Clinical trials
Every registered trial of Polymyxin B
69 studies, 16 still enrolling.
Plain-Language Summary
Plain-language reading of the public trial registries.
In short
- Polymyxin B has a real but limited body of human research.
- 69 registered studies in total.
- 16 are still enrolling people, so this is active research, not just history.
What kind of research
- 62 studies actually gave the peptide to volunteers and measured what happened. This is the kind of study that can show whether something works.
- About 7,472 people took part in those.
- A further 7 studies only looked at records of people already taking it. These are counted separately because nobody was given the peptide for the study, so they cannot prove cause and effect.
How far along it is
- 21 trials have reached phase 3 or 4 — the large, late-stage trials regulators rely on to approve a drug.
- 11 have published results in the medical literature that anyone can read.
- The research spans 44 countries.
A registered trial is a plan, not a result. Registration means a study was declared in advance; it says nothing about whether the peptide worked, and a trial can be registered and then abandoned.
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Showing 69 of 69 trials for Polymyxin B.
EAA-Guided AN69-oXiris and PMX-HP Therapy in Septic Patients
Kyoung Moo Im
Hemoperfusion · Sepsis · ICU · Endotoxin Levels
BV100-010
Bioversys S.A.S.
Hospital-acquired bacterial pneumonia including ventilator-associated bacterial pneumonia caused by carbapenem-resistant Acinetobacter baumannii-calcoaceticus complex
Safety, Pharmacokinetics and Efficacy of BV100 Plus Low Dose Polymyxin B Plus Ceftazidime/Avibactam, or Plus Cefiderocol in Patients With Pulmonary and Extrapulmonary Infections Due to Carbapenem-resistant Acinetobacter Baumannii-calcoaceticus Complex
BioVersys AG
Ventilator Associated Bacterial Pneumonia (VABP) · Hospital Acquired Bacterial Pneumonia (HABP) · Blood Stream Infection · Meningitis, Bacterial
Study on the Safety and Efficacy of Polymyxin E2 Methanesulfonate for Injection in the Treatment of Hospital-Acquired Bacterial Pneumonia/Ventilator-Associated Bacterial Pneumonia Caused by Carbapenem-Resistant Gram-Negative Bacteria
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Hospital-acquired Bacterial Pneumonia/Ventilator-associated Bacterial Pneumonia
Named in the study description rather than as the headline intervention — often a drug given alongside the one being tested.
Intracalvariosseous Plus Intravenous Antibiotics for Moderate-to-Severe Bacterial Meningitis
yilong Wang
Blood-Brain Barrier · Bacterial Meningitis
A Phase I Study Comparing the Safety, Pharmacokinetics and Renal Effects of VRP-034 and Marketed Polymyxin B in Healthy Volunteers
Venus Remedies Limited
Healthy Volunteers
Sebum Metabolomics and Lipidomics for Clinical Applications
National Taiwan University Hospital
Acne · Atopic Dermatitis · Seborrheic Dermatitis · Psoriasis
Efficacy and Safety of BV100 Plus Low Dose Polymyxin B Versus Colistin Plus High-dose Ampicillin/Sulbactam in Patients With Hospital-acquired or Ventilator-associated Bacterial Pneumonia Due to Carbapenem-resistant Acinetobacter Baumannii-calcoaceticus Complex
BioVersys SAS
Hospital Acquired Bacterial Pneumonia (HABP) · Ventilator Associated Bacterial Pneumonia (VABP) · Colistin Resistanrt ABC · Acinetobacter Baumannii-calcoaceticus Complex
ASK0912 Versus Polymyxin B for Injection in Adults With Hospital-Acquired or Ventilator-Associated Bacterial Pneumonia
Jiangsu Aosaikang Pharmaceutical Co., Ltd.
Ventilator-associated Bacterial Pneumonia (VABP) · Hospital-acquired Bacterial Pneumonia (HABP)
A Single Centre, Open-label, 2-period Fixed-sequence, Phase I Clinical Study to Evaluate the Effect of BV100 on the Pharmacokinetics of Polymyxin B in Healthy Volunteers
BioVersys SAS
Healthy Adult Participants
BV100-011
Bioversys S.A.S.
Healthy volunteer trial. Intended indication: treatment of infections due to A. baumannii.
