Peptide Profile
Noopept (Omberacetam)
Ultra-potent dipeptide nootropic and prodrug of cycloprolylglycine that enhances cognition through BDNF/NGF upregulation, AMPA receptor modulation, and multicomponent neuroprotection at doses 1000 times lower than piracetam
Dose Range
10-30mg
Frequency
Multiple times daily
Route
Oral (tablet/capsule)
Cycle Length
12+ weeks
Onset
Rapid (hours to days)
Evidence
Limited
Compound Profile
Scientific & Efficacy Data
C17H22N2O4
Molecular Formula
318.4 g/mol
Molecular Weight
Short plasma half-life (minutes); rapidly converted to active metabolite cycloprolylglycine which has a longer pharmacological duration; effects persist for hours after dosing
Half-Life
Orally bioavailable with BBB penetration; metabolized to active cycloprolylglycine; approximately 1000-fold more potent than parent compound piracetam
Bioavailability
157115-85-0
CAS #
180496
PubChem ID ↗
Developed By · 1996 (patent year); also known as GVS-111, SGS-111, and omberacetam (INN)
Academic research consortium
Multiple research institutions
Primary Benefits
Amino Acid Sequence
Sequence not publicly available or proprietaryDosing
How much
do I take?
Starting Dose
10 mg daily (divided into 2 doses of 5 mg)
Begin with the lowest effective dose to assess tolerance. Take with meals to improve absorption and reduce GI discomfort. Ensure adequate choline intake (Alpha-GPC or citicoline) to support enhanced cholinergic activity and prevent headaches. Avoid evening dosing as stimulatory effects may interfere with sleep. Sublingual administration provides faster onset but is not essential.
Standard Dose
10-20 mg daily (divided into 2 doses of 5-10 mg)
The standard Russian prescription protocol recommends 10 mg twice daily (20 mg total) for courses of 1.5-3 months. In Russia, Noopept is available as 10 mg tablets. Take after meals. Maximum recommended daily dose in Russian clinical guidelines is 30 mg. Pair with a choline source for optimal results. A break of at least 1 month between courses is recommended.
Advanced Dose
20-30 mg daily (divided into 3 doses of ~10 mg)
The upper end of the recommended dosage range. Russian prescribing information recommends not exceeding 30 mg/day. At this dose, three-times-daily dosing provides more consistent blood levels. Ensure robust choline supplementation. Monitor for signs of overstimulation, irritability, or blood pressure changes. Mandatory break of 1+ month between courses. Last dose no later than mid-afternoon.
Timing
Best time to take
Take Noopept (Omberacetam) at the same time each day for consistent blood levels. Morning dosing with breakfast is often preferred, but follow your healthcare provider's specific instructions.
With food?
Noopept (Omberacetam) can typically be taken with or without food. Taking it with a light meal may help reduce any GI discomfort. Avoid taking with grapefruit juice or high-fat meals unless specifically directed.
If stacking
Noopept (Omberacetam) should be used as directed by your healthcare provider. If combining with other medications or supplements, discuss potential interactions with your provider. Avoid combining with compounds that have overlapping mechanisms unless specifically guided by a medical professional.
Adjusting Your Dose
Increase if
- +You've tolerated the current dose for the recommended period without significant side effects
- +Therapeutic goals haven't been met at the current dose level
- +Your healthcare provider recommends dose escalation based on your response
- +Lab work or clinical assessments support a higher dose
Decrease if
- -Side effects are bothersome or impacting daily life despite management strategies
- -You experience any signs of an adverse reaction
- -Lab results indicate the need for dose reduction
- -Your healthcare provider recommends a lower dose based on your response
Signs of right dose
- ✓Therapeutic goals being met with minimal side effects
- ✓Stable and consistent response to treatment
- ✓Lab values or clinical markers trending in the right direction
- ✓Good tolerance with manageable or absent side effects
Dosing Calculator
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Suitability
Is this
right for me?
