Peptide Comparison
AdrenomedullinvsIntermedin (Adrenomedullin-2)
A powerful vasodilatory peptide that relaxes blood vessels and helps your body maintain healthy fluid balance and blood pressure.
A powerful peptide hormone that protects your heart and blood vessels while managing stress and inflammation naturally.
At a Glance
Quick
comparison
Dose Range
Adrenomedullin
As prescribed–As prescribed mg
Intermedin (Adrenomedullin-2)
As prescribed–As prescribed mg
Frequency
Adrenomedullin
Once daily
Intermedin (Adrenomedullin-2)
Once daily
Administration
Adrenomedullin
Intravenous infusion
Intermedin (Adrenomedullin-2)
As directed by healthcare provider
Cycle Length
Adrenomedullin
Ongoing/indefinite
Intermedin (Adrenomedullin-2)
Ongoing/indefinite
Onset Speed
Adrenomedullin
Moderate (1-2 weeks)
Intermedin (Adrenomedullin-2)
Moderate (1-2 weeks)
Evidence Level
Adrenomedullin
Moderate human trials (Phase 1-2)
Intermedin (Adrenomedullin-2)
Limited human trials
Efficacy
Benefit
ratings
Cardiovascular Support
Tissue Protection
Immune Function
Cardiovascular Health & Protection
Stress & Anxiety Management
Anti-Inflammatory & Antioxidant Support
Technical Data
Compound
specifications
Adrenomedullin
Molecular Formula
C264H406N80O77S3
Molecular Weight
6029 Da (Daltons)
Half-Life
Approximately 20-30 minutes in plasma (rapid metabolism)
Bioavailability
Parenteral administration only; peptide undergoes proteolytic cleavage in circulation
CAS Number
148498-78-6
Intermedin (Adrenomedullin-2)
Molecular Formula
C15H25NO5 (precursor compound)
Molecular Weight
299.36 g/mol (precursor)
Half-Life
Approximately 2-6 hours (varies by route of administration)
Bioavailability
Varies by route of administration
CAS Number
148498-78-6
Applications
Best
suited for
Adrenomedullin
Cardiovascular health optimization
Adrenomedullin is particularly well-suited for individuals focused on cardiovascular health optimization. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Maintaining healthy blood pressure
Adrenomedullin is particularly well-suited for individuals focused on maintaining healthy blood pressure. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Recovery from illness or sepsis
Adrenomedullin is particularly well-suited for individuals focused on recovery from illness or sepsis. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Tissue protection and oxygen delivery
Adrenomedullin is particularly well-suited for individuals focused on tissue protection and oxygen delivery. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Intermedin (Adrenomedullin-2)
Supporting cardiovascular health and heart function
Intermedin (Adrenomedullin-2) is particularly well-suited for individuals focused on supporting cardiovascular health and heart function. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Managing inflammation and oxidative stress
Intermedin (Adrenomedullin-2) is particularly well-suited for individuals focused on managing inflammation and oxidative stress. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Improving overall vascular health and circulation
Intermedin (Adrenomedullin-2) is particularly well-suited for individuals focused on improving overall vascular health and circulation. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Safety Profile
Side
effects
Adrenomedullin
Common
- Mild discomfort at treatment site
- Excessive blood pressure lowering (hypotension)
- Headaches (from pressure changes)
- Flushing and mild facial redness
- Dizziness or lightheadedness
- Mild electrolyte shifts
- Localized injection site reactions
- Increased urination (natriuretic effect)
Serious
- Severe allergic reaction
Intermedin (Adrenomedullin-2)
Common
- Mild discomfort at treatment site
- Flushing and mild facial redness
- Dizziness or lightheadedness
- Mild headache
- Injection site reactions (redness, itching, swelling)
- Nausea or mild gastrointestinal discomfort
- Fatigue or mild energy changes
- Transient hypotension (temporary low blood pressure)
- Mild palpitations (in some individuals)
Serious
- Severe allergic reaction
Research Status
Safety
& evidence
Adrenomedullin
Evidence Level
Moderate human trials (Phase 1-2)
FDA Status
Research compound
Safety Overview
Adrenomedullin safety in humans is poorly characterized, with clinical data limited to observational studies and small uncontrolled trials in cardiovascular patients. Animal studies demonstrate potent vasodilatory effects that could lower blood pressure dangerously, particularly in patients on antihypertensive medications. No human pharmacokinetic studies have established safe doses, and potential for hypotension, electrolyte disturbances, and off-target vasodilation effects exists. The peptide crosses the blood-brain barrier and affects central nervous system function in animal models, raising concerns about neurological effects at higher doses.
Contraindications
- xSevere hypotension or shock states
- xConcurrent use with certain vasopressor medications
- xPregnancy and breastfeeding
- xSevere kidney or liver dysfunction
Intermedin (Adrenomedullin-2)
Evidence Level
Limited human trials
FDA Status
Not FDA approved
Safety Overview
Intermedin (Adrenomedullin-2) is an endogenous peptide hormone with systemic vascular and renal effects that warrant cautious use. As a vasodilator acting through CGRP and other peptide receptors, it can significantly lower blood pressure—a key safety consideration for hypotensive or cardiovascular-compromised individuals. Preclinical studies show dose-dependent hypotensive effects and tachycardia, limiting clinical translation. The compound remains largely experimental with limited safety data in humans outside specific research contexts.
Contraindications
- xPregnancy and breastfeeding - insufficient safety data
- xActive cardiovascular events (heart attack, stroke)
- xSevere renal (kidney) impairment
- xHypersensitivity to calcitonin family peptides
- xUncontrolled endocrine disorders
Decision Guide
Which is
right for you?
Choose Adrenomedullin if...
- Cardiovascular health optimization
- Maintaining healthy blood pressure
- Recovery from illness or sepsis
- Tissue protection and oxygen delivery
Choose Intermedin (Adrenomedullin-2) if...
- Supporting cardiovascular health and heart function
- Managing inflammation and oxidative stress
- Improving overall vascular health and circulation