Plain-Language Summary
Plain-language reading of the public trial registries.
In short
- Ganirelix has a real but limited body of human research.
- 97 registered studies in total.
- 9 are still enrolling people, so this is active research, not just history.
What kind of research
- 82 studies actually gave the peptide to volunteers and measured what happened. This is the kind of study that can show whether something works.
- About 15,296 people took part in those.
- A further 15 studies only looked at records of people already taking it. These are counted separately because nobody was given the peptide for the study, so they cannot prove cause and effect.
How far along it is
- 45 trials have reached phase 3 or 4 — the large, late-stage trials regulators rely on to approve a drug.
- 24 have published results in the medical literature that anyone can read.
- The research spans 21 countries.
A registered trial is a plan, not a result. Registration means a study was declared in advance; it says nothing about whether the peptide worked, and a trial can be registered and then abandoned.
Filter
Showing 97 of 97 trials for Ganirelix.
Is the Diurnal Variation in Circulating Levels of Cortisol Reflected in Follicular Fluid of Preovulatory Follicles Close to Ovulation?
ART Fertility Clinics LLC
Healthy
Named in the study description rather than as the headline intervention — often a drug given alongside the one being tested.
IVF Outcomes With Time-Lapse Culture: Comparison Between PPOS and GnRH Antagonist Protocols
Hanoi Medical University
Infertility (IVF Patients) · Embryo Morphokinetics · Progestins Primed Ovarian Stimulation
Named in the study description rather than as the headline intervention — often a drug given alongside the one being tested.
hCG Priming in Women With Diminished Ovarian Reserve
Kristine Loessl
Infertility, Female · Ovarian Reserve · In Vitro Fertilization (IVF)
Named in the study description rather than as the headline intervention — often a drug given alongside the one being tested.
PPOS (Progestin Primed Ovarian Stimulation) and Corifollitropin Alfa (CFA) Cross-over Study
University Hospital, Ghent
Ovarian Stimulation · Quality of Life · Preimplantation Genetic Testing · Fertility Preservation
P-CCROSS
Universitair Ziekenhuis Gent
Subfertility
Named in the study description rather than as the headline intervention — often a drug given alongside the one being tested.
Protocol with Progestin-primed Ovarian Stimulation (PPOS) in conventional treatment from the start of stimulation vs protocol with GnRH antagonists as a pituitary suppressor in patients who are going to undergo DUOSTIM with embryo accumulation for PGT-A of the embryos.
Ginefiv S.L.
Female infertility
Named in the study description rather than as the headline intervention — often a drug given alongside the one being tested.
Disentangling the Effects of Daily Stress, Sleep, and Sex Hormones on Accelerated Vascular Aging in Midlife Women
University of Delaware
Estrogen · Premenopause
Protocol with Progestin-primed Ovarian Stimulation (PPOS) from the Beginning of Stimulation Versus Protocol with GnRH Antagonists for Ovarian Stimulation in Patients Undergoing DUOSTIM with Embryo Accumulation for PGT-A.
Ginefiv
Stimulation in the Ovary · Embryo · Oocyte · Oocyte Retrieval
Possible Action of Resveratrol in Improving the Outcomes of IVF/ICSI in Couples With Unexplained Infertility
Andros Day Surgery Clinic
Unexplained Infertility
Sub-therapeutic GnRH- Antagonist Treatment to Rectify LH Pulsatility in Lean Women With PCOS.
University Hospital, Lille
Polycystic Ovary Syndrome
2022_0016
Centre Hospitalier Universitaire De Lille
Polycystic ovarian
Named in the study description rather than as the headline intervention — often a drug given alongside the one being tested.
Impact of IVF Hormonal Therapy on Endometrial Receptivity and Endometrial Senescent Cell Pathological Accumulation
Fundación IVI
Endometrial Receptivity
Named in the study description rather than as the headline intervention — often a drug given alongside the one being tested.
Efficacy of Micronized Natural Progesterone vs GnRH Antagonist in the Prevention of LH Peak During Ovarian Stimulation.
Instituto Bernabeu
IVF
To Compare the Efficacy and Safety of Oral SHR 7280 Tablets With Ganirelix Acetate Injection in Infertile Female Subjects
Jiangsu HengRui Medicine Co., Ltd.
