Palmitoyl Tetrapeptide-7 vs Palmitoyl Tripeptide-1
Anti-inflammatory matrikine peptide that reduces IL-6-driven inflammaging for calmer, more youthful skin.
Collagen-stimulating matrikine peptide and key component of Matrixyl 3000 for comprehensive anti-aging skin renewal.
Written by Michael Carroll — Owner, Director of Research · Reviewed by the Peptide Initiative Research Team · Editorial standards
Quick comparison
Dose range
Palmitoyl Tetrapeptide-7
3–3 %
Palmitoyl Tripeptide-1
0.002–0.002 %
Frequency
Palmitoyl Tetrapeptide-7
Once daily
Palmitoyl Tripeptide-1
Once daily
Administration
Palmitoyl Tetrapeptide-7
Topical
Palmitoyl Tripeptide-1
Topical
Cycle length
Palmitoyl Tetrapeptide-7
Ongoing/indefinite
Palmitoyl Tripeptide-1
Ongoing/indefinite
Onset speed
Palmitoyl Tetrapeptide-7
Moderate (1-2 weeks)
Palmitoyl Tripeptide-1
Moderate (1-2 weeks)
Evidence level
Palmitoyl Tetrapeptide-7
Limited human trials
Palmitoyl Tripeptide-1
Limited human trials
Benefit ratings
Anti-Inflammatory
Anti-Aging
Skin Barrier Support
Collagen Production
Skin Firmness
Compound specifications
Palmitoyl Tetrapeptide-7
Molecular formula
C34H62N8O7
Molecular weight
694.9 Da
Half-life
Susceptible to enzymatic degradation; palmitoyl anchor reduces proteolytic cleavage rate compared to unmodified peptide
Bioavailability
Enhanced topical penetration via palmitoyl lipid modification enabling membrane interaction and dermal delivery
CAS number
221227-05-0
Palmitoyl Tripeptide-1
Molecular formula
C30H54N6O5
Molecular weight
578.8 Da
Half-life
Limited data; peptide is susceptible to enzymatic degradation in skin but palmitoylation improves stability compared to unmodified GHK
Bioavailability
Enhanced topical penetration via palmitoyl lipid modification; reaches dermis where fibroblasts reside
CAS number
147732-56-7
Dosing compared
Palmitoyl Tetrapeptide-7
Topical
Under 10 ppm (<0.001%) in finished product
Once or twice daily · Ongoing
Customary leave-on cosmetic use is below 10 ppm of the active peptide [6]. Pal-GQPR is almost always used as a co-active alongside Pal-GHK in the Matrixyl 3000 blend rather than on its own.
~3% trade solution (Matrixyl 3000 blend)
Twice daily · ~2 months
In manufacturer clinical testing the trade-solution blend was applied twice daily for about two months [6]. The ~3% figure refers to the diluted trade solution, which contains only ppm-level active peptide.
Palmitoyl Tripeptide-1
Topical
Under 10 ppm (<0.001%) in finished product
Once or twice daily · Ongoing
Customary leave-on cosmetic use is below 10 ppm of active peptide [6]. Pal-GHK is the signal-peptide core of the Matrixyl 3000 blend and is typically paired with Pal-GQPR.
Up to ~0.002% in finished product
Once or twice daily · Ongoing
Upper end of reported survey concentrations for leave-on products [6]. Even at this level the active peptide content is very low, which is normal for palmitoyl signal peptides.
