Peptide Profile
Immunoxel (Dzherelo)
Ukrainian botanical immunomodulator that supercharges tuberculosis treatment and restores immune function in HIV patients
Dose Range
25-50drops
Frequency
Multiple times daily
Route
Oral (liquid drops)
Cycle Length
8-12 weeks
Onset
Moderate (1-2 weeks)
Evidence
Moderate
Compound Profile
Scientific & Efficacy Data
N/A — multi-component herbal phytoconcentrate
Molecular Formula
N/A — complex botanical mixture of multiple plant compounds
Molecular Weight
Not precisely characterized; immunomodulatory effects develop over days to weeks of consistent dosing
Half-Life
Good oral and sublingual bioavailability; sublingual lozenges shown equivalent to twice-daily oral liquid
Bioavailability
Proprietary combination
CAS #
Not available (proprietary combination)
PubChem Status
Developed By · 1980
Volodymyr Pylypchuk
Ekomed LLC, Ukraine
Primary Benefits
Dramatically improves tuberculosis sputum conversion and lung healing when combined with standard anti-TB drugs
Expands CD4+ T-cells, improves immune ratios, and restores balanced cytokine production in immunocompromised patients
Reduces opportunistic infections by 75% and boosts natural immune defenses against secondary diseases
Amino Acid Sequence
N/A — Immunoxel is a botanical extract, not a peptide; contains concentrated water-alcohol extract of medicinal plantsDosing
How much
do I take?
Starting Dose
25 drops twice daily (oral liquid)
Lower dose to assess tolerance; taken with water or directly under the tongue
Standard Dose
50 drops twice daily (oral liquid) OR 1 sublingual lozenge once daily
Standard clinical protocol used in Ukrainian TB treatment programs; sublingual shown equivalent to oral liquid
Advanced Dose
50 drops twice daily combined with Anemin
Enhanced protocol combining Immunoxel with Anemin for maximum cytokine modulation in severe cases
Timing
Best time to take
Morning and evening doses, spaced approximately 12 hours apart
With food?
Can be taken with or without food; sublingual lozenges dissolve under the tongue regardless of meals
If stacking
Take alongside standard TB medications as prescribed; no timing conflicts with anti-TB drugs reported in clinical trials
Adjusting Your Dose
Increase if
- +Well-tolerated at starting dose after 1-2 weeks with no GI issues
- +Sputum conversion has not occurred after 4 weeks of standard therapy
- +Healthcare provider recommends advancing to combination protocol with Anemin
Decrease if
- -Experiencing persistent gastrointestinal discomfort
- -Mild allergic symptoms appear (skin rash, itching)
- -Nausea that doesn't resolve within the first few days
Signs of right dose
- ✓Sputum smear conversion to negative within 1-2 months
- ✓Weight gain and improved appetite
- ✓Reduced fever and improved energy levels
- ✓Rising CD4+ T-cell counts on blood tests (in HIV patients)
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Suitability
Is this
right for me?
Best For
Tuberculosis Adjunct Treatment
Immunoxel's strongest evidence is as an add-on to standard TB drugs. A meta-analysis of 6 clinical trials found patients receiving Immunoxel were 3.19 times more likely to become sputum-negative compared to TB drugs alone. In one study, 84.1% of patients converted within 1 month versus only 19% on placebo.
HIV/TB Coinfection Immune Support
For patients battling both HIV and TB simultaneously, Immunoxel offers remarkable immune benefits. Clinical trials showed CD4+ T-cell counts increased by 71.2% in just 2 months, viral load decreased significantly, and opportunistic infections dropped from 12 episodes to just 3 compared to standard therapy alone.
Drug-Resistant Tuberculosis Support
Immunoxel has been studied in multidrug-resistant (MDR-TB) and extensively drug-resistant (XDR-TB) patients where standard treatments often struggle. Its immune-boosting effects help the body fight TB even when the bacteria resist front-line drugs.
Consider Alternatives If
Who Should Avoid
Do not use if
- ×You are allergic to any of the botanical ingredients (Aloe, Yarrow, Echinacea, St. John's Wort, Knotgrass, or others in the formulation)
- ×You are pregnant or breastfeeding — safety has not been established for these populations
- ×You intend to use it as a replacement for standard TB or HIV treatment — it is ONLY an adjunct therapy
- ×You have severe liver disease — the liquid formulation contains an alcohol base
Use with caution if
- !You are taking immunosuppressant medications — Immunoxel may counteract their effects
- !You are on St. John's Wort-sensitive medications (certain antivirals, birth control) — the formulation contains this herb
- !You have a history of severe plant allergies — start with a lower dose and monitor
- !You are taking medications metabolized by CYP enzymes — some herbal components may interact
- !You have diabetes — monitor blood sugar as some plant components may affect glucose levels
Administration
How do I
use it?
