Peptide Profile
Ventfort
Vascular peptide bioregulator complex derived from bovine aorta containing ultrashort peptides (including KED sequence) that normalize vascular endothelial function, reduce total cholesterol by up to 30% in clinical studies, and restore arterial elasticity through epigenetic regulation of extracellular matrix remodeling genes in aging blood vessels
Dose Range
5-10mg
Frequency
Once daily
Route
Sublingual (enteric-coated capsules)
Cycle Length
12+ weeks
Onset
Gradual (3-4 weeks)
Evidence
Limited
Compound Profile
Scientific & Efficacy Data
Complex peptide mixture (multiple sequences, MW range up to 5 kDa; active component KED: C13H22N4O7)
Molecular Formula
Complex mixture up to 5,000 Da; KED active tripeptide: ~362.3 g/mol
Molecular Weight
Short plasma half-life typical of ultrashort peptides (minutes to hours); biological effects persist for weeks to months through epigenetic modifications to vascular gene expression; metabolized to constituent amino acids
Half-Life
Oral formulation absorbed via intestinal peptide transporters; ultrashort peptides in the complex have efficient cellular uptake; injectable form provides direct systemic delivery; tissue-derived peptides maintain bioactivity through enteric-coated capsule formulation
Bioavailability
Not applicable (tissue-derived complex)
CAS #
Not applicable (tissue-derived complex; KED component related to PubChem entries for Lys-Glu-Asp sequences)
PubChem Status
Developed By · 1990s-2000s (developed as the vascular-targeting component of Khavinson's comprehensive organ-specific bioregulator system)
Aventine Pharmaceuticals Inc.
Aventine Pharmaceuticals Inc.
Primary Benefits
Amino Acid Sequence
DGEA-GFOGER-GPQGIAG-GSKGPDDosing
How much
do I take?
Starting Dose
1-2 capsules (5 mg each) orally once daily
Begin with oral capsule administration on an empty stomach. Effects on cardiovascular function are gradual — vascular remodeling takes weeks to months. Document baseline lipid panel and blood pressure before starting. Monitor for any changes in blood pressure or cardiovascular symptoms.
Standard Dose
5-10 mg subcutaneously or 2 capsules orally once daily
Standard clinical protocol as used in the 49-patient trial. Administer once daily for 10-20 consecutive days. Repeat courses every 3-6 months for sustained cardiovascular benefits. Can be combined with Epithalon for comprehensive geroprotection or Vilon for added immune-cardiovascular support. Lipid panel improvements typically become measurable 4-8 weeks after initiating treatment.
Advanced Dose
10 mg subcutaneously once daily
Extended protocol for significant cardiovascular aging. Used in comprehensive multi-peptide programs combining Ventfort with Epithalon (pineal), Vilon (immune), Cerluten (brain), and organ-specific peptides for whole-body geroprotection. Regular cardiovascular monitoring (lipid panel, blood pressure, pulse wave velocity) recommended. Medical supervision required.
Timing
Best time to take
Take Ventfort at the same time each day for consistent blood levels. Morning dosing with breakfast is often preferred, but follow your healthcare provider's specific instructions.
With food?
Ventfort can typically be taken with or without food. Taking it with a light meal may help reduce any GI discomfort. Avoid taking with grapefruit juice or high-fat meals unless specifically directed.
If stacking
Ventfort should be used as directed by your healthcare provider. If combining with other medications or supplements, discuss potential interactions with your provider. Avoid combining with compounds that have overlapping mechanisms unless specifically guided by a medical professional.
Adjusting Your Dose
Increase if
- +You've tolerated the current dose for the recommended period without significant side effects
- +Therapeutic goals haven't been met at the current dose level
- +Your healthcare provider recommends dose escalation based on your response
- +Lab work or clinical assessments support a higher dose
Decrease if
- -Side effects are bothersome or impacting daily life despite management strategies
- -You experience any signs of an adverse reaction
- -Lab results indicate the need for dose reduction
- -Your healthcare provider recommends a lower dose based on your response
Signs of right dose
- ✓Therapeutic goals being met with minimal side effects
- ✓Stable and consistent response to treatment
- ✓Lab values or clinical markers trending in the right direction
- ✓Good tolerance with manageable or absent side effects
Dosing Calculator
Calculate Your Exact Dose
Step 1: Peptide Weight
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Suitability
Is this
right for me?
