Peptide Profile
CJC-1295 (No DAC)
A modified growth hormone-releasing hormone that boosts your body's natural GH pulses for better recovery, deeper sleep, and improved body composition.
Dose Range
100-300mcg
Frequency
Once daily
Route
Subcutaneous injection
Cycle Length
8-12 weeks
Onset
Moderate (1-2 weeks)
Evidence
Moderate
Compound Profile
Scientific & Efficacy Data
C152H252N44O42
Molecular Formula
3367.9 g/mol
Molecular Weight
30 minutes to 2 hours
Half-Life
~100% (subcutaneous)
Bioavailability
863288-34-0
CAS #
56841945
PubChem ID ↗
Developed By · 2005
ConjuChem Research Team
ConjuChem Biotechnologies
Primary Benefits
Effectively stimulates natural GH release in pulsatile pattern, especially when combined with GHRPs
One of the most reliably noticed benefits, with deeper sleep and more refreshed mornings
Enhances workout recovery and tissue repair through elevated GH and IGF-1 levels
Amino Acid Sequence
Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH2Dosing
How much
do I take?
Starting Dose
100 mcg
Start here to assess tolerance and response. Best taken before bed to align with natural GH release during sleep.
Standard Dose
100-150 mcg
Most effective protocol for general health benefits. Often combined with a GHRP like Ipamorelin for enhanced effects.
Advanced Dose
150-300 mcg
Higher dosing for experienced users seeking maximum GH stimulation. Always combined with a GHRP for synergistic effects.
Timing
Best time to take
Before bed on empty stomach (most popular), or morning fasted and pre-workout
With food?
Take on an empty stomach - wait at least 2 hours after eating and 30-60 minutes before eating
If stacking
Best combined with Ipamorelin at the same time for synergistic GH release. Inject both peptides simultaneously for maximum pulse.
Adjusting Your Dose
Increase if
- +Tolerating current dose well with no side effects
- +Not experiencing noticeable sleep or recovery improvements
- +Body composition changes have plateaued
- +Want to add a second daily dose
Decrease if
- -Experiencing persistent water retention
- -Tingling or numbness is uncomfortable
- -Feeling overly fatigued
- -Injection site reactions are bothersome
Signs of right dose
- ✓Deeper, more restful sleep
- ✓Improved recovery between workouts
- ✓Gradual improvements in body composition
- ✓Increased energy and vitality
Dosing Calculator
Calculate Your Exact Dose
Step 1: Peptide Weight
Find the weight printed on your peptide vial label
Look here!
The peptide weight is printed on the label
Look here!
The weight is on the label
Suitability
Is this
right for me?
Best For
Natural Growth Hormone Optimization
Perfect for those wanting to boost their body's own GH production rather than using synthetic growth hormone. Mimics the natural pulsatile release pattern your pituitary uses.
Workout Recovery and Muscle Building
Athletes and fitness enthusiasts use it to accelerate recovery between training sessions, support lean muscle development, and reduce body fat over time.
Sleep Quality Enhancement
Because GH is naturally released during deep sleep, many users report dramatically improved sleep quality with more vivid dreams and feeling more refreshed upon waking.
Anti-Aging and Vitality
As GH levels decline with age, CJC-1295 helps restore more youthful hormone patterns, potentially improving skin quality, energy levels, and overall well-being.
Synergistic Peptide Stacking
Designed to work hand-in-hand with GHRPs like Ipamorelin. When combined, these peptides amplify each other's effects for significantly greater GH release than either alone.
Consider Alternatives If
Who Should Avoid
Do not use if
- ×You have active cancer or a history of cancer (GH may promote tumor growth)
- ×You are pregnant or breastfeeding
- ×You have a pituitary tumor or untreated pituitary disorder
- ×You have had an allergic reaction to GHRH or its analogs
- ×You have uncontrolled diabetes or diabetic retinopathy
- ×You have active Cushing's disease or syndrome
Use with caution if
- !You have diabetes (may affect blood sugar regulation)
- !You are taking insulin or diabetes medications
- !You have carpal tunnel syndrome (GH may worsen symptoms)
- !You have a history of joint pain or arthritis
- !You are over 65 years old (start with lower doses)
- !You have impaired kidney or liver function
Administration
How do I
use it?