Optimising TREATment for Severe Gram-Negative Bacterial Infections
National University of Singapore
Bloodstream Infection · Ventilator Associated Bacterial Pneumonia · Hospital Acquired Bacterial Pneumonia · Carbapenem Resistant Bacterial Infection
The Safety and Microbial Changes in the Use of Intranasal Neosporin®
Hospital Universitario Dr. Jose E. Gonzalez
Teste the Safety of (Polymyxin B Sulfate 500,000 IU, Bacitracin Zinc 40,000 IU, Neomycin Sulfate 0.35g Neomycin Base) Intranasally
A Study on the Combination Therapy of Eravacycline for Treating Carbapenem-Resistant Acinetobacter Baumannii Pneumonia
Peking University Third Hospital
Pneumonitis · Acinetobacter Baumannii
Named in the study description rather than as the headline intervention — often a drug given alongside the one being tested.
To Evaluate the Pharmacokinetics and Safety of TQD3524 for Injection in Renal Impairment Subjects
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Multi-resistant Gram-negative Bacteria Cause Infection
Named in the study description rather than as the headline intervention — often a drug given alongside the one being tested.
Intraventricular Administration of Intracranial Infections Caused by （Carbapenem-resistant Gram-negative Bacilli）CRGNB
Second Affiliated Hospital, Zhejiang University, School of Medicine
Intracranial Infections
Comparison of Epithelial Lining Fluid and Blood Pharmacokinetics and Pharmacodynamics of Intravenous and Intravenous Plus Nebulized Polymyxin B in Multidrug Resistant Bacteria Ventilator-associated Pneumonia Patients
Southeast University, China
Polymyxin B · Ventilator-associated Pneumonia · Multidrug Resistant Bacterial Infection · Pharmacogenomic Drug Interaction
PK of BV100 in Patients VABP Suspected or Confirmed to Be Due to CRAB
BioVersys AG
Ventilator Associated Pneumonia
A Study of the Clinical Benefit of Tobramycin Inhalation Solution
Qianfoshan Hospital
Bronchiectasis · Cystic Fibrosis · Lung Infection
Named in the study description rather than as the headline intervention — often a drug given alongside the one being tested.
Different Methods of Aerosolized Polymyxin B Inhalation for Treating Carbapenem-Resistant Gram-Negative Bacterial Pneumonia.
Fujian Medical University Union Hospital
Carbapenem-Resistant Enterobacteriaceae Infection · Pneumonia - Bacterial
Topical Antibacterial Agents for Prevention of COVID-19
Yale University
COVID-19 · SARS-CoV2 Infection
Named in the study description rather than as the headline intervention — often a drug given alongside the one being tested.
Retentive Strength of Denture Adhesives on Various RR Ridges
Altamash Institute of Dental Medicine
Retentive Strength of Denture Adhesives
A Pharmacokinetic Study of Polymyxin B in Healthy Subjects and Subjects With Renal Insufficiency
TTY Biopharm
Antibiotic Toxicity
Dropless Pars Plana Vitrectomy Study
Massachusetts Eye and Ear Infirmary
Rhegmatogenous Retinal Detachment
Evaluating a Dropless Postoperative Regimen After Cataract Surgery in a Vulnerable, County-hospital Population
University of California, San Francisco
Cataract · Surgery · Compliance, Patient · Compliance, Medication
Named in the study description rather than as the headline intervention — often a drug given alongside the one being tested.
Efficacy and Safety of Hemoperfusion With Polymyxin B in Septic Shock Associated With Severe Endotoxemia in Cardiac Surgery Patients (РМХ vs SS)
Petrovsky National Research Centre of Surgery
Multiple Organ Dysfunction With Severe Endotoxemia
SAD/MAD Safety and PK Study of QPX9003 (Novel Polymyxin) in Normal Healthy Volunteers
Qpex Biopharma, Inc.
Bacterial Infections
Efficacy and Safety of Selective Digestive Decontamination in the ICU With High Rates of Antibiotic-resistant Bacteria
MEDSI Clinical Hospital 1, ICU
Pneumonia, Ventilator-Associated · Pneumonia · Bloodstream Infection · Sepsis
Management of Ventilation Acquired Pneumonia Caused by Pseudomonas and Acinetobacter Organisms in a Pediatric Center
Beni-Suef University
Ventilation Acquired Pneumonia
Study of the Safety, Tolerability, and PK of MRX-8 Administered Intravenously to HVs in SAD and MAD Cohorts
MicuRx
Safety
Named in the study description rather than as the headline intervention — often a drug given alongside the one being tested.
