Sexual Health Protocol
Kisspeptin-10Complete Dosing & Administration Guide
A powerful reproductive hormone regulator that acts like the master switch for your body's fertility system—triggering the release of hormones that control everything from ovulation to testosterone production.
Dose Range
50-100mcg
Frequency
Once daily
Route
Subcutaneous injection
Cycle Length
4-6 weeks
Dosing
How much
do I take?
Starting Dose
50 mcg
Start low to assess your body's response. Kisspeptin works quickly—you may notice hormonal effects within hours. This dose is enough to stimulate LH release without overwhelming your system.
Standard Dose
100 mcg
The commonly studied dose in clinical trials. This provides robust LH and FSH stimulation while remaining well-tolerated. In men, expect noticeable effects on testosterone within days.
Advanced Dose
100-200 mcg
Higher doses are typically used in clinical research settings, particularly for IVF protocols. The twice-daily approach (8-12 hours apart) maintains more consistent hormone stimulation. Should only be used under medical supervision.
Timing
Best time to take
Morning administration works well for most goals, as it aligns with your body's natural cortisol awakening response and gives hormones time to rise during your active hours. For fertility protocols, timing may be adjusted based on cycle phase.
With food?
Kisspeptin can be taken regardless of food timing. Injection absorption isn't significantly affected by meals, so choose whatever time works best for your routine.
If stacking
If combining with other peptides like PT-141 for sexual health, space injections by at least 30 minutes. Don't combine with GnRH antagonists as they directly counteract kisspeptin's mechanism. Can be used alongside clomiphene for enhanced reproductive hormone support.
Adjusting Your Dose
Increase if
- +You've completed starting doses with no side effects and want stronger hormonal response
- +Blood work shows minimal LH/FSH response to current dose
- +Working with a physician on fertility protocols requiring more robust stimulation
Decrease if
- -You experience persistent flushing or feeling overheated
- -Headaches don't resolve after the first few days
- -You notice heart racing or palpitations
- -Blood pressure increases significantly
Signs of right dose
- ✓Noticeable improvement in energy and well-being (related to hormone optimization)
- ✓For men: improved morning erections and libido
- ✓Blood work showing healthy LH, FSH, and sex hormone levels
- ✓No significant side effects between doses
Dosing Calculator
Calculate Your Exact Dose
Step 1: Peptide Weight
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The peptide weight is printed on the label
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Administration
How do I
use it?
Reconstitution
What you need
- •Bacteriostatic water (BAC water)—the preservative keeps it safe for multiple uses
- •Insulin syringes (29-31 gauge)—thin needles for comfortable injections
- •Alcohol swabs for cleaning vial tops and injection sites
- •Your kisspeptin-10 powder vial
Injection
Route
Subcutaneous injection (just under the skin)—the most practical method for self-administration with good absorption
Best sites
- •Belly fat area (about 2 inches away from your belly button)
- •Front or outer thigh (middle section)
- •Back of the upper arm
Technique
- 1.Wash your hands thoroughly with soap and water
- 2.Clean the injection site with an alcohol swab and let it air dry completely
- 3.Pinch about an inch of skin to create a fold
- 4.Insert the needle at a 45-90 degree angle (45 if you're lean, 90 if you have more tissue)
- 5.Push the plunger slowly and steadily—kisspeptin is a small volume
- 6.Wait 3-5 seconds before removing the needle
- 7.Apply light pressure if needed—don't rub
Storage
Signs of degradation
Sample Daily Schedule
Safety
Is it
safe?
Safety Profile
Kisspeptin has demonstrated an excellent safety profile across multiple clinical trials at Imperial College London and other research centers. Studies involving healthy volunteers and patients with reproductive disorders have shown no serious adverse events. The most common effects—flushing and feeling warm—are related to its mechanism of action and resolve quickly. Importantly, kisspeptin doesn't cause anxiety or negative psychological effects, which was confirmed in a study of 95 participants.
Safety data comes primarily from Phase 1-2 clinical trials conducted at major research institutions including Imperial College London. Studies have included both men and women, healthy volunteers and patients with reproductive disorders like HSDD and hypothalamic amenorrhea. While the safety profile looks promising, long-term studies are still ongoing.
Common Side Effects
Experienced by some users
Flushing or warmth
Temporary feeling of warmth or reddening of the skin, particularly in the face and chest. This is related to kisspeptin's effects on the vascular system.
Management: This typically resolves within 30-60 minutes. Stay hydrated and avoid hot environments immediately after injection. Consider evening dosing if bothersome.
Injection site reactions
Mild redness, slight swelling, or minor irritation where you injected. Common with any subcutaneous injection.
Management: Rotate injection sites between belly, thigh, and arm. Use proper technique with alcohol prep. Usually resolves within 24 hours.
Mild headache
Some users report headaches, possibly related to the rapid hormonal changes kisspeptin triggers.
Management: Stay well-hydrated before and after injection. These typically improve as your body adjusts over the first few days.
Less Common
- •Temporary heart rate increase
- •Dizziness
These typically resolve with continued use or dose adjustment.
Stop and Seek Help If
- ×Any signs of allergic reaction—stop immediately and seek medical help
- ×Persistent flushing or overheating that doesn't improve with dose reduction
- ×Significant increases in blood pressure or heart rate
- ×Worsening of any hormone-sensitive condition
- ×Unexpected breast tissue changes in men (gynecomastia symptoms)
- ×Your treatment protocol is complete or goals achieved
Kisspeptin-10 is a research compound, not an FDA-approved medication. Never start, stop, or change your dosing without guidance from a qualified healthcare provider. This information is for educational purposes only—not medical advice.
Interactions
With other peptides
- ✓Both affect sexual function through different pathways. Can be used together for enhanced sexual health benefits—space injections 30+ minutes apart.
- !Both stimulate GnRH/gonadotropin release. Using together may cause excessive hormonal stimulation. Generally not needed together as mechanisms overlap.
- ✓Can be combined in fertility protocols. HCG acts downstream of kisspeptin's effects. Commonly used together in IVF under medical supervision.
- ✓No known interactions. Different mechanisms and targets. Safe to use together for different goals.
With medications
- !GnRH antagonists (Cetrorelix, Ganirelix) - These directly block the receptor that kisspeptin ultimately activates. Do not combine—they work against each other.
- !Testosterone replacement therapy - Exogenous testosterone suppresses LH release, which is what kisspeptin stimulates. Using together defeats the purpose of kisspeptin.
- ✓Blood pressure medications - Kisspeptin can temporarily affect blood pressure. Monitor more closely. Not necessarily dangerous but requires attention.
- ✓Fertility medications (Clomiphene, Letrozole) - Can be combined in fertility protocols. May have synergistic effects on hormone stimulation. Use under medical supervision.
With supplements
- ✓D-Aspartic Acid - Both aim to stimulate natural testosterone production. May have additive effects. Monitor for overstimulation.
- ✓Zinc - Zinc supports testosterone production and is safe to combine. May enhance kisspeptin's hormonal effects.
- ✓Ashwagandha - Safe to combine. Ashwagandha may support stress-related hormonal issues while kisspeptin works on the direct signaling pathway.
- ✓DIM (Diindolylmethane) - Safe to use together. DIM helps with estrogen metabolism while kisspeptin focuses on GnRH/gonadotropin pathway.
Want the Full Picture?
View the complete Kisspeptin-10 research profile including mechanism of action, clinical studies, effectiveness timeline, and FAQ.
View Full Kisspeptin-10 Profile