Eagle LogoPEPTIDE INITIATIVE

Peptide Database

Goals
Fat LossMuscle BuildingInjury HealingAnti-AgingCognitive EnhancementSleep OptimizationImmune SupportGut HealingSkin RejuvenationSexual Health
Peptides
5-Amino-1MQ
Weight Management
Abarelix
Hormone Support
Acetyl Hexapeptide-3 (Argireline)
Cosmetic
Adipotide
Weight Management
Adrenomedullin
Healing & Recovery
Alexamorelin
Growth Hormone
Angiotensin (1-7)
Healing & Recovery
AOD-9604
Weight Management
Apelin-13
Healing & Recovery
ARA-290 (Cibinetide)
Healing & Recovery
Bestatin (Ubenimex)
Immune
BPC-157
Healing & Recovery
Buserelin
Hormone Support
Cagrilintide
Weight Management
CagriSema
Weight Management
Capromorelin
Growth Hormone
Cartalax
Anti-Aging
Cathelicidin (hCAP-18 / Synthetic Derivatives)
Immune
Cerebrolysin
Cognitive
Cerluten
Cognitive
Cetrorelix
Hormone Support
Chonluten
Immune
CJC-1295 (No DAC)
Growth Hormone
CJC-1295 with DAC
Growth Hormone
Cortexin
Cognitive
Crystagen
Immune
Daptomycin
Immune
Defensin (HBD-2)
Immune
Defensin (HBD-3)
Immune
Degarelix
Hormone Support
Dihexa
Cognitive
DSIP (Delta Sleep-Inducing Peptide)
Sleep & Recovery
Dulaglutide
Weight Management
Enalapril
Healing & Recovery
Epithalon
Anti-Aging
Exenatide
Weight Management
Fertirelin
Hormone Support
FOXO4-DRI
Anti-Aging
Ganirelix
Hormone Support
GHK-Cu (Copper Peptide)
Cosmetic
GHRH (1-29)
Growth Hormone
GHRP-2
Growth Hormone
GHRP-6 (Growth Hormone Releasing Peptide-6)
Growth Hormone
Glutathione
Anti-Aging
Gonadorelin (GnRH)
Hormone Support
Gramicidin
Immune
Hexarelin
Growth Hormone
Human Chorionic Gonadotropin (HCG)
Hormone Support
Human Growth Hormone (HGH)
Growth Hormone
IGF-1 LR3
Growth Hormone
Immunoxel (Dzherelo)
Immune
Imunofan
Immune
Intermedin (Adrenomedullin-2)
Healing & Recovery
Ipamorelin
Growth Hormone
Kisspeptin-10
Sexual Health
KPV (Alpha-MSH Fragment)
Healing & Recovery
Lactoferricin B
Immune
Larazotide
Healing & Recovery
Lentinan
Immune
Leuphasyl
Cosmetic
Leuprolide
Hormone Support
Liraglutide
Weight Management
Livagen
Anti-Aging
Lixisenatide
Weight Management
LL-37
Immune
Macimorelin
Growth Hormone
Magainin-2
Immune
Mazdutide
Weight Management
Melanotan-2
Cosmetic
MK-677 (Ibutamoren)
Growth Hormone
MOTS-c
Metabolic
Myristoyl Pentapeptide-17
Cosmetic
N-Acetyl Selank
Cognitive
N-Acetyl Semax Amidate
Cognitive
NAD+
Mitochondrial
Nafarelin
Hormone Support
Natriuretic Peptide (ANP)
Healing & Recovery
Nesiritide (BNP)
Healing & Recovery
Nisin
Immune
Noopept (Omberacetam)
Cognitive
Orforglipron
Weight Management
Ovagen
Anti-Aging
Oxytocin Acetate
Hormone Support
P21 (P021)
Cognitive
PACAP-38
Healing & Recovery
Palmitoyl Oligopeptide
Cosmetic
Palmitoyl Pentapeptide-4 (Matrixyl)
Cosmetic
Palmitoyl Tetrapeptide-7
Cosmetic
Palmitoyl Tripeptide-1
Cosmetic
Pancragen
Metabolic
PEG-MGF
Healing & Recovery
Pemvidutide
Weight Management
Pentadecapeptide (BPC Analog)
Healing & Recovery
Pidotimod
Immune
Pinealon
Cognitive
PNC-27
Immune
Polymyxin B
Immune
Pralmorelin (GHRP-2)
Growth Hormone
Pramlintide
Weight Management
Prostamax
Hormone Support
PT-141 (Bremelanotide)
Sexual Health
Relaxin-2 (Serelaxin)
Healing & Recovery
Retatrutide
Weight Management
Selank
Cognitive
Semaglutide
Weight Management
Semax
Cognitive
Sermorelin
Growth Hormone
Setmelanotide
Weight Management
SLU-PP-332
Metabolic
SM-130686
Growth Hormone
Snap-8
Cosmetic
SS-31 (Elamipretide)
Mitochondrial
Substance P Antagonists
Healing & Recovery
Survodutide
Weight Management
SYN-AKE
Cosmetic
Tabimorelin
Growth Hormone
TB-500
Healing & Recovery
Tesamorelin
Growth Hormone
Testagen
Hormone Support
Thymalin
Immune
Thymopentin (TP-5)
Immune
Thymopoietin
Immune
Thymosin Alpha-1
Immune
Thymosin Beta-4
Healing & Recovery
Thymulin (FTS)
Immune
Thymulin Analog (PAT)
Healing & Recovery
Tirzepatide
Weight Management
Tripeptide-29
Cosmetic
Triptorelin
Hormone Support
Ularitide
Healing & Recovery
Urocortin
Healing & Recovery
Ventfort
Anti-Aging
Vesilute
Hormone Support
Vilon
Immune
VIP (Vasoactive Intestinal Peptide)
Healing & Recovery
Xenin-25
Metabolic
Ziconotide (Prialt)
Healing & Recovery
Total Peptides: 137
Back to Home

