GHK-Cu
Copper-GHK Tripeptide Complex
GHK-Cu is a naturally occurring copper peptide complex composed of the tripeptide glycyl-L-histidyl-L-lysine (GHK) bound to copper ions. Originally discovered in human plasma and wound healing processes, this bioactive peptide demonstrates remarkable regenerative properties through its ability to stimulate collagen synthesis, enhance angiogenesis, and modulate antioxidant enzyme activity. GHK-Cu is extensively researched for its anti-aging applications in skin health, wound healing, and hair growth, with over 30 years of clinical studies supporting its safety and efficacy.
GHK-Cu Dosing Guide
What It's Used For
GHK-Cu is a naturally occurring copper peptide complex that revolutionizes anti-aging therapy and wound healing. This powerful tripeptide bound to copper ions stimulates collagen synthesis, accelerates tissue repair, and promotes cellular regeneration through activation of over 4,000 genes associated with healing and anti-aging processes.
Skin Rejuvenation
- Reduces wrinkles by up to 36% in clinical studies
- Increases skin thickness and elasticity by 24%
- Improves skin clarity and reduces age spots
- Stimulates collagen and elastin production
Wound Healing
- Accelerates healing by 40-60% compared to controls
- Promotes new blood vessel formation
- Reduces scar formation and improves appearance
- Effective for diabetic ulcers and chronic wounds
Hair Growth
- Increases hair density by 22% in studies
- Improves hair thickness by 28%
- Stimulates hair follicle activity
- Effective for androgenetic alopecia
How Much to Take
Topical Application
Daily Skincare: 0.05-2% concentration
Eye Area: 2% concentration (delicate skin)
Frequency: Once or twice daily
Amount: One dollop (≈50mg GHK-Cu)
Research Injection
Starting Dose: 0.5-1mg daily (weeks 1-2)
Maintenance: 1-1.5mg daily (weeks 3-4)
Optimal: 1.5-2mg daily (weeks 5-6)
Maximum: 2mg daily (weeks 7-8)
Frequency
Daily injection or 5 days on, 2 days off protocol
Timing
Morning injection with topical application in evening
Adjustment
Start low, assess tolerance, gradually increase dose
How Long to Use It
Standard Cycle: 4-8 weeks on, followed by 2-4 weeks off for optimal results and to prevent tolerance.
Initial Results: Visible skin improvements within 2-4 weeks of consistent use.
Optimal Results: 8-12 weeks of consistent use for maximum benefits.
Maintenance: Can repeat cycles as needed with appropriate breaks between cycles.
Important: GHK-Cu can be used long-term with appropriate cycling. Many users maintain excellent results with periodic cycles rather than continuous use, allowing the body to maintain sensitivity to the peptide.
Need-to-Know Information
How It Works
Think of GHK-Cu as your skin's personal renovation crew! The copper acts like a master craftsman's tool, helping build strong, flexible collagen scaffolding that keeps skin firm and youthful. Meanwhile, the peptide part sends out chemical messages telling your skin cells to 'wake up and repair!' - like a construction foreman directing workers. It also acts like a security system, boosting your skin's natural antioxidant defenses while carefully controlling the enzymes that break down old collagen.
Key Benefits
Skin Quality: 36% reduction in fine lines and 27% improvement in skin clarity
Wound Healing: 40-60% faster healing rate compared to controls
Collagen Production: 24% increase in skin thickness and elasticity
Hair Growth: 22% increase in density and 28% improvement in thickness
Who Should Avoid
- Wilson's disease or copper metabolism disorders
- Known allergy to copper compounds
- Severe liver dysfunction
- Active skin infections at application site
- Pregnancy and breastfeeding (consult doctor)
Common Side Effects
- Mild skin irritation (rare, <3% of users)
- Temporary copper taste with systemic use
- Minor redness at injection site
- Temporary skin sensitivity to sunlight
- Mild burning sensation initially
Storage & Injection
Before Reconstitution
- Room temperature for short-term (weeks)
- Freeze at -20°C for long-term storage
- Protect from light and moisture
- Keep in original vial until ready
After Reconstitution
- Refrigerate at 2-8°C (36-46°F)
- Use within 30 days of mixing
- Never freeze reconstituted solution
- Keep away from direct light
Injection Sites
- Subcutaneous: abdomen, thigh, upper arm
- Near injury site for targeted healing
- Scalp for hair growth (shallow injection)
Method
- Use insulin syringe for precision
- 45-90 degree angle subcutaneous
- Rotate injection sites regularly
Tips
- Allow vial to reach room temperature
- Clean injection site with alcohol
- Inject slowly to minimize discomfort
Example Schedule
*Indicates most common maintenance doses
Daily Routine Example
Morning: Subcutaneous injection of 1-2mg GHK-Cu
Evening: Apply topical GHK-Cu cream/serum if desired
Consistency: Same time daily for optimal results
Dosing Flexibility:
- Can split daily dose into two injections
- May combine with topical application
- 5 days on, 2 days off protocol is also effective
Extra Tips for Best Results
Optimizing Absorption
- Apply to clean, slightly damp skin
- Use after dermarolling for enhanced penetration
- Avoid mixing with strong acids
- Wait 30 minutes before other products
Combination Strategies
- Pairs well with vitamin C (applied separately)
- Synergistic with red light therapy
- Combine with microneedling treatments
- Works well with hyaluronic acid serums
Maximizing Benefits
- Stay hydrated (8+ glasses water daily)
- Protect skin from sun exposure
- Get 7-9 hours quality sleep
- Maintain adequate copper levels through diet
Safety Considerations
- Always perform patch test before first use
- Start with lower doses to assess tolerance
- Maintain sterile technique for injections
- Never share needles or vials
Expected Results Timeline:
- Week 1-2: Improved skin hydration and texture
- Week 2-4: Visible reduction in fine lines, enhanced wound healing
- Week 4-8: Significant wrinkle reduction, increased skin firmness
- Week 8-12: Maximum benefits achieved, notable hair improvements
Discontinue Use If:
- Severe allergic reaction (swelling, difficulty breathing)
- Persistent injection site infection
- Symptoms of copper toxicity (nausea, vomiting, metallic taste)
- Unexplained dizziness or significant blood pressure drop
- Severe skin irritation that doesn't improve
Medical Disclaimer
GHK-Cu is used in cosmetic applications and research settings. This information is for educational purposes only and should not be construed as medical advice. Individual results may vary. Consult healthcare providers for appropriate skincare regimens.