Adrenomedullin vs TB-500
A powerful vasodilatory peptide that relaxes blood vessels and helps your body maintain healthy fluid balance and blood pressure.
A powerful fragment of thymosin beta-4 that acts like your body's repair signal—speeding up healing of muscles, tendons, and tissues by promoting cell migration and new blood vessel growth right where you need it most.
Written by Michael Carroll — Owner, Director of Research · Reviewed by the Peptide Initiative Research Team · Editorial standards
Quick comparison
Dose range
Adrenomedullin
10–10 ng/kg/min
TB-500
2–2.5 mg
Frequency
Adrenomedullin
Once daily
TB-500
Twice weekly
Administration
Adrenomedullin
Intravenous infusion
TB-500
Subcutaneous injection
Cycle length
Adrenomedullin
Ongoing/indefinite
TB-500
4-6 weeks
Onset speed
Adrenomedullin
Moderate (1-2 weeks)
TB-500
Moderate (1-2 weeks)
Evidence level
Adrenomedullin
Moderate human trials (Phase 1-2)
TB-500
Moderate human trials (Phase 1-2)
Benefit ratings
Cardiovascular Support
Tissue Protection
Immune Function
Healing Speed
Tissue Repair
Anti-Scarring
Compound specifications
Adrenomedullin
Molecular formula
C264H406N80O77S3
Molecular weight
6029 Da (Daltons)
Half-life
Approximately 20-30 minutes in plasma (rapid metabolism)
Bioavailability
Parenteral administration only; peptide undergoes proteolytic cleavage in circulation
CAS number
148498-78-6
TB-500
Molecular formula
C38H68N10O14
Molecular weight
889.01 g/mol
Half-life
2-3 days (systemic)
Bioavailability
High via subcutaneous injection (~100%)
CAS number
885340-08-9
Dosing compared
Adrenomedullin
Intravenous
5 ng/kg/min
Continuous infusion, 8 hours per day · 14 days (trial protocol)
Adrenomedullin is given as a slow drip into a vein in clinical trials, not by self-injection. This low dose was the bottom step tested for steroid-resistant ulcerative colitis. [4]
10 ng/kg/min
Continuous infusion, 8 hours per day · 14 days (trial protocol)
Middle dose tested in the ulcerative colitis trial. [4]
15 ng/kg/min
Continuous infusion, 8 hours per day · 14 days (trial protocol)
This higher dose was the only one that significantly improved disease scores in the trial. The same 15 ng/kg/min rate was also tested safely in healthy volunteers. [4][5]
TB-500
Subcutaneous
2-2.5 mg
Twice weekly · Loading phase, 4-6 weeks
Research peptide with no human trials of the fragment; [9] loading doses used in practice [6].
2-2.5 mg
Once weekly · Maintenance after loading
Maintenance dose used in practice following the loading phase [6].
Best suited for
Adrenomedullin
Cardiovascular health optimization
Adrenomedullin is particularly well-suited for individuals focused on cardiovascular health optimization. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Maintaining healthy blood pressure
Adrenomedullin is particularly well-suited for individuals focused on maintaining healthy blood pressure. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Recovery from illness or sepsis
Adrenomedullin is particularly well-suited for individuals focused on recovery from illness or sepsis. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Tissue protection and oxygen delivery
Adrenomedullin is particularly well-suited for individuals focused on tissue protection and oxygen delivery. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
TB-500
Athletes Recovering from Muscle Injuries
If you've pulled a hamstring, strained your back, or torn a muscle, TB-500 helps accelerate the healing process by promoting cell migration to the injury site and supporting new blood vessel growth. It's especially useful for injuries that just won't seem to fully heal [1][5].
Tendon and Ligament Problems
Tendons and ligaments are notoriously slow healers because they have poor blood supply. TB-500 promotes angiogenesis (new blood vessel formation) and helps repair these stubborn connective tissue injuries—think Achilles tendonitis, tennis elbow, or rotator cuff issues [5].
Post-Surgical Recovery
After surgery, your body needs to repair a lot of tissue quickly. TB-500 supports wound healing, reduces inflammation, and may help minimize scar tissue formation. Some protocols use it alongside traditional recovery to potentially speed up the healing timeline [1][4].
Chronic Inflammation and Slow Healers
Some people just heal slowly—whether due to age, diabetes, or other factors. TB-500 helps regulate the inflammatory response and promotes the cellular processes needed for tissue repair. It essentially tells your body to focus healing resources where they're needed most [1].
Side effects
Adrenomedullin
Common
- Mild discomfort at treatment site
- Excessive blood pressure lowering (hypotension)
- Headaches (from pressure changes)
- Flushing and mild facial redness
- Dizziness or lightheadedness
- Mild electrolyte shifts
- Localized injection site reactions
- Increased urination (natriuretic effect)
Serious
- Severe allergic reaction
TB-500
Common
- Injection site redness
- Mild fatigue or lethargy
- Mild headache
- Slight flushing
Uncommon
- Head rush or lightheadedness
- Temporary nausea
Serious
- Allergic reaction
Safety & evidence
Adrenomedullin
Evidence level
Moderate human trials (Phase 1-2)
FDA status
Research compound
Safety overview
Adrenomedullin safety in humans is poorly characterized, with clinical data limited to observational studies and small uncontrolled trials in cardiovascular patients. Animal studies demonstrate potent vasodilatory effects that could lower blood pressure dangerously, particularly in patients on antihypertensive medications. No human pharmacokinetic studies have established safe doses, and potential for hypotension, electrolyte disturbances, and off-target vasodilation effects exists. The peptide crosses the blood-brain barrier and affects central nervous system function in animal models, raising concerns about neurological effects at higher doses.
Contraindications
- Severe hypotension or shock states
- Concurrent use with certain vasopressor medications
- Pregnancy and breastfeeding
- Severe kidney or liver dysfunction
TB-500
Evidence level
Moderate human trials (Phase 1-2)
FDA status
Research compound
Safety overview
TB-500 has shown a good safety profile across preclinical studies and limited human research. It's a fragment of thymosin beta-4, a naturally occurring protein in your body involved in healing. Most side effects are mild and transient, primarily injection site reactions. However, large-scale clinical trials are still needed to fully establish its safety profile in humans [1].
Contraindications
- Pregnancy or planning to become pregnant
- Currently breastfeeding
- Active cancer or history of cancer
- Known allergy to peptide components
- Children and adolescents
Which is right for you?
Choose Adrenomedullin if...
- Cardiovascular health optimization
- Maintaining healthy blood pressure
- Recovery from illness or sepsis
- Tissue protection and oxygen delivery
Choose TB-500 if...
- Accelerating injury recovery
- Tendon and ligament healing
- Reducing chronic inflammation
- Post-surgical recovery support