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Peptide Database

Goals
Fat LossMuscle BuildingInjury HealingAnti-AgingCognitive EnhancementSleep OptimizationImmune SupportGut HealingSkin RejuvenationSexual Health
Peptides
Adipotide
Weight Management
AOD-9604
Weight Management
BPC-157
Healing & Recovery
Cagrilintide
Weight Management
CJC-1295
Growth Hormone
DSIP
Sleep & Recovery
Epithalon
Anti-Aging
GHK-Cu
Anti-Aging
GHRP-2
Growth Hormone
HCG
Hormone Support
Hexarelin
Growth Hormone
HGH
Growth Hormone
IGF-1 LR3
Growth Hormone
Kisspeptin
Hormone Support
Melanotan-2
Cosmetic
MOTS-C
Metabolic
NAD+
Anti-Aging
Oxytocin Acetate
Hormone Support
PEG-MGF
Recovery
PNC-27
Cancer Research
PT-141
Sexual Health
Retatrutide
Weight Management
Selank
Cognitive
Semaglutide
Weight Management
Semax
Cognitive
Sermorelin
Growth Hormone
Snap-8
Cosmetic
SS-31
Mitochondrial
TB-500
Healing & Recovery
Tesamorelin
Growth Hormone
Thymosin Alpha-1
Immune
Tirzepatide
Weight Management
Total Peptides: 32
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Peptide Comparison

Kisspeptin-10vsPT-141 (Bremelanotide)

A powerful reproductive hormone regulator that acts like the master switch for your body's fertility system—triggering the release of hormones that control everything from ovulation to testosterone production.

The first FDA-approved peptide that works through your brain to reignite sexual desire—think of it as flipping the 'on' switch for arousal rather than just boosting blood flow like traditional ED meds.

Sexual HealthSexual Health

At a Glance

Quick
comparison

Dose Range

Kisspeptin-10

50–100 mcg

PT-141 (Bremelanotide)

1.75–2 mg

Frequency

Kisspeptin-10

Once daily

PT-141 (Bremelanotide)

As needed

Administration

Kisspeptin-10

Subcutaneous injection

PT-141 (Bremelanotide)

Subcutaneous injection

Cycle Length

Kisspeptin-10

4-6 weeks

PT-141 (Bremelanotide)

Ongoing/indefinite

Onset Speed

Kisspeptin-10

Rapid (hours to days)

PT-141 (Bremelanotide)

Rapid (hours to days)

Evidence Level

Kisspeptin-10

Moderate human trials (Phase 1-2)

PT-141 (Bremelanotide)

Strong human trials (Phase 3 or FDA approved)

Efficacy

Benefit
ratings

Kisspeptin-10
PT-141 (Bremelanotide)

Hormone Activation

Kisspeptin-1094%
PT-141 (Bremelanotide)0%

Sexual Health

Kisspeptin-1089%
PT-141 (Bremelanotide)0%

Fertility Support

Kisspeptin-1092%
PT-141 (Bremelanotide)0%

Sexual Desire

Kisspeptin-100%
PT-141 (Bremelanotide)92%

On-Demand Use

Kisspeptin-100%
PT-141 (Bremelanotide)95%

Clinical Evidence

Kisspeptin-100%
PT-141 (Bremelanotide)98%

Technical Data

Compound
specifications

Kisspeptin-10

Molecular Formula

C63H83N17O14

Molecular Weight

1302.45 g/mol

Half-Life

~4 minutes (IV); slightly longer subcutaneously

Bioavailability

High when injected; lower intranasal but still effective

CAS Number

374675-21-5

PT-141 (Bremelanotide)

Molecular Formula

C50H68N14O10

Molecular Weight

1025.2 g/mol

Half-Life

2.7 hours

Bioavailability

~100% (subcutaneous injection)

CAS Number

189691-06-3

Protocols

Dosing
tiers

Kisspeptin-10

starting

50 mcg

Once daily

1-2 weeks

Start low to assess your body's response. Kisspeptin works quickly—you may notice hormonal effects within hours. This dose is enough to stimulate LH release without overwhelming your system.

standard

100 mcg

Once daily

4-6 weeks

The commonly studied dose in clinical trials. This provides robust LH and FSH stimulation while remaining well-tolerated. In men, expect noticeable effects on testosterone within days.

advanced

100-200 mcg

Once or twice daily

As directed by physician

Higher doses are typically used in clinical research settings, particularly for IVF protocols. The twice-daily approach (8-12 hours apart) maintains more consistent hormone stimulation. Should only be used under medical supervision.

PT-141 (Bremelanotide)

starting

1 mg

As needed (45 min before activity)

Trial period

Starting low helps you gauge your response to nausea, which is the most common side effect. If you tolerate 1mg well, you can increase to the standard dose. Never take more than one dose in 24 hours.

standard

1.75 mg

As needed (45 min before activity)

Ongoing as needed

This is the FDA-approved dose for treating HSDD in women. Clinical trials showed this dose provides the best balance of effectiveness and tolerability. Don't exceed 8 doses per month.

advanced

2 mg

As needed (45 min before activity)

Ongoing as needed

Some research protocols and clinicians use up to 2mg, though 1.75mg is the FDA-approved dose. Higher doses increase the risk of nausea without necessarily improving effectiveness. Stay within the 8 doses per month limit.