Reconstitution
What you need
- •Immunoxel liquid bottle (original sealed)
- •Clean measuring dropper or pipette
- •Small glass of water (if not taking drops directly)
Injection
Route
N/A — Immunoxel is taken orally or sublingually, NOT by injection
Best sites
- •Under the tongue (sublingual — for lozenges and pastilles)
- •Swallowed with water (oral — for liquid drops)
Technique
- 1.For liquid: Count prescribed drops into a small glass of water, or place drops directly under the tongue
- 2.For sublingual lozenges: Place one lozenge under your tongue and let it dissolve completely — do not chew or swallow whole
- 3.Take at approximately the same times each day for best results
- 4.Continue taking alongside all prescribed TB/HIV medications as directed by your doctor
Storage
Signs of degradation
Sample Daily Schedule
Safety
Is it
safe?
Safety Profile
Immunoxel has demonstrated a favorable safety profile across multiple clinical trials involving hundreds of patients with TB and TB/HIV coinfection. No serious adverse events have been reported in published studies. It is approved by Ukraine's Ministry of Health and has been used clinically since the late 1980s. Side effects are generally mild and gastrointestinal in nature.
Safety data comes from Phase 2 and Phase 3 clinical trials conducted primarily in Ukraine, along with a 2021 systematic review and meta-analysis of 6 clinical trials. While evidence is encouraging, most studies are open-label and larger double-blind randomized trials are still needed to fully establish safety in diverse populations.
Common Side Effects
Experienced by some users
Well-tolerated in most patients
Clinical trials consistently report that most patients experience no significant adverse effects from Immunoxel when taken as directed alongside standard medications.
Management: Simply follow the prescribed dosing schedule and report any unusual symptoms to your healthcare provider.
Mild gastrointestinal discomfort
Some patients report mild stomach upset, bloating, or nausea, especially when starting the liquid formulation. This is likely due to the alcohol-based extract.
Management: Take with food or a small glass of water. Symptoms usually resolve within the first few days. Switch to sublingual formulation if GI issues persist.
Less Common
- •Temporary taste changes
- •Mild allergic skin reactions
- •Mild headache
These typically resolve with continued use or dose adjustment.
Stop and Seek Help If
- ×Signs of allergic reaction (widespread rash, swelling, difficulty breathing)
- ×Persistent gastrointestinal problems that don't resolve within a week
- ×Your doctor advises discontinuation due to medication interactions
- ×Completion of your TB treatment course (Immunoxel is typically used for the duration of TB therapy)
- ×Worsening of symptoms despite continued use (consult your medical team)
Always consult your healthcare provider before starting or stopping Immunoxel. This product should only be used as an adjunct to standard medical treatment, never as a replacement. It is not FDA approved and is primarily available in Ukraine.
Interactions
With other peptides
- ✓Different mechanism (thymic peptide vs botanical); no known conflict; theoretically complementary immune support
- ✓Both support immune function through different pathways; no interaction data available
- ✓Both are immunomodulators; combining may have additive effects; consult healthcare provider
With medications
- ✓Anti-TB drugs (isoniazid, rifampicin, pyrazinamide, ethambutol) - Safe and beneficial combination — this is the primary intended use; all clinical trials used this combination
- ✓Antiretroviral therapy (ARVs) - Clinical trials showed favorable results combining Immunoxel with ART; however, St. John's Wort content may affect some ARV levels — discuss with doctor
- !Immunosuppressants - May counteract immunosuppressive effects; avoid combining without specialist guidance
- !Warfarin and blood thinners - Some herbal components may affect coagulation; monitor INR closely
- !Oral contraceptives - St. John's Wort in the formulation may reduce effectiveness of hormonal birth control
With supplements
- ✓Vitamin D - Complementary immune support; both beneficial in TB treatment; safe combination
- ✓Zinc - Both support immune function; no known interactions; safe together
- ✓Anemin (herbal phytoconcentrate) - Specifically studied in combination with Immunoxel; synergistic cytokine modulation
- ✓Probiotics - Both support immune health; may help with any GI side effects from the herbal extract
Effectiveness
Does it
work?
