Peptide Profile
Thymopentin (TP-5)
Immune-boosting pentapeptide fragment that enhances T-cell function and dendritic cell maturation
Dose Range
1-2mg
Frequency
Once daily
Route
Subcutaneous injection
Cycle Length
4-6 weeks
Onset
Moderate (1-2 weeks)
Evidence
Moderate
Compound Profile
Scientific & Efficacy Data
C30H49N9O9
Molecular Formula
679.8
Molecular Weight
30 seconds to few minutes in plasma
Half-Life
Sustained release via subcutaneous route
Bioavailability
69558-55-0
CAS #
451417
PubChem ID ↗
Developed By · 1979
Gideon Goldstein
Memorial Sloan-Kettering Cancer Center / Immunobiology Research Institute
Primary Benefits
Directly activates T-cells and dendritic cells to strengthen immune response and resistance to infection
Improves ejection fraction and exercise capacity while reducing harmful inflammatory cytokines in heart failure patients
Restores immune function after surgery or major stress by protecting critical immune signaling pathways
Amino Acid Sequence
Arg-Lys-Asp-Val-Tyr (RKDVY)Dosing
How much
do I take?
Timing
Best time to take
Morning injection for consistency
With food?
Can be taken with or without food; no food interactions
If stacking
Can be combined with other immune-supporting supplements; allow 2 hours between other injections
Adjusting Your Dose
Increase if
- +Well-tolerated after 2 weeks
- +Minimal side effects observed
- +Seeking enhanced immune response
Decrease if
- -Experiencing persistent local reactions
- -Fever develops
- -Unusual fatigue occurs
Signs of right dose
- ✓Improved energy levels after 1-2 weeks
- ✓Better recovery from exercise
- ✓Enhanced overall well-being
- ✓Improved wound healing
Dosing Calculator
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Suitability
Is this
right for me?
Best For
Immune System Enhancement
Thymopentin directly increases T-cell function and promotes dendritic cell maturation, making it ideal for people seeking to boost immune response naturally
Cardiac Health Support
Clinical trials show thymopentin improves ejection fraction and exercise capacity in elderly heart failure patients while enhancing immune markers
Post-Surgery Recovery
Helps restore immune function after major surgery and protects important immune responses during recovery period
Consider Alternatives If
Who Should Avoid
Do not use if
- ×Pregnant or breastfeeding
- ×Severely immunocompromised without medical supervision
- ×Allergic to peptide medications
Use with caution if
- !Taking immunosuppressive medications - consult healthcare provider
- !Recent live vaccine - wait at least 2 weeks
- !History of severe allergies - start with lower dose
- !On high-dose corticosteroids - may reduce effectiveness
Administration
How do I
use it?
Reconstitution
What you need
- •Thymopentin vial
- •Sterile saline (0.9% sodium chloride)
- •Sterile syringe (1 mL)
- •Sterile needle (25-27 gauge)
- •Alcohol swabs
- •Sterile vial for mixing
Injection
Route
Subcutaneous (preferred) or Intravenous
Best sites
- •Abdomen (2 inches from navel)
- •Front of thighs
- •Outer upper arm (with assistance)
- •Rotate sites daily to prevent irritation
Technique
- 1.Clean injection site with alcohol swab, let dry 30 seconds
- 2.Pinch skin to create fold
- 3.Insert needle at 45-90 degree angle
- 4.Push plunger slowly
- 5.Withdraw needle, apply gentle pressure with new swab
- 6.Do not massage injection site
Storage
Signs of degradation
Sample Daily Schedule
Safety
Is it
safe?
Safety Profile
Thymopentin is well-tolerated with minimal side effects reported in clinical trials. Most adverse events are mild and local. No serious safety concerns have emerged from decades of clinical use in China and Europe.
Safety profile established through Phase 1-2 clinical trials in cardiac disease, rheumatoid arthritis, HIV, and burns. Dosages up to 100 mg/day IV studied without serious adverse effects.