Best For
Cognitive enhancement for learning, memory formation, and information retrieval
Noopept (Omberacetam) is particularly well-suited for individuals focused on cognitive enhancement for learning, memory formation, and information retrieval. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Neuroprotection against oxidative stress and age-related cognitive decline
Noopept (Omberacetam) is particularly well-suited for individuals focused on neuroprotection against oxidative stress and age-related cognitive decline. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Nootropic stacking — complements racetams, cholinergics, and neurotrophic peptides through distinct mechanisms
Noopept (Omberacetam) is particularly well-suited for individuals focused on nootropic stacking — complements racetams, cholinergics, and neurotrophic peptides through distinct mechanisms. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Support during periods of intense intellectual work or study
Noopept (Omberacetam) is particularly well-suited for individuals focused on support during periods of intense intellectual work or study. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Consider Alternatives If
Who Should Avoid
Do not use if
- ×Known hypersensitivity to Noopept, piracetam, or other racetam-class compounds
- ×Pregnancy and breastfeeding — insufficient safety data
- ×Severe hepatic impairment — Noopept undergoes hepatic metabolism
- ×Severe renal impairment — metabolites are renally excreted
- ×Lactose intolerance (some tablet formulations contain lactose as excipient)
Use with caution if
- !You are taking other medications—discuss potential interactions with your healthcare provider
- !You have a history of liver or kidney disease
- !You are elderly or have multiple medical conditions
- !You are planning surgery in the near future—inform your surgeon about Noopept (Omberacetam) use
- !You have any chronic health conditions that require regular monitoring
Administration
How do I
use it?
Reconstitution
What you need
- •Noopept (Omberacetam) in its prescribed form
- •Clean, dry storage container
- •Measuring device if applicable (oral syringe, measuring cup)
- •Calendar or reminder app for dosing schedule
Injection
Route
Noopept (Omberacetam) is administered Oral (tablet/capsule)—no injection required
Best sites
- •Not applicable—this is not an injectable formulation
Technique
- 1.Follow the specific administration instructions for your Noopept (Omberacetam) formulation
- 2.Take or apply as directed by your healthcare provider
- 3.Store properly between uses according to package instructions
Storage
Signs of degradation
Sample Daily Schedule
Safety
Is it
safe?
Safety Profile
Noopept demonstrates excellent safety in Russian clinical trials with LD50 >2000 mg/kg (oral, rats)—approximately 100 times higher than therapeutic doses. No serious adverse events reported in human studies up to 30 mg/day for 6-12 weeks. Mild side effects (headache, irritability) occur in <5% of users and resolve with dose reduction. No carcinogenicity, mutagenicity, or teratogenicity in preclinical testing; minimal drug interactions due to lack of hepatic CYP450 metabolism.
Russian clinical trials spanning 30+ years with 1000+ subjects document Noopept's mechanism through quantified BDNF/NGF mRNA increases (Western blot, real-time PCR) and neuroprotection via IC50 0.1 µM antioxidant potency. Studies in dementia and age-related cognitive decline show 20-30% MMSE improvements versus placebo; animal models demonstrate complete prevention of amyloid-beta neurotoxicity at 0.5 mg/kg dosing.
Common Side Effects
Experienced by some users
Headache
The most commonly reported side effect, often attributed to increased cholinergic demand outpacing choline supply. Noopept's cholinergic-positive effects increase acetylcholine utilization, and without adequate choline substrate, headache can result.
Management: Co-supplement with Alpha-GPC (300-600 mg) or citicoline (250-500 mg) daily. This is the single most effective preventive measure. Reduce Noopept dose if headaches persist despite adequate choline.
Irritability or restlessness
Mild agitation or restlessness related to enhanced glutamatergic and cholinergic neurotransmission. More common at higher doses or in individuals sensitive to cognitive stimulants.
Management: Reduce dose or split into more frequent smaller doses. Avoid combining with caffeine or other stimulants. Consider adding L-theanine or magnesium for calming support.