Reconstitution
What you need
- •Bacteriostatic water (BAC water)
- •Insulin syringe (29-31 gauge)
- •Alcohol swabs
- •Sterile vial of CJC-1295 powder
Injection
Route
Subcutaneous injection into fatty tissue
Best sites
- •Abdomen (2 inches from navel)
- •Lower belly fat roll
- •Upper thigh (front or outer)
Technique
- 1.Clean injection site with alcohol swab and let dry
- 2.Pinch a fold of skin between thumb and forefinger
- 3.Insert needle at 45-90 degree angle into pinched skin
- 4.Inject solution slowly
- 5.Remove needle and apply light pressure (do not rub)
Storage
Signs of degradation
Sample Daily Schedule
Safety
Is it
safe?
Safety Profile
CJC-1295 without DAC has been studied in Phase 1-2 human clinical trials with a favorable safety profile. The most common side effects are mild and include injection site reactions and temporary flushing. Because it stimulates natural GH release rather than providing exogenous GH, it maintains the body's feedback mechanisms.
Human studies at doses up to 90mcg/kg showed no serious adverse events. However, most research has been relatively short-term. Long-term safety data in humans is limited compared to FDA-approved medications.
Common Side Effects
Experienced by some users
Injection site reactions
Temporary redness, swelling, or mild pain at injection site
Management: Rotate injection sites, ensure proper technique, apply ice if needed
Flushing or warmth
Brief feeling of warmth or facial flushing shortly after injection
Management: Usually resolves within 15-30 minutes, no treatment needed
Water retention
Mild fluid retention, especially in first few weeks
Management: Usually temporary, reduce sodium intake if bothersome
Increased appetite
GH stimulation can increase hunger
Management: Plan meals accordingly, can be beneficial for muscle-building goals
Less Common
- •Tingling or numbness
- •Headache
These typically resolve with continued use or dose adjustment.
Stop and Seek Help If
- ×Signs of allergic reaction (hives, swelling, difficulty breathing)
- ×Persistent severe headaches that don't improve
- ×Significant joint pain or carpal tunnel symptoms
- ×Development of diabetes symptoms (excessive thirst, frequent urination)
- ×Any concerning changes in moles or skin growths
- ×Planned surgery (stop 1-2 weeks before)
Always consult with a healthcare provider before starting or stopping peptide therapy. This information is for educational purposes and does not replace medical advice.
Interactions
With other peptides
- ✓Excellent synergy - GHRH + GHRP combination amplifies GH release 3-5x more than either alone
- ✓Strong synergy but may increase hunger more than Ipamorelin combination
- ✓Effective combination with moderate hunger increase
- ✓Can be used together for enhanced healing and recovery
- !Redundant - do not combine as both are GHRH analogs
With medications
- !Insulin - May affect blood sugar regulation, monitor closely
- !Diabetes medications - GH can increase blood sugar - may need dose adjustments
- !Glucocorticoids (Prednisone) - May reduce effectiveness of CJC-1295
- ✓Thyroid medications - Generally safe but monitor thyroid levels
With supplements
- ✓Arginine - May enhance GH release, safe to combine
- ✓GABA - May support GH release and sleep quality
- ✓Melatonin - Safe for bedtime dosing, may enhance sleep benefits
- ✓High-dose carbohydrates - Eating carbs/sugar before injection blunts GH response - avoid
Effectiveness
Does it
work?
