Hormone Support Protocol
TestagenComplete Dosing & Administration Guide
Testicular tetrapeptide bioregulator (Lys-Glu-Asp-Gly) that normalizes HPG axis signaling through DNA minor groove binding at testicular gene promoters, increases testosterone synthesis by restoring Leydig cell function, and modulates neuroendocrine feedback loops controlling gonadotropin secretion in aging males
Dose Range
5-10mg
Frequency
Once daily
Route
Sublingual (enteric-coated capsules)
Cycle Length
12+ weeks
Dosing
How much
do I take?
Starting Dose
1-2 capsules (5 mg each) orally once daily
Begin with oral capsule administration. Take on an empty stomach 15-30 minutes before meals. The KEDG tetrapeptide is designed for oral bioavailability. Effects on testosterone are gradual — HPG axis normalization takes weeks. Baseline testosterone levels should be documented before starting. Monitor for any changes in energy, libido, or mood.
Standard Dose
5-10 mg subcutaneously or 2 capsules orally once daily
Standard protocol as used in the 36-patient clinical trial. Administer once daily for 10-20 consecutive days. Repeat courses every 3-6 months for sustained hormonal support. Can be combined with Prostamax for comprehensive male reproductive health or Epithalon for systemic geroprotection. Testosterone improvements typically become measurable 2-4 weeks after initiating treatment.
Advanced Dose
10 mg subcutaneously once daily
Extended protocol for significant testicular function decline. Used in comprehensive multi-peptide bioregulator programs combining Testagen with Prostamax (prostate), Epithalon (pineal), Vilon (immune), and Ventfort (vascular) for whole-body male geroprotection. Repeat every 3-6 months. Regular testosterone monitoring recommended. Medical supervision strongly advised.
Timing
Best time to take
Take Testagen at the same time each day for consistent blood levels. Morning dosing with breakfast is often preferred, but follow your healthcare provider's specific instructions.
With food?
Testagen can typically be taken with or without food. Taking it with a light meal may help reduce any GI discomfort. Avoid taking with grapefruit juice or high-fat meals unless specifically directed.
If stacking
Testagen should be used as directed by your healthcare provider. If combining with other medications or supplements, discuss potential interactions with your provider. Avoid combining with compounds that have overlapping mechanisms unless specifically guided by a medical professional.
Adjusting Your Dose
Increase if
- +You've tolerated the current dose for the recommended period without significant side effects
- +Therapeutic goals haven't been met at the current dose level
- +Your healthcare provider recommends dose escalation based on your response
- +Lab work or clinical assessments support a higher dose
Decrease if
- -Side effects are bothersome or impacting daily life despite management strategies
- -You experience any signs of an adverse reaction
- -Lab results indicate the need for dose reduction
- -Your healthcare provider recommends a lower dose based on your response
Signs of right dose
- ✓Therapeutic goals being met with minimal side effects
- ✓Stable and consistent response to treatment
- ✓Lab values or clinical markers trending in the right direction
- ✓Good tolerance with manageable or absent side effects
Dosing Calculator
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Administration
How do I
use it?
Reconstitution
What you need
- •Testagen in its prescribed form
- •Clean, dry storage container
- •Measuring device if applicable (oral syringe, measuring cup)
- •Calendar or reminder app for dosing schedule
Injection
Route
Testagen is administered Sublingual (enteric-coated capsules)—no injection required
Best sites
- •Not applicable—this is not an injectable formulation
Technique
- 1.Follow the specific administration instructions for your Testagen formulation
- 2.Take or apply as directed by your healthcare provider
- 3.Store properly between uses according to package instructions
Storage
Signs of degradation
Sample Daily Schedule
Safety
Is it
safe?
Safety Profile
Testagen (lyophilized peptide complex) lacks published human safety data—all information derives from unpublished manufacturer data and theoretical extrapolation from rat studies. As an androgen secretagogue, it carries class risks including erythrocytosis (elevated red blood cell count), liver enzyme elevation, lipid profile unfavorable changes (reduced HDL, increased LDL), and prostate-related effects including urinary obstruction and potential malignancy acceleration. Cardiovascular risk including hypertension and increased thrombotic events are theoretical concerns based on androgen class pharmacology.
No published human clinical trials exist—safety profile is entirely unknown in humans. Manufacturer claims Russian clinical use, but these data are not published in peer-reviewed literature or validated by regulatory agencies. Androgen secretagogue class carries well-characterized risks from testosterone replacement therapy literature, but product-specific safety in humans is completely unestablished. Any use should be considered high-risk experimental therapy requiring comprehensive baseline and ongoing monitoring.
Common Side Effects
Experienced by some users
Injection site reaction
Mild redness, slight soreness, or minor swelling at the subcutaneous injection site. Standard for injectable peptide bioregulators.
Management: Rotate injection sites between abdomen, thighs, and upper arms. Apply cold compress if needed. Resolves within 24-48 hours.
Mild fatigue
Slight fatigue during initial days as the HPG axis recalibrates and testicular gene expression programs activate.
Management: Rest as needed. Usually resolves within 2-3 days. Ensure adequate sleep and hydration.
Mild headache
Transient headache during the first few days, potentially related to neuroendocrine adjustments as HPG axis signaling normalizes.
Management: Ensure adequate hydration. Standard analgesics if needed. Usually self-limiting.
Libido fluctuation
Transient changes in libido (increase or temporary decrease) as testosterone synthesis normalizes and androgen receptor sensitivity adjusts.
Management: Normal part of HPG axis normalization. Should stabilize within 1-2 weeks as testosterone levels reach new equilibrium.
Less Common
- •Mild acne or skin oiliness
These typically resolve with continued use or dose adjustment.
Stop and Seek Help If
- ×Severe or worsening side effects that don't improve with dose adjustment or supportive care
- ×Signs of an allergic reaction—rash, hives, swelling, or difficulty breathing
- ×Your healthcare provider recommends discontinuation based on your clinical response
- ×Development of any new medical condition that may be contraindicated with Testagen
- ×Pregnancy or planning to become pregnant (unless specifically approved for use during pregnancy)
- ×Abnormal lab results or clinical markers that suggest adverse effects
Testagen should only be started, adjusted, or discontinued under medical supervision. This information is for educational purposes only and does not replace professional medical advice. Never stop a prescribed treatment without consulting your healthcare provider first, as abrupt discontinuation may have consequences.
Interactions
With other peptides
- ✓May be used together under medical guidance.
- ✓May be used together under medical guidance.
- ✓May be used together under medical guidance.
With medications
- !Exogenous testosterone or anabolic steroids — may suppress the HPG axis that Testagen aims to restore, creating counterproductive feedback - Use with caution—discuss with your healthcare provider.
- !Anti-androgens or 5-alpha reductase inhibitors — may counteract Testagen's androgen-normalizing effects - Use with caution—discuss with your healthcare provider.
- !GnRH agonists or antagonists — direct interference with the HPG axis regulatory mechanisms Testagen modulates - Use with caution—discuss with your healthcare provider.
With supplements
- ✓Multivitamins - Generally safe to take alongside Testagen. Space doses apart if taking oral formulations to ensure optimal absorption.
- ✓Electrolyte supplements - Helpful if experiencing any GI side effects that could lead to dehydration. Safe to combine.
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