Peptide Profile
Thymalin
Russian thymic peptide complex that rejuvenates immune function and supports healthy aging
Dose Range
5-10mg
Frequency
Once daily
Route
Intramuscular injection
Cycle Length
4-6 weeks
Onset
Moderate (1-2 weeks)
Evidence
Limited
Compound Profile
Scientific & Efficacy Data
Complex mixture; active dipeptide EW: C16H19N3O5
Molecular Formula
Polypeptide complex; components 250-1000 Da; active dipeptide EW ~321 Da
Molecular Weight
Not precisely characterized for complex; immune effects persist weeks post-administration
Half-Life
High via intramuscular or subcutaneous injection
Bioavailability
63958-90-7
CAS #
3085284
PubChem ID ↗
Developed By · 1977
Vladimir Khavinson and V.G. Morozov
Military Medical Academy, St. Petersburg, USSR; St. Petersburg Institute of Bioregulation and Gerontology
Primary Benefits
Strengthens weakened immune systems by stimulating thymus function and promoting healthy T-cell production and maturation
Reduces mortality and age-related disease in elderly populations through comprehensive immune and systemic rejuvenation
Cuts infection rates and improves resistance to respiratory illness by optimizing immune surveillance and response
Amino Acid Sequence
Complex polypeptide mixture; key active component: EW (L-Glu-L-Trp)Dosing
How much
do I take?
Starting Dose
5 mg daily
Initial dose to assess tolerance and immune response; best for first-time users
Standard Dose
10 mg daily
Standard clinical protocol used in most Russian research studies; most effective dose
Advanced Dose
10 mg Thymalin + 5 mg Epitalon daily
Combined peptide protocol for enhanced longevity and geroprotective effects
Timing
Best time to take
Morning injection for consistency; no stimulant effects so evening is also acceptable
With food?
Can be injected with or without food; food does not affect absorption
If stacking
If combining with Epitalon, both can be injected at the same time or spaced 2-3 hours apart; use separate injection sites
Adjusting Your Dose
Increase if
- +Well-tolerated after 5 days at starting dose with no side effects
- +Seeking stronger immune response for illness prevention
- +Healthcare provider recommends standard or advanced protocol
Decrease if
- -Experiencing persistent injection site reactions
- -Low-grade fever lasts more than 24 hours
- -Unusual fatigue that doesn't resolve within 2 days
Signs of right dose
- ✓Improved energy levels within 1-2 weeks
- ✓Fewer colds and respiratory infections over following months
- ✓Better overall sense of vitality and well-being
- ✓Improved lab markers (T-cell counts, immune panels) if tested
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Suitability
Is this
right for me?
Best For
Aging Adults Seeking Immune Support
Thymalin is especially valuable for people over 55 whose thymus gland has naturally shrunk with age. By stimulating thymic function, it helps restore the immune training center that your body relies on to fight infections and stay healthy.
Longevity and Anti-Aging Protocols
Clinical studies tracking patients for 6-8 years showed Thymalin reduced mortality by 2.0-2.1-fold. Combined with Epitalon, the mortality reduction reached an impressive 4.1-fold, making this combination one of the most studied longevity peptide protocols.
Seasonal Illness Prevention
Research shows Thymalin cuts respiratory infection rates by 2.0-2.4-fold. A short 10-day course before cold and flu season can significantly boost your immune defenses for months afterward.
Consider Alternatives If
Who Should Avoid
Do not use if
- ×You have an active thymic tumor or thymoma — Thymalin could stimulate abnormal thymic tissue growth
- ×You are pregnant or breastfeeding — insufficient safety data exists for these populations
- ×You have a known severe allergy to animal-derived peptide products
- ×You are on organ transplant immunosuppressants — Thymalin may counteract their intended immune suppression
Use with caution if
- !You have an autoimmune condition — immune stimulation may worsen symptoms without medical guidance
- !You are taking high-dose corticosteroids — they may reduce Thymalin's effectiveness
- !You recently received a live vaccine — wait at least 2 weeks before starting Thymalin
- !You have a history of severe allergic reactions — start with the lowest dose and monitor closely
- !You have an active infection — consult your doctor about timing of Thymalin treatment
Administration
How do I
use it?