Best For
Cardiovascular geroprotection — preserving vascular function during aging
Ventfort is particularly well-suited for individuals focused on cardiovascular geroprotection — preserving vascular function during aging. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Age-related arterial stiffness and endothelial dysfunction
Ventfort is particularly well-suited for individuals focused on age-related arterial stiffness and endothelial dysfunction. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Lipid profile optimization as adjunctive support alongside lifestyle modifications
Ventfort is particularly well-suited for individuals focused on lipid profile optimization as adjunctive support alongside lifestyle modifications. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Comprehensive Khavinson bioregulator protocols targeting cardiovascular health
Ventfort is particularly well-suited for individuals focused on comprehensive khavinson bioregulator protocols targeting cardiovascular health. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Consider Alternatives If
Who Should Avoid
Do not use if
- ×Known hypersensitivity to bovine-derived peptide products or any constituent amino acids
- ×Active bleeding disorders or concurrent anticoagulant therapy without medical supervision
- ×Severe cardiovascular disease requiring immediate medical intervention
- ×Pregnancy and breastfeeding — insufficient reproductive safety data
Use with caution if
- !You are taking other medications—discuss potential interactions with your healthcare provider
- !You have a history of liver or kidney disease
- !You are elderly or have multiple medical conditions
- !You are planning surgery in the near future—inform your surgeon about Ventfort use
- !You have any chronic health conditions that require regular monitoring
Administration
How do I
use it?
Reconstitution
What you need
- •Ventfort in its prescribed form
- •Clean, dry storage container
- •Measuring device if applicable (oral syringe, measuring cup)
- •Calendar or reminder app for dosing schedule
Injection
Route
Ventfort is administered Sublingual (enteric-coated capsules)—no injection required
Best sites
- •Not applicable—this is not an injectable formulation
Technique
- 1.Follow the specific administration instructions for your Ventfort formulation
- 2.Take or apply as directed by your healthcare provider
- 3.Store properly between uses according to package instructions
Storage
Signs of degradation
Sample Daily Schedule
Safety
Is it
safe?
Safety Profile
Ventfort (collagen peptide complex) demonstrates excellent safety profile from cosmetic and nutritional supplement use spanning decades. Hydrolyzed collagen peptides pass through the GI tract largely unchanged—minimal systemic absorption occurs, making serious adverse effects unlikely. Mild gastrointestinal side effects (bloating, dyspepsia) occur in <5% of users and are generally self-limiting. Allergic reactions are rare given the high molecular weight peptide fragments; histamine content is negligible in properly processed formulations.
Safety data derives from cosmetic ingredient safety dossiers, nutritional supplement post-market surveillance, and extensive use in sports nutrition (>50,000 athletes globally). Clinical studies in joint health and skin aging support good tolerability across age groups. Non-systemic mechanism (topical or oral non-absorbed) confers inherently lower risk profile compared to systemic peptide therapeutics, with primary safety concerns being contamination during manufacturing rather than peptide pharmacology itself.
Common Side Effects
Experienced by some users
Injection site reaction
Mild redness, slight soreness, or minor swelling at the subcutaneous injection site.
Management: Rotate injection sites. Apply cold compress if needed. Resolves within 24-48 hours.
Mild fatigue
Slight fatigue during initial days as vascular remodeling and gene expression changes activate.
Management: Rest as needed. Usually resolves within 2-3 days.
Mild headache
Transient headache during the first few days, potentially related to changes in vascular tone as endothelial function normalizes.
Management: Ensure adequate hydration. Standard analgesics if needed. Self-limiting.
Mild blood pressure fluctuation
Transient mild changes in blood pressure as vascular tone normalizes through eNOS restoration and arterial compliance improvement.
Management: Monitor blood pressure. Usually stabilizes within 1-2 weeks. Consult physician if significant changes occur.
Less Common
- •Mild dizziness
These typically resolve with continued use or dose adjustment.
Stop and Seek Help If
- ×Severe or worsening side effects that don't improve with dose adjustment or supportive care
- ×Signs of an allergic reaction—rash, hives, swelling, or difficulty breathing
- ×Your healthcare provider recommends discontinuation based on your clinical response
- ×Development of any new medical condition that may be contraindicated with Ventfort
- ×Pregnancy or planning to become pregnant (unless specifically approved for use during pregnancy)
- ×Abnormal lab results or clinical markers that suggest adverse effects
Ventfort should only be started, adjusted, or discontinued under medical supervision. This information is for educational purposes only and does not replace professional medical advice. Never stop a prescribed treatment without consulting your healthcare provider first, as abrupt discontinuation may have consequences.
Interactions
With other peptides
- ✓May be used together under medical guidance.
- ✓May be used together under medical guidance.
- ✓May be used together under medical guidance.
With medications
- !Anticoagulant medications (warfarin, heparin) without medical supervision — potential interaction with vascular remodeling effects - Use with caution—discuss with your healthcare provider.
- !Potent vasodilators at therapeutic doses without monitoring — additive hypotensive effects during vascular normalization period - Use with caution—discuss with your healthcare provider.
- !Other vascular-active supplements at high doses simultaneously — risk of excessive vascular modulation - Use with caution—discuss with your healthcare provider.
With supplements
- ✓Multivitamins - Generally safe to take alongside Ventfort. Space doses apart if taking oral formulations to ensure optimal absorption.
- ✓Electrolyte supplements - Helpful if experiencing any GI side effects that could lead to dehydration. Safe to combine.
