Intermedin (Adrenomedullin-2) vs Thymosin Beta-4
A powerful peptide hormone that protects your heart and blood vessels while managing stress and inflammation naturally.
The body's natural healing peptide that accelerates tissue repair and reduces inflammation
Written by Michael Carroll — Owner, Director of Research · Reviewed by the Peptide Initiative Research Team · Editorial standards
Quick comparison
Dose range
Intermedin (Adrenomedullin-2)
As prescribed–As prescribed mg
Thymosin Beta-4
2–5 mg
Frequency
Intermedin (Adrenomedullin-2)
Once daily
Thymosin Beta-4
Twice weekly
Administration
Intermedin (Adrenomedullin-2)
As directed by healthcare provider
Thymosin Beta-4
Subcutaneous injection
Cycle length
Intermedin (Adrenomedullin-2)
Ongoing/indefinite
Thymosin Beta-4
8-12 weeks
Onset speed
Intermedin (Adrenomedullin-2)
Moderate (1-2 weeks)
Thymosin Beta-4
Moderate (1-2 weeks)
Evidence level
Intermedin (Adrenomedullin-2)
Limited human trials
Thymosin Beta-4
Moderate human trials (Phase 1-2)
Benefit ratings
Cardiovascular Health & Protection
Stress & Anxiety Management
Anti-Inflammatory & Antioxidant Support
Wound Healing
Inflammation Reduction
Tissue Regeneration
Compound specifications
Intermedin (Adrenomedullin-2)
Molecular formula
C15H25NO5 (precursor compound)
Molecular weight
299.36 g/mol (precursor)
Half-life
Approximately 2-6 hours (varies by route of administration)
Bioavailability
Varies by route of administration
CAS number
148498-78-6
Thymosin Beta-4
Molecular formula
C212H350N56O78S
Molecular weight
4963
Half-life
Dose-dependent (increases with higher doses)
Bioavailability
100% (subcutaneous and intravenous)
CAS number
77591-33-4
Dosing compared
Intermedin (Adrenomedullin-2)
Thymosin Beta-4
Subcutaneous injection
2-5 mg (community injectable practice for 'TB-500')
Once or twice weekly · 4-6 week loading phase, then weekly maintenance
Documented community/research-practice injectable dosing for tissue repair; thymosin beta-4 has ~100% bioavailability by the subcutaneous route [1]. Not an FDA-approved use.
Topical ophthalmic (eye drops)
0.1% (1 mg/mL) RGN-259 solution, 1 drop
Several times daily (e.g. up to 5x/day) · 4 weeks
0.1% RGN-259 ophthalmic solution used in phase III neurotrophic keratopathy and dry-eye trials, applied as eye drops several times daily for ~4 weeks [5].
Intravenous injection
450-1200 mg
IV push daily for the first 3 days, then weekly · Total of 7 doses over ~5 weeks
Doses studied in the RGN-352 acute myocardial infarction clinical program, given IV after PCI [6].
Best suited for
Intermedin (Adrenomedullin-2)
Supporting cardiovascular health and heart function
Intermedin (Adrenomedullin-2) is particularly well-suited for individuals focused on supporting cardiovascular health and heart function. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Managing inflammation and oxidative stress
Intermedin (Adrenomedullin-2) is particularly well-suited for individuals focused on managing inflammation and oxidative stress. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Improving overall vascular health and circulation
Intermedin (Adrenomedullin-2) is particularly well-suited for individuals focused on improving overall vascular health and circulation. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Thymosin Beta-4
Post-Surgery Recovery
Accelerates healing of surgical wounds and reduces post-operative inflammation and scarring
Chronic Wound Management
Helps pressure ulcers, venous stasis ulcers, and other slow-healing wounds progress faster
Tissue Regeneration
Supports repair of damaged tissues from injury, burns, or degenerative conditions
Side effects
Intermedin (Adrenomedullin-2)
Common
- Mild discomfort at treatment site
- Flushing and mild facial redness
- Dizziness or lightheadedness
- Mild headache
- Injection site reactions (redness, itching, swelling)
- Nausea or mild gastrointestinal discomfort
- Fatigue or mild energy changes
- Transient hypotension (temporary low blood pressure)
- Mild palpitations (in some individuals)
Serious
- Severe allergic reaction
Thymosin Beta-4
Common
- Injection site redness
- Injection site swelling
Uncommon
- Temporary mild headache
- Mild bruising at injection site
- Transient fatigue
Serious
- Allergic reaction
Safety & evidence
Intermedin (Adrenomedullin-2)
Evidence level
Limited human trials
FDA status
Not FDA approved
Safety overview
Intermedin (Adrenomedullin-2) is an endogenous peptide hormone with systemic vascular and renal effects that warrant cautious use. As a vasodilator acting through CGRP and other peptide receptors, it can significantly lower blood pressure—a key safety consideration for hypotensive or cardiovascular-compromised individuals. Preclinical studies show dose-dependent hypotensive effects and tachycardia, limiting clinical translation. The compound remains largely experimental with limited safety data in humans outside specific research contexts.
Contraindications
- Pregnancy and breastfeeding - insufficient safety data
- Active cardiovascular events (heart attack, stroke)
- Severe renal (kidney) impairment
- Hypersensitivity to calcitonin family peptides
- Uncontrolled endocrine disorders
Thymosin Beta-4
Evidence level
Moderate human trials (Phase 1-2)
FDA status
Research compound
Safety overview
Thymosin Beta-4 is a naturally occurring peptide found in all cells and body fluids in the human body. Clinical trials have demonstrated excellent safety even at very high doses. IV studies showed doses up to 1260 mg were well tolerated with no serious adverse events.
Contraindications
- Active systemic infections
- Severe immunosuppression
- Hypersensitivity to thymosin or any component
- Pregnancy (insufficient safety data)
Which is right for you?
Choose Intermedin (Adrenomedullin-2) if...
- Supporting cardiovascular health and heart function
- Managing inflammation and oxidative stress
- Improving overall vascular health and circulation
Choose Thymosin Beta-4 if...
- Recovering from injuries or surgery
- Improving wound healing speed
- Reducing inflammation
- Minimizing scar formation