Infertile Female Subjects Undergoing Controlled Ovarian Hyperstimulation to Suppress Premature LH Surge and Prevent Early Ovulation
DPOS Versus GnRH Antagonist Protocol for Oocyte Accumulation in Low Ovarian Reserve Patients: An RCT
Tam Anh TP. Ho Chi Minh General Hospital
Diminished Ovarian Reserve
Named in the study description rather than as the headline intervention — often a drug given alongside the one being tested.
To Investigate Efficacy and Safety of a Single Injection of GenSci094 for Ovarian Stimulation Using Daily Recombinant FSH as Reference
Changchun GeneScience Pharmaceutical Co., Ltd.
Infertility
MONACO
Universitair Ziekenhuis Gent
Subfertility
Named in the study description rather than as the headline intervention — often a drug given alongside the one being tested.
GnRH Antagonist Pre-treatment in the Early Follicular Phase for Resolution of a Baseline Functional Ovarian Cyst
Assaf-Harofeh Medical Center
IVF · Ovarian Cysts
Named in the study description rather than as the headline intervention — often a drug given alongside the one being tested.
GnRH Antagonist Pre-treatment for the Prevention of Asynchronous Follicular Growth
Assaf-Harofeh Medical Center
IVF
hCG Priming in Women With Low Ovarian Reserve
Rigshospitalet, Denmark
Infertility, Female · Ovarian Reserve · In Vitro Fertilization
Named in the study description rather than as the headline intervention — often a drug given alongside the one being tested.
Desogestrel Versus GnRH Antagonist in IVF/ICSI
Casa di Cura Privata Villa Mafalda
IVF · Infertility
The Rate of Embryo Euploidy in Progestin-primed Ovarian Stimulation Cycles
Casa di Cura Privata Villa Mafalda
IVF · Infertility
Live Birth Rate Between PPOS and GnRH Antagonist Protocol in Patients With Anticipated High Ovarian Response
ShangHai Ji Ai Genetics & IVF Institute
IVF · GnRH Antagonist · PPOS
Hormonal Mechanisms of Sleep Restriction - Axis Study in Older Men and Postmenopausal Women
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Sleep Restriction
Ovarian Hyperstimulation and Fibrin Clot Properties.
Jagiellonian University
Fibrin Blood Clot · Infertility, Female · Endometriosis
Named in the study description rather than as the headline intervention — often a drug given alongside the one being tested.
Anti-Müllerian Hormone (AMH) Measured With Fully Automated Assay Versus AFC in the Prediction of Ovarian Response
Andros Day Surgery Clinic
Ovarian Response
Named in the study description rather than as the headline intervention — often a drug given alongside the one being tested.
Initiation of Ovarian Stimulation With Recombinant-human FSH (Bemfola®) in the Late Follicular Phase
Universitair Ziekenhuis Brussel
Infertility, Female
Named in the study description rather than as the headline intervention — often a drug given alongside the one being tested.
Corifollitropin Alpha and Ovarian Response
Hospital de Clinicas de Porto Alegre
Infertility, Female
Named in the study description rather than as the headline intervention — often a drug given alongside the one being tested.
Luteal Phase-start Ovarian Stimulation With Corifollitropin Alfa
Fundacion Dexeus
Infertility
Named in the study description rather than as the headline intervention — often a drug given alongside the one being tested.
Letrozole in Stimulated IVF Cycles
The University of Hong Kong
Subfertility
Named in the study description rather than as the headline intervention — often a drug given alongside the one being tested.
DuoStim in Cases of PGT: Comparison of Embryo Quantity and Embryonic Quality Using MitoScore
IVI Madrid
Infertility, Female
Mechanisms of Hypertension in Women With Polycystic Ovary Syndrome
Yale University
Polycystic Ovary Syndrome · Hypertension
Effectiveness of Estradiol Valerate Pretreatment in Antagonist Protocol for Poor Ovarian Response Patient
Reproductive & Genetic Hospital of CITIC-Xiangya
Infertility
Cetrorelix and Ganirelix Flexible Protocol for (IVF)
Università degli Studi 'G. d'Annunzio' Chieti e Pescara
Infertility/Sterility
Usefulness of Medroxyprogesterone Acetate in Follicular Phase in Oocyte Donors. Undergoing Ovarian Stimulation
Instituto Valenciano de Infertilidad, IVI VALENCIA
Infertility
Hormonal Mechanisms of Sleep Restriction - Axis Study
Peter y. Liu
Sleep Restriction
Single Follicular Dexarelix for LH Suppression During Ovarian Stimulation in Oocyte Donors.