Condition Spotlight

Lyme Disease
Fatigue

One of the most brutal parts of chronic Lyme disease is the crushing fatigue. We're not talking 'I stayed up too late' tired - this is 'I slept 12 hours and still can't get off the couch' exhaustion.

Written by Michael Carroll — Owner, Director of Research · Reviewed by the Peptide Initiative Research Team · Editorial standards

The Problem

Your Cells Have Power Plants
And Lyme Wrecks Them

Brain Fog

Even thinking feels exhausting

Heavy Muscles

Your body feels weighed down

No Energy

Running on backup generators

Understanding Mitochondria

The Energy Crisis Inside Your Cells

Inside almost every cell in your body are tiny structures called mitochondria. Think of them as microscopic power plants that convert the food you eat into usable energy called ATP - the fuel your cells run on. When you have Lyme disease, the bacteria (Borrelia burgdorferi) and the inflammation it triggers basically throw a wrench into these power plants. The mitochondria get damaged, produce less energy, and start leaking harmful byproducts called reactive oxygen species - basically cellular exhaust fumes that damage everything around them.

"Your cells are running on backup generators instead of full power."

The result? Your brain feels foggy. Your muscles feel heavy. Even thinking feels exhausting. This is where peptide therapy comes in - each one attacks the energy crisis from a different angle.

The Solutions

3 Peptides
3 Angles of Attack

2015

MOTS-C

The Metabolic Reset Button

A naturally occurring peptide encoded in your mitochondrial DNA that optimizes fuel usage and metabolism.

Role

Tuning the engine for better fuel efficiency

2001

Humanin

The Cellular Bodyguard

A protective peptide your mitochondria naturally produce, discovered by researchers studying Alzheimer's disease.

Role

Bodyguard keeping workers safe

Learn more

Clinical Trials

SS-31

The Mitochondrial Mechanic

A synthetic peptide specifically designed by scientists to penetrate deep into mitochondria and fix problems at the source.

