Oxytocin Acetate
Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH₂
Oxytocin Acetate is a synthetic form of the naturally occurring neuropeptide hormone oxytocin. FDA-approved for obstetric uses including labor induction, augmentation, and postpartum hemorrhage prevention. In research settings, it shows promise for treating autism spectrum disorders and enhancing social cognition through its effects on oxytocin receptors in the brain and peripheral tissues.
Oxytocin Acetate Dosing Guide
Primary Benefits
- Induces and strengthens uterine contractions during labor
- Prevents and treats postpartum hemorrhage effectively
- Facilitates milk ejection reflex for breastfeeding
- Enhances maternal-infant bonding after delivery
- Improves social cognition in autism spectrum disorder
How It Works
Oxytocin Acetate binds to oxytocin receptors (OXTR), which are G-protein coupled receptors located in uterine myometrium, mammary glands, and central nervous system. Receptor activation triggers phospholipase C activation, leading to increased intracellular calcium levels and smooth muscle contraction. In the CNS, oxytocin modulates neurotransmitter release affecting social behavior, stress response, and maternal bonding through hypothalamic-pituitary pathways.
Quick Reference
Typical Dosage Range
Labor induction begins with 0.5-1 mU/min IV, increasing by 1-2 mU/min every 30-60 minutes until adequate contractions achieved (maximum 20 mU/min). Postpartum hemorrhage prevention uses 10 IU intramuscular immediately after delivery. Treatment of active bleeding employs 10-40 IU in 500-1000mL IV fluid. Research protocols for autism use 24-48 IU intranasal spray daily.
Administration Methods
Primary route is intravenous continuous infusion using controlled infusion pumps for precise dosing during labor. Intramuscular injection in deltoid or gluteal muscle for single-dose applications like PPH prevention. Intranasal spray formulations used in research settings for CNS effects. Subcutaneous administration rarely used clinically but employed in some research protocols.
Medical Disclaimer
Oxytocin Acetate is FDA-approved for obstetric uses and requires medical supervision. This information is for educational purposes and should not replace consultation with healthcare providers. Individual results may vary. Proper monitoring is essential during all clinical applications.