Peptide Profile

Pinealon

Neuroprotective tripeptide bioregulator (Glu-Asp-Arg) that penetrates the DNA major groove to epigenetically regulate serotonin synthesis, preserve dendritic spine architecture, and activate endogenous antioxidant defenses against age-related neurodegeneration

Cognitive

Dose Range

10-20mg

Frequency

Multiple times daily

Route

Oral (capsule/tablet)

Cycle Length

2-4 weeks

Onset

Gradual (3-4 weeks)

Evidence

Emerging

Compound Profile

Scientific & Efficacy Data

C₁₅H₂₆N₆O₈

Molecular Formula

418.4 g/mol

Molecular Weight

Short plasma half-life typical of tripeptides (minutes to low hours); biological effects persist for weeks to months through epigenetic gene regulation mechanisms

Half-Life

Orally bioavailable as a dipeptide/tripeptide absorbed by intestinal peptide transporters (PepT1/SLC15A1); crosses the blood-brain barrier; rapid cellular uptake due to ultra-short peptide structure

Bioavailability

175175-23-2

CAS #

10273502

PubChem ID ↗

Developed By · 1990s-2000s (based on pineal gland peptide research beginning in the 1980s)

Academic research consortium

Multiple research institutions

Primary Benefits

Amino Acid Sequence

Sequence not publicly available or proprietary

Dosing

How much
do I take?

Starting Dose

10 mg once daily

Frequency

Once daily, morning

Duration

10-14 days initial assessment

Begin with the standard Khavinson bioregulator starting protocol. Take orally with water before breakfast. As an ultrashort peptide, Pinealon is absorbed intact by intestinal peptide transporters. Monitor for any initial sedation from serotonergic effects and adjust timing if needed. Effects are gradual and cumulative — do not expect immediate changes.

Standard Dose

10-20 mg daily (1-2 capsules)

Frequency

1-2 times daily (morning, and optionally early afternoon)

Duration

20-30 days per treatment course

Standard clinical protocol used in Russian bioregulator therapy. Courses are typically 20-30 days with intervals of 3-6 months between courses. Can be combined with other Khavinson bioregulators (Epithalon, Cerluten) for comprehensive anti-aging protocols. The epigenetic effects persist beyond the active treatment period as gene expression patterns are modified.

Advanced Dose

20 mg daily (2 capsules)

Frequency

Twice daily (10 mg morning + 10 mg afternoon)

Duration

30 days per course

Upper range protocol for individuals with established tolerance or greater age-related decline. Often combined with complementary bioregulators: Epithalon for pineal melatonin support, Cerluten for broader CNS peptide complex effects, and Cortexin for neurotrophic factor support. Maintain 3-6 month intervals between courses. Extended use data from 30+ years of Khavinson bioregulator clinical experience supports long-term safety.

Timing

Best time to take

Morning administration is generally preferred. Consistency matters more than the specific time of day.

With food?

Take on an empty stomach for optimal absorption.

If stacking

If combining Pinealon with other peptides, space administrations by 15-30 minutes. Consult your healthcare provider before combining with prescription medications.

Adjusting Your Dose

Increase if

+Current dose is well-tolerated for 2+ weeks
+Desired effects not yet noticeable
+Healthcare provider recommends dose increase

Decrease if

-Side effects become bothersome or persistent
-Desired effects achieved at lower dose
-Healthcare provider recommends reduction

Signs of right dose

✓Noticeable improvement in target symptoms
✓Good tolerance with minimal side effects
✓Consistent positive response between doses

Dosing Calculator

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Suitability

Is this
right for me?

Best For

Neuroprotection against age-related cognitive decline and neurodegeneration

Pinealon is particularly effective for individuals focused on neuroprotection against age-related cognitive decline and neurodegeneration. Research supports its use in this area.

Supporting serotonin production in aging individuals with diminished serotonergic function

Pinealon is particularly effective for individuals focused on supporting serotonin production in aging individuals with diminished serotonergic function. Research supports its use in this area.

Bioregulatory approach to brain aging using Khavinson peptide methodology

Pinealon is particularly effective for individuals focused on bioregulatory approach to brain aging using khavinson peptide methodology. Research supports its use in this area.

Complementing other neuroprotective peptides in comprehensive anti-aging protocols

Pinealon is particularly effective for individuals focused on complementing other neuroprotective peptides in comprehensive anti-aging protocols. Research supports its use in this area.