Evidence Level
Moderate human trials
What to Expect
Week 1-2 (Starting Phase)
What you might notice
- •Mild herbal taste from the formulation
- •Possible brief GI adjustment (mild nausea or bloating)
- •Some patients notice improved appetite within the first week
What's normal
- •Mild gastrointestinal effects as your body adjusts to the botanical compounds
- •No dramatic changes yet — immune modulation takes time to build
- •The herbal taste of the liquid or sublingual formulation
What's next
- →Continue taking as prescribed alongside your TB/HIV medications
- →If GI issues persist, try taking with food or switching to sublingual lozenges
- →Move from starting dose to standard dose if well-tolerated
Week 2-4 (Early Response Phase)
What you might notice
- •Improved energy levels and reduced fatigue
- •Beginning of fever reduction in TB patients
- •Early signs of weight stabilization or gain
- •Some TB patients may begin sputum conversion
What's normal
- •Gradual improvement — not overnight transformation
- •Continued need for all standard medications
- •Some fluctuation in symptoms day-to-day
What's next
- →Continue the full course — most benefits emerge over 1-4 months
- →Your doctor will monitor sputum smears and blood work
- →Report any new symptoms to your healthcare team
Month 1-4 (Peak Response Phase)
What you might notice
- •Significant sputum conversion (84% within 1 month in sublingual trial)
- •Measurable weight gain and improved nutrition status
- •Rising CD4+ T-cell counts in HIV patients (71% increase in studies)
- •Reduced frequency of opportunistic infections
- •Healing of lung cavitations visible on chest X-ray
- •Reduced inflammatory markers (lower leukocyte counts, ESR)
What's normal
- •Major clinical improvements should be evident by month 2-4
- •Some patients respond faster than others depending on disease severity
- •Continued need for all standard medications throughout treatment
What's next
- →Complete the full treatment course as prescribed (typically 2-6 months)
- →Your doctor will determine when treatment can be safely stopped
- →Regular monitoring of TB culture, CD4 counts, and viral load continues
Signs It's Working
TB Treatment Response
- ✓Sputum smear conversion to negative
- ✓Resolution of lung cavitations on chest X-ray
- ✓Fever reduction and defervescence
- ✓Weight gain and improved appetite
- ✓Reduced inflammatory markers (leukocytes, ESR)
Immune Function Improvement
- ✓Rising CD4+ T-cell counts on blood tests
- ✓Improved CD4/CD8 ratio
- ✓Decreased viral load in HIV patients
- ✓Fewer opportunistic infections
- ✓Better overall energy and sense of well-being
Not Seeing Results?
Common reasons
- •Not taking consistently — Immunoxel works best with regular twice-daily dosing; missed doses reduce effectiveness
- •Using without standard TB/HIV medications — Immunoxel is an ADJUNCT therapy, not a standalone treatment
- •GI issues causing poor absorption — try sublingual formulation instead of oral liquid for better tolerance
- •Expired product — check expiration date; botanical extracts lose potency over time
- •Expecting too-rapid results — clinical improvements typically emerge over 2-4 weeks of consistent use
- •Drug interactions — St. John's Wort content may affect levels of certain medications; consult your doctor
Key Research
"Dzherelo (Immunoxel) as adjunctive therapy to standard antituberculosis treatment: systematic review and meta-analysis"
Hariyanto TI et al., 2021
Finding: When researchers combined data from 6 TB studies involving nearly 500 patients, Immunoxel boosted the power of standard TB drugs by more than threefold, making patients three times more likely to clear the infection. The herbal supplement also dramatically reduced fevers while helping the body fight back against the bacteria.
View Study"Clinical validation of sublingual formulations of Immunoxel (Dzherelo) as adjuvant immunotherapy in treatment of TB patients"
Efremenko YV, Arjanova OV, Prihoda ND et al., 2012
Finding: TB patients who let Immunoxel dissolve under their tongue cleared their lungs at a rate of 84% in just one month, versus only 19% in patients taking placebo. Remarkably, the herbal helper worked equally well regardless of age, weight, gender, or whether the TB was drug-resistant or combined with HIV.
View Study"Enhancement of efficacy of tuberculosis drugs with Immunoxel in HIV-infected patients with active pulmonary TB"
Arjanova OV, Prihoda ND, Yurchenko LV et al., 2009
Finding: In patients suffering from both TB and HIV, adding Immunoxel to standard TB drugs quadrupled their chances of clearing the infection (from 16% to 67%) and cut secondary infections from 12 down to 3. Patients also gained nearly 6 pounds, reversing the severe weight loss typical of dual infection.
View Study"Changes in CD4+ T-cells and HIV RNA resulting from combination of anti-TB therapy with Dzherelo in TB/HIV patients"
Nikolaeva LG, Maystat TV, Masyuk LA et al., 2009
Finding: The herbal extract Immunoxel alone—without any antiretroviral drugs—expanded patients' HIV-fighting CD4 cells by 71%, jumping from 174 to 283 cells in just 2 months and reducing HIV copies in 70% of those treated. This suggests the botanical blend awakens the immune system's dormant power.
View Study"Cytokine profiles of HIV patients with pulmonary TB resulting from adjunct immunotherapy with Dzherelo and Anemin"
Nikolaeva LG, Maystat TV, Pylypchuk VS et al., 2008
Finding: Immunoxel works by tuning the immune orchestra—ramping up the protective chemical signals IL-2 and interferon-gamma by 61%, while silencing the inflammatory alarm bells TNF-alpha. This immune rebalancing allows the body to mount an effective counterattack against tuberculosis.
View StudyFrequently Asked Questions