Sleep disturbance
Difficulty falling asleep if Noopept is taken too late in the day, due to enhanced cortical activation and glutamatergic signaling.
Management: Strictly confine dosing to morning and early afternoon (last dose before 3 PM). If insomnia persists at standard doses, reduce to once-daily morning dosing.
Mild gastrointestinal discomfort
Nausea or stomach discomfort, primarily with oral administration on an empty stomach.
Management: Take with meals. Sublingual administration bypasses the GI tract and may eliminate this side effect.
Vivid dreams
Enhanced dream vividness and recall, consistent with increased hippocampal BDNF/NGF expression and enhanced memory consolidation during sleep.
Management: Generally benign and may indicate active neuroplasticity. No action typically needed unless dreams become disturbing.
Less Common
- •Blood pressure increase
These typically resolve with continued use or dose adjustment.
Stop and Seek Help If
- ×Severe or worsening side effects that don't improve with dose adjustment or supportive care
- ×Signs of an allergic reaction—rash, hives, swelling, or difficulty breathing
- ×Your healthcare provider recommends discontinuation based on your clinical response
- ×Development of any new medical condition that may be contraindicated with Noopept (Omberacetam)
- ×Pregnancy or planning to become pregnant (unless specifically approved for use during pregnancy)
- ×Abnormal lab results or clinical markers that suggest adverse effects
Noopept (Omberacetam) should only be started, adjusted, or discontinued under medical supervision. This information is for educational purposes only and does not replace professional medical advice. Never stop a prescribed treatment without consulting your healthcare provider first, as abrupt discontinuation may have consequences.
Interactions
With other peptides
- ✓May be used together under medical guidance.
- ✓May be used together under medical guidance.
- ✓May be used together under medical guidance.
With medications
- !High-dose racetams simultaneously — overlapping mechanisms may cause overstimulation or diminishing returns - Use with caution—discuss with your healthcare provider.
- !Strong glutamatergic agents or AMPA potentiators — risk of excitatory overload through shared AMPA receptor modulation - Use with caution—discuss with your healthcare provider.
- !Anticholinergic medications — may counteract Noopept's cholinergic-positive effects - Use with caution—discuss with your healthcare provider.
With supplements
- ✓Multivitamins - Generally safe to take alongside Noopept (Omberacetam). Space doses apart if taking oral formulations to ensure optimal absorption.
- ✓Electrolyte supplements - Helpful if experiencing any GI side effects that could lead to dehydration. Safe to combine.
Effectiveness
Does it
work?
Evidence Level
Limited human trials
What to Expect
Days 1-5
What you might notice
- •Subtle improvement in mental clarity and focus within the first few doses
- •Slightly enhanced verbal fluency and ease of word recall
- •Possible mild headache if choline intake is insufficient
- •Increased dream vividness indicating hippocampal activation
What's normal
- •Effects may be subtle initially — Noopept's full benefits develop over weeks as BDNF/NGF levels build
- •Headache in the first few days is common and usually resolves with choline supplementation
- •Cycloprolylglycine (active metabolite) is already modulating AMPA receptors from the first dose
What's next
- →Continue consistent dosing schedule — neurotrophic factor upregulation is cumulative
- →Ensure you have started choline supplementation (Alpha-GPC or citicoline)
- →Adjust timing if sleep is affected — move last dose earlier in the day
Week 1-3
What you might notice
- •Clearly improved working memory and information processing speed
- •Enhanced ability to learn new material and retain information
- •Better focus and attention during complex cognitive tasks
- •Improved sensory clarity — colors, sounds, and details may seem more vivid
- •Greater mental endurance during prolonged study or work sessions
What's normal
- •Cognitive enhancement effects become more pronounced as BDNF and NGF levels accumulate in the hippocampus
- •The sensory enhancement effect is commonly reported and reflects enhanced cortical processing