Assisting Nature
Infertility · Premature Ovarian Failure
Named in the study description rather than as the headline intervention — often a drug given alongside the one being tested.
To Compare and Evaluate the Efficacy and Safety of Ganilever PFS(Prefilled Syringe) and Orgalutran®
LG Life Sciences
Controlled Ovarian Stimulation
Menopause Effects on Vascular Function
University of Delaware
Cardiovascular Risk Factor
Named in the study description rather than as the headline intervention — often a drug given alongside the one being tested.
Progevera 10 mg® Versus Orgalutran® in Ovarian Stimulation Cycles of Oocyte Donors
Fundació Privada Eugin
Infertility
Effectiveness and Safety Study of Fixed Versus Flexible of Gonadotropin-releasing Hormone Antagonist Protocol
Chong Qing Reproducive and Genetic Institute
Infertility
Type of Gonadotropin and Embryo Kinetics of Development
IVI Madrid
Infertility
Named in the study description rather than as the headline intervention — often a drug given alongside the one being tested.
Letrozole in Assisted Reproductive Technology
Assiut University
to Evaluate Letrozole as a Modality for Minimal Ovarian Stimulation in ICSI Cycles .
Named in the study description rather than as the headline intervention — often a drug given alongside the one being tested.
Efficacy of Recombinant FSH/GnRH Antagonist Protocol With and Without LH Adjunct for Egg Bank Donation
Michigan Reproductive Medicine
Egg Donation
An Efficacy and Safety Study of Corifollitropin Alfa (MK-8962) in Contrast to Recombinant FSH for Use in Controlled Ovarian Stimulation of Indian Women (P07056, Also Known as MK-8962-029)
Organon and Co
Infertility
Effect of Treatment With Corifollitropin Alpha in Vitro Fertilization in Patients With Poor Ovarian Response.
Instituto de Investigacion Sanitaria La Fe
Infertility
Corifollitropin Alfa Followed by Menotropin for Poor Ovarian Responders Trial
Universitair Ziekenhuis Brussel
Infertility · Poor Ovarian Response
The Results of Preimplantation Genetic Diagnosis and Preimplantation Genetic Screening of Embryos Obtained From GnRH-agonist Long and GnRH-antagonist Ovarian Stimulation Protocol
European Hospital
Embryo's Genetic and Chromosomal Quality
Evolutive Potential of Embryos Obtained From Oocytes After Luteal Phase Ovarian Stimulation
Fundacion Dexeus
INFERTILITY · Fertility Preservation · Ovulation Induction · Vitrification
Effect of GnRH Antagonist vs Agonist Long on IVF Outcome, Peak Estradiol Level,and Duration of Stimulation
Main Line Fertility Center
Fertility
Delayed Start to Ovarian Stimulation
University of California, San Francisco
Diminished Ovarian Reserve · Infertility · In Vitro Fertilization
Proteomics & Glyco-Proteomic Analysis of Follicular Fluid
University of Cincinnati
Polycystic Ovary Syndrome · Normal Volunteers
Named in the study description rather than as the headline intervention — often a drug given alongside the one being tested.
Single Injection of Ganirelix in Gonadotropin Intrauterine Insemination (IUI) Cycles
Houston Fertility Institute
Compare Pregnancy Rates Between FSH Stimulation and FSH and · GnRH Antagonist
Corifollitropin Alfa Compared to Daily rFSH in Poor Responders Undergoing ICSI
Aristotle University Of Thessaloniki
Subfertility
Named in the study description rather than as the headline intervention — often a drug given alongside the one being tested.
Proposed Research Protocol For Male Infertility
HaEmek Medical Center, Israel
Male Infertility
Named in the study description rather than as the headline intervention — often a drug given alongside the one being tested.
