Adipotide
Prohibitin-targeting peptide 1 (Prohibitin-TP01)
Adipotide is a revolutionary experimental vascular-targeting peptidomimetic designed to induce selective apoptosis in blood vessels supplying white adipose tissue. Also known as Prohibitin-TP01, FTPP (Fat-Targeted Proapoptotic Peptide), or TP-1, it represents a completely novel approach to weight management through direct fat cell elimination rather than appetite suppression. While clinical development was discontinued in 2019 due to nephrotoxicity concerns, preclinical studies demonstrated remarkable efficacy with up to 30% weight reduction in rodent models and 11% weight loss in primate studies over just 28 days.
Adipotide Dosing Guide
What It's Used For
Adipotide is a synthetic peptide that targets fat cells by disrupting their blood supply, leading to targeted fat cell death. It works by binding to specific receptors (ANXA2 and prohibitin) found primarily on blood vessels supplying white adipose tissue.
Weight Loss and Fat Reduction
- Reduces white adipose tissue by cutting off blood supply to fat cells
- Promotes rapid weight loss through targeted fat cell apoptosis
Metabolic Health
- Improves insulin sensitivity and glucose tolerance
- Reduces insulin resistance markers
Body Composition
- Decreases body mass index (BMI) and abdominal circumference
- Targets visceral fat deposits linked to metabolic disorders
Diabetes Management Support
- Shows potential for improving Type 2 diabetes markers
- Enhances metabolic function through fat reduction
How Much to Take
Dose
0.01 mg per kg of body weight per day
- For a 200 lb (90 kg) person: approximately 0.9 mg daily
- For a 150 lb (68 kg) person: approximately 0.68 mg daily
How Often
- Once daily subcutaneous injection
- Consistent timing each day for optimal results
When to Inject
- Inject at the same time each day (morning or evening)
- Best administered on an empty stomach
- Maintain consistent schedule throughout cycle
How Long to Use It
- Cycle Length: Use for 28 days (4 weeks), followed by a break of 4-8 weeks
- Protocol Variation: Some protocols suggest tapering doses in weeks 3-4
- Repeat Cycles: Can be repeated after adequate break period if needed
Need-to-Know Information
How It Works
- Binds to prohibitin and ANXA2 receptors on fat tissue blood vessels
- Causes apoptosis (programmed death) of fat cells by cutting off blood supply
- Specifically targets white adipose tissue while sparing brown fat
Key Benefits
- Rapid Weight Loss: Studies show 11% body weight reduction in 28 days
- Improved Insulin Sensitivity: Enhanced glucose metabolism
- Targeted Fat Loss: Reduces visceral and subcutaneous fat
- Metabolic Enhancement: Improved markers for Type 2 diabetes
Who Should Avoid It
- Pregnant or breastfeeding individuals
- Those with kidney disease or impaired kidney function
- Individuals with cardiovascular conditions
- Anyone with active cancer (consult doctor)
Possible Side Effects
- Mild kidney function changes (usually reversible)
- Nausea or decreased appetite
- Injection site reactions
- Dehydration risk
- Temporary changes in electrolyte balance
How to Mix and Store It
Mixing Instructions
- Use bacteriostatic water to reconstitute the peptide
- Example: Add 2 mL of bacteriostatic water to a 10 mg vial
- This creates a 5 mg/mL concentration
- For a 0.9 mg dose, draw 0.18 mL into the syringe
Storage
- Store mixed vials in the fridge at 2-8°C
- Use within 28-30 days after reconstitution
- Unmixed vials: Store in freezer at -20°C for long-term storage
- Keep away from direct light
How to Inject
Injection Method
Where to Inject: Subcutaneous (under the skin) in fatty areas like stomach, thigh, or buttocks
Injection Tips:
- Rotate injection sites daily to prevent irritation
- Pinch skin fold and insert needle at 45-90 degree angle
- Inject slowly and steadily
- Clean injection site with alcohol swab before injecting
Example Dosing Schedule
Week 1-2
- Full dose based on body weight (0.01 mg/kg)
- Morning injection before breakfast
Week 3-4
- Option to maintain full dose or taper to 0.5-0.75 of initial dose
- Continue morning injection schedule
Post-Cycle
- 4-8 week break before considering another cycle
Extra Tips for Best Results
Monitor Kidney Function
- Consider baseline kidney function tests before starting
- Watch for signs of dehydration or electrolyte imbalance
- Stay well-hydrated throughout the cycle
Support Fat Loss
- Maintain a balanced, nutrient-rich diet
- Include moderate exercise to enhance results
- Focus on protein intake to preserve lean muscle
Track Your Progress
- Take weekly body measurements and photos
- Monitor weight changes and body composition
- Keep a log of any side effects or changes
Hydration is Key
- Drink plenty of water throughout the cycle
- Monitor urine color as hydration indicator
- Consider electrolyte supplementation if needed
Start Conservative
- Consider starting with a lower dose for the first few days
- Gradually increase to full dose if well-tolerated
- Stop immediately if severe side effects occur
Combine Wisely
- Can potentially be stacked with other peptides after research
- Avoid combining with other experimental compounds initially
- Consult with knowledgeable practitioners about combinations
Medical Disclaimer
CRITICAL WARNING: Adipotide clinical development was permanently discontinued due to unacceptable nephrotoxicity. All human trials were terminated early. This information is for educational purposes only. Adipotide is NOT approved for any human use and carries severe kidney damage risks. Consult healthcare providers for approved weight management alternatives.