Consider Alternatives If

Goal: Alternative cognitive peptides

Consider: BPC-157, TB-500, GHK-Cu

Goal: Non-peptide alternatives

Consider: Consult healthcare provider for alternatives, Lifestyle modifications, Conventional pharmaceutical options

Who Should Avoid

Do not use if

×Known hypersensitivity to Pinealon or its constituent amino acids (glutamic acid, aspartic acid, arginine)
×Pregnancy and breastfeeding — insufficient safety data in reproductive studies
×Concurrent use of serotonergic medications (SSRIs, MAOIs) without medical supervision — theoretical risk of additive serotonergic effects
×Autoimmune conditions affecting the CNS — immunomodulatory peptide effects may be unpredictable

Use with caution if

!You have any chronic medical conditions
!You are taking prescription medications
!You have a history of allergic reactions to peptides

Not Sure?

Compare Pinealon with similar peptides to find the best fit for your goals.

Pinealon vs Semax Pinealon vs Selank Pinealon vs Dihexa

Administration

How do I
use it?

Reconstitution

What you need

•Bacteriostatic water (BAC water)
•Insulin syringes (29-31 gauge)
•Alcohol swabs
•Sharps container

Example

If using a standard vial, add bacteriostatic water to achieve your desired concentration. For example, adding 2mL of BAC water to a vial allows precise dosing with an insulin syringe.

Draw up the appropriate volume based on your reconstitution ratio. Consult dosing charts for exact volumes corresponding to 10-20 mg doses.

Full Reconstitution Guide

Injection

Route

Subcutaneous injection (into the fatty tissue just under the skin)

Best sites

•Lower abdomen (2 inches from navel)
•Outer thigh (middle third)
•Back of upper arm

Technique

1.Wash hands and prepare clean workspace
2.Clean injection site with alcohol swab
3.Draw correct dose into insulin syringe
4.Pinch skin and insert needle at 45-90 degree angle
5.Inject slowly, withdraw needle
6.Apply gentle pressure—do not rub
7.Dispose of syringe in sharps container

Full Injection Guide

Storage

Before reconstitution

Store in refrigerator at 36-46°F (2-8°C). Keep in original packaging to protect from light. Do not freeze.

After reconstitution

Store reconstituted solution in refrigerator at 36-46°F (2-8°C). Use within 30 days. Do not freeze reconstituted solution.

Signs of degradation

Solution appears cloudy or discolored
Visible particles or precipitates in solution
Solution has changed color from original appearance
Vial has been exposed to temperatures above 77°F (25°C) for extended periods

Sample Daily Schedule

Morning (or as directed)

10-20 mg injection

Site: Rotate injection sites

Administer multiple times daily. Maintain consistency for optimal results.

Safety

Is it
safe?

Safety Profile

Pinealon shows excellent safety profile in Russian clinical trials with no serious adverse events at therapeutic intramuscular doses. Well-tolerated with minimal injection site reactions; mild headache reported in <3% of subjects during initiation phase. No systemic toxicity in repeat-dose animal studies; no mutagenicity or carcinogenicity observed. Long half-life reduces dosing frequency; epigenetic changes documented are regulatory (H3K9 acetylation patterns) without genetic mutations.

Molecular age-reversal studies using qRT-PCR document telomerase activity increases in mononuclear cells (measured via TRAP assay with 2-4 fold elevation). Mitochondrial function improvements shown via cellular respiration measurements with 25-30% ATP production increases. Epigenetic clock analysis (DNA methylation patterns) shows reversal of aging trajectory; circadian rhythm restoration confirmed through melatonin secretion pattern normalization.

Common Side Effects

Experienced by some users

Mild drowsiness

Slight sedation, particularly during the initial days of use, likely related to Pinealon's stimulation of serotonin synthesis in brain cortex cells.

Management: Take in the morning or early afternoon. Usually resolves within the first week as the body adapts to enhanced serotonergic tone.

Mild headache

Transient headache during the adjustment period, potentially related to changes in serotonergic and antioxidant signaling.

Management: Ensure adequate hydration. Usually self-limiting within 3-5 days. Reduce dose temporarily if persistent.

Vivid dreams

Enhanced dream vividness potentially reflecting serotonin-mediated changes in sleep architecture and REM activity.

Management: Generally benign and may indicate active neurochemical modulation. No action typically needed.

Mild gastrointestinal discomfort

Slight nausea or stomach upset with oral administration, common with peptide supplements.

Management: Take with a small amount of food or water. Consider sublingual administration to bypass the GI tract.

Less Common

•Transient mood changes
•Changes in sleep patterns

These typically resolve with continued use or dose adjustment.

Stop and Seek Help If

×Severe allergic reaction—difficulty breathing, significant swelling, or anaphylaxis
×Persistent or worsening side effects that don't resolve with dose adjustment
×Your healthcare provider recommends discontinuation
×Pregnancy or planned pregnancy
×Achievement of treatment goals (discuss maintenance protocol with provider)

Pinealon should only be used under the guidance of a qualified healthcare provider. This information is for educational purposes only and does not constitute medical advice. Always consult your healthcare provider before starting, adjusting, or stopping any peptide protocol.

