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Peptide Database

Goals
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Peptides
5-Amino-1MQ
Weight Management
Abarelix
Hormone Support
Acetyl Hexapeptide-3 (Argireline)
Cosmetic
Adipotide
Weight Management
Adrenomedullin
Healing & Recovery
Alexamorelin
Growth Hormone
Angiotensin (1-7)
Healing & Recovery
AOD-9604
Weight Management
Apelin-13
Healing & Recovery
ARA-290 (Cibinetide)
Healing & Recovery
Bestatin (Ubenimex)
Immune
BPC-157
Healing & Recovery
Buserelin
Hormone Support
Cagrilintide
Weight Management
CagriSema
Weight Management
Capromorelin
Growth Hormone
Cartalax
Anti-Aging
Cathelicidin (hCAP-18 / Synthetic Derivatives)
Immune
Cerebrolysin
Cognitive
Cerluten
Cognitive
Cetrorelix
Hormone Support
Chonluten
Immune
CJC-1295 (No DAC)
Growth Hormone
CJC-1295 with DAC
Growth Hormone
Cortexin
Cognitive
Crystagen
Immune
Daptomycin
Immune
Defensin (HBD-2)
Immune
Defensin (HBD-3)
Immune
Degarelix
Hormone Support
Dihexa
Cognitive
DSIP (Delta Sleep-Inducing Peptide)
Sleep & Recovery
Dulaglutide
Weight Management
Enalapril
Healing & Recovery
Epithalon
Anti-Aging
Exenatide
Weight Management
Fertirelin
Hormone Support
FOXO4-DRI
Anti-Aging
Ganirelix
Hormone Support
GHK-Cu (Copper Peptide)
Cosmetic
GHRH (1-29)
Growth Hormone
GHRP-2
Growth Hormone
GHRP-6 (Growth Hormone Releasing Peptide-6)
Growth Hormone
Glutathione
Anti-Aging
Gonadorelin (GnRH)
Hormone Support
Gramicidin
Immune
Hexarelin
Growth Hormone
Human Chorionic Gonadotropin (HCG)
Hormone Support
Human Growth Hormone (HGH)
Growth Hormone
IGF-1 LR3
Growth Hormone
Immunoxel (Dzherelo)
Immune
Imunofan
Immune
Intermedin (Adrenomedullin-2)
Healing & Recovery
Ipamorelin
Growth Hormone
Kisspeptin-10
Sexual Health
KPV (Alpha-MSH Fragment)
Healing & Recovery
Lactoferricin B
Immune
Larazotide
Healing & Recovery
Lentinan
Immune
Leuphasyl
Cosmetic
Leuprolide
Hormone Support
Liraglutide
Weight Management
Livagen
Anti-Aging
Lixisenatide
Weight Management
LL-37
Immune
Macimorelin
Growth Hormone
Magainin-2
Immune
Mazdutide
Weight Management
Melanotan-2
Cosmetic
MK-677 (Ibutamoren)
Growth Hormone
MOTS-c
Metabolic
Myristoyl Pentapeptide-17
Cosmetic
N-Acetyl Selank
Cognitive
N-Acetyl Semax Amidate
Cognitive
NAD+
Mitochondrial
Nafarelin
Hormone Support
Natriuretic Peptide (ANP)
Healing & Recovery
Nesiritide (BNP)
Healing & Recovery
Nisin
Immune
Noopept (Omberacetam)
Cognitive
Orforglipron
Weight Management
Ovagen
Anti-Aging
Oxytocin Acetate
Hormone Support
P21 (P021)
Cognitive
PACAP-38
Healing & Recovery
Palmitoyl Oligopeptide
Cosmetic
Palmitoyl Pentapeptide-4 (Matrixyl)
Cosmetic
Palmitoyl Tetrapeptide-7
Cosmetic
Palmitoyl Tripeptide-1
Cosmetic
Pancragen
Metabolic
PEG-MGF
Healing & Recovery
Pemvidutide
Weight Management
Pentadecapeptide (BPC Analog)
Healing & Recovery
Pidotimod
Immune
Pinealon
Cognitive
PNC-27
Immune
Polymyxin B
Immune
Pralmorelin (GHRP-2)
Growth Hormone
Pramlintide
Weight Management
Prostamax
Hormone Support
PT-141 (Bremelanotide)
Sexual Health
Relaxin-2 (Serelaxin)
Healing & Recovery
Retatrutide
Weight Management
Selank
Cognitive
Semaglutide
Weight Management
Semax
Cognitive
Sermorelin
Growth Hormone
Setmelanotide
Weight Management
SLU-PP-332
Metabolic
SM-130686
Growth Hormone
Snap-8
Cosmetic
SS-31 (Elamipretide)
Mitochondrial
Substance P Antagonists
Healing & Recovery
Survodutide
Weight Management
SYN-AKE
Cosmetic
Tabimorelin
Growth Hormone
TB-500
Healing & Recovery
Tesamorelin
Growth Hormone
Testagen
Hormone Support
Thymalin
Immune
Thymopentin (TP-5)
Immune
Thymopoietin
Immune
Thymosin Alpha-1
Immune
Thymosin Beta-4
Healing & Recovery
Thymulin (FTS)
Immune
Thymulin Analog (PAT)
Healing & Recovery
Tirzepatide
Weight Management
Tripeptide-29
Cosmetic
Triptorelin
Hormone Support
Ularitide
Healing & Recovery
Urocortin
Healing & Recovery
Ventfort
Anti-Aging
Vesilute
Hormone Support
Vilon
Immune
VIP (Vasoactive Intestinal Peptide)
Healing & Recovery
Xenin-25
Metabolic
Ziconotide (Prialt)
Healing & Recovery
Total Peptides: 137
Back to Home
Back to Daptomycin

