Peptide Comparison
LarazotidevsTB-500
Restore your intestinal barrier and protect against gluten damage
A powerful fragment of thymosin beta-4 that acts like your body's repair signal—speeding up healing of muscles, tendons, and tissues by promoting cell migration and new blood vessel growth right where you need it most.
At a Glance
Quick
comparison
Dose Range
Larazotide
250 mcg–1000 mcg mcg
TB-500
2–5 mg
Frequency
Larazotide
Once daily
TB-500
Twice weekly
Administration
Larazotide
Oral (capsule or tablet)
TB-500
Subcutaneous injection
Cycle Length
Larazotide
Ongoing/indefinite
TB-500
4-6 weeks
Onset Speed
Larazotide
Moderate (1-2 weeks)
TB-500
Moderate (1-2 weeks)
Evidence Level
Larazotide
Strong human trials (Phase 3 or FDA approved)
TB-500
Moderate human trials (Phase 1-2)
Efficacy
Benefit
ratings
Intestinal Barrier Protection
Celiac Disease Management
Safety & Tolerability
Healing Speed
Tissue Repair
Anti-Scarring
Technical Data
Compound
specifications
Larazotide
Molecular Formula
C34H59N9O12
Molecular Weight
785.9 g/mol
Half-Life
Unknown - acts primarily as local intestinal barrier regulator rather than systemic drug
Bioavailability
Orally administered; acts locally on intestinal epithelium with minimal systemic absorption
CAS Number
206899-25-6
TB-500
Molecular Formula
C38H68N10O14
Molecular Weight
889.01 g/mol
Half-Life
2-3 days (systemic)
Bioavailability
High via subcutaneous injection (~100%)
CAS Number
885340-08-9
Protocols
Dosing
tiers
Larazotide
TB-500
Applications
Best
suited for
Larazotide
Managing celiac disease symptoms despite strict gluten avoidance
Larazotide is particularly well-suited for individuals focused on managing celiac disease symptoms despite strict gluten avoidance. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Reducing accidental gluten exposure damage
Larazotide is particularly well-suited for individuals focused on reducing accidental gluten exposure damage. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Restoring digestive comfort and nutrient absorption
Larazotide is particularly well-suited for individuals focused on restoring digestive comfort and nutrient absorption. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Supporting intestinal healing and barrier function
Larazotide is particularly well-suited for individuals focused on supporting intestinal healing and barrier function. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
TB-500
Athletes Recovering from Muscle Injuries
If you've pulled a hamstring, strained your back, or torn a muscle, TB-500 helps accelerate the healing process by promoting cell migration to the injury site and supporting new blood vessel growth. It's especially useful for injuries that just won't seem to fully heal.
Tendon and Ligament Problems
Tendons and ligaments are notoriously slow healers because they have poor blood supply. TB-500 promotes angiogenesis (new blood vessel formation) and helps repair these stubborn connective tissue injuries—think Achilles tendonitis, tennis elbow, or rotator cuff issues.
Post-Surgical Recovery
After surgery, your body needs to repair a lot of tissue quickly. TB-500 supports wound healing, reduces inflammation, and may help minimize scar tissue formation. Some protocols use it alongside traditional recovery to potentially speed up the healing timeline.
Chronic Inflammation and Slow Healers
Some people just heal slowly—whether due to age, diabetes, or other factors. TB-500 helps regulate the inflammatory response and promotes the cellular processes needed for tissue repair. It essentially tells your body to focus healing resources where they're needed most.
Safety Profile
Side
effects
Larazotide
Common
- Headache
- Nausea
- Abdominal Cramping
- Fatigue
Uncommon
- Transient Diarrhea
Serious
- Allergic Reaction
TB-500
Common
- Injection site redness
- Mild fatigue or lethargy
- Mild headache
- Slight flushing
Uncommon
- Head rush or lightheadedness
- Temporary nausea
Serious
- Allergic reaction
Research Status
Safety
& evidence
Larazotide
Evidence Level
Strong human trials (Phase 3 or FDA approved)
FDA Status
Not FDA approved
Safety Overview
Larazotide (ALX-0061, AT-1001) is a synthetic tight-junction regulator that improved intestinal barrier function in Phase 2 celiac disease trials with favorable safety. The mechanism—zonula occludens-1 modulation—is specific to epithelial tight junctions without broad immunosuppression. Gastrointestinal side effects (nausea, diarrhea, abdominal pain) occur in 10-20% of patients but are typically mild and resolve with dose adjustment or continued exposure. FDA feedback on Phase 3 trials indicated efficacy trends but required additional manufacturing and clinical data before approval consideration.
Contraindications
- xKnown hypersensitivity to larazotide or any component
- xSevere gastrointestinal obstruction
- xActive untreated infections (may require monitoring)
- xPregnancy and breastfeeding (limited safety data)
TB-500
Evidence Level
Moderate human trials (Phase 1-2)
FDA Status
Research compound
Safety Overview
TB-500 has shown a good safety profile across preclinical studies and limited human research. It's a fragment of thymosin beta-4, a naturally occurring protein in your body involved in healing. Most side effects are mild and transient, primarily injection site reactions. However, large-scale clinical trials are still needed to fully establish its safety profile in humans.
Contraindications
- xPregnancy or planning to become pregnant
- xCurrently breastfeeding
- xActive cancer or history of cancer
- xKnown allergy to peptide components
- xChildren and adolescents
Decision Guide
Which is
right for you?
Choose Larazotide if...
- Managing celiac disease symptoms despite strict gluten avoidance
- Reducing accidental gluten exposure damage
- Restoring digestive comfort and nutrient absorption
- Supporting intestinal healing and barrier function
Choose TB-500 if...
- Accelerating injury recovery
- Tendon and ligament healing
- Reducing chronic inflammation
- Post-surgical recovery support