Peptide Profile
SM-130686
Experimental oral growth hormone secretagogue with anabolic potential from preclinical research
Dose Range
5-20mg
Frequency
Multiple times daily
Route
Oral capsule or powder
Cycle Length
8-12 weeks
Onset
Moderate (1-2 weeks)
Evidence
Moderate
Compound Profile
Scientific & Efficacy Data
C22H24Cl2F3N3O3
Molecular Formula
506.3 g/mol (as HCl salt)
Molecular Weight
Not published in humans (preclinical only)
Half-Life
28% in rats (oral administration)
Bioavailability
259667-25-9
CAS #
9914145
PubChem ID ↗
Developed By · 2001
Jun Nagamine et al.
Sumitomo Pharmaceuticals Co. Ltd (Discovery Research Laboratories II, Osaka, Japan) — now Dainippon Sumitomo Pharma
Primary Benefits
Preclinical data shows dose-dependent increases in fat-free mass and body weight in rats given 10 mg/kg twice daily. No human data. Potential moderate benefit for lean mass building if human response matches animal models, but benefit is theoretical and unproven. Requires proper training and nutrition to manifest.
GH accelerates tissue repair and collagen synthesis. Rat studies suggest improved training capacity and reduced soreness. Potential benefit for athletic recovery, but magnitude and safety in humans unknown. Evidence is limited to animal models only.
GH supports metabolic rate and fat mobilization. Limited evidence in preclinical work suggests possible fat loss potential. High uncertainty regarding human metabolic effects. Antagonism of insulin action may worsen glucose control in some individuals, offsetting benefits.
Amino Acid Sequence
N/A — Non-peptide small molecule (oxindole-based growth hormone secretagogue)Dosing
How much
do I take?
Timing
Best time to take
With meals (improves absorption and tolerability)
With food?
Recommended — take with breakfast, lunch, or dinner to enhance bioavailability
If stacking
Take consistently at same times daily. Morning and evening dosing supports natural GH pulse during sleep and wakefulness.
Adjusting Your Dose
Increase if
- +No side effects after 2 weeks
- +Desired GH stimulation not achieved (measure via IGF-1 if possible)
- +Body composition goals not met after 6-8 weeks at current dose
Decrease if
- -Appetite becomes excessive or uncomfortable
- -Joint pain or swelling develops
- -Sleep disturbances occur
- -Blood glucose fluctuations noticed (especially in diabetics)
Signs of right dose
- ✓Improved sense of well-being and energy
- ✓Gradual lean muscle gains (2-4 lbs per month)
- ✓Better recovery from training
- ✓Increased appetite without discomfort
Dosing Calculator
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Suitability
Is this
right for me?
Best For
Lean Mass Building in Trained Athletes
SM-130686 targets GHS-R to stimulate GH release, which supports anabolic processes. Preclinical studies in rats showed significant increases in fat-free mass and body weight when combined with resistance training principles.
Age-Related GH Decline
As a GHS-R agonist, SM-130686 may help restore physiological GH secretion in adults experiencing age-related decline. The oral route is convenient for long-term administration.
Recovery and Performance
GH supports tissue repair, collagen synthesis, and recovery. May benefit individuals engaged in intensive resistance training or athletic performance work.
Consider Alternatives If
Who Should Avoid
Do not use if
- ×You are pregnant or breastfeeding (no safety data)
- ×You have active malignancy or history of cancer (GH promotes cell growth)
- ×You have severe uncontrolled diabetes (GH antagonizes insulin action)
- ×You are in drug-tested sports (research compound, likely banned)
Use with caution if
- !You have diabetes (may require insulin adjustment)
- !You have history of sleep apnea (GH can worsen)
- !You have carpal tunnel syndrome (GH may exacerbate)
- !You are taking insulin or glucose-lowering medications
- !You have cardiovascular risk factors (GH effects on heart not fully known)
Administration
How do I
use it?
Reconstitution
What you need
- •Not applicable — oral formulation
Injection
Route
Not applicable — oral formulation only
Best sites
- •N/A
Technique
- 1.N/A
Storage
Signs of degradation
Sample Daily Schedule
Safety
Is it
safe?
Safety Profile
SM-130686 is a research compound that has never been tested in humans. All safety and efficacy data come from animal studies (primarily rats). No human clinical trials have been conducted. Use carries unknown risks. Potential side effects based on GH physiology and limited preclinical work.
PRECLINICAL ONLY — This compound has not entered human clinical trials. No FDA data available. Safety profile in humans is completely unknown. All dosing is extrapolated from rat studies and should not be considered established for human use. This is an experimental research compound.
Common Side Effects
Experienced by some users
Appetite stimulation
GHS-R agonists increase appetite through ghrelin-like action on hypothalamus. May be mild to moderate depending on dose and sensitivity.
Management: Eat planned meals to satisfy appetite. Stay hydrated. If excessive, reduce dose or frequency.
Transient water retention
GH promotes sodium retention and fluid shifts. Usually mild and resolves within days of stopping. Can slightly increase body weight independent of muscle gain.
Management: Maintain normal hydration and electrolyte intake. Reduction is natural when discontinuing. Monitor weight trends over 2-week intervals.
Less Common
- •Joint or muscle aches
- •Transient changes in blood glucose
These typically resolve with continued use or dose adjustment.
