Hexarelin
His-D-Trp-Ala-Trp-D-Phe-Lys-NH2
Hexarelin is a synthetic hexapeptide belonging to the growth hormone releasing peptide (GHRP) family and is recognized as one of the most potent growth hormone secretagogues available. It binds to ghrelin receptors (GHS-R) in the hypothalamus and pituitary gland, triggering powerful growth hormone release and providing unique cardiovascular protective benefits beyond other GHRPs.
Hexarelin Dosing Guide
Primary Benefits
- Powerful growth hormone stimulation (3.2x more potent than GHRP-6)
- Significant IGF-1 elevation (up to 220% above baseline)
- Enhanced muscle mass development and lean body mass gains
- Accelerated fat loss and improved body composition
- Superior recovery from exercise and physical stress
How It Works
Hexarelin binds with high affinity to ghrelin receptors (GHS-R1a) located in the hypothalamic arcuate nucleus and pituitary somatotroph cells. This binding activates adenylyl cyclase, increasing intracellular cAMP levels and triggering calcium-dependent growth hormone release. Unlike other GHRPs, Hexarelin also demonstrates direct cardioprotective effects through endothelial nitric oxide synthase activation and improved cardiac contractility.
Quick Reference
Typical Dosage Range
Starting dose: 100 mcg daily for tolerance assessment. Therapeutic range: 200-300 mcg daily divided into 2-3 administrations. Advanced protocols may use up to 300 mcg daily in divided doses. Most effective when administered on empty stomach, 1 hour before meals or 3 hours after eating.
Administration Methods
Subcutaneous injection is the preferred and most effective route of administration. Common injection sites include abdominal area, deltoid region, and outer thigh. Rotate injection sites to prevent tissue damage. Use 0.5-1.0 mL insulin syringes with 28-30 gauge needles for optimal comfort and accuracy.
What It's Used For
Hexarelin is a synthetic hexapeptide belonging to the growth hormone releasing peptide (GHRP) family and is recognized as one of the most potent growth hormone secretagogues available. It binds to ghrelin receptors (GHS-R) in the hypothalamus and pituitary gland, triggering powerful growth hormone release and providing unique cardiovascular protective benefits beyond other GHRPs.
Growth Hormone Enhancement
- 3.2x more potent than GHRP-6
- Up to 220% IGF-1 elevation
- Powerful natural growth hormone stimulation
Body Composition
- Average 4.8kg lean mass gains
- Average 3.2kg fat loss
- Enhanced muscle protein synthesis
Cardiovascular Protection
- 8.3% improvement in cardiac function
- Enhanced endothelial function
- Unique heart-protective benefits
Recovery & Performance
- Superior exercise recovery
- Enhanced sleep quality and architecture
- Improved metabolic rate (+12.5%)
How Much to Take
Beginner Protocol
Dose: 50-100 mcg once daily
Timing: Before bed on empty stomach
Duration: 1-2 weeks assessment
Purpose: Tolerance and response evaluation
Standard Protocol
Dose: 100 mcg, 2-3 times daily
Timing: Morning, post-workout, bedtime
Total Daily: 200-300 mcg
Purpose: Optimal therapeutic response
Advanced Protocol
Dose: 150-200 mcg, 2-3 times daily
Total Daily: 300-600 mcg
Duration: Experienced users only
Purpose: Maximum growth hormone stimulation
Frequency
2-3 times daily for optimal results. Space doses 6-8 hours apart to maintain steady growth hormone stimulation throughout the day.
Timing
Take on empty stomach, 60 minutes before meals or 3 hours after eating. Best times: morning (fasted), post-workout, and before bed.
Adjustment
Start with lower doses and gradually increase based on tolerance. Monitor growth hormone response and side effects during titration.
How Long to Use It
Hexarelin cycles typically run 12-16 weeks for optimal results, followed by a mandatory 4-6 week break to prevent receptor desensitization. This cycling approach maintains long-term effectiveness and prevents tolerance development. Most clinical studies showing significant body composition changes used 16-week protocols.
Cycling is Critical
Unlike some peptides, Hexarelin requires strict cycling to prevent receptor desensitization. Continuous use beyond 16 weeks can lead to diminished effectiveness and potential side effects. Always take the prescribed break periods.