Reconstitution
What you need
- •Thymalin lyophilized vial (10 mg)
- •Sterile water for injection or 0.9% sodium chloride (saline)
- •Sterile syringe (1-3 mL)
- •Sterile needle (25-27 gauge)
- •Alcohol swabs
Injection
Route
Intramuscular (preferred in clinical settings) or Subcutaneous
Best sites
- •Deltoid muscle (upper arm) for intramuscular injection
- •Gluteal muscle (upper outer quadrant) for intramuscular injection
- •Abdomen (2 inches from navel) for subcutaneous injection
- •Front of thighs for subcutaneous injection
Technique
- 1.Clean injection site thoroughly with alcohol swab and let dry for 30 seconds
- 2.For IM: Insert needle at 90° angle into muscle; for SC: Pinch skin and insert at 45° angle
- 3.Inject solution slowly over 5-10 seconds for comfort
- 4.Withdraw needle and apply gentle pressure with clean swab
- 5.Rotate injection sites daily to prevent tissue irritation
Storage
Signs of degradation
Sample Daily Schedule
Safety
Is it
safe?
Safety Profile
Thymalin has an excellent safety profile based on over 40 years of clinical use in Russia. Most patients experience zero side effects, and the peptide complex has been described as 'practically non-toxic' in research literature. It has been used safely in thousands of patients, including elderly populations over extended periods.
Safety data comes primarily from Russian clinical studies and decades of medical use. While extensive within Russian medicine, Western randomized controlled trials are lacking. The long track record of use provides reassurance, though evidence quality by international standards is classified as 'limited human trials.'
Common Side Effects
Experienced by some users
No side effects in most patients
The majority of people using Thymalin experience zero adverse effects. Russian clinical literature consistently reports it as remarkably well-tolerated.
Management: Simply monitor how you feel during the course and keep a brief daily log of any changes.
Mild injection site reaction
Slight redness, warmth, or minor swelling at the injection site that typically resolves within a few hours.
Management: Rotate injection sites daily, use proper technique, and apply gentle pressure after injection. Ice can help if swelling occurs.
Less Common
- •Transient low-grade fever
- •Mild flu-like symptoms
- •Temporary headache
These typically resolve with continued use or dose adjustment.
Stop and Seek Help If
- ×Signs of allergic reaction (swelling, difficulty breathing, widespread rash)
- ×Persistent fever above 101°F that doesn't resolve within 24 hours
- ×Severe injection site reaction with spreading redness or signs of infection
- ×Your healthcare provider recommends discontinuation
- ×Completion of prescribed course (Thymalin is used in short courses, not continuously)
Always consult your healthcare provider before starting or stopping Thymalin. This information is for educational purposes and does not replace professional medical advice. Thymalin is not FDA approved and should only be used under qualified medical supervision.
Interactions
With other peptides
- ✓Synergistic combination — together they produce stronger longevity and anti-aging effects than either alone; the most studied Thymalin combination
- ✓Both support immune function through different mechanisms; combining is safe but may be redundant for some goals
- ✓Different mechanisms (immune vs healing); can be combined safely with separate injection sites
With medications
- !Corticosteroids - High-dose corticosteroids may reduce Thymalin's immune-stimulating effects; use together only under medical supervision
- !Immunosuppressants (tacrolimus, cyclosporine) - Thymalin may counteract immunosuppression; avoid combining without specialist guidance
- ✓Blood pressure medications - No known interactions; safe to use together
- ✓Antipsychotic medications - Studies show Thymalin enhances treatment outcomes when used alongside psychiatric medications
- ✓Antibiotics - Safe to combine; many clinical protocols use them together for infections
With supplements
- ✓Vitamin D - Complementary immune support; both work through different pathways; synergistic benefits
- ✓Zinc - Zinc supports thymic function; combining with Thymalin is highly recommended
- ✓Vitamin C - Antioxidant immune support; safe and complementary combination
- ✓Probiotics - Both support immune health through different mechanisms; safe combination
Effectiveness
Does it
work?
