Peptide Comparison
Palmitoyl Tripeptide-1vsSnap-8
Collagen-stimulating matrikine peptide and key component of Matrixyl 3000 for comprehensive anti-aging skin renewal.
An advanced 8-amino-acid peptide that relaxes facial muscles from the outside in—think of it as 'Botox in a bottle' that you apply to your skin to smooth expression lines without needles or injections.
At a Glance
Quick
comparison
Dose Range
Palmitoyl Tripeptide-1
0.5%–3% %
Snap-8
3–10 %
Frequency
Palmitoyl Tripeptide-1
Once daily
Snap-8
Once daily
Administration
Palmitoyl Tripeptide-1
Topical
Snap-8
Topical application
Cycle Length
Palmitoyl Tripeptide-1
Ongoing/indefinite
Snap-8
Ongoing/indefinite
Onset Speed
Palmitoyl Tripeptide-1
Moderate (1-2 weeks)
Snap-8
Moderate (1-2 weeks)
Evidence Level
Palmitoyl Tripeptide-1
Limited human trials
Snap-8
Moderate human trials (Phase 1-2)
Efficacy
Benefit
ratings
Collagen Production
Anti-Aging
Skin Firmness
Wrinkle Reduction
Muscle Relaxation
Skin Smoothing
Technical Data
Compound
specifications
Palmitoyl Tripeptide-1
Molecular Formula
C30H54N6O5
Molecular Weight
578.8 Da
Half-Life
Limited data; peptide is susceptible to enzymatic degradation in skin but palmitoylation improves stability compared to unmodified GHK
Bioavailability
Enhanced topical penetration via palmitoyl lipid modification; reaches dermis where fibroblasts reside
CAS Number
147732-56-7
Snap-8
Molecular Formula
C41H70N16O16S
Molecular Weight
1075.16 g/mol
Half-Life
Topical activity persists 12-24 hours on skin
Bioavailability
Penetrates stratum corneum; reaches viable epidermis with appropriate formulation
CAS Number
868844-74-0
Protocols
Dosing
tiers
Palmitoyl Tripeptide-1
Snap-8
Applications
Best
suited for
Palmitoyl Tripeptide-1
Individuals seeking comprehensive collagen stimulation through topical skincare
Palmitoyl Tripeptide-1 is particularly well-suited for individuals focused on individuals seeking comprehensive collagen stimulation through topical skincare. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Those with aging skin showing loss of firmness, elasticity, and density
Palmitoyl Tripeptide-1 is particularly well-suited for individuals focused on those with aging skin showing loss of firmness, elasticity, and density. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
People looking for non-invasive alternatives to injectable collagen treatments
Palmitoyl Tripeptide-1 is particularly well-suited for individuals focused on people looking for non-invasive alternatives to injectable collagen treatments. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Those seeking GHK-based skin benefits without copper peptide formulation complexity
Palmitoyl Tripeptide-1 is particularly well-suited for individuals focused on those seeking ghk-based skin benefits without copper peptide formulation complexity. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Snap-8
Expression Line Fighters
If you've noticed those lines that form when you smile, frown, or squint are starting to stick around even when your face is relaxed, Snap-8 is designed exactly for this. It works on the muscle-skin connection that creates these dynamic wrinkles.
Botox-Curious but Needle-Shy
Love the idea of smoother skin but not ready for injections? Snap-8 offers a topical alternative that works through a similar mechanism as Botox—just gentler and without the commitment. Perfect for testing the waters of muscle-relaxing anti-aging.
Prevention-Focused Millennials
Starting in your late 20s or early 30s with preventive skincare? Snap-8 can help keep expression lines from becoming permanent fixtures by calming the repetitive muscle movements that eventually etch wrinkles into your skin.
Sensitive Skin Types
Unlike some anti-aging actives that can be harsh, Snap-8 is remarkably well-tolerated. If retinoids make your skin angry or acids cause irritation, peptides like Snap-8 offer effective anti-aging without the drama.
Safety Profile
Side
effects
Palmitoyl Tripeptide-1
Common
- Temporary Skin Irritation
- Mild Redness
- Dryness
- Mild Peeling
Uncommon
- Contact Dermatitis
Serious
- Skin Sensitization from Fragmented Peptide
Snap-8
Common
- Mild tingling sensation
- Temporary redness
- Skin dryness
Uncommon
- Contact irritation
- Skin tightness
Serious
- Allergic reaction
Research Status
Safety
& evidence
Palmitoyl Tripeptide-1
Evidence Level
Limited human trials
FDA Status
Research compound
Safety Overview
Palmitoyl tripeptide-1 demonstrates excellent cosmetic safety with GRAS/safe-for-use designation in topical formulations at concentrations up to 2%. No serious adverse events in 20+ years of cosmetic industry use; mild erythema (<1% of subjects) at high concentrations (>5%). Dermal penetration limited to stratum corneum; no systemic absorption in vitro. Compatible with common skincare ingredients.
Contraindications
- xKnown hypersensitivity to palmitoyl tripeptide-1 or related peptide ingredients
- xActive skin infections or severely compromised skin barrier at application site
- xOpen wounds or actively inflamed dermatitis in treatment area
- xNo known systemic contraindications for topical cosmetic use
Snap-8
Evidence Level
Moderate human trials (Phase 1-2)
FDA Status
Not FDA approved
Safety Overview
Snap-8 has an excellent safety profile backed by extensive cosmetic industry testing. As a topical peptide, it works locally on the skin without systemic absorption, making it much safer than injectable alternatives. Clinical studies show it's well-tolerated even with long-term daily use, with adverse events limited to occasional mild skin irritation in sensitive individuals. It's considered safe for most skin types and has been used in cosmetic formulations worldwide since the mid-2000s.
Contraindications
- xKnown allergy to peptide ingredients
- xActive skin infections at application site
- xOpen wounds or severe skin irritation
- xPregnancy (as a precaution due to limited data)
Decision Guide
Which is
right for you?
Choose Palmitoyl Tripeptide-1 if...
- Individuals seeking comprehensive collagen stimulation through topical skincare
- Those with aging skin showing loss of firmness, elasticity, and density
- People looking for non-invasive alternatives to injectable collagen treatments
- Those seeking GHK-based skin benefits without copper peptide formulation complexity
Choose Snap-8 if...
- Wrinkle reduction
- Expression line smoothing
- Preventive anti-aging
- Non-invasive cosmetic enhancement