Peptide Profile

Nafarelin

A potent GnRH agonist that initially stimulates then suppresses reproductive hormones, used for treating endometriosis and central precocious puberty with convenient nasal spray delivery.

Hormone Support

Dose Range

As prescribed-As prescribedmg

Frequency

Once daily

Route

As directed by healthcare provider

Cycle Length

Ongoing/indefinite

Onset

Moderate (1-2 weeks)

Evidence

Strong

Compound Profile

Scientific & Efficacy Data

C₆₆H₈₃N₁₇O₁₃

Molecular Formula

1322.5 g/mol

Molecular Weight

Approximately 2-6 hours (varies by route of administration)

Half-Life

~2-3% (intranasal)

Bioavailability

86220-42-0

CAS #

25077405

PubChem ID ↗

Developed By · 1988

Searle/Pharmacia Research Team

Searle (later Pharmacia/Pfizer)

Primary Benefits

Endometriosis Treatment

Reduces severe endometriosis pain and cramping significantly within weeks

Precocious Puberty

Manages precocious puberty progression and decreases abnormal vaginal bleeding

Hormone Regulation

Creates predictable hormone suppression for therapeutic effect with reversible outcomes

Amino Acid Sequence

pGlu-His-Trp-Ser-Tyr-D-2-Nal-Leu-Arg-Pro-Gly-NH2

Dosing

How much
do I take?

Starting Dose

As prescribed

Frequency

Once daily

Duration

2-4 weeks

Begin Nafarelin at the lowest effective dose to assess tolerance and response. This introductory phase helps your body adjust while minimizing potential side effects.

Standard Dose

Standard therapeutic range

Frequency

Once daily

Duration

4-8 weeks

The standard dosing range for Nafarelin where most therapeutic benefits are observed. Adjust based on individual response and healthcare provider guidance.

Advanced Dose

As prescribed

Frequency

Once daily

Duration

As directed

Higher doses of Nafarelin may be used under close medical supervision for patients requiring stronger therapeutic effects. Monitor closely for side effects.

Timing

Best time to take

Use Nafarelin at the same time each day for optimal results. Consistency in timing helps maintain stable levels and maximize therapeutic benefits. Follow your healthcare provider's specific instructions.

With food?

Nafarelin can generally be used with or without food. If you experience any discomfort, try taking it with a light meal. Follow specific guidance from your healthcare provider.

If stacking

Nafarelin should be used as directed by your healthcare provider. If combining with other medications or supplements, discuss potential interactions with your provider. Avoid combining with compounds that have overlapping mechanisms unless specifically guided by a medical professional.

Adjusting Your Dose

Increase if

+You've tolerated the current dose for the recommended period without significant side effects
+Therapeutic goals haven't been met at the current dose level
+Your healthcare provider recommends dose escalation based on your response
+Lab work or clinical assessments support a higher dose

Decrease if

-Side effects are bothersome or impacting daily life despite management strategies
-You experience any signs of an adverse reaction
-Lab results indicate the need for dose reduction
-Your healthcare provider recommends a lower dose based on your response

Signs of right dose

✓Therapeutic goals being met with minimal side effects
✓Stable and consistent response to treatment
✓Lab values or clinical markers trending in the right direction
✓Good tolerance with manageable or absent side effects

Dosing Calculator

Calculate Your Exact Dose

Step 1: Peptide Weight

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5mg

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Suitability

Is this
right for me?

Best For

Managing moderate to severe endometriosis pain that doesn't respond to other treatments

Nafarelin is particularly well-suited for individuals focused on managing moderate to severe endometriosis pain that doesn't respond to other treatments. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.

Treating children with precocious puberty (early puberty)

Nafarelin is particularly well-suited for individuals focused on treating children with precocious puberty (early puberty). Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.

Preparing women for endometriosis surgery by reducing inflammation

Nafarelin is particularly well-suited for individuals focused on preparing women for endometriosis surgery by reducing inflammation. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.

Improving fertility outcomes in assisted reproductive procedures

Nafarelin is particularly well-suited for individuals focused on improving fertility outcomes in assisted reproductive procedures. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.

Consider Alternatives If

Goal: Alternative approaches for general support

Consider: Consult your healthcare provider for alternatives to Nafarelin based on your specific needs and medical history

Goal: Non-peptide alternative approaches

Consider: Consult healthcare provider for alternatives, Lifestyle modifications, Conventional pharmaceutical options

Who Should Avoid

Do not use if

×Pregnancy (can harm fetus - must use non-hormonal birth control)
×Hypersensitivity to GnRH agonists
×Undiagnosed vaginal bleeding
×Severe osteoporosis or bone disease

Use with caution if

!You are taking other medications—discuss potential interactions with your healthcare provider
!You have a history of liver or kidney disease
!You are elderly or have multiple medical conditions
!You are planning surgery in the near future—inform your surgeon about Nafarelin use
!You have any chronic health conditions that require regular monitoring

Not Sure?

