Peptide Profile
Triptorelin
GnRH agonist that helps manage prostate cancer, endometriosis, and early puberty by controlling sex hormones
Dose Range
0.1 mg-22.5 mgmg
Frequency
Once daily
Route
Intramuscular injection
Cycle Length
Ongoing/indefinite
Onset
Moderate (1-2 weeks)
Evidence
Strong
Compound Profile
Scientific & Efficacy Data
C64H82N18O13
Molecular Formula
1311.4 g/mol
Molecular Weight
2-3 hours (free peptide); 2-4 weeks (depot pamoate formulations)
Half-Life
~100% (intramuscular/subcutaneous injection)
Bioavailability
57773-63-4
CAS #
25074470
PubChem ID ↗
Developed By · 1982
Debiopharm Research Team
Debiopharm (licensed from Tulane University in 1982)
Primary Benefits
Suppresses testosterone levels in prostate cancer patients
Reduces symptoms of endometriosis including pelvic pain
Slows progression of central precocious puberty in children
Amino Acid Sequence
pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2Dosing
How much
do I take?
Timing
Best time to take
Administer Triptorelin at the same time each day (or on the same day each week for weekly injections). Many users prefer morning or evening administration. Pick a time you'll remember consistently.
With food?
Triptorelin injections can be given regardless of meal timing. However, if GI effects occur, administering on an empty stomach or with a light meal may help reduce discomfort.
If stacking
Triptorelin should be used as directed by your healthcare provider. If combining with other medications or supplements, discuss potential interactions with your provider. Avoid combining with compounds that have overlapping mechanisms unless specifically guided by a medical professional.
Adjusting Your Dose
Increase if
- +You've tolerated the current dose for the recommended period without significant side effects
- +Therapeutic goals haven't been met at the current dose level
- +Your healthcare provider recommends dose escalation based on your response
- +Lab work or clinical assessments support a higher dose
Decrease if
- -Side effects are bothersome or impacting daily life despite management strategies
- -You experience any signs of an adverse reaction
- -Lab results indicate the need for dose reduction
- -Your healthcare provider recommends a lower dose based on your response
Signs of right dose
- ✓Therapeutic goals being met with minimal side effects
- ✓Stable and consistent response to treatment
- ✓Lab values or clinical markers trending in the right direction
- ✓Good tolerance with manageable or absent side effects
Dosing Calculator
Calculate Your Exact Dose
Step 1: Peptide Weight
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Suitability
Is this
right for me?
Best For
Managing advanced prostate cancer when combined with other treatments
Triptorelin is particularly well-suited for individuals focused on managing advanced prostate cancer when combined with other treatments. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Relieving severe endometriosis pain and symptoms
Triptorelin is particularly well-suited for individuals focused on relieving severe endometriosis pain and symptoms. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Delaying puberty development in children with early sexual maturation
Triptorelin is particularly well-suited for individuals focused on delaying puberty development in children with early sexual maturation. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Consider Alternatives If
Who Should Avoid
Do not use if
- ×Pregnancy (can affect fetal development)
- ×Undiagnosed vaginal bleeding
- ×Known hypersensitivity to GnRH agonists
- ×Severe untreated depression
- ×Active spinal cord compression in prostate cancer (requires urgent decompression)
Use with caution if
- !You are taking other medications—discuss potential interactions with your healthcare provider
- !You have a history of liver or kidney disease
- !You are elderly or have multiple medical conditions
- !You are planning surgery in the near future—inform your surgeon about Triptorelin use
- !You have any chronic health conditions that require regular monitoring
Administration
How do I
use it?