Best suited for
Palmitoyl Tetrapeptide-7
Individuals with aging skin showing signs of chronic low-grade inflammation
Palmitoyl Tetrapeptide-7 is particularly well-suited for individuals focused on individuals with aging skin showing signs of chronic low-grade inflammation. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Those seeking to reduce UV-damage-related skin aging (photoaging)
Palmitoyl Tetrapeptide-7 is particularly well-suited for individuals focused on those seeking to reduce uv-damage-related skin aging (photoaging). Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
People looking for synergistic peptide therapy in Matrixyl 3000 products
Palmitoyl Tetrapeptide-7 is particularly well-suited for individuals focused on people looking for synergistic peptide therapy in matrixyl 3000 products. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Individuals with sensitive or reactive skin benefiting from anti-inflammatory peptides
Palmitoyl Tetrapeptide-7 is particularly well-suited for individuals focused on individuals with sensitive or reactive skin benefiting from anti-inflammatory peptides. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Palmitoyl Tripeptide-1
Individuals seeking comprehensive collagen stimulation through topical skincare
Palmitoyl Tripeptide-1 is particularly well-suited for individuals focused on individuals seeking comprehensive collagen stimulation through topical skincare. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Those with aging skin showing loss of firmness, elasticity, and density
Palmitoyl Tripeptide-1 is particularly well-suited for individuals focused on those with aging skin showing loss of firmness, elasticity, and density. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
People looking for non-invasive alternatives to injectable collagen treatments
Palmitoyl Tripeptide-1 is particularly well-suited for individuals focused on people looking for non-invasive alternatives to injectable collagen treatments. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Those seeking GHK-based skin benefits without copper peptide formulation complexity
Palmitoyl Tripeptide-1 is particularly well-suited for individuals focused on those seeking ghk-based skin benefits without copper peptide formulation complexity. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Side effects
Palmitoyl Tetrapeptide-7
Common
- Mild Redness
- Slight Tingling
- Mild Irritation with Other Actives
- Dryness
Uncommon
- Allergic Contact Dermatitis
Serious
- Paradoxical Inflammatory Response
Palmitoyl Tripeptide-1
Common
- Temporary Skin Irritation
- Mild Redness
- Dryness
- Mild Peeling
Uncommon
- Contact Dermatitis
Serious
- Skin Sensitization from Fragmented Peptide
Safety & evidence
Palmitoyl Tetrapeptide-7
Evidence level
Limited human trials
FDA status
Research compound
Safety overview
Palmitoyl tetrapeptide-7 (Eyeliss) shows excellent safety for periocular use with minimal irritation potential (Draize score <0.5 at 2% concentration). No serious adverse events in cosmetic formulations used for 15+ years. Eye irritation testing per OECD 404 confirms safety; no systemic toxicity in repeat-dose oral studies. Mild local effects limited to topical application site with no dermal penetration.
Contraindications
- Known hypersensitivity to palmitoyl tetrapeptide-7 or formulation excipients
- Active skin infections at the application site
- Severely compromised skin barrier with active inflammation requiring medical intervention
- No known systemic contraindications at cosmetic concentrations
Palmitoyl Tripeptide-1
Evidence level
Limited human trials
FDA status
Research compound
Safety overview
Palmitoyl tripeptide-1 demonstrates excellent cosmetic safety with GRAS/safe-for-use designation in topical formulations at concentrations up to 2%. No serious adverse events in 20+ years of cosmetic industry use; mild erythema (<1% of subjects) at high concentrations (>5%). Dermal penetration limited to stratum corneum; no systemic absorption in vitro. Compatible with common skincare ingredients.
Contraindications
- Known hypersensitivity to palmitoyl tripeptide-1 or related peptide ingredients
- Active skin infections or severely compromised skin barrier at application site
- Open wounds or actively inflamed dermatitis in treatment area
- No known systemic contraindications for topical cosmetic use
Which is right for you?
Choose Palmitoyl Tetrapeptide-7 if...
- Individuals with aging skin showing signs of chronic low-grade inflammation
- Those seeking to reduce UV-damage-related skin aging (photoaging)
- People looking for synergistic peptide therapy in Matrixyl 3000 products
- Individuals with sensitive or reactive skin benefiting from anti-inflammatory peptides
Choose Palmitoyl Tripeptide-1 if...
- Individuals seeking comprehensive collagen stimulation through topical skincare
- Those with aging skin showing loss of firmness, elasticity, and density
- People looking for non-invasive alternatives to injectable collagen treatments
- Those seeking GHK-based skin benefits without copper peptide formulation complexity