Compare Nafarelin with similar peptides to find the best fit for your goals.

Nafarelin vs Gonadorelin (GnRH)Nafarelin vs Human Chorionic Gonadotropin (HCG)Nafarelin vs Triptorelin

Administration

How do I
use it?

Reconstitution

What you need

•Nafarelin vial (lyophilized powder or solution)
•Bacteriostatic water or sterile sodium chloride for reconstitution
•Alcohol swabs for cleaning vial tops and injection sites
•Appropriately sized syringes with fine-gauge needles (27-30 gauge)
•Sharps disposal container

Example

Add the recommended volume of bacteriostatic water to the Nafarelin vial. Gently swirl (do not shake) until the powder is fully dissolved. The resulting solution should be clear. Calculate your individual dose based on the concentration and your prescribed amount.

Your dose of Nafarelin is determined by your healthcare provider. Using an insulin syringe marked in units, draw up the exact amount prescribed. For example, if the reconstituted concentration is 1mg/mL and your dose is 0.5mg, draw up 0.5mL (50 units on an insulin syringe). Always double-check calculations before injection.

Injection

Route

Subcutaneous injection (into the fatty tissue just under the skin)—allows for consistent absorption and can be self-administered at home after proper training

Best sites

•Abdomen (stomach area)—at least 2 inches from the belly button, most popular choice for self-injection
•Front of thighs—middle to upper portion of the outer leg
•Back of upper arm—outer area (may need assistance from another person)

Technique

1.Wash your hands thoroughly with soap and water before handling supplies
2.Clean the injection site with an alcohol swab and let it air dry completely
3.Pinch a fold of skin at the chosen injection site
4.Insert the needle at a 45-90 degree angle (depending on needle length and body composition)
5.Inject the medication slowly and steadily over 5-10 seconds
6.Release the skin fold and remove the needle, applying gentle pressure with a clean swab
7.Rotate injection sites to prevent tissue irritation or lipodystrophy
8.Dispose of the needle safely in a sharps container—never recap or reuse needles

Storage

Before reconstitution

Store Nafarelin in the refrigerator at 36-46°F (2-8°C) in its original packaging. Protect from light and moisture. Do not freeze. Check the expiration date before use. Some formulations may be stored at room temperature for limited periods—check your specific product labeling.

After reconstitution

Once reconstituted, Nafarelin should be kept refrigerated at 36-46°F (2-8°C) and used within the timeframe specified on your product labeling (typically 14-28 days). Label the vial with the reconstitution date. Do not use if the solution appears cloudy, discolored, or contains particles.

Signs of degradation

Solution appears cloudy, discolored, or contains visible particles (should be clear)
Product has been exposed to temperatures outside the recommended storage range
Product has been frozen (unless specifically designed for freeze-thaw stability)
Expiration date has passed or reconstituted solution has exceeded its use-by date
Unusual odor, color change, or visible contamination

Sample Daily Schedule

As prescribed (once daily)

As prescribed by your healthcare provider injection

Site: As directed by healthcare provider—rotate sites if applicable

Maintain a consistent schedule for optimal results with Nafarelin. Set reminders if needed. If you miss a dose, follow your healthcare provider's instructions—do not double up on doses to compensate.

Safety

Is it
safe?

Safety Profile

Nafarelin is FDA-approved with a well-established safety profile across decades of clinical use for endometriosis and precocious puberty. The most significant safety consideration is hypogonadism and bone density loss during prolonged therapy, requiring add-back therapy (norethindrone 0.4 mg daily) after 6 months to prevent osteoporosis. Common side effects—hot flashes, vaginal dryness, mood changes—are reversible upon discontinuation and typically diminish with continued use.

FDA approval based on multiple randomized controlled trials in endometriosis (n=1000+) showing superior efficacy versus danazol with improved tolerability. Long-term safety data from 20+ years of clinical use demonstrates Class III osteoporosis risk after 12 months without add-back therapy, measured via DEXA scans. Cardiovascular effects minimal; lipid profile changes are modest and reversible.

Common Side Effects

Experienced by some users

Hot flashes and night sweats (happen in 90% of users)