Peptide Comparison
Palmitoyl Pentapeptide-4 (Matrixyl)vsPalmitoyl Tripeptide-1
Collagen-boosting signal peptide clinically proven to reduce wrinkles and fine lines in photoaged skin.
Collagen-stimulating matrikine peptide and key component of Matrixyl 3000 for comprehensive anti-aging skin renewal.
At a Glance
Quick
comparison
Dose Range
Palmitoyl Pentapeptide-4 (Matrixyl)
3 ppm–100 ppm mg
Palmitoyl Tripeptide-1
0.5%–3% %
Frequency
Palmitoyl Pentapeptide-4 (Matrixyl)
Once daily
Palmitoyl Tripeptide-1
Once daily
Administration
Palmitoyl Pentapeptide-4 (Matrixyl)
Topical
Palmitoyl Tripeptide-1
Topical
Cycle Length
Palmitoyl Pentapeptide-4 (Matrixyl)
Ongoing/indefinite
Palmitoyl Tripeptide-1
Ongoing/indefinite
Onset Speed
Palmitoyl Pentapeptide-4 (Matrixyl)
Moderate (1-2 weeks)
Palmitoyl Tripeptide-1
Moderate (1-2 weeks)
Evidence Level
Palmitoyl Pentapeptide-4 (Matrixyl)
Limited human trials
Palmitoyl Tripeptide-1
Limited human trials
Efficacy
Benefit
ratings
Anti-Wrinkle
Collagen Production
Skin Rejuvenation
Anti-Aging
Skin Firmness
Technical Data
Compound
specifications
Palmitoyl Pentapeptide-4 (Matrixyl)
Molecular Formula
C39H75N7O10
Molecular Weight
802.1 Da
Half-Life
Approximately 20-30 minutes in skin (rapidly degraded by aminopeptidases; palmitoylation improves stability vs unmodified KTTKS)
Bioavailability
Topical penetration through stratum corneum to dermis; detected at 4.2 µg/cm² in SC, 2.8 µg/cm² in epidermis, 0.3 µg/cm² in dermis
CAS Number
214047-00-4
Palmitoyl Tripeptide-1
Molecular Formula
C30H54N6O5
Molecular Weight
578.8 Da
Half-Life
Limited data; peptide is susceptible to enzymatic degradation in skin but palmitoylation improves stability compared to unmodified GHK
Bioavailability
Enhanced topical penetration via palmitoyl lipid modification; reaches dermis where fibroblasts reside
CAS Number
147732-56-7
Applications
Best
suited for
Palmitoyl Pentapeptide-4 (Matrixyl)
Individuals seeking non-invasive anti-wrinkle treatment
Palmitoyl Pentapeptide-4 (Matrixyl) is particularly well-suited for individuals focused on individuals seeking non-invasive anti-wrinkle treatment. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Those with photoaged skin showing fine lines and loss of firmness
Palmitoyl Pentapeptide-4 (Matrixyl) is particularly well-suited for individuals focused on those with photoaged skin showing fine lines and loss of firmness. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
People looking to boost collagen production through topical skincare
Palmitoyl Pentapeptide-4 (Matrixyl) is particularly well-suited for individuals focused on people looking to boost collagen production through topical skincare. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Sensitive skin types seeking well-tolerated anti-aging actives
Palmitoyl Pentapeptide-4 (Matrixyl) is particularly well-suited for individuals focused on sensitive skin types seeking well-tolerated anti-aging actives. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Palmitoyl Tripeptide-1
Individuals seeking comprehensive collagen stimulation through topical skincare
Palmitoyl Tripeptide-1 is particularly well-suited for individuals focused on individuals seeking comprehensive collagen stimulation through topical skincare. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Those with aging skin showing loss of firmness, elasticity, and density
Palmitoyl Tripeptide-1 is particularly well-suited for individuals focused on those with aging skin showing loss of firmness, elasticity, and density. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
People looking for non-invasive alternatives to injectable collagen treatments
Palmitoyl Tripeptide-1 is particularly well-suited for individuals focused on people looking for non-invasive alternatives to injectable collagen treatments. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Those seeking GHK-based skin benefits without copper peptide formulation complexity
Palmitoyl Tripeptide-1 is particularly well-suited for individuals focused on those seeking ghk-based skin benefits without copper peptide formulation complexity. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Safety Profile
Side
effects
Palmitoyl Pentapeptide-4 (Matrixyl)
Common
- Mild Tingling
- Transient Redness
- Dryness with Exfoliants
- Mild Irritation
Uncommon
- Contact Dermatitis
Serious
- Excessive Collagen Synthesis and Scar Risk
Palmitoyl Tripeptide-1
Common
- Temporary Skin Irritation
- Mild Redness
- Dryness
- Mild Peeling
Uncommon
- Contact Dermatitis
Serious
- Skin Sensitization from Fragmented Peptide
Research Status
Safety
& evidence
Palmitoyl Pentapeptide-4 (Matrixyl)
Evidence Level
Limited human trials
FDA Status
Research compound
Safety Overview
Palmitoyl pentapeptide-4 (Matrixyl) demonstrates excellent dermatological safety with GRAS/safe-for-cosmetic status; extensively used in anti-aging skincare for 20+ years with no serious adverse events. Skin irritation potential is minimal at recommended 2-3% concentrations (irritation index <0.5). No systemic absorption via intact skin; confined to epidermis/dermis per Franz diffusion cell studies. Stability in formulations verified through HPLC analysis.
Contraindications
- xKnown hypersensitivity to palmitoyl pentapeptide-4 or formulation excipients
- xActive skin infections at the application site
- xSeverely compromised skin barrier with open wounds
- xNo known systemic contraindications at cosmetic concentrations
Palmitoyl Tripeptide-1
Evidence Level
Limited human trials
FDA Status
Research compound
Safety Overview
Palmitoyl tripeptide-1 demonstrates excellent cosmetic safety with GRAS/safe-for-use designation in topical formulations at concentrations up to 2%. No serious adverse events in 20+ years of cosmetic industry use; mild erythema (<1% of subjects) at high concentrations (>5%). Dermal penetration limited to stratum corneum; no systemic absorption in vitro. Compatible with common skincare ingredients.
Contraindications
- xKnown hypersensitivity to palmitoyl tripeptide-1 or related peptide ingredients
- xActive skin infections or severely compromised skin barrier at application site
- xOpen wounds or actively inflamed dermatitis in treatment area
- xNo known systemic contraindications for topical cosmetic use
Decision Guide
Which is
right for you?
Choose Palmitoyl Pentapeptide-4 (Matrixyl) if...
- Individuals seeking non-invasive anti-wrinkle treatment
- Those with photoaged skin showing fine lines and loss of firmness
- People looking to boost collagen production through topical skincare
- Sensitive skin types seeking well-tolerated anti-aging actives
Choose Palmitoyl Tripeptide-1 if...
- Individuals seeking comprehensive collagen stimulation through topical skincare
- Those with aging skin showing loss of firmness, elasticity, and density
- People looking for non-invasive alternatives to injectable collagen treatments
- Those seeking GHK-based skin benefits without copper peptide formulation complexity