Clinical trials
Every registered trial of Kisspeptin-10
33 studies, 5 still enrolling.
Plain-Language Summary
Plain-language reading of the public trial registries.
In short
- Kisspeptin-10 has a real but limited body of human research.
- 33 registered studies in total.
- 5 are still enrolling people, so this is active research, not just history.
What kind of research
- 29 studies actually gave the peptide to volunteers and measured what happened. This is the kind of study that can show whether something works.
- About 1,718 people took part in those.
- A further 4 studies only looked at records of people already taking it. These are counted separately because nobody was given the peptide for the study, so they cannot prove cause and effect.
How far along it is
- 3 trials have reached phase 3 or 4 — the large, late-stage trials regulators rely on to approve a drug.
- 9 have published results in the medical literature that anyone can read.
- The research spans 7 countries.
A registered trial is a plan, not a result. Registration means a study was declared in advance; it says nothing about whether the peptide worked, and a trial can be registered and then abandoned.
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Showing 33 of 33 trials for Kisspeptin-10.
Investigating how a natural hormone called kisspeptin affects social and emotional brain processing
Imperial College London
Neurotypical and neurodivergent (autistic) men
Kisspeptin to Quantify GnRH Neuronal Function in Health and Disease
Stephanie B. Seminara, MD
Reproductive Disorder · Neurodegeneration · SARS-CoV 2 · Long COVID
Kisspeptin Administration Subcutaneously to Patients With Hypothalamic Amenorrhea
Stephanie B. Seminara, MD
Hypothalamic Amenorrhea · Hypogonadotropic Hypogonadism
Investigating the role of nitric oxide on reproductive hormones in humans
Imperial College London
The role of nitric oxide on reproductive hormone responses in healthy individuals and individuals with reproductive disorders.
Physiological study of kisspeptin in post-menopausal health
Imperial College London
Post-menopausal women who are at a higher risk of conditions affecting the liver, bone and brain.
Functional Proteins in Polycystic Ovary Syndrome
Jagiellonian University
Reproductive Age · PCOS (Polycystic Ovary Syndrome)
Investigating the effects of kisspeptin in postmenopausal women with low sexual desire
Imperial College London
Postmenopausal women with distressing low sexual desire caused by Hypoactive Sexual Desire Disorder, according to the International Classification of Diseases 11th Revision (ICD-11), including categorisation as both acquired (versus lifelong) and generalised (versus situational).
Recall by Genotype: Neuropeptide Stimulation
Stephanie B. Seminara, MD
Reproductive Disorder
Dampening the Reproductive Axis With Continuous Kisspeptin
Stephanie B. Seminara, MD
Reproductive Disorder · PCOS · Polycystic Ovary Syndrome
Clinical studies to examine the effect of kisspeptin in delayed puberty
Imperial College London
Children with delayed puberty
Evaluation of Some Puberty-related Hormones Among Children and Adolescents With Chronic Kidney Diseases
Sohag University
Evaluation of Some Puberty-related Hormones Among Children and Adolescents With Chronic Kidney Diseases
Kisspeptin Administration Subcutaneously to Patients With IHH
Stephanie B. Seminara, MD
Hypogonadotropic Hypogonadism
Kisspeptin Administration Subcutaneously to Patients With Reproductive Disorders
Stephanie B. Seminara, MD
Hypothalamic Amenorrhea · Hypogonadotropic Hypogonadism
Evaluation of Kisspeptin Stimulated Insulin Secretion With Hyperglycemic Clamp
Massachusetts General Hospital
Metabolic Disease
Evaluation of Kisspeptin Glucose-Stimulated Insulin Secretion With Oral Glucose Tolerance Test
Massachusetts General Hospital
Metabolic Diseases
Investigating the effects of the hormone kisspeptin on human brain activity
Imperial College London
Investigation of brain processing in Hypoactive Sexual Desire Disorder
Molecules Associated with Pediatric Obesity
Istanbul University - Cerrahpasa
OBESITY
Named in the study description rather than as the headline intervention — often a drug given alongside the one being tested.
Clinical studies to examine the effects of intranasal kisspeptin delivery on reproductive hormones
Imperial College London
Reproductive disorders
Evaluation of Kisspeptin Glucose-Stimulated Insulin Secretion With Physiologic Mixed Meal Tolerance
Stephanie B. Seminara, MD
Insulin · Glucose · Healthy Volunteers · Women
How do hormones affect reproduction and metabolism in people with type 2 diabetes and people who do not have type 2 diabetes?
Imperial College London
Reproductive hormone effects
Named in the study description rather than as the headline intervention — often a drug given alongside the one being tested.
Prolonged Pulsatile Kisspeptin Administration in Hypogonadotropic Hypogonadism
Stephanie B. Seminara, MD
Hypogonadotropic Hypogonadism
Administration of Kisspeptin in Patients With Hyperprolactinemia
Massachusetts General Hospital
Hyperprolactinemia · Hypogonadism
What is the effect of the natural occurring hormone kisspeptin on reproductive hormone secretion in humans?
Imperial College London
Conditions that can impair fertility
Named in the study description rather than as the headline intervention — often a drug given alongside the one being tested.
Serum Kisspeptin Levels in Infertile Women
Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Infertility, Female · Unexplained Infertility · Anovulation
Age-dependent Changes in the Responsiveness of Hypothalamic Pituitary Gonadal Axis in Men
Quaid-e-Azam University
Sterility, Reproductive
Link Between the Sensitivity of Kisspeptin Signalling and Pubertal Onset in Boys.
Ghulam Nabi
Reproductive Physiological Phenomena
Neuropeptides in Human Reproduction
Massachusetts General Hospital
Hypogonadotropic Hypogonadism
Reproductive Hormones During Sustained Administration of Kisspeptin
Imperial College London
Fertility Disorders · Hypothalamic Dysfunction
KP-10 and Insulin Secretion in Men
Quaid-e-Azam University
Kisspeptin Action on Insulin in Healthy Normal Men · Kisspeptin Action on Insulin in Obese Diabetic Men
Kisspeptin in the Evaluation of Delayed Puberty
Massachusetts General Hospital
Delayed Puberty · Kallmann Syndrome · Hypogonadotropic Hypogonadism · GnRH Deficiency
The Use of the Hormone Kisspeptin in 'in Vitro Fertilisation' (IVF) Treatment
Imperial College London
Infertility
Elucidating Kisspeptin Physiology by Blocking Kisspeptin Signaling
Massachusetts General Hospital
Hypogonadotropic Hypogonadism · Healthy Postmenopausal Women · Agonadism
Kisspeptin Administration in the Adult
Massachusetts General Hospital
Hypogonadotropic Hypogonadism · Kallmann Syndrome · GnRH Deficiency · PCOS
Sources: ClinicalTrials.gov, the EU Clinical Trials Information System and ISRCTN, deduplicated so a study registered in more than one registry is counted once. A study is listed when Kisspeptin-10 is named as an intervention. A registered trial is a plan, not a result — registration says nothing about whether the peptide worked.