Intermedin (Adrenomedullin-2) vs TB-500
A powerful peptide hormone that protects your heart and blood vessels while managing stress and inflammation naturally.
A powerful fragment of thymosin beta-4 that acts like your body's repair signal—speeding up healing of muscles, tendons, and tissues by promoting cell migration and new blood vessel growth right where you need it most.
Written by Michael Carroll — Owner, Director of Research · Reviewed by the Peptide Initiative Research Team · Editorial standards
Quick comparison
Dose range
Intermedin (Adrenomedullin-2)
As prescribed–As prescribed mg
TB-500
2–2.5 mg
Frequency
Intermedin (Adrenomedullin-2)
Once daily
TB-500
Twice weekly
Administration
Intermedin (Adrenomedullin-2)
As directed by healthcare provider
TB-500
Subcutaneous injection
Cycle length
Intermedin (Adrenomedullin-2)
Ongoing/indefinite
TB-500
4-6 weeks
Onset speed
Intermedin (Adrenomedullin-2)
Moderate (1-2 weeks)
TB-500
Moderate (1-2 weeks)
Evidence level
Intermedin (Adrenomedullin-2)
Limited human trials
TB-500
Moderate human trials (Phase 1-2)
Benefit ratings
Cardiovascular Health & Protection
Stress & Anxiety Management
Anti-Inflammatory & Antioxidant Support
Healing Speed
Tissue Repair
Anti-Scarring
Compound specifications
Intermedin (Adrenomedullin-2)
Molecular formula
C15H25NO5 (precursor compound)
Molecular weight
299.36 g/mol (precursor)
Half-life
Approximately 2-6 hours (varies by route of administration)
Bioavailability
Varies by route of administration
CAS number
148498-78-6
TB-500
Molecular formula
C38H68N10O14
Molecular weight
889.01 g/mol
Half-life
2-3 days (systemic)
Bioavailability
High via subcutaneous injection (~100%)
CAS number
885340-08-9
Dosing compared
Intermedin (Adrenomedullin-2)
TB-500
Subcutaneous
2-2.5 mg
Twice weekly · Loading phase, 4-6 weeks
Research peptide with no human trials of the fragment; [9] loading doses used in practice [6].
2-2.5 mg
Once weekly · Maintenance after loading
Maintenance dose used in practice following the loading phase [6].
Best suited for
Intermedin (Adrenomedullin-2)
Supporting cardiovascular health and heart function
Intermedin (Adrenomedullin-2) is particularly well-suited for individuals focused on supporting cardiovascular health and heart function. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Managing inflammation and oxidative stress
Intermedin (Adrenomedullin-2) is particularly well-suited for individuals focused on managing inflammation and oxidative stress. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Improving overall vascular health and circulation
Intermedin (Adrenomedullin-2) is particularly well-suited for individuals focused on improving overall vascular health and circulation. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
TB-500
Athletes Recovering from Muscle Injuries
If you've pulled a hamstring, strained your back, or torn a muscle, TB-500 helps accelerate the healing process by promoting cell migration to the injury site and supporting new blood vessel growth. It's especially useful for injuries that just won't seem to fully heal [1][5].
Tendon and Ligament Problems
Tendons and ligaments are notoriously slow healers because they have poor blood supply. TB-500 promotes angiogenesis (new blood vessel formation) and helps repair these stubborn connective tissue injuries—think Achilles tendonitis, tennis elbow, or rotator cuff issues [5].
Post-Surgical Recovery
After surgery, your body needs to repair a lot of tissue quickly. TB-500 supports wound healing, reduces inflammation, and may help minimize scar tissue formation. Some protocols use it alongside traditional recovery to potentially speed up the healing timeline [1][4].
Chronic Inflammation and Slow Healers
Some people just heal slowly—whether due to age, diabetes, or other factors. TB-500 helps regulate the inflammatory response and promotes the cellular processes needed for tissue repair. It essentially tells your body to focus healing resources where they're needed most [1].
Side effects
Intermedin (Adrenomedullin-2)
Common
- Mild discomfort at treatment site
- Flushing and mild facial redness
- Dizziness or lightheadedness
- Mild headache
- Injection site reactions (redness, itching, swelling)
- Nausea or mild gastrointestinal discomfort
- Fatigue or mild energy changes
- Transient hypotension (temporary low blood pressure)
- Mild palpitations (in some individuals)
Serious
- Severe allergic reaction
TB-500
Common
- Injection site redness
- Mild fatigue or lethargy
- Mild headache
- Slight flushing
Uncommon
- Head rush or lightheadedness
- Temporary nausea
Serious
- Allergic reaction
Safety & evidence
Intermedin (Adrenomedullin-2)
Evidence level
Limited human trials
FDA status
Not FDA approved
Safety overview
Intermedin (Adrenomedullin-2) is an endogenous peptide hormone with systemic vascular and renal effects that warrant cautious use. As a vasodilator acting through CGRP and other peptide receptors, it can significantly lower blood pressure—a key safety consideration for hypotensive or cardiovascular-compromised individuals. Preclinical studies show dose-dependent hypotensive effects and tachycardia, limiting clinical translation. The compound remains largely experimental with limited safety data in humans outside specific research contexts.
Contraindications
- Pregnancy and breastfeeding - insufficient safety data
- Active cardiovascular events (heart attack, stroke)
- Severe renal (kidney) impairment
- Hypersensitivity to calcitonin family peptides
- Uncontrolled endocrine disorders
TB-500
Evidence level
Moderate human trials (Phase 1-2)
FDA status
Research compound
Safety overview
TB-500 has shown a good safety profile across preclinical studies and limited human research. It's a fragment of thymosin beta-4, a naturally occurring protein in your body involved in healing. Most side effects are mild and transient, primarily injection site reactions. However, large-scale clinical trials are still needed to fully establish its safety profile in humans [1].
Contraindications
- Pregnancy or planning to become pregnant
- Currently breastfeeding
- Active cancer or history of cancer
- Known allergy to peptide components
- Children and adolescents
Which is right for you?
Choose Intermedin (Adrenomedullin-2) if...
- Supporting cardiovascular health and heart function
- Managing inflammation and oxidative stress
- Improving overall vascular health and circulation
Choose TB-500 if...
- Accelerating injury recovery
- Tendon and ligament healing
- Reducing chronic inflammation
- Post-surgical recovery support