Angiotensin (1-7) vs TB-500
The heart-friendly peptide that balances your blood pressure and protects your cardiovascular system
A powerful fragment of thymosin beta-4 that acts like your body's repair signal—speeding up healing of muscles, tendons, and tissues by promoting cell migration and new blood vessel growth right where you need it most.
Written by Michael Carroll — Owner, Director of Research · Reviewed by the Peptide Initiative Research Team · Editorial standards
Quick comparison
Dose range
Angiotensin (1-7)
100–100 mcg/kg
TB-500
2–2.5 mg
Frequency
Angiotensin (1-7)
Once daily
TB-500
Twice weekly
Administration
Angiotensin (1-7)
As directed by healthcare provider
TB-500
Subcutaneous injection
Cycle length
Angiotensin (1-7)
Ongoing/indefinite
TB-500
4-6 weeks
Onset speed
Angiotensin (1-7)
Moderate (1-2 weeks)
TB-500
Moderate (1-2 weeks)
Evidence level
Angiotensin (1-7)
Moderate human trials (Phase 1-2)
TB-500
Moderate human trials (Phase 1-2)
Benefit ratings
Heart Health & Protection
Blood Pressure Balance
Anti-Inflammatory Support
Healing Speed
Tissue Repair
Anti-Scarring
Compound specifications
Angiotensin (1-7)
Molecular formula
C41H62N12O11
Molecular weight
899.02 g/mol
Half-life
Approximately 2-6 hours (varies by route of administration)
Bioavailability
Varies by route of administration
CAS number
25016-41-7
TB-500
Molecular formula
C38H68N10O14
Molecular weight
889.01 g/mol
Half-life
2-3 days (systemic)
Bioavailability
High via subcutaneous injection (~100%)
CAS number
885340-08-9
Dosing compared
Angiotensin (1-7)
Subcutaneous
100 mcg/kg
Once daily after each chemotherapy session · Up to 6 chemotherapy cycles
In a cancer trial, this dose was injected under the skin after chemo to help protect platelet counts. A higher 300 mcg/kg dose was also tested but did not work better. [4]
Intravenous
0.5 mg/kg
Once daily · Up to 10 days
In a COVID-19 study, the lab-made form (called TXA-127) was given as a daily drip into a vein. No serious drug-related side effects were seen. [5]
TB-500
Subcutaneous
2-2.5 mg
Twice weekly · Loading phase, 4-6 weeks
Research peptide with no human trials of the fragment; [9] loading doses used in practice [6].
2-2.5 mg
Once weekly · Maintenance after loading
Maintenance dose used in practice following the loading phase [6].
Best suited for
Angiotensin (1-7)
Cardiovascular health and heart protection
Angiotensin (1-7) is particularly well-suited for individuals focused on cardiovascular health and heart protection. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Blood pressure management and hypertension
Angiotensin (1-7) is particularly well-suited for individuals focused on blood pressure management and hypertension. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Recovery from heart-related conditions
Angiotensin (1-7) is particularly well-suited for individuals focused on recovery from heart-related conditions. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Anti-inflammatory support
Angiotensin (1-7) is particularly well-suited for individuals focused on anti-inflammatory support. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
TB-500
Athletes Recovering from Muscle Injuries
If you've pulled a hamstring, strained your back, or torn a muscle, TB-500 helps accelerate the healing process by promoting cell migration to the injury site and supporting new blood vessel growth. It's especially useful for injuries that just won't seem to fully heal [1][5].
Tendon and Ligament Problems
Tendons and ligaments are notoriously slow healers because they have poor blood supply. TB-500 promotes angiogenesis (new blood vessel formation) and helps repair these stubborn connective tissue injuries—think Achilles tendonitis, tennis elbow, or rotator cuff issues [5].
Post-Surgical Recovery
After surgery, your body needs to repair a lot of tissue quickly. TB-500 supports wound healing, reduces inflammation, and may help minimize scar tissue formation. Some protocols use it alongside traditional recovery to potentially speed up the healing timeline [1][4].
Chronic Inflammation and Slow Healers
Some people just heal slowly—whether due to age, diabetes, or other factors. TB-500 helps regulate the inflammatory response and promotes the cellular processes needed for tissue repair. It essentially tells your body to focus healing resources where they're needed most [1].
Side effects
Angiotensin (1-7)
Common
- Hypotension (Low Blood Pressure)
- Dizziness or Lightheadedness
- Injection Site Reactions
- Headache
Serious
- Hyperkalemia (High Potassium)
TB-500
Common
- Injection site redness
- Mild fatigue or lethargy
- Mild headache
- Slight flushing
Uncommon
- Head rush or lightheadedness
- Temporary nausea
Serious
- Allergic reaction
Safety & evidence
Angiotensin (1-7)
Evidence level
Moderate human trials (Phase 1-2)
FDA status
Research compound
Safety overview
Angiotensin (1-7) is not FDA-approved and has no completed human clinical trials, with all safety data limited to animal studies and in vitro mechanistic work. Animal studies suggest potential benefits in hypertension and cardiac remodeling but also reveal risks of hypotension, particularly with concurrent ACE inhibitor or ARB therapy. The peptide's effects on systemic inflammation and immune function in animal models are not validated in humans. No pharmacokinetic data exists defining safe doses, optimal delivery routes, or organ accumulation patterns in humans.
Contraindications
- Severe hypotension or uncontrolled low blood pressure
- Acute myocardial infarction in early stages
- Concurrent use with certain ACE inhibitors without medical supervision
- Pregnancy and breastfeeding (insufficient safety data)
TB-500
Evidence level
Moderate human trials (Phase 1-2)
FDA status
Research compound
Safety overview
TB-500 has shown a good safety profile across preclinical studies and limited human research. It's a fragment of thymosin beta-4, a naturally occurring protein in your body involved in healing. Most side effects are mild and transient, primarily injection site reactions. However, large-scale clinical trials are still needed to fully establish its safety profile in humans [1].
Contraindications
- Pregnancy or planning to become pregnant
- Currently breastfeeding
- Active cancer or history of cancer
- Known allergy to peptide components
- Children and adolescents
Which is right for you?
Choose Angiotensin (1-7) if...
- Cardiovascular health and heart protection
- Blood pressure management and hypertension
- Recovery from heart-related conditions
- Anti-inflammatory support
Choose TB-500 if...
- Accelerating injury recovery
- Tendon and ligament healing
- Reducing chronic inflammation
- Post-surgical recovery support