Common Side Effects
Experienced by some users
Local injection site reaction
Mild redness, swelling, or soreness at injection site lasting a few hours to a day
Management: Rotate injection sites, apply ice if needed, use proper injection technique
Mild fatigue
Temporary tiredness, usually transient as body adjusts to immune stimulation
Management: Rest, ensure adequate sleep, stay hydrated; typically resolves within days
Transient fever
Low-grade fever as immune system responds, usually 99-101°F
Management: Monitor temperature, stay hydrated, fever typically passes within 24 hours
Less Common
- •Muscle aches
- •Mild headache
These typically resolve with continued use or dose adjustment.
Stop and Seek Help If
- ×Severe allergic reaction or anaphylaxis
- ×Persistent high fever above 102°F
- ×Severe local injection site reaction with spreading infection signs
- ×Signs of uncontrolled immune activation (severe fatigue, swollen lymph nodes)
- ×Doctor's recommendation due to new medical condition
Consult healthcare provider before stopping treatment. Do not stop abruptly without medical guidance.
Interactions
With other peptides
- !
- !
- !
With medications
- !
- !
- !
With supplements
- ✓
- ✓
- ✓
Effectiveness
Does it
work?
Evidence Level
Moderate human trials
What to Expect
Week 1
What you might notice
- •Possible mild injection site reaction
- •Body adjusting to immune stimulation
- •Possible transient mild fatigue
What's normal
- •Mild redness at injection site for few hours
- •Low-grade temperature elevation
- •Slight soreness at injection area
What's next
- →Continue with standard dosing
- →Rotate injection sites
- →Monitor for any persistent reactions
Weeks 2-4
What you might notice
- •Improved energy and recovery
- •Better sleep quality
- •Enhanced sense of well-being
- •Faster wound healing if applicable
What's normal
- •Occasional mild fatigue as immune system strengthens
- •Transient mild fever response
- •Continued local site reactions with proper rotation
What's next
- →Assess tolerance and effectiveness
- →Can increase to 2 mg if desired and well-tolerated
- →Continue daily injections as planned
Weeks 5-6
What you might notice
- •Noticeable improvement in immune markers if tested
- •Better resistance to minor infections
- •Sustained energy improvements
- •Enhanced athletic recovery
What's normal
- •Minimal side effects by week 5-6
- •Consistent injection site responses
- •Body fully adapted to peptide
What's next
- →Complete the 4-6 week cycle as planned
- →Consider 2-4 week break before next cycle
- →Retest immune markers if desired
Signs It's Working
Immune markers
- ✓Increased CD3+ and CD4+ T-cell counts
- ✓Enhanced white blood cell function
- ✓Improved response to vaccines
- ✓Better immune memory formation
Physical improvements
- ✓Faster recovery from workouts
- ✓Quicker wound healing
- ✓Improved energy levels
- ✓Better sleep quality
- ✓Reduced susceptibility to colds
Not Seeing Results?
Common reasons
- •Improper injection technique - ensure you're using correct angle and depth
- •Not rotating injection sites - varies location daily to prevent tissue damage
- •Reconstituted peptide degraded - check for cloudiness, discoloration, or age
- •Expecting too-rapid results - immune changes take 1-2 weeks minimum
- •Combining with immunosuppressants - these reduce effectiveness significantly
- •Inadequate dosing or inconsistent schedule - maintain daily routine for best results
Key Research
"Thymopentin (TP-5) enhances immune function in HIV and cancer patients"
Jiang Y, et al., 2015
Finding: This study investigated the properties and effects of Thymopentin (TP-5), contributing to our understanding of its mechanism of action and potential therapeutic applications.
View Study"Thymopentin modulates T cell receptor signaling and immune tolerance"
Valone FH, et al., 2017
Finding: This study investigated the properties and effects of Thymopentin (TP-5), contributing to our understanding of its mechanism of action and potential therapeutic applications.
View Study"Thymopentin peptide in age-related immune decline and vaccination response"
Provinciali M, et al., 2019
Finding: This study investigated the properties and effects of Thymopentin (TP-5), contributing to our understanding of its mechanism of action and potential therapeutic applications.
View Study"TP-5 prevents chemotherapy-induced immunosuppression"
Gaidano G, et al., 2014
Finding: This study investigated the properties and effects of Thymopentin (TP-5), contributing to our understanding of its mechanism of action and potential therapeutic applications.
View StudyFrequently Asked Questions