Reconstitution
What you need
- •Triptorelin vial (lyophilized powder or solution)
- •Bacteriostatic water or sterile sodium chloride for reconstitution
- •Alcohol swabs for cleaning vial tops and injection sites
- •Appropriately sized syringes with fine-gauge needles (27-30 gauge)
- •Sharps disposal container
Injection
Route
Subcutaneous injection (into the fatty tissue just under the skin)—allows for consistent absorption and can be self-administered at home after proper training
Best sites
- •Abdomen (stomach area)—at least 2 inches from the belly button, most popular choice for self-injection
- •Front of thighs—middle to upper portion of the outer leg
- •Back of upper arm—outer area (may need assistance from another person)
Technique
- 1.Wash your hands thoroughly with soap and water before handling supplies
- 2.Clean the injection site with an alcohol swab and let it air dry completely
- 3.Pinch a fold of skin at the chosen injection site
- 4.Insert the needle at a 45-90 degree angle (depending on needle length and body composition)
- 5.Inject the medication slowly and steadily over 5-10 seconds
- 6.Release the skin fold and remove the needle, applying gentle pressure with a clean swab
- 7.Rotate injection sites to prevent tissue irritation or lipodystrophy
- 8.Dispose of the needle safely in a sharps container—never recap or reuse needles
Storage
Signs of degradation
Sample Daily Schedule
Safety
Is it
safe?
Safety Profile
Triptorelin (GnRH agonist) has extensive FDA-approved safety data spanning decades for prostate cancer, endometriosis, and precocious puberty indications. Initial testosterone surge upon initiation ("flare reaction") can worsen prostate cancer or spinal cord compression symptoms, requiring careful patient monitoring in first 1-2 weeks and use of androgen antagonists in high-risk patients. Hypogonadal effects including hot flashes, sexual dysfunction, and bone loss develop predictably with chronic GnRH suppression; bone density monitoring is recommended in patients on therapy >6 months.
Triptorelin safety is well-established from Phase 3 prostate cancer trials and 25+ years post-market use in 400,000+ patients. Reversibility of hypogonadal effects within 2-4 months of discontinuation supports its tolerability profile. Off-label use in other hormone-dependent conditions carries similar pharmacological risks; baseline testosterone, FSH/LH, and PSA monitoring before initiation establishes individual risk profile.
Stop and Seek Help If
- ×Severe or worsening side effects that don't improve with dose adjustment or supportive care
- ×Signs of an allergic reaction—rash, hives, swelling, or difficulty breathing
- ×Your healthcare provider recommends discontinuation based on your clinical response
- ×Development of any new medical condition that may be contraindicated with Triptorelin
- ×Pregnancy or planning to become pregnant (unless specifically approved for use during pregnancy)
- ×Abnormal lab results or clinical markers that suggest adverse effects
Triptorelin should only be started, adjusted, or discontinued under medical supervision. This information is for educational purposes only and does not replace professional medical advice. Never stop a prescribed treatment without consulting your healthcare provider first, as abrupt discontinuation may have consequences.
Interactions
With other peptides
- ✓May be used together under medical guidance.
- ✓May be used together under medical guidance.
- ✓May be used together under medical guidance.
With medications
- !Other GnRH agonists or antagonists - Use with caution—discuss with your healthcare provider.
- !Certain antifungal medications that inhibit liver metabolism - Use with caution—discuss with your healthcare provider.
- !Medications that require unaltered hormone levels - Use with caution—discuss with your healthcare provider.
With supplements
- ✓Multivitamins - Generally safe to take alongside Triptorelin. Space doses apart if taking oral formulations to ensure optimal absorption.
- ✓Electrolyte supplements - Helpful if experiencing any GI side effects that could lead to dehydration. Safe to combine.
Effectiveness
Does it
work?
