Peptide Comparison
Gonadorelin (GnRH)vsTriptorelin
The master hormone that controls your reproductive system and fertility
GnRH agonist that helps manage prostate cancer, endometriosis, and early puberty by controlling sex hormones
At a Glance
Quick
comparison
Dose Range
Gonadorelin (GnRH)
0.1-1.5–3-10 mg
Triptorelin
0.1 mg–22.5 mg mg
Frequency
Gonadorelin (GnRH)
Once daily
Triptorelin
Once daily
Administration
Gonadorelin (GnRH)
Subcutaneous injection
Triptorelin
Intramuscular injection
Cycle Length
Gonadorelin (GnRH)
Ongoing/indefinite
Triptorelin
Ongoing/indefinite
Onset Speed
Gonadorelin (GnRH)
Moderate (1-2 weeks)
Triptorelin
Moderate (1-2 weeks)
Evidence Level
Gonadorelin (GnRH)
Moderate human trials (Phase 1-2)
Triptorelin
Strong human trials (Phase 3 or FDA approved)
Efficacy
Benefit
ratings
Reproductive Health
Hormone Balance
Ovulation Support
Hormone Regulation
Cancer Management
Endometriosis Relief
Technical Data
Compound
specifications
Gonadorelin (GnRH)
Molecular Formula
C55H75N17O13
Molecular Weight
1182.3
Half-Life
2-4 minutes
Bioavailability
Varies by route: ~5-20% (intranasal), 100% (IV/IM injections)
CAS Number
34973-08-5
Triptorelin
Molecular Formula
C64H82N18O13
Molecular Weight
1311.4 g/mol
Half-Life
2-3 hours (free peptide); 2-4 weeks (depot pamoate formulations)
Bioavailability
~100% (intramuscular/subcutaneous injection)
CAS Number
57773-63-4
Applications
Best
suited for
Gonadorelin (GnRH)
Improving fertility and conception chances
Gonadorelin (GnRH) is particularly well-suited for individuals focused on improving fertility and conception chances. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Regulating irregular menstrual cycles
Gonadorelin (GnRH) is particularly well-suited for individuals focused on regulating irregular menstrual cycles. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Enhancing reproductive hormone levels
Gonadorelin (GnRH) is particularly well-suited for individuals focused on enhancing reproductive hormone levels. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Supporting natural pregnancy attempts
Gonadorelin (GnRH) is particularly well-suited for individuals focused on supporting natural pregnancy attempts. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Triptorelin
Managing advanced prostate cancer when combined with other treatments
Triptorelin is particularly well-suited for individuals focused on managing advanced prostate cancer when combined with other treatments. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Relieving severe endometriosis pain and symptoms
Triptorelin is particularly well-suited for individuals focused on relieving severe endometriosis pain and symptoms. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Delaying puberty development in children with early sexual maturation
Triptorelin is particularly well-suited for individuals focused on delaying puberty development in children with early sexual maturation. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Safety Profile
Side
effects
Gonadorelin (GnRH)
Common
- Mild headache
- Local injection site reactions (redness, swelling)
- Temporary hot flashes
- Mood changes or emotional sensitivity
- Nausea or mild stomach upset
- Allergic skin reactions
- Dizziness or lightheadedness
- Temporary changes in vision
- Joint or muscle aches
- Insomnia or sleep disturbances
- Severe allergic reactions (difficulty breathing, swelling)
- Severe hormonal imbalance symptoms
- Ovarian hyperstimulation syndrome (OHSS)
- Signs of blood clots (chest pain, leg swelling)
- Severe mood changes or depression
Serious
- Severe allergic reaction
Triptorelin
Research Status
Safety
& evidence
Gonadorelin (GnRH)
Evidence Level
Moderate human trials (Phase 1-2)
FDA Status
FDA approved for this use
Safety Overview
Gonadorelin is native GnRH and carries the safety profile established over 40+ years of clinical use in reproductive endocrinology. As the body's natural hormone, it produces minimal local side effects when dosed appropriately. The critical safety concern with gonadorelin is the initial flare effect within 24-48 hours of first dose—temporary elevation in FSH and LH—which can paradoxically suppress sex hormones before the desired stimulation occurs. This flare makes gonadorelin unsuitable for some conditions and explains why synthetic analogs (agonists, antagonists) are preferred in many modern fertility protocols.
Contraindications
- xPregnancy or breastfeeding
- xHormone-sensitive cancers (breast, prostate, ovarian)
- xSevere pituitary or hypothalamic disease
- xUndiagnosed abnormal vaginal bleeding
- xKnown hypersensitivity to GnRH
Triptorelin
Evidence Level
Strong human trials (Phase 3 or FDA approved)
FDA Status
FDA approved for this use
Safety Overview
Triptorelin (GnRH agonist) has extensive FDA-approved safety data spanning decades for prostate cancer, endometriosis, and precocious puberty indications. Initial testosterone surge upon initiation ("flare reaction") can worsen prostate cancer or spinal cord compression symptoms, requiring careful patient monitoring in first 1-2 weeks and use of androgen antagonists in high-risk patients. Hypogonadal effects including hot flashes, sexual dysfunction, and bone loss develop predictably with chronic GnRH suppression; bone density monitoring is recommended in patients on therapy >6 months.
Contraindications
- xPregnancy (can affect fetal development)
- xUndiagnosed vaginal bleeding
- xKnown hypersensitivity to GnRH agonists
- xSevere untreated depression
- xActive spinal cord compression in prostate cancer (requires urgent decompression)
Decision Guide
Which is
right for you?
Choose Gonadorelin (GnRH) if...
- Improving fertility and conception chances
- Regulating irregular menstrual cycles
- Enhancing reproductive hormone levels
- Supporting natural pregnancy attempts
Choose Triptorelin if...
- Managing advanced prostate cancer when combined with other treatments
- Relieving severe endometriosis pain and symptoms
- Delaying puberty development in children with early sexual maturation