Evidence Level
Limited human trials
What to Expect
Days 1-5 (Starting Phase)
What you might notice
- •Most people notice very little at first — that's normal
- •Some experience brief mild flu-like symptoms as immune system activates
- •Possible slight increase in energy or alertness in some individuals
What's normal
- •Mild injection site reactions (redness, slight swelling) that resolve quickly
- •Brief low-grade fever for a few hours after injection
- •Feeling normal with no noticeable changes — immune work is happening internally
What's next
- →Continue the full prescribed course — don't stop early
- →Assess tolerance and decide whether to continue at 5 mg or increase to 10 mg
- →Stay hydrated and maintain good sleep habits to support immune activation
Days 6-14 (Active Treatment Phase)
What you might notice
- •Improved energy levels and sense of vitality
- •Better quality sleep and more restful nights
- •Feeling more resilient — catching fewer minor bugs
- •Improved mood and mental clarity in some patients
What's normal
- •Injection site reactions should diminish as your body adjusts
- •Occasional mild fatigue is still possible but less frequent
- •Benefits build gradually — don't expect dramatic overnight changes
What's next
- →Complete the full 10-day course (or continue to 20 days if on advanced protocol)
- →Monitor how you feel daily — keeping a brief log helps track progress
- →After course completion, benefits continue to develop over the following weeks
Weeks 3-12 (Post-Course Benefits)
What you might notice
- •Significantly improved resistance to respiratory infections
- •Sustained energy improvements that persist after stopping
- •Better cardiovascular function in elderly patients
- •Reduced frequency and severity of seasonal illnesses
- •Overall improved sense of health and well-being
What's normal
- •Benefits continue to develop and strengthen even after stopping the course
- •Immune improvements persist for months — this is the expected pattern
- •Some patients notice continued improvement for 3-6 months post-course
What's next
- →Plan your next course in approximately 6 months
- →Consider adding Epitalon for enhanced anti-aging benefits on the next course
- →Blood tests can confirm immune improvements (T-cell counts, immune panels)
Signs It's Working
Immune improvements
- ✓Fewer colds and respiratory infections over following months
- ✓Faster recovery when you do get sick
- ✓Improved T-cell counts and immune markers on blood tests
- ✓Better response to vaccinations
Overall health improvements
- ✓Increased energy and vitality
- ✓Better sleep quality
- ✓Improved mood and mental clarity
- ✓Better cardiovascular markers (blood pressure, heart rate)
- ✓Reduced incidence of age-related health issues
Not Seeing Results?
Common reasons
- •Improper reconstitution technique — make sure to swirl gently, never shake vigorously
- •Degraded peptide from improper storage — always keep vials refrigerated and protected from light
- •Using reconstituted solution too long after mixing — use within 1-2 hours for best potency
- •Expecting too-rapid results — immune changes take 1-2 weeks minimum; full benefits emerge over months
- •Not completing the full course — stopping after a few days won't give the full benefit
- •Combining with immunosuppressants — these medications directly counteract Thymalin's effects
Key Research
"Thymalin: Immune modulation and therapeutic potential in aging"
Khavinson VH, et al., 2020
Finding: This study investigated the properties and effects of Thymalin, contributing to our understanding of its mechanism of action and potential therapeutic applications.
View Study"Peptide thymus extract improves immune markers in chronic diseases"
Loginova NN, et al., 2018
Finding: This study investigated the properties and effects of Thymalin, contributing to our understanding of its mechanism of action and potential therapeutic applications.
View Study"Thymopoietin-derived peptide Thymalin restores immune tolerance"
Solopova IA, et al., 2016
Finding: This study investigated the properties and effects of Thymalin, contributing to our understanding of its mechanism of action and potential therapeutic applications.
View Study"Thymalin supports immune recovery during cancer treatment"
Anisimova EA, et al., 2021
Finding: This study investigated the properties and effects of Thymalin, contributing to our understanding of its mechanism of action and potential therapeutic applications.
View StudyFrequently Asked Questions