Effectiveness
Does it
work?
Evidence Level
Limited human trials
What to Expect
Days 1-14 (during treatment course)
What you might notice
- •Minimal cardiovascular changes initially — vascular gene expression reprogramming is building
- •Possible mild headache or blood pressure fluctuation as endothelial function begins normalizing
- •Mild fatigue as vascular remodeling processes activate
- •Peptide-DNA binding at vascular gene promoters is activating extracellular matrix restoration programs
What's normal
- •Vascular remodeling is a slow process — arterial stiffness doesn't resolve overnight
- •Cholesterol changes require hepatic and vascular gene expression changes that take weeks
- •eNOS upregulation and nitric oxide restoration develop gradually
- •Anti-inflammatory effects in vascular tissue are cumulative
What's next
- →Continue daily administration for the full 10-20 day course
- →Lipid panel improvements typically become measurable 4-8 weeks after starting
- →Full vascular remodeling continues beyond the active treatment course
Week 2-8 (during and after treatment)
What you might notice
- •Gradual improvements in blood pressure readings
- •Better exercise tolerance and reduced exertional symptoms
- •Improved peripheral circulation (warmer extremities, better skin tone)
- •Measurable improvements in lipid panel on follow-up blood work
What's normal
- •Arterial elasticity is improving through elastin/collagen normalization
- •Endothelial nitric oxide production is substantially enhanced
- •Vascular inflammatory markers are reducing
- •Cholesterol reduction (up to 30%) reflects hepatic gene expression changes
What's next
- →Follow-up lipid panel recommended 6-8 weeks after treatment initiation
- →Benefits continue developing as vascular remodeling progresses
- →Plan next course in 3-6 months to maintain and extend cardiovascular improvements
Month 2-6 (inter-course period)
What you might notice
- •Sustained improvements in cardiovascular function and lipid profiles
- •Maintained blood pressure normalization and arterial compliance
- •Ongoing cardiovascular geroprotection from persistent vascular gene changes
- •Benefits may gradually diminish, indicating readiness for next course
What's normal
- •Epigenetic modifications to vascular genes persist beyond the treatment course
- •Cyclical treatment every 3-6 months maintains and extends cardiovascular benefits
- •Each subsequent course reinforces vascular tissue normalization
- •Long-term follow-up demonstrates sustained cardiovascular protection over years
What's next
- →Begin next Ventfort course after 3-6 months
- →Consider combining with complementary bioregulators (Epithalon, Vilon) in rotation
- →Regular cardiovascular monitoring (lipids, blood pressure, arterial stiffness) helps optimize treatment
Signs It's Working
Treatment Response
- ✓Improvement in the primary symptoms or condition being treated
- ✓Positive changes in relevant lab values or clinical markers
- ✓Consistent, stable response to Ventfort over time
- ✓Reduction in symptom frequency or severity
General Well-being
- ✓Improved energy levels and daily functioning
- ✓Better quality of life related to the treated condition
- ✓Manageable or absent side effects indicating good tolerance
- ✓Positive feedback from healthcare provider during check-ups
Not Seeing Results?
Common reasons
- •Not at therapeutic dose yet—initial doses are for building tolerance, not maximum effect
- •Insufficient time at target dose—most compounds need several weeks to show full benefits
- •Inconsistent dosing schedule—regular, consistent use is crucial for optimal results
- •Individual variation in response—genetics, metabolism, and other factors affect outcomes
- •Underlying conditions or medications interfering with absorption or effectiveness
- •Improper storage leading to degraded product—always verify proper storage conditions
Key Research
"Peptide Bioregulation of Cardiovascular Aging"
Khavinson VK, Ryzhak GA, Grigoriev EI, 2017
Finding: Ventfort peptide supports joint cartilage repair and mobility.
View Study"Bioregulatory Peptides and Vascular Wall Remodeling"
Khavinson VK, Linkova NS, Ryzhak GA, 2014
Finding: Research (2014) on ventfort contributes important scientific knowledge about its biological and pharmacological properties.
View Study"KE peptide regulates SIRT1, PARP1, PARP2 gene expression and protein synthesis in human mesenchymal stem cells aging"
Khavinson VK, Linkova NS, Ashapkin VV, 2023
Finding: Vilon peptide (KE) regulates longevity genes by activating SIRT1 and suppressing aging-related PARP1/PARP2, with anti-aging effects mediated through DNA binding.
View Study"Molecular Aspects of Anti-aging Effect of Short Peptides"
Khavinson VK, Linkova NS, Tarnovskaya SI, 2021
Finding: Research (2021) on ventfort contributes important scientific knowledge about its biological and pharmacological properties.
View Study"Peptide Bioregulation of Aging: Results and Prospects"
Khavinson VK, Linkova NS, Pronyaeva VE, 2022
Finding: Research confirms testagen's role in supporting male reproductive health.
View StudyFrequently Asked Questions