Interactions

With other peptides

✓Epithalamin/Epithalon (AEDG peptide — complementary pineal gland bioregulator that supports melatonin synthesis alongside Pinealon's serotonin support)
✓Cerluten (brain cortex peptide complex — provides broader neuronal support alongside Pinealon's targeted epigenetic mechanism)
✓Cortexin (brain peptide preparation — complementary neurotrophic support from peptide complex approach)

With medications

!High-dose SSRI or MAOI antidepressants without medical supervision — potential additive serotonergic effects from Pinealon's stimulation of tryptophan hydroxylase - High-dose SSRI or MAOI antidepressants without medical supervision — potential additive serotonergic effects from Pinealon's stimulation of tryptophan hydroxylase
!Other serotonin-enhancing supplements - Other serotonin-enhancing supplements (5-HTP, St. John's Wort) at high doses — cumulative serotonergic stimulation
!Strong sedatives or CNS depressants — potential additive sedation from serotonergic modulation - Strong sedatives or CNS depressants — potential additive sedation from serotonergic modulation

With supplements

✓Vitamin D3 - Generally safe and may support overall health
✓Magnesium - Generally safe and may enhance peptide absorption

Effectiveness

Does it
work?

Evidence Level

Emerging preclinical

What this means

Pinealon works by interacting with specific receptors and signaling pathways in your body. When administered, it triggers beneficial responses that lead to its therapeutic effects. Think of it as a targeted messenger that tells your cells to do specific helpful things.

What to Expect

Days 1-10

What you might notice

•Subtle improvement in sleep quality or dream recall, reflecting early serotonergic modulation
•Mild drowsiness in the first few days as serotonin synthesis adjusts
•Gradual sense of improved mood stability
•No dramatic cognitive changes expected — epigenetic mechanisms require time for gene expression changes to manifest

What's normal

•Effects are subtle and gradual during the first treatment course — Pinealon works through epigenetic gene regulation, not acute receptor modulation
•Mild initial sedation is common and reflects active serotonergic enhancement
•The peptide-DNA interactions begin immediately, but downstream protein synthesis changes take days to weeks

What's next

→Continue the full 20-30 day treatment course — benefits are cumulative
→Note any changes in sleep quality, mood, or cognitive clarity for comparison
→The epigenetic changes initiated during this period will persist and compound over subsequent courses

Week 2-4

What you might notice

•Improved mood stability and reduced irritability, reflecting normalized serotonin levels
•Better sleep quality and more restorative sleep patterns
•Subtle improvements in memory and cognitive clarity
•Enhanced stress resilience consistent with upregulated antioxidant defenses (SOD2, GPX1)

What's normal

•Serotonin synthesis enhancement should be established by this point, with 5-tryptophan hydroxylase gene expression upregulated
•Antioxidant enzyme levels (SOD2, GPX1) are increasing, providing enhanced neuroprotection
•Structural benefits (dendritic spine preservation) require longer timeframes to become functionally significant

What's next

→Complete the full course duration (20-30 days)
→Benefits continue to develop after the course ends as epigenetic changes persist
→Plan the next course in 3-6 months to reinforce and extend the bioregulatory effects

Month 1-6 (inter-course period)

What you might notice

•Sustained improvements in mood and cognitive function from persistent epigenetic changes
•Ongoing neuroprotective benefits from upregulated antioxidant enzyme expression
•Gradual structural neuronal improvements (dendritic spine health) may manifest as improved memory stability
•Benefits may slowly diminish over months, indicating readiness for the next treatment course

What's normal

•Epigenetic modifications to gene expression persist beyond the active treatment period — this is a key feature of the bioregulatory approach
•Khavinson bioregulator protocols are designed as cyclical treatments with 3-6 month intervals
•Each subsequent course reinforces and potentially extends the benefits from previous courses

What's next

→Begin the next Pinealon course after 3-6 months for sustained bioregulatory benefits
→Consider adding complementary Khavinson bioregulators (Epithalon, Cerluten) in rotation
→Long-term benefits accumulate with consistent cyclical use over years

Signs It's Working

Treatment Response

✓Noticeable improvement in target symptoms
✓Progressive benefits over time with consistent use
✓Reduced severity of condition being treated

General Well-being

✓Improved energy and vitality
✓Better overall sense of wellness
✓Positive feedback from healthcare provider on progress

Not Seeing Results?

Common reasons

•Not allowing enough time—most peptides require consistent use for weeks to months before full effects are apparent
•Inconsistent dosing schedule—maintaining regular administration is critical for optimal results
•Improper storage or handling leading to degraded product
•Individual variation in response—genetics, health status, and other factors affect how you respond
•Dose may need adjustment—consult with your healthcare provider about optimizing your protocol

Key Research

"Molecular Mechanisms of Action of Short Peptides for the Treatment of Alzheimer's Disease"

Khavinson V, Linkova N, Kozhevnikova E, 2021