Safety of Sabin Inactivated Poliovirus Vaccine in Adults, Children and Infants and Lot Consistency Immunogenicity, and Safety of the msIPV in 2 Months Old Infants
Sinovac Biotech Co., Ltd
Poliomyelitis
Named in the study description rather than as the headline intervention — often a drug given alongside the one being tested.
The Diagnostic and Prognostic Value of Presepsin in Sepsis
University of Foggia
Septic Shock
Named in the study description rather than as the headline intervention — often a drug given alongside the one being tested.
Detection of Colistin-resistant Isolates From Patients of Intensive Care Units and Oncohaematology Wards.
University Hospital, Bordeaux
Colistin Resistance in Bacteria
Study of Subretinally Injected ATSN-101 Administered in Patients With Leber Congenital Amaurosis Caused by Biallelic Mutations in GUCY2D
Atsena Therapeutics Inc.
Leber Congenital Amaurosis · LCA · LCA1
Study to Evaluate the Efficacy and Safety of Intravenous Sulbactam-ETX2514 in the Treatment of Patients With Infections Caused by Acinetobacter Baumannii-calcoaceticus Complex
Entasis Therapeutics
Acinetobacter Baumannii-calcoaceticus Complex · Hospital-acquired Bacterial Pneumonia · Ventilator-associated Bacterial Pneumonia · Bacteremia
Named in the study description rather than as the headline intervention — often a drug given alongside the one being tested.
The Combined Antibiotic Therapy for Carbapenem Resistant Klebsiella Pneumoniae
Shanghai 10th People's Hospital
Antibiotic Resistant Infection
Melatonin for Renal Protection in Patients Receiving Polymyxin B
Hospital de Clinicas de Porto Alegre
Acute Kidney Injury · Melatonin · Polymyxin B Adverse Reaction
Named in the study description rather than as the headline intervention — often a drug given alongside the one being tested.
Topical Antibiotic Prophylaxis for Eyelids
University of California, San Francisco
Antibiotic Side Effect · Eyelid; Wound · Eyelid Diseases · Surgical Wound Infection
Named in the study description rather than as the headline intervention — often a drug given alongside the one being tested.
Polymyxin B Monotherapy vs Combination Therapy in Critically Ill Patients With Multi-drug Resistant Pathogens
University of Puerto Rico
Trauma · Resistant Infection · Critical Illness
Intravitreal Carboplatin for the Treatment of Participants With Recurrent or Refractory Intraocular Retinoblastoma
St. Jude Children's Research Hospital
Retinoblastoma
Named in the study description rather than as the headline intervention — often a drug given alongside the one being tested.
Study of Cefiderocol (S-649266) or Best Available Therapy for the Treatment of Severe Infections Caused by Carbapenem-resistant Gram-negative Pathogens
Shionogi
Healthcare-associated Pneumonia (HCAP) · Bloodstream Infections (BSI) · Hospital Acquired Pneumonia (HAP) · Complicated Urinary Tract Infection (cUTI)
Named in the study description rather than as the headline intervention — often a drug given alongside the one being tested.
Gut Decontamination In Pediatric Allogeneic Hematopoietic
Dana-Farber Cancer Institute
Hematopoietic Stem Cell Transplantation (HSCT) · Acute GVH Disease
Optimizing Clinical Use of Polymyxin B
Rutgers, The State University of New Jersey
Pneumonia · Blood Stream Infection · Urinary Tract Infections · Respiratory Tract Infection (Including Tracheobronchitis)
Named in the study description rather than as the headline intervention — often a drug given alongside the one being tested.
A Study to Evaluate the Safety and Immunogenicity of Monovalent OPV2 in Children Aged 1 to 5 Years in Lithuania
Fidec Corporation
Poliomyelitis
Named in the study description rather than as the headline intervention — often a drug given alongside the one being tested.
Assessment of the Efficacy of POLYGYNAX® in the Empirical Treatment of Infectious Vaginitis
Laboratoire Innotech International
Vaginitis
Named in the study description rather than as the headline intervention — often a drug given alongside the one being tested.