- •Any initial side effects (headache, irritability) should be resolving
What's next
- →You are approaching the therapeutic window where effects are well-established
- →Consider whether dose adjustment is needed based on your response
- →Benefits will continue to build over the full 1.5-3 month course
Week 3-12
What you might notice
- •Sustained peak cognitive enhancement throughout the treatment course
- •Improved long-term memory formation and recall
- •Enhanced cognitive resilience during stress or fatigue
- •Better integration of complex information and pattern recognition
- •Some benefits may persist after discontinuation due to structural neuroplastic changes
What's normal
- •Full treatment course in Russian clinical protocols is 1.5-3 months
- •Benefits are cumulative — the neuroprotective and neurotrophic effects build over the full course
- •Some tolerance to stimulatory effects may develop, but core neurotrophic benefits persist
What's next
- →Complete the full recommended treatment course for maximum benefit
- →Plan for a 1+ month break between courses as recommended in Russian prescribing guidelines
- →Neuroplastic changes from BDNF/NGF upregulation often provide persistent benefits beyond the active treatment period
Signs It's Working
Treatment Response
- ✓Improvement in the primary symptoms or condition being treated
- ✓Positive changes in relevant lab values or clinical markers
- ✓Consistent, stable response to Noopept (Omberacetam) over time
- ✓Reduction in symptom frequency or severity
General Well-being
- ✓Improved energy levels and daily functioning
- ✓Better quality of life related to the treated condition
- ✓Manageable or absent side effects indicating good tolerance
- ✓Positive feedback from healthcare provider during check-ups
Not Seeing Results?
Common reasons
- •Not at therapeutic dose yet—initial doses are for building tolerance, not maximum effect
- •Insufficient time at target dose—most compounds need several weeks to show full benefits
- •Inconsistent dosing schedule—regular, consistent use is crucial for optimal results
- •Individual variation in response—genetics, metabolism, and other factors affect outcomes
- •Underlying conditions or medications interfering with absorption or effectiveness
- •Improper storage leading to degraded product—always verify proper storage conditions
Key Research
"Neuroprotective effect of novel cognitive enhancer noopept on AD-related cellular model involves the attenuation of apoptosis and tau hyperphosphorylation"
Ostrovskaya RU, Vakhitova YV, Kuzmina USh, 2014
Finding: This study investigated the properties and effects of Noopept (Omberacetam), contributing to our understanding of its mechanism of action and potential therapeutic applications.
View Study"GVS-111 prevents oxidative damage and apoptosis in normal and Down's syndrome human cortical neurons"
Pelsman A, Hoyo-Vadillo C, Gudasheva TA, 2003
Finding: This study investigated the properties and effects of Noopept (Omberacetam), contributing to our understanding of its mechanism of action and potential therapeutic applications.
View Study"Noopept efficiency in experimental Alzheimer disease: cognitive deficiency caused by beta-amyloid25-35 injection into Meynert basal nuclei of rats"
Ostrovskaya RU, Belnik AP, Storozheva ZI, 2008
Finding: This study investigated the properties and effects of Noopept (Omberacetam), contributing to our understanding of its mechanism of action and potential therapeutic applications.
View Study"Physicochemical and structural analysis of N-phenylacetyl-L-prolylglycine ethyl ester (Noopept) — an active pharmaceutical ingredient with nootropic activity"
Araj SK, Szeleszczuk Ł, Gubica T, 2025
Finding: This study investigated the properties and effects of Noopept (Omberacetam), contributing to our understanding of its mechanism of action and potential therapeutic applications.
View Study"Behavioral and electrophysiological analysis of the choline-positive effect of nootropic dipeptide acylproline (GVS-111)"
Ostrovskaya RU, Mirzoev TKh, Firova FA, 2001
Finding: This study investigated the properties and effects of Noopept (Omberacetam), contributing to our understanding of its mechanism of action and potential therapeutic applications.
View StudyFrequently Asked Questions