derived peptide mixture containing neurotrophic and neuroprotective peptides. Used clinically in Europe and other regions for cognitive decline and stroke recovery.

Role

Brain food - direct nutrients for neural tissue

Approved 2010

Tesamorelin

The Cognitive-Metabolic Enhancer

A growth hormone-releasing hormone (GHRH) analog being studied for cognitive function benefits. Approved for treating HIV-related lipodystrophy, now being researched for age-related cognitive decline.

Role

Signaling your pituitary to produce more youth-promoting hormone

The Strategy

How They Work Together
Together

PeptidePrimary RoleAnalogy
Semax

The Neural Growth Stimulator

Fertilizer for your neurons, helping them grow new connections

Selank

The Immune-Cognitive Bridge

Training your brain's defense squad to be smarter fighters

Dihexa

The Connection Multiplier

Supercharging the cables connecting your neurons

BPC-157

The Neuroprotector

Protective scaffolding for brain cells under stress

Cerebrolysin

The Brain Cell Nutrient Complex

Brain food - direct nutrients for neural tissue

Tesamorelin

The Cognitive-Metabolic Enhancer

Signaling your pituitary to produce more youth-promoting hormone

6 Angles of Attack

Growth and Plasticity

Semax, Selank, and Dihexa stimulate nerve growth factors (NGF, BDNF) that build and strengthen neural connections

Neuroprotection

BPC-157 and Cerebrolysin protect existing neural tissue from further damage and inflammation

Metabolic and Vascular Support

Tesamorelin and improved blood flow ensure brain cells have adequate energy and nutrients

Synergistic Effect

Together they address neural growth, protection, repair, and metabolic support simultaneously

Important Considerations

Reality Check
What to Keep in Mind

Research Is Still Emerging

While peptides show promise for cognitive decline, much of this research is still being conducted. Some peptides are approved clinically in specific regions (Semax and Selank in Russia), while others remain investigational.

Individual Response Varies

Not everyone responds equally to peptide therapy. Some see dramatic improvements, others see modest gains. Genetics, lifestyle, severity of decline, and adherence all matter significantly.

Professional Guidance Required

Work with a healthcare provider experienced in peptide therapy and cognitive assessment. Proper dosing, monitoring, and medical oversight are important for safety and efficacy.

Lifestyle Is Essential

Peptides work best when paired with optimized sleep, exercise, nutrition, and cognitive engagement. Peptides without lifestyle changes will show limited benefit.

This information is for educational purposes only and should not be considered medical advice. Always consult with a qualified healthcare provider before starting any new treatment.

Realistic Expectations

What to Expect: A Realistic Timeline

An honest breakdown based on research and clinical reports.

What's Happening Inside

Peptides are entering your system and beginning to signal growth factors. Neural connections are starting to receive growth signals, but actual strengthening and new connection formation takes longer.

What You Might Notice

  • Possibly subtle mood or motivation improvements
  • Some people report slightly sharper thinking in moments
  • Sleep quality may improve slightly
  • Energy levels may be more stable

Watch For

The first few weeks are about cellular signaling beginning - don't expect dramatic cognitive improvements yet. Some people notice nothing this early, and that's normal.

Realistic Expectations

You're laying groundwork at the cellular level. Patience is essential.

Administration Guide

Dosing Protocols & Timing

General guidelines based on research literature and clinical reports. Work with a healthcare provider experienced in peptide therapy to customize for your situation.

Important: These are general guidelines. Don't self-prescribe based on internet articles. Work with a qualified healthcare provider.

Semax

250-500 mcg per day

Common Protocols

  • Conservative: 500 mcg daily (nasal spray or injection)
  • Standard: 500 mcg twice daily (morning and afternoon)
  • Higher dose: 1000 mcg daily

Timing Considerations

  • Morning administration preferred - aligns with natural ACTH rhythm
  • Intranasal spray is common delivery method (250-500 mcg per nostril)
  • Subcutaneous injection is also available (1-2 mg weekly)
  • Take on empty stomach for intranasal administration

Cycling

Often used in intensive protocols early after injury (continuous for 4-8 weeks), then reassessment. Some practitioners use 3 months on, 1 month off for chronic TBI recovery.

Primarily intranasal or subcutaneous administration. Penetrates blood-brain barrier efficiently.

Beyond Peptides

Lifestyle Strategies for Living Well

Peptides work best as part of a comprehensive approach. Click each category to explore evidence-based strategies.

At a Glance

Quick Reference Card

Peptide Overview

PeptideWhat It DoesTypical DoseTiming
Semax
The Neural Growth Stimulator250-500 mcg per dayMorning administration preferred - aligns with natural ACTH rhythm
Selank
The Immune-Cognitive Bridge250-500 mcg per doseOptimal: 1-2 hours before bed for anxiety reduction before sleep
Dihexa
The Connection Multiplier50-250 mcg per weekFlexible timing - can be dosed any time of day
BPC-157
The Neuroprotector250-500 mcg per doseCan be taken at any time, though morning dosing is often preferred
Cerebrolysin
The Brain Cell Nutrient Complex5-30 mL daily (depending on concentration)Usually given as daily injections during treatment phases
Tesamorelin
The Cognitive-Metabolic Enhancer0.1-0.2 mg dailyEvening injection (before bed) aligns with natural GH surge during sleep

Early Wins to Watch

  • Improved word retrieval
  • Better concentration on focused tasks
  • Reduced mental fog episodes
  • Slightly faster thinking speed

Support Stack

Omega-3 fatty acidsLion's Mane mushroomMagnesium glycinateVitamin D3B-complex vitaminsAcetyl-L-carnitineNACAlpha-lipoic acid

Lifestyle Priorities

  • Consistent 7-9 hour sleep schedule
  • Regular aerobic exercise 4-5x weekly
  • Omega-3 rich nutrition
  • Cognitive engagement and learning
  • Social interaction

Cognitive decline doesn't have to be your future. Age-related memory loss and cognitive impairment are addressable - not inevitable. Peptides represent a genuine scientific breakthrough in stimulating your brain's ability to repair and strengthen itself. Recovery isn't instantaneous, but with consistency and the right support, many people experience meaningful improvement.

Your brain remains plastic throughout life. These peptides help reactivate that plasticity. Keep learning, keep moving, keep engaging. Your brain is worth the effort.