Randomized-controlled Trial (RCT) on Combination Antibiotic for Infections Caused by Gram-negative Bacteria
Tan Tock Seng Hospital
Bacteremia · Healthcare-associated Pneumonia · Ventilator-associated Pneumonia
The Pilot Study of the Efficacy of Polymyxin-B Hemoperfusion in Critically Ill Patients With Severe Sepsis
Chulalongkorn University
Severe Sepsis
Efficacy of Polymyxin B Against Infections Caused by Extensively Drug-resistant (XDR) Gram-Negative Bacteria
Mahidol University
Hospital Infection
Antibiotic Irrigation for Pancreatoduodenectomy
Indiana University
Surgery · Infection
Patients Response to Early Switch To Oral:Osteomyelitis Study
Julio Ramirez
Osteomyelitis
Effect of Systemic Oxygen on Corneal Epithelial Wound Healing in Diabetic Patients Undergoing Pars Plana Vitrectomy
Universiti Sains Malaysia
Corneal Diseases
Frozen Versus Fresh Corneal Carriers for the Boston KPro Type I Donor Carriers
Marie-Claude Robert
Corneal Blindness · Boston Keratoprosthesis Type I Candidate
Named in the study description rather than as the headline intervention — often a drug given alongside the one being tested.
Umbilical Cord Care for the Prevention of Colonization
University of Virginia
Line Insertion Site · Central Line-associated Bloodstream Infection (CLABSI)
Named in the study description rather than as the headline intervention — often a drug given alongside the one being tested.
Two Trabecular Micro-bypass Stents & Postoperative Travoprost to Treat Glaucoma Subjects on Two Hypotensive Agents
Glaukos Corporation
Open-angle Glaucoma
Named in the study description rather than as the headline intervention — often a drug given alongside the one being tested.
Endotoxin Adsorber Hemoperfusion and Microcirculation
National Taiwan University Hospital
Sepsis
Named in the study description rather than as the headline intervention — often a drug given alongside the one being tested.
Topical Umbilical Cord Care for the Prevention of Colonization and Invasive Infections
University of Virginia
Colonization
Named in the study description rather than as the headline intervention — often a drug given alongside the one being tested.
Comparison Between Bandage Contact Lens and Pressure Patching for The Erosion Area and Pain Scale in Corneal Erosion Patients
Udayana University
Erosion; Cornea, Traumatic
Named in the study description rather than as the headline intervention — often a drug given alongside the one being tested.
Effectiveness of Polymyxin B Sulphate + Prednisolone + Benzocaine + Clioquinol in Acute and Sub-acute Dermatitis Eczematous
EMS
Eczema
Impact of Early Peri-operative Use of Polymyxin-B Hemoperfusion in Septic Patients Undergoing Emergent Abdominal Surgery
University Hospital, Geneva
Abdominal Sepsis · Peritonitis · Colon Perforation
Safety and Efficacy Study of Besivance™ for Treatment of Congenital Nasolacrimal Duct Obstruction in Children
Rutgers, The State University of New Jersey
Congenital Nasolacrimal Duct Obstruction
Study of Ear Comfort Ear Drops to Treat AOE Cases Compared to DexOtic & Otidin(R)
Assuta Hospital Systems
Acute Otitis Externa
Named in the study description rather than as the headline intervention — often a drug given alongside the one being tested.
The Effect of Glaucoma Drops on of the Duration of a Pure Intraocular Gas Bubble
Jason Hsu, MD
Scleral Buckling
Clearance of Nasal Staphylococcus Aureus With Triple Antibiotic Ointment
Northwestern University
Nasal Carriers of Staphylococcus Aureus
Open Study of the Efficacy of the Local Treatment With Polygynax of Bacterial and/or Mycotic Vaginitis
Laboratoire Innotech International
Vaginitis
Alcohol 20% for Separation of Pterygium and Comparison of Different Wound Closure Methods
Soroka University Medical Center
Pterygium
Named in the study description rather than as the headline intervention — often a drug given alongside the one being tested.
Comparison of Combination Antibiotics Eyedrop to Artificial Tear in Hordeolum After Incision and Curettage
Chulalongkorn University
Hordeolum
The Effects of Polymyxin-B Protects on Sepsis Induced Kidney Dysfunction: a Randomized Clinical Trial
University of Turin, Italy
Gram-Negative Bacterial Infections · Sepsis
Early Use of Polymyxin B Hemoperfusion in Abdominal Sepsis
St. Bortolo Hospital
Gram-Negative Bacterial Infections · Sepsis · Septic Shock
Treatment of Acyclovir-Resistant Mucocutaneous Herpes Simplex Disease in Patients With AIDS: Open Label Pilot Study of Topical Trifluridine
National Institute of Allergy and Infectious Diseases (NIAID)
Herpes Simplex · HIV Infections
Sources: ClinicalTrials.gov, the EU Clinical Trials Information System and ISRCTN, deduplicated so a study registered in more than one registry is counted once. A study is listed when Polymyxin B is named as an intervention. A registered trial is a plan, not a result — registration says nothing about whether the peptide worked.