Ovarian Response Prediction in In Vitro Fertilization (IVF) Patients
University Hospital Schleswig-Holstein
Infertility, Subfertility
Preimplantation Genetic Diagnosis (PGD) With Gonadotropin-releasing Hormone (GnRH) Agonist Versus Antagonist
Universitair Ziekenhuis Brussel
Reproductive Endocrinology · Fertility · Optimal Stimulation Protocol
Pretreatment With Estradiol Valerate
Universitair Ziekenhuis Brussel
Infertility
Named in the study description rather than as the headline intervention — often a drug given alongside the one being tested.
A Comparative Study of Two Patterns of Controlled Ovarian Hyperstimulation in Mid Follicular Phase or Early Luteal Phase for Egg Donors
Parc de Salut Mar
Stimulation in the Ovary
Named in the study description rather than as the headline intervention — often a drug given alongside the one being tested.
An additional rescue dose of GnRH antagonist administered the day before hCG trigger is effective to prevent ovarian hyperstimulation syndrome (OHSS) in IVF/ICSI antagonist cycles at risk for OHSS without affecting the reproductive outcomes
IAKENTRO (Greece)
Ovarian hyperstimulation syndrome (OHSS), ovarian stimulation, GnRH antagonist, IVF
Named in the study description rather than as the headline intervention — often a drug given alongside the one being tested.
Metformin and gonadotrophin-releasing hormone (GnRH) antagonist co-treatment in in-vitro fertilisation (IVF) for women with polycystic ovary syndrome (PCOS)
Leeds Teaching Hospitals NHS Trust (UK)
Polycystic ovary syndrome
Named in the study description rather than as the headline intervention — often a drug given alongside the one being tested.
Oral Microdose Lupron Versus Luteal Estradiol Trial in Poor Responder In Vitro Fertilization (IVF) Patients
Weill Medical College of Cornell University
Infertility
Trial Comparing Start Stimulation of Recombinant Follicle Stimulating Hormone (rFSH) on Cycle Day 2 Versus Cycle Day 5 in In Vitro Fertilization (IVF)
UMC Utrecht
in Vitro Fertilization · Ovulation Induction
Short Versus Long Protocol for IVF and IVF+ICSI
Peter Hornnes, MD, DMSc
Infertility · Ovarian Hyperstimulation Syndrome · Quality of Life · Live Birth
Named in the study description rather than as the headline intervention — often a drug given alongside the one being tested.
MENOPUR® Versus FOLLISTIM®
Ferring Pharmaceuticals
Infertility
Premature Luteinization Prevention by GnRH Antagonist in Patients Undergoing IUI
IVI Madrid
Infertility
A Study of the Effects of a Novel Ovarian Stimulation Regimen on Embryo Aneuploidy Rates in In Vitro Fertilization (IVF)
Bart CJM Fauser
In Vitro Fertilization
Antagonist/Letrozole in Poor Responders
Yazd Research & Clinical Center for Infertility
Ovarian Stimulation
Agonist Gonadotropin-Releasing Hormone (GnRH) Versus Antagonist GnRH
Yazd Research & Clinical Center for Infertility
Infertility
Compromised Microcirculation in Women With Polycystic Ovary Syndrome
Yale University
Polycystic Ovary Syndrome
Clomiphene Citrate (CC)/Gonadotropin/Gonadotropin Releasing Hormone (GnRH) Antagonist Versus Gonadotropin/GnRH Agonist
Yazd Research & Clinical Center for Infertility
Ovarian Stimulation
Named in the study description rather than as the headline intervention — often a drug given alongside the one being tested.