Stop and Seek Help If
- ×Severe or worsening joint pain (possible early carpal tunnel)
- ×Uncontrolled blood glucose elevation (especially if diabetic)
- ×Signs of edema or swelling in hands/feet that doesn't resolve
- ×Development of numbness or tingling in hands (median nerve compression)
- ×Severe sleep disturbances or mood changes
- ×Any signs of allergic reaction (rash, difficulty breathing, swelling)
- ×Diagnosis of cancer during treatment
- ×Symptoms suggestive of acromegaly progression (facial coarsening, hand/feet growth)
This is a research compound with no human safety data. Serious side effects are possible and unknown. If any concerning symptoms develop, discontinue immediately and seek medical evaluation. Unknown long-term effects. Do not combine with other GH secretagogues. This is NOT medical advice. Consult a physician before use.
Interactions
With other peptides
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With medications
- !
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With supplements
- ✓
- ✓
- ✓
- ✓
Effectiveness
Does it
work?
Evidence Level
Moderate human trials
What to Expect
Week 1-2
What you might notice
- •Appetite increase (often noticeable within first 3-5 days)
- •Mild increase in energy or sense of well-being
- •Possible mild joint or muscle achiness (growth phase discomfort)
What's normal
- •Transient water retention (2-3 lbs weight gain is normal)
- •Mild appetite stimulation without discomfort
- •No dramatic changes in body composition (too early)
- •Possible slight sleep improvement
What's next
- →Assess tolerance at starting dose
- →If well tolerated, prepare to increase to standard dose in Week 3
- →Monitor for any concerning symptoms
- →Establish consistent training and nutrition routine
Week 3-6
What you might notice
- •Gradual increase in lean muscle appearance (if training consistently)
- •Better recovery between training sessions
- •Sustained appetite stimulation
- •Possible slight waist reduction (fat loss) depending on diet
What's normal
- •Body weight stable or slight increase (muscle gain + water retention)
- •Continued mild joint aches or 'growing pains' (usually mild)
- •Improved sense of vitality and mood
- •Possible slight insulin resistance (check fasting glucose if diabetic)
What's next
- →If at standard dose with good tolerance, may remain there through Week 12
- →If minimal effects seen, consider dose increase to advanced tier in Week 7
- →Continue progressive resistance training for compound to work optimally
- →Monitor blood glucose if at risk for diabetes
Week 7-12
What you might notice
- •More noticeable lean mass gains (expect 2-4 lbs per month of true muscle)
- •Visible improvement in muscle definition and vascularity
- •Sustained recovery and reduced muscle soreness
- •Possible body weight increase of 5-12 lbs depending on diet
What's normal
- •Appetite remains elevated throughout cycle
- •Transient water retention may persist (normal with GH stimulation)
- •Continued modest improvements in training performance
- •Energy levels sustained at elevated baseline
- •No major escalation of side effects if dose stable
What's next
- →At Week 10-12, begin planning cycle off (taper not necessary for oral compound)
- →Discontinue and allow GH levels to normalize (takes 2-4 weeks)
- →Maintain training and nutrition to preserve gains
- →Take 4-8 week break before considering re-dosing (limited human data on cycling)
- →Have follow-up bloodwork if possible, especially glucose and IGF-1
Signs It's Working
Physical performance
- ✓Improved strength gains during progressive resistance training
- ✓Faster recovery between training sessions (less delayed muscle soreness)
- ✓Increased training volume capacity (can do more reps or sets at same intensity)
- ✓Better endurance and reduced fatigue during workouts
Body composition
- ✓Visible increase in muscle size and definition (especially arms, shoulders, chest)
- ✓Decrease in body fat percentage (with proper diet) despite weight increase
- ✓Improved muscle separation and vascularity
- ✓Waist remains stable or slight decrease while weight increases (indicator of muscle gain)
General well-being
- ✓Increased appetite and food enjoyment
- ✓Elevated mood and sense of well-being
- ✓Improved energy throughout the day
- ✓Better sleep quality and duration
Not Seeing Results?
Common reasons
- •Inadequate resistance training stimulus (SM-130686 amplifies training effect; must train hard)
- •Poor diet with insufficient protein (need 1-1.2g per lb body weight to capitalize on GH effect)
- •Inconsistent dosing schedule or missed doses (daily consistency is critical)
- •Tolerance developed or low bioavailability absorption (take with meals; ensure digestive health)
- •Unrealistic expectations or too-short cycle (results appear over 6-8 weeks; faster gains than natural but not overnight)
Key Research
"Pharmacological profile of a new orally active growth hormone secretagogue, SM-130686"
Nagamine J et al., 2001
Finding: This study investigated the properties and effects of SM-130686, contributing to our understanding of its mechanism of action and potential therapeutic applications.
View Study"Synthesis and pharmacological profile of SM-130686 and related compounds"
Nagamine J et al., 2006
Finding: This study investigated the properties and effects of SM-130686, contributing to our understanding of its mechanism of action and potential therapeutic applications.
View Study"Common structural basis for constitutive activity of the ghrelin receptor family"
Holst B et al., 2009
Finding: This study investigated the properties and effects of SM-130686, contributing to our understanding of its mechanism of action and potential therapeutic applications.
View StudyFrequently Asked Questions