Evidence Level
Moderate human trials
What to Expect
Week 1-2
What you might notice
- •Improved sleep quality and deeper rest
- •More vivid dreams
- •Subtle increase in energy levels
- •Possible mild water retention
- •Injection site may be slightly red initially
What's normal
- •Sleep improvements are often the first noticeable effect
- •Mild side effects like flushing are common and temporary
- •Don't expect dramatic physical changes yet
What's next
- →Continue at starting dose if tolerating well
- →Track sleep quality and energy in a journal
- →Consider adding a GHRP if not already stacking
Week 3-4
What you might notice
- •Faster recovery between workouts
- •Improved skin appearance and hydration
- •Gradual fat loss beginning
- •Better workout performance
- •Sustained energy throughout the day
What's normal
- •Recovery benefits become more apparent
- •Physical changes are still subtle
- •Side effects should be minimal by now
What's next
- →Consider increasing dose if effects are mild
- →Ensure proper nutrition to support muscle growth
- →May add second daily dose for enhanced results
Week 5-8
What you might notice
- •Noticeable improvements in body composition
- •Increased lean muscle mass
- •Continued fat reduction
- •Better skin elasticity and appearance
- •Improved sense of well-being
What's normal
- •Body composition changes become visible
- •IGF-1 levels peak after consistent use
- •Full benefits developing
What's next
- →Continue protocol through week 8-12
- →Consider lab work to check IGF-1 levels
- →Maintain consistent injection schedule
Week 9-12+
What you might notice
- •Sustained improvements in muscle and fat ratio
- •Continued enhanced recovery
- •Stable sleep and energy benefits
- •Overall improved physical performance
- •Anti-aging effects more noticeable
What's normal
- •Benefits plateau at optimal levels
- •Consistent results with continued use
- •Some users cycle off for 4-8 weeks before restarting
What's next
- →Decide on cycling strategy with healthcare provider
- →May take 4-8 week break before next cycle
- →Maintain lifestyle factors to preserve gains
Signs It's Working
Sleep and Recovery
- ✓Falling asleep faster and sleeping more deeply
- ✓Waking up feeling more refreshed
- ✓More vivid or memorable dreams
- ✓Faster recovery between workouts
- ✓Less muscle soreness after training
Body Composition
- ✓Gradual reduction in body fat
- ✓Increased lean muscle mass
- ✓Improved muscle definition
- ✓Clothes fitting differently (looser around waist, tighter around shoulders)
- ✓Better muscle pumps during workouts
Overall Vitality
- ✓Improved energy throughout the day
- ✓Better skin quality and elasticity
- ✓Stronger nails and healthier hair
- ✓Improved mood and sense of well-being
- ✓Enhanced exercise performance
Not Seeing Results?
Common reasons
- •Not taking on empty stomach - food (especially carbs) blunts GH release significantly
- •Not combining with a GHRP - CJC-1295 alone produces modest effects; pairing with Ipamorelin multiplies results
- •Dose too low - some individuals need higher doses for noticeable effects
- •Poor quality peptide - ensure source tests for purity and potency
- •Inconsistent dosing schedule - daily consistent timing is important for best results
- •Not enough time - meaningful body composition changes take 6-12 weeks
- •Improper storage - degraded peptide from improper refrigeration won't work
Key Research
"Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults"
Teichman et al., 2006
Finding: Single injection increased GH levels 2-10 fold for 6+ days and IGF-1 levels 1.5-3 fold for 9-11 days. No serious adverse events were reported in healthy adults.
View Study"Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295"
Ionescu M, Frohman LA, 2006
Finding: CJC-1295 increased GH secretion while preserving the natural pulsatile pattern. Basal GH levels increased 7.5-fold and IGF-1 increased 45% one week after injection.
View Study"Once-daily administration of CJC-1295 normalizes growth in the GHRH knockout mouse"
Alba M, Fintini D, Sagazio A et al., 2006
Finding: Daily CJC-1295 treatment restored normal body weight, length, and body composition in growth hormone-deficient mice, demonstrating its ability to normalize GH-dependent growth.
View Study"Activation of the GH/IGF-1 axis by CJC-1295 results in serum protein profile changes in normal adult subjects"
Sackmann-Sala L, Ding J, Frohman LA et al., 2009
Finding: CJC-1295 administration caused measurable changes in serum protein profiles, indicating activation of the GH/IGF-1 axis with potential biomarkers of GH activity.
View StudyFrequently Asked Questions