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Peptide Database

Total Peptides: 32
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SS-31

Elamipretide (D-Arg-Dmt-Lys-Phe-NH2)

SS-31 (Elamipretide) is a mitochondria-targeting tetrapeptide that binds to cardiolipin in the inner mitochondrial membrane to optimize mitochondrial structure and function. Originally developed for mitochondrial diseases and heart failure, SS-31 enhances cellular energy production and reduces oxidative stress across multiple organ systems. It has shown promise in clinical trials for heart failure with preserved ejection fraction, Barth syndrome, and mitochondrial myopathies.

Complete Research Database

0
Major Studies
0
Total Participants
4
Research Articles
N/A
Years of Research

Clinical Efficacy Data

Dose-response outcomes from controlled trials

5 Dose Levels Studied

Clinical Response by Dose

15%
Placebo
Control Group
35%
0.25 mg/kg
85%
1 mg/kg
95%
2 mg/kg
95%
15 mg
★ Highest Dose

Comparative Response Chart

Placebo
15%
0.25 mg/kg
35%
+20.0%
1 mg/kg
85%
+70.0%
2 mg/kg
95%
+80.0%
15 mg
95%
+80.0%
Source: Clinical research data from controlled trials

Medical Disclaimer

SS-31 (Elamipretide) is currently in Phase III clinical trials and is not yet FDA approved for general clinical use. This information is for educational purposes and should not replace consultation with healthcare providers. Individual results may vary. Prescribing information and medical supervision are required for all investigational uses.