Role

Mechanic fixing the broken parts

The Strategy

How They Work Together
Together

PeptidePrimary RoleAnalogy
MOTS-C

The Metabolic Reset Button

Tuning the engine for better fuel efficiency

Humanin

The Cellular Bodyguard

Bodyguard keeping workers safe

SS-31

The Mitochondrial Mechanic

Mechanic fixing the broken parts

3 Angles of Attack

Metabolic Optimization

MOTS-c optimizes how your cells use fuel, ensuring energy production runs efficiently

Cellular Protection

Humanin prevents damaged cells from dying prematurely, preserving tissue function

Structural Repair

SS-31 repairs the physical machinery inside mitochondria

Synergistic Effect

Together they address energy production, protection, and repair simultaneously

Important Considerations

Reality Check
What to Keep in Mind

Not a Magic Bullet

Peptides support healing but don't replace treating underlying infections. Work with a Lyme-literate doctor for comprehensive care.

Research is Ongoing

While promising, some of this research is still emerging. Individual results vary significantly.

Professional Guidance

Work with a healthcare provider experienced in peptide therapy. Proper dosing and monitoring matter.

This information is for educational purposes only and should not be considered medical advice. Always consult with a qualified healthcare provider before starting any new treatment.

Realistic Expectations

What to Expect: A Realistic Timeline

An honest breakdown based on research and clinical reports.

What's Happening Inside

The peptides are getting to work, but you're mostly in the 'building up' phase. SS-31 starts concentrating in mitochondria quickly (within hours), but cellular repair takes time.

What You Might Notice

  • Possibly nothing dramatic yet - and that's okay
  • Some people report subtle shifts in sleep quality
  • Slight reduction in that 'heavy' feeling in muscles
  • Maybe a few moments of mental clarity that surprise you

Watch For

Some people experience a brief uptick in fatigue or mild flu-like feelings as cellular cleanup begins. This is sometimes called a 'healing response' - your body clearing out damaged cellular components. It's temporary.

Realistic Expectations

Don't expect miracles. You're laying groundwork.

Administration Guide

Dosing Protocols & Timing

General guidelines based on research literature and clinical reports. Work with a healthcare provider experienced in peptide therapy to customize for your situation.

Important: These are general guidelines. Don't self-prescribe based on internet articles. Work with a qualified healthcare provider.

MOTS-C

5-10 mg per week

Common Protocols

  • Option A: 5 mg subcutaneous injection, twice weekly (e.g., Monday and Thursday)
  • Option B: 10 mg subcutaneous injection, once weekly
  • Loading: Some practitioners start with 5 mg three times weekly for first 2 weeks, then drop to twice weekly

Timing Considerations

  • Best administered in the morning, as it affects metabolism and energy
  • Can be taken with or without food
  • Some people prefer dosing before planned physical activity
  • Avoid dosing late in the day as it may interfere with sleep

Cycling

8-12 weeks on, 4 weeks off (some use continuous protocols for chronic conditions)

Beyond Peptides

Lifestyle Strategies for Living Well

Peptides work best as part of a comprehensive approach. Click each category to explore evidence-based strategies.

At a Glance

Quick Reference Card

Peptide Overview

PeptideWhat It DoesTypical DoseTiming
MOTS-C
The Metabolic Reset Button5-10 mg per weekBest administered in the morning, as it affects metabolism and energy
Humanin
The Cellular Bodyguard1-5 mg per dayCan be administered any time of day
SS-31
The Mitochondrial Mechanic10-50 mg per dayOnce daily dosing is standard

Early Wins to Watch

  • Better sleep quality
  • Energy windows appearing
  • Reduced brain fog episodes
  • Faster recovery from activity

Support Stack

CoQ10PQQB vitaminsMagnesiumD-riboseAlpha-lipoic acidAcetyl-L-carnitine

Lifestyle Priorities

  • Sleep consistency
  • Paced movement
  • Anti-inflammatory nutrition
  • Stress management
  • Detox support

Living with Lyme disease is genuinely hard. These peptides represent a real opportunity to address one of the core mechanisms making you feel awful. Recovery isn't linear - there will be setbacks. But there can also be gradual improvement, returning function, and moments where you remember what it felt like to be well.

Keep advocating for yourself. Keep trying things. Remember that mitochondria are remarkably good at healing when given the right support.