A Study to Assess the Efficacy and Safety of Ganirelix (Orgalutran®) Treatment in Chinese Women Undergoing Controlled Ovarian Stimulation for in Vitro Fertilization (IVF) or Intra Cytoplasmatic Sperm Injection (ICSI) (Study 38651)(P05703)
Organon and Co
Controlled Ovarian Stimulation
Pregnancy and Neonatal Follow-up of Ongoing Pregnancies Established in Clinical Trial P05690 (Care Program) (P05710)
Organon and Co
Pregnancy · Neonates
Sex Hormones and Atherosclerosis Prevention in Perimenopausal Women
University of Colorado, Denver
Arterial Stiffening · Aging · Menopause
Modified Natural Cycle Offers a Chance of Pregnancy in Patients With Poor Response and High Basal FSH
Eugonia
Infertility · Premature Ovarian Failure
To Investigate Efficacy and Safety of a Single Injection of Org 36286 for Ovarian Stimulation Using Daily Recombinant FSH as Reference (Ensure)(P05690/MK-8962-001)
Organon and Co
Infertility
Follow-up Protocol on the Outcome of Frozen-thawed Embryo Transfer Cycles From Clinical Trial P05690 (P05711)
Organon and Co
In Vitro Fertilization
Pregnancy and Neonatal Follow-up of Ongoing Pregnancies Established in Clinical Trial P05787 (P05712)
Organon and Co
Pregnancy · Neonates
A Study to Investigate the Efficacy and Safety of a Single Injection of Corifollitropin Alfa (Organon 36286) for Ovarian Stimulation Using Daily Recombinant Follicle Stimulating Hormone (FSH) as Reference (P05787)
Organon and Co
In Vitro Fertilization
Follow-up Study of Frozen-thawed Embryo Transfer (FTET) Cycles After Cryopreservation of Embryos in Clinical Trial P05787 (P05716)
Organon and Co
In Vitro Fertilization
Follicle-Stimulating Hormone (FSH) and the Onset of Puberty
University of Utah
Delayed Puberty · Precocious Puberty
Sex Hormones and Orthostatic Tolerance
Yale University
Orthostatic Intolerance
A Novel Approach to Endometrial Preparation in Recipients of Donor Eggs
Kelly, Maureen, M.D.
Implantation, Embryo
The Effects of Estradiol and Progesterone on Arginine Vasopressin Regulation and Serum Sodium Concentration
Yale University
Exercise Induced Hyponatremia
Luteal Phase FSH in the IVF Poor Responder
University of Pennsylvania
Infertility
Comparison of the Long GnRH Agonist Protocol and the Flexible GnRH Antagonist Protocol of Ovarian Stimulation
Eugonia
Infertility
Post-Marketing Surveillance of the Safety and Efficacy of Orgalutran (Ganirelix)®
Organon and Co
Fertilization in Vitro
Mild Versus Conventional Ovarian Stimulation Treatment for In Vitro Fertilization
Erasmus Medical Center
Subfertility
Named in the study description rather than as the headline intervention — often a drug given alongside the one being tested.
Early Follicular Supplementation of Ganirelix in IVF 2004
The Baruch Padeh Medical Center, Poriya
Infertility · IVF Treatment
Administration of GnRH Antagonist to Oocyte Donation Recipients
Centro Ginecologia y Obstetricia.
Pregnancy · Embryo Implantation
Comparison Between GnRH Agonist and GnRH Antagonist Protocols of Ovarian Stimulation in PCOS Patients
Eugonia
Polycystic Ovary Syndrome · Ovarian Hyperstimulation Syndrome
A Study to Compare the Safety and Efficacy of Cetrotide® 3 Milligram (mg) Versus Antagon™ in Women Undergoing Ovarian Stimulation
EMD Serono
Infertile Women Undergoing Assisted Reproductive Technology (ART)
Flexible GnRH Antagonist vs Flare up GnRH Agonist Protocol in Poor Responders
Eugonia
Infertility · Premature Ovarian Failure
A Phase 2, Trial to Investigate the Dose-Response Relationship of a Single Injection of Org 36286 (Corifollitropin Alfa) to Initiate Multiple Follicular Growth in a Controlled Ovarian (Study 38826)(P06055)(COMPLETED)
Organon and Co
Fertilization
Named in the study description rather than as the headline intervention — often a drug given alongside the one being tested.
Japanese Bridging Trial of Org 37462 (Study P05969)(COMPLETED)
Organon and Co
Controlled Ovarian Stimulation
Investigate Dose of Org 36286 to Initiate Multiple Follicular Growth in a Controlled Ovarian Hyperstimulation Protocol for IVF or IVF/ICSI (P07015)
Organon and Co
Infertility · In Vitro Fertilization
Monitor the Incidence of Congenital Malformations in Infants of Women Who Have Been Treated With Ganirelix (Orgalutran®)(Study 38644)(P05966)(COMPLETED)
Organon and Co
Pregnancy · Neonates
Sources: ClinicalTrials.gov, the EU Clinical Trials Information System and ISRCTN, deduplicated so a study registered in more than one registry is counted once. A study is listed when Ganirelix is named as an intervention. A registered trial is a plan, not a result — registration says nothing about whether the peptide worked.