Growth Hormone Protocol
Pralmorelin (GHRP-2)Complete Dosing & Administration Guide
A powerful hexapeptide that stimulates growth hormone release—used clinically in Japan for GH testing and studied for healing and anti-inflammatory effects.
Dose Range
100-300mcg
Frequency
Once daily
Route
Subcutaneous injection
Cycle Length
4-6 weeks
Dosing
How much
do I take?
Starting Dose
50-100 mcg
Begin conservatively to assess individual responsiveness and side effect tolerance. Administer subcutaneously in abdomen or thigh.
Standard Dose
100-200 mcg
Most individuals find optimal response and tolerability in this range. Typical use case for GH axis stimulation and recovery support.
Advanced Dose
200-300 mcg
Higher doses used in intensive research or competitive athletic settings. Requires previous GHRP experience and close monitoring. Risk-benefit ratio increases.
Timing
Best time to take
Administer on an empty stomach (2+ hours after meals, 30+ minutes before eating) to maximize GH response. Fasting state enhances peptide efficacy.
With food?
Food intake, especially carbohydrates and amino acids, blunts the GH response. Maintain a gap of at least 2 hours post-meal for optimal effect.
If stacking
If combining with CJC-1295, space injections 15-30 minutes apart for synergistic effect. Avoid injecting into the same body site within 48 hours.
Adjusting Your Dose
Increase if
- +No observable GH response (elevated fasting glucose, minimal flush sensation)
- +Baseline GH-deficient and diagnostic testing shows poor response
- +Recovery progress is slower than expected after 2 weeks
- +Individual has significant peptide experience and tolerates well
Decrease if
- -Experiencing persistent headaches, dizziness, or flushing
- -Blood pressure spikes during dosing windows
- -Carpal tunnel symptoms develop
- -Excessive appetite stimulation interferes with diet adherence
Signs of right dose
- ✓Mild to moderate flush 5-15 minutes post-injection (indicates GH release)
- ✓Improved energy and stamina during training or daily activities
- ✓Faster recovery from soreness and improved sleep quality
- ✓Visible improvements in muscle tone or injury healing within 4 weeks
Dosing Calculator
Calculate Your Exact Dose
Step 1: Peptide Weight
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Administration
How do I
use it?
Reconstitution
What you need
- •Lyophilized GHRP-2 vial (typically 5-10 mg per vial)
- •Bacteriostatic water (0.9% benzyl alcohol saline solution)
- •Insulin syringe (29-31 gauge, 1 mL)
- •Alcohol swabs (70% isopropyl)
- •Sterile needle for drawing bacteriostatic water
- •Sterile needle for injection
Injection
Route
Subcutaneous injection into fatty tissue (adipose layer between skin and muscle)
Best sites
- •Lower abdomen (2 inches to the side of your navel) - easiest self-injection site
- •Outer thigh (lateral quadriceps area) - alternate site for variety
- •Back of upper arm (triceps area) - requires a partner or mirror for comfort
Technique
- 1.Clean injection site with alcohol swab in circular motion, allow to air dry (5-10 seconds)
- 2.Pinch a fold of skin and fat between thumb and forefinger to lift tissue away from muscle
- 3.Insert needle at 45-90 degree angle into the pinched fold (should be painless if done correctly)
- 4.Push plunger slowly and steadily to inject the full dose (takes 3-5 seconds)
- 5.Withdraw needle, release skin fold, and apply gentle pressure with fresh alcohol swab for 10 seconds
Storage
Signs of degradation
Sample Daily Schedule
Safety
Is it
safe?
Safety Profile
Pralmorelin (GHRP-2) has been safely used in diagnostic settings in Japan for decades and is well-tolerated in most individuals when used at appropriate doses. The peptide is synthetic and chemically stable, with low immunogenicity risk. However, it is NOT FDA approved and should only be used under medical supervision or within research protocols. Long-term safety data in healthy humans is limited.
Most safety evidence comes from short-term diagnostic studies (single or few-dose protocols) and animal research. Long-term use in therapeutic dosing is not extensively studied in humans. Users should be aware they are using a research compound with limited long-term safety profiling.
Common Side Effects
Experienced by some users
Facial flushing
Mild to moderate warmth and redness in face/neck area occurring 5-15 minutes post-injection. Resolves within 30-60 minutes. Results from vasodilation triggered by rapid GH release.
Management: Completely benign. If severe, reduce dose slightly or slow injection speed. Stays hydrated and avoid hot beverages immediately post-injection.
Transient headache
Mild headache 1-2 hours post-injection, typically lasting 1-4 hours. Usually mild and self-limited. More common with higher doses or on empty stomach.
Management: Take over-the-counter pain reliever (acetaminophen or ibuprofen) if bothersome. Stay hydrated. Usually resolves with continued use as body adjusts.
Increased appetite
GHRP-2 stimulates hunger signals, though less pronounced than GHRP-6. Typically mild appetite increase for 2-4 hours post-injection. Manageable with diet discipline.
Management: Eat protein-rich snacks post-injection if needed. Timing injections before meals can help. If appetite becomes disruptive, reduce dose or switch to less appetite-stimulating alternatives like Ipamorelin.
Temporary dizziness or lightheadedness
Brief episodes of dizziness (minutes to hours) related to rapid blood pressure or fluid shifts. Usually mild and self-resolving. More common in dehydrated individuals.
Management: Ensure adequate hydration before and after injection. Sit or lie down if dizziness occurs. Avoid sudden position changes post-injection. Rare, disappears with repeated use.
Less Common
- •Carpal tunnel-like sensations
- •Joint or muscle aches
- •Sleep quality changes
These typically resolve with continued use or dose adjustment.
Stop and Seek Help If
- ×Severe or persistent headaches that worsen despite dose reduction
- ×Uncontrolled blood pressure elevation during dosing windows
- ×Development of new joint pain or swelling that interferes with daily function
- ×Signs of allergic reaction (rash, swelling, difficulty breathing)
- ×Any signs of infection at injection site (increasing redness, warmth, drainage)
- ×Planned surgery or acute hospitalization (discuss with medical team first)
This list is for educational purposes only and does not replace medical judgment. Always consult with a healthcare provider before starting, modifying, or stopping any peptide protocol. Pralmorelin is not FDA approved and should only be used under qualified medical supervision or within approved research settings.
Interactions
With other peptides
- ✓Synergistic GH stimulus via dual mechanism (GHRH + GHRP). Often combined for enhanced results. Space injections 15-30 minutes apart.
- !Both GHRPs work through similar mechanism. Combining offers minimal additional benefit and increases side effects. Avoid stacking.
- !Both are GHRPs with overlapping function. GHRP-2 is more potent; stacking with GHRP-6 is redundant and increases appetite effects unnecessarily.
- ✓Synergistic effect on muscle protein synthesis. Safe to combine; enhances anabolic response. Ensure both are used responsibly.
With medications
- !
- !
- !
- !
With supplements
- ✓
- ✓
- ✓
- ✓
- ✓
Want the Full Picture?
View the complete Pralmorelin (GHRP-2) research profile including mechanism of action, clinical studies, effectiveness timeline, and FAQ.
View Full Pralmorelin (GHRP-2) Profile