HCG
Human Chorionic Gonadotropin
Human Chorionic Gonadotropin (HCG) is a glycoprotein hormone naturally produced during pregnancy that mimics luteinizing hormone (LH) activity. It's FDA-approved for fertility treatments and hypogonadism in men. HCG stimulates testosterone production in males and triggers ovulation in females, making it valuable for hormone support, fertility preservation during testosterone therapy, and reproductive treatments.
HCG Dosing Guide
Primary Benefits
- Stimulates natural testosterone production in men
- Prevents testicular atrophy during TRT
- Maintains fertility and spermatogenesis
- Triggers ovulation in fertility treatments
- Supports luteal phase progesterone production
How It Works
HCG functions as a luteinizing hormone (LH) analog, binding with high affinity to the LH/chorionic gonadotropin receptor (LHCGR), a G-protein coupled receptor expressed primarily in gonadal tissues. Upon binding, it activates the Gs protein pathway, elevating intracellular cyclic adenosine monophosphate (cAMP) levels. This triggers protein kinase A (PKA) activation, leading to steroidogenesis through upregulation of steroidogenic acute regulatory (StAR) protein and enzymes like CYP11A1 and CYP17A1. In males, this results in testosterone synthesis by Leydig cells. In females, it induces ovulation and progesterone production by corpus luteum cells.
Quick Reference
Typical Dosage Range
For male hypogonadism and fertility preservation: 1,000-2,500 IU administered 2-3 times weekly via subcutaneous injection. For female ovulation induction: single intramuscular injection of 5,000-10,000 IU administered 34-38 hours after last FSH injection. For maintenance during TRT: 250-500 IU twice weekly subcutaneously. Duration varies from single doses for ovulation to ongoing therapy for testosterone support. Dosing should be individualized based on hormone monitoring and clinical response.
Administration Methods
HCG is administered via subcutaneous injection using insulin syringes for smaller doses (250-500 IU) or intramuscular injection for larger doses (>1,000 IU). Subcutaneous sites include abdomen, thigh, or upper arm, rotated to prevent lipodystrophy. Intramuscular administration uses larger needles in the gluteal or deltoid muscle. Reconstitution requires bacteriostatic water, typically at concentrations of 1,000-5,000 IU/mL. Timing is critical - evening administration is preferred for men to mimic natural LH rhythms.
What It's Used For
Human Chorionic Gonadotropin (HCG) is a glycoprotein hormone naturally produced during pregnancy that mimics luteinizing hormone (LH) activity. It's FDA-approved for fertility treatments and hypogonadism in men. HCG stimulates testosterone production in males and triggers ovulation in females, making it valuable for hormone support, fertility preservation during testosterone therapy, and reproductive treatments.
Testosterone Production
Stimulates natural testosterone production in men by mimicking luteinizing hormone (LH) activity. Helps maintain healthy hormone levels during testosterone replacement therapy.
Fertility Preservation
Maintains sperm production and fertility during hormone therapy. Prevents testicular atrophy and preserves reproductive function.
Ovulation Induction
Triggers ovulation in women during fertility treatments. FDA-approved for reproductive health applications with proven efficacy.
How Much to Take
Men (Hormone Support)
Women (Fertility)
Frequency
Men: 2-3 times weekly (Monday/Wednesday/Friday schedule). Women: Single injection per cycle as directed.
Timing
Evening injections preferred for men to mimic natural LH rhythms. Maintain consistent schedule for best results.
Adjustment
Dose based on hormone monitoring and clinical response. Regular blood work essential for optimization.
How Long to Use It
With TRT (Men)
Can be used continuously alongside testosterone therapy to maintain natural production and fertility.
Post-Cycle Recovery
Use for 8-16 weeks to restore natural hormone production after testosterone or steroid use.
Fertility Protocol
Minimum 3-6 months needed for sperm production improvement. Women use single doses per cycle.
Important Monitoring
Regular hormone monitoring essential. Watch for estrogen elevation, especially with higher doses or prolonged use. Discontinue if adverse effects occur.
Need-to-Know Information
How It Works
HCG functions as a luteinizing hormone (LH) analog, binding with high affinity to the LH/chorionic gonadotropin receptor (LHCGR), a G-protein coupled receptor expressed primarily in gonadal tissues. Upon binding, it activates the Gs protein pathway, elevating intracellular cyclic adenosine monophosphate (cAMP) levels. This triggers protein kinase A (PKA) activation, leading to steroidogenesis through upregulation of steroidogenic acute regulatory (StAR) protein and enzymes like CYP11A1 and CYP17A1. In males, this results in testosterone synthesis by Leydig cells. In females, it induces ovulation and progesterone production by corpus luteum cells.
Key Benefits
Who Should Avoid It
Possible Side Effects
Storage & Injection
Storage Requirements
Mixing Instructions
Injection Sites
Subcutaneous: stomach fat, thigh, or upper arm. Intramuscular: thigh or glute muscle for larger doses.
Method
Use insulin syringe for subQ injections. Clean injection site with alcohol. Rotate sites to prevent lumps.
Tips
Draw slowly to avoid bubbles. Change needle if switching from drawing to injection. Store syringes safely.
Example Schedule
Men - TRT Support Protocol (Low Dose)
Evening injections preferred to mimic natural LH rhythm. Maintain consistent schedule for optimal results.
Men - Post-Cycle Recovery (High Dose)
Use for 8-16 weeks to restore natural testosterone production. Monitor hormone levels throughout protocol.
Missed Dose Protocol
If you miss a dose, take it as soon as you remember if it's within 24 hours. If more than 24 hours have passed, skip the missed dose and continue with your regular schedule. Do not double dose to make up for missed injections.
Extra Tips for Best Results
Monitor Hormones
Combination Protocols
Fertility Optimization
Safety Precautions
Expected Results Timeline
Important Safety Information
HCG is FDA-approved for specific fertility indications and hormone support. This information is for educational purposes only. Always use under medical supervision with appropriate hormone monitoring. Discontinue and consult healthcare provider if adverse effects occur.
Medical Disclaimer
HCG is FDA-approved for specific fertility indications and testosterone replacement therapy support. This information is for educational purposes only and should not replace consultation with healthcare providers. Use only under medical supervision with appropriate monitoring.