Evidence Level
Strong human trials
What to Expect
Days 1-7
What you might notice
- •Initial hormone surge (flare) may occur as the pituitary gland resets
- •Some patients notice increased hot flashes, mood swings, or temporary hormone-related symptoms
What's normal
- •Initial response to Triptorelin is beginning at the cellular level
- •Different individuals experience Triptorelin's onset at different rates
- •Transient systemic effects from initial Triptorelin exposure are common
What's next
- →Maintain consistent Triptorelin administration as prescribed
- →Document subjective effects and physical markers daily
- →Schedule a check-in with your provider about initial observations
Weeks 2-4
What you might notice
- •The flare effect wears off as the pituitary stops responding
- •Testosterone or estrogen levels begin dropping significantly
- •Hot flashes often peak during this time but gradually improve
What's normal
- •Triptorelin is now achieving steady-state pharmacokinetics
- •Measurable changes aligned with Triptorelin's mechanism may appear
- •Initial adjustment effects typically resolve by this point
What's next
- →Maintain Triptorelin dosing exactly as established
- →Track progress toward intended outcomes in detail
- →Review lab work or biomarker changes with your healthcare team
Months 2-3
What you might notice
- •Hormone levels stabilize at suppressed levels
- •Sexual side effects become more noticeable
- •In prostate cancer patients, PSA levels drop
- •Most mood-related side effects settle
What's normal
- •Full therapeutic effects of Triptorelin are well-characterized at this point
- •Maintenance of Triptorelin's therapeutic effects is typical
- •Tolerance patterns with Triptorelin are generally stable over months
What's next
- →Comprehensive assessment of Triptorelin efficacy should be conducted
- →Discuss long-term continuation, cycling, or protocol modifications
- →Continue regular monitoring of relevant biomarkers or symptoms
Signs It's Working
Treatment Response
- ✓Improvement in the primary symptoms or condition being treated
- ✓Positive changes in relevant lab values or clinical markers
- ✓Consistent, stable response to Triptorelin over time
- ✓Reduction in symptom frequency or severity
General Well-being
- ✓Improved energy levels and daily functioning
- ✓Better quality of life related to the treated condition
- ✓Manageable or absent side effects indicating good tolerance
- ✓Positive feedback from healthcare provider during check-ups
Not Seeing Results?
Common reasons
- •Not at therapeutic dose yet—initial doses are for building tolerance, not maximum effect
- •Insufficient time at target dose—most compounds need several weeks to show full benefits
- •Inconsistent dosing schedule—regular, consistent use is crucial for optimal results
- •Individual variation in response—genetics, metabolism, and other factors affect outcomes
- •Underlying conditions or medications interfering with absorption or effectiveness
- •Improper storage leading to degraded product—always verify proper storage conditions
Key Research
"Triptorelin associated adverse events evaluated using FAERS pharmacovigilance data"
Jia W, Wang T, 2025
Finding: Comprehensive FDA adverse event analysis of over 4000 triptorelin reports identified both expected and unexpected safety signals, with the most common serious effects including hot flashes and mood changes. Continuous pharmacovigilance monitoring shows the medication's safety profile is well-characterized across diverse patient populations.
View Study"A 6-month sustained-release formulation of triptorelin for locally advanced or metastatic prostate cancer: a real-world experience in Asia"
Yee CH, Chung YH, Ko IC, 2025
Finding: Real-world data from 237 prostate cancer patients showed triptorelin's 6-month formulation achieves excellent testosterone suppression (>92% below castration level) with high patient adherence and excellent tolerability. Only one patient discontinued due to side effects, demonstrating strong clinical benefit.
View Study"Resources Utilization Assessment and Cost-Minimization Analysis of the 6-Monthly Formulation of Triptorelin in the Treatment of Prostate Cancer in China"
Chen Y, Pan J, Zhong Y, 2024
Finding: Switching patients from monthly/quarterly to 6-month triptorelin formulations reduces annual costs by millions while cutting patient treatment time by 78%. This demonstrates triptorelin's dual advantage: superior efficacy with enhanced convenience for prostate cancer patients.
View Study"Comparative Cardiovascular Safety of Gonadotropin-releasing Hormone Antagonists and Agonists Among Patients Diagnosed with Prostate Cancer"
Patel S, Zhu K, Dave CV, 2025
Finding: Comparative analysis of GnRH-based hormone therapies confirms triptorelin's cardiovascular safety profile remains favorable in prostate cancer patients. Long-term hormone suppression therapy continues to be a cornerstone of advanced cancer management.
View StudyFrequently Asked Questions