Applications

Best
suited for

Kisspeptin-10

Fertility and IVF Support

Kisspeptin is showing remarkable promise as a safer alternative to traditional IVF triggers. Unlike hCG, it dramatically reduces the risk of ovarian hyperstimulation syndrome (OHSS)—a potentially dangerous IVF complication. Studies show kisspeptin can mature eggs effectively while keeping ovarian volume 3x smaller than with hCG.

Natural Testosterone Optimization in Men

Rather than replacing your testosterone from outside (which shuts down natural production), kisspeptin tells your brain to make more. It stimulates LH release, which signals your testes to produce testosterone naturally. This approach maintains fertility and testicular function—unlike exogenous testosterone.

Low Sexual Desire (Hypoactive Sexual Desire Disorder)

Clinical trials have shown kisspeptin enhances brain activity in regions involved in sexual arousal and attraction. In men with HSDD, it increased penile response by up to 56% and improved happiness about sex. In women, it modulated brain areas involved in sexual and attraction processing.

Hypothalamic Amenorrhea Recovery

For women who've lost their periods due to stress, low body weight, or over-exercise, kisspeptin can help restart the reproductive system. It acts on the hypothalamus to reinitiate GnRH pulsing—the first step in bringing periods back naturally.

PT-141 (Bremelanotide)

Women with Low Sexual Desire (HSDD)

PT-141 is FDA-approved specifically for premenopausal women with acquired, generalized hypoactive sexual desire disorder—when you used to have normal desire but it's faded, and it's causing real distress in your life. It's the only approved treatment that works through brain pathways rather than hormones.

Men Who Don't Respond to Viagra-Type Medications

While not FDA-approved for men, clinical research shows PT-141 may help men with erectile dysfunction who don't respond to PDE5 inhibitors like Viagra or Cialis. Because it works through the brain rather than blood vessels, it offers a completely different approach.

Those Wanting On-Demand Treatment

Unlike daily medications like flibanserin (Addyi), PT-141 is used only when you want it—take it 45 minutes before intimacy. This gives you control over timing without committing to daily pills.

People Seeking to Address the 'Wanting' Part of Intimacy

Many sexual health treatments focus on the physical mechanics (blood flow, lubrication). PT-141 is unique because it targets desire itself—the psychological 'wanting' that initiates intimacy. It works on your brain's arousal circuits.

Safety Profile

Side
effects

Kisspeptin-10

Common

  • Flushing or warmth
  • Injection site reactions
  • Mild headache

Uncommon

  • Temporary heart rate increase
  • Dizziness

Serious

  • Allergic reaction

PT-141 (Bremelanotide)

Common

  • Nausea
  • Facial flushing
  • Headache
  • Injection site reactions

Uncommon

  • Skin darkening (hyperpigmentation)

Serious

  • Blood pressure increase

Research Status

Safety
& evidence

Kisspeptin-10

Evidence Level

Moderate human trials (Phase 1-2)

FDA Status

Research compound

Safety Overview

Kisspeptin has demonstrated an excellent safety profile across multiple clinical trials at Imperial College London and other research centers. Studies involving healthy volunteers and patients with reproductive disorders have shown no serious adverse events. The most common effects—flushing and feeling warm—are related to its mechanism of action and resolve quickly. Importantly, kisspeptin doesn't cause anxiety or negative psychological effects, which was confirmed in a study of 95 participants.

Contraindications

  • xPregnancy or planning to become pregnant
  • xHormone-sensitive cancers (breast, prostate, ovarian)
  • xKnown allergy to peptide components
  • xChildren and adolescents (unless under specialist care for delayed puberty)

PT-141 (Bremelanotide)

Evidence Level

Strong human trials (Phase 3 or FDA approved)

FDA Status

FDA approved for this use

Safety Overview

PT-141 has undergone rigorous FDA review and was approved in 2019 based on two large Phase 3 clinical trials involving over 1,200 women. The most common side effect is nausea (affecting about 40% of users), which typically decreases with repeated use. The drug causes transient increases in blood pressure (average 2-3 mmHg) and slight decreases in heart rate, which is why it's contraindicated in uncontrolled hypertension. Long-term safety data from the 52-week extension study showed no new safety concerns.

Contraindications

  • xUncontrolled high blood pressure
  • xCardiovascular disease
  • xHistory of heart attack or stroke
  • xPregnancy or planning pregnancy
  • xCurrently breastfeeding

Decision Guide

Which is
right for you?

Choose Kisspeptin-10 if...

  • Fertility support and optimization
  • Natural testosterone enhancement
  • IVF treatment (oocyte maturation)
  • Sexual health and libido improvement

Choose PT-141 (Bremelanotide) if...

  • Restoring sexual desire
  • Treating hypoactive sexual desire disorder (HSDD)
  • Enhancing arousal response
  • Supporting intimacy when desire is low
Kisspeptin-10 vs PT-141 (Bremelanotide) — Peptide Comparison | Peptide Initiative