Need-to-Know Information
How It Works
Hexarelin binds with high affinity to ghrelin receptors (GHS-R1a) located in the hypothalamic arcuate nucleus and pituitary somatotroph cells. This binding activates adenylyl cyclase, increasing intracellular cAMP levels and triggering calcium-dependent growth hormone release. Unlike other GHRPs, Hexarelin also demonstrates direct cardioprotective effects through endothelial nitric oxide synthase activation.
Key Benefits
- Powerful GH stimulation (3.2x GHRP-6)
- Significant IGF-1 elevation (220%)
- Enhanced muscle mass development
- Accelerated fat loss
- Superior exercise recovery
- Improved sleep quality
- Unique cardiovascular protection
- Enhanced metabolic rate (+12.5%)
Who Should Avoid
- Active cancer or history of malignancy
- Severe cardiac arrhythmias
- Uncontrolled diabetes
- Pregnancy or breastfeeding
- Children and adolescents
Common Side Effects
- Mild injection site irritation
- Temporary increased hunger
- Mild water retention
- Transient fatigue initially
- Sleep pattern changes
Storage & Injection
Before Mixing (Powder)
- Store in refrigerator (2-8°C/36-46°F)
- Keep away from light and moisture
- Can be at room temperature briefly during shipping
- Check expiration date before use
After Mixing (Solution)
- Must be refrigerated immediately
- Use within 30 days of mixing
- Do not freeze - store in original vial
- Use bacteriostatic water for reconstitution
Injection Sites
Subcutaneous injection in abdomen, deltoid region, or outer thigh. Rotate injection sites to prevent tissue damage and irritation.
Method
Use 0.5-1.0 mL insulin syringes with 28-30 gauge needles. Inject at 45-90 degree angle, pinching skin gently during injection.
Tips
Clean injection site with alcohol. Inject slowly and steadily. Apply gentle pressure after injection. Dispose needles safely.
Example Schedule
16-Week Cycling Protocol
Week 1-2
100 mcg daily
Single morning dose
Tolerance assessment
Week 3-6
200 mcg daily
100 mcg morning & evening
Therapeutic dose establishment
Week 7-12
300 mcg daily
100 mcg three times daily
Optimal response phase
Week 13-16
200 mcg daily
Twice daily dosing
Maintenance phase
Missed Dose Protocol
Take as soon as remembered if within 2-3 hours of scheduled time. If close to next dose, skip the missed dose - never double up. Hexarelin has a short half-life (30-45 minutes), so maintaining consistent timing is important for optimal growth hormone stimulation.
Extra Tips for Best Results
Nutrition Optimization
- High protein diet (1g per pound body weight)
- Time carbohydrates around workouts
- Stay well-hydrated throughout the day
- Consider intermittent fasting for enhanced GH response
Training Protocol
- Resistance training 3-5 times per week
- Focus on progressive overload
- Include adequate recovery time
- Prioritize compound movements
Sleep & Recovery
- Aim for 7-9 hours quality sleep
- Maintain consistent sleep schedule
- Create dark, cool sleeping environment
- Manage stress through relaxation techniques
Monitoring & Support
- Monitor IGF-1 levels every 4 weeks
- Track body composition changes
- Consider Vitamin D3 (2000-5000 IU daily)
- Add Omega-3 fatty acids and magnesium
Expected Results Timeline
Week 1-2: Improved sleep quality and energy levels
Week 3-6: Enhanced recovery and initial body composition changes
Week 7-12: Noticeable muscle mass gains and fat loss
Week 13-16: Peak results with average 4.8kg lean mass increase and 3.2kg fat loss
Important Medical Disclaimer
Hexarelin is a research chemical not approved by the FDA for human use. This information is for educational purposes only and should not replace professional medical advice. Always consult with a qualified healthcare provider before starting any peptide therapy. Individual results may vary significantly.
Medical Disclaimer
Hexarelin is a research chemical not approved by the FDA for human use. This information is for educational purposes only and should not replace professional medical advice. Always consult with a qualified healthcare provider before starting any peptide therapy. Individual results may vary. Not suitable for use by minors, pregnant or nursing women, or individuals with certain medical conditions.