anti aging

Anti-Aging & Longevity Protocol

Target the biological mechanisms of aging at the cellular level

moderate evidence

A multi-pathway approach to slowing biological aging using peptides that activate telomerase, optimize growth hormone, modulate gene expression toward youthful patterns, and rejuvenate immune function. Based on decades of research into the fundamental mechanisms of aging.

intermediate

Difficulty

4-8 weeks

First Results

3-6 months (cyclical)

Duration

$200-600

Monthly Cost

Overview

Who This Protocol
Is Designed For

“Aging isn't just wrinkles and gray hair - it's a collection of biological processes: shortening telomeres, declining growth hormone, shifting gene expression, and immune system deterioration. This protocol targets each of these pathways with specific peptides backed by research showing measurable improvements in biological age markers.”

Ideal Candidates

Adults 35+ noticing early signs of aging (energy decline, slower recovery, sleep changes)
Health-conscious individuals seeking proactive longevity strategies
Those with family history of age-related conditions who want to optimize healthspan
People who have optimized diet/exercise and want to add targeted interventions

Contraindications

Active cancer or history of cancer (growth-promoting peptides are contraindicated)
Autoimmune conditions (immune-modulating peptides require careful consideration)
Pregnant or breastfeeding women
Uncontrolled diabetes or metabolic disorders

Expected Outcome

Most users report improved energy, better sleep quality, and enhanced recovery within 4-8 weeks. Longer-term benefits (3-6 months) may include improved body composition, skin quality, and cognitive function. Measurable changes in biomarkers like IGF-1, inflammatory markers, and potentially telomere length can be tracked with appropriate testing.

The Science

Mechanism of Action
& Evidence Base

How It Works

Peptide

Mechanism

Biological Rationale

Targeted metabolic intervention at the receptor level

This protocol targets four major aging pathways: (1) Telomere maintenance via Epithalon-induced telomerase activation, allowing cells to divide longer without entering senescence. (2) Growth hormone optimization via CJC-1295/Ipamorelin, restoring youthful GH pulsatility that declines ~14% per decade after 30. (3) Gene expression modulation via GHK-Cu, which shifts expression of 1,400+ genes toward patterns seen in 20-25 year olds. (4) Immune rejuvenation via thymic peptides that counteract thymus involution.

Aging occurs because multiple protective systems decline simultaneously. Telomeres shorten with each cell division until cells stop dividing or become senescent. Growth hormone and IGF-1 drop, reducing tissue repair capacity. Gene expression shifts toward pro-inflammatory, pro-aging patterns. The thymus shrinks, weakening adaptive immunity. Addressing multiple pathways simultaneously creates synergistic anti-aging effects.

Human Studies

Animal Studies

In Vitro Studies

moderate

Evidence Strength

Key Findings

Epithalon extended cell lifespan past the Hayflick limit and restored telomere length to early-passage levels in human fibroblasts
CJC-1295 produced sustained 2-10x increases in GH and 1.5-3x increases in IGF-1 for 6-11 days after single injection
GHK-Cu modulates gene expression toward patterns seen in 20-25 year olds, affecting 1,400+ genes
Long-term NMN (NAD+ precursor) increased female mouse lifespan by 8.5% and reduced frailty in both sexes
Thymalin normalized immune parameters in elderly COVID-19 patients with compromised immunity

Limitations

Most telomere/lifespan studies are in cells or animals - human longevity data is limited
Long-term safety data for multi-year use is sparse
Individual responses vary significantly based on baseline health and genetics
Measuring true biological age changes requires specialized testing

Protocol Tiers

Choose Your
Protocol Level

Best For

First-time users, those wanting to test response before committing to full protocol, budget-conscious approach

Cycle Duration

8-12 weeks

Off-Cycle

4-6 weeks

Start with GH optimization using CJC-1295 and Ipamorelin. This is the most immediately noticeable intervention - better sleep, recovery, and energy within weeks. Good foundation before adding other peptides.

Peptide

CJC-1295 (without DAC)

Dose Range

100-200 mcg

Frequency

daily

Route

subcutaneous

Duration

8-12 weeks

Timing

30-60 minutes before bed on empty stomach

Special Instructions

Usually combined with Ipamorelin in same injection. Some use 5 days on, 2 days off to prevent desensitization.

Peptide

Ipamorelin

Dose Range

100-200 mcg

Frequency

daily

Route

subcutaneous

Duration

8-12 weeks

Timing

Same injection as CJC-1295, 30-60 min before bed

Special Instructions

Can be mixed in same syringe as CJC-1295. Very clean side effect profile compared to other GHRPs (minimal hunger/cortisol increase).

When to Stop

Persistent joint pain or carpal tunnel symptoms (sign of excess GH)
Significant unexplained water retention
Any signs of glucose intolerance

Peptide Database

Anti-Aging & Longevity Protocol

Who This ProtocolIs Designed For

Ideal Candidates

Contraindications

Mechanism of Action& Evidence Base

Peptide

Key Findings

Limitations

Choose YourProtocol Level

CJC-1295 (without DAC)

Ipamorelin

When to Stop

Who This Protocol
Is Designed For

Mechanism of Action
& Evidence Base

Choose Your
Protocol Level