Clinical trials

Every registered trial of Daptomycin

113 studies, 7 still enrolling.

Plain-Language Summary

Plain-language reading of the public trial registries.

In short

  • Daptomycin has a real but limited body of human research.
  • 113 registered studies in total.
  • 7 are still enrolling people, so this is active research, not just history.

What kind of research

  • 98 studies actually gave the peptide to volunteers and measured what happened. This is the kind of study that can show whether something works.
  • About 22,640 people took part in those.
  • A further 15 studies only looked at records of people already taking it. These are counted separately because nobody was given the peptide for the study, so they cannot prove cause and effect.

How far along it is

  • 51 trials have reached phase 3 or 4 — the large, late-stage trials regulators rely on to approve a drug.
  • 28 have published results in the medical literature that anyone can read.
  • The research spans 35 countries.

A registered trial is a plan, not a result. Registration means a study was declared in advance; it says nothing about whether the peptide worked, and a trial can be registered and then abandoned.

Filter

Showing 113 of 113 trials for Daptomycin.

  • 2024-513298-29-00Ongoing75 enrolled2026

    22-CONS-01

    Centre Hospitalier Universitaire De Nice

    Osteoarticular infections on equipment

    Named in the study description rather than as the headline intervention — often a drug given alongside the one being tested.

  • NCT07376889Phase 4Recruiting2,096 enrolled2026

    Combination Antibiotic Therapy for Staphylococcus Aureus Bacteremia

    Intermountain Health Care, Inc.

    Staphylococcus Aureus Bacteremia

    Named in the study description rather than as the headline intervention — often a drug given alongside the one being tested.

  • NCT07148960Phase 4Enrolling By Invitation300 enrolled2025

    Does Staphylococcus Aureus Bacteremia Early Dual Therapy Improve Outcomes?

    West Virginia University

    Staphylococcus Aureus Bacteremia

  • 2024-519186-21-01Ongoing264 enrolled2025

    Efficacy of seven and fourteen days of antibiotic treatment in uncomplicated Staphylococcus aureus bacteremia: A randomized, non-blinded, non-inferiority interventional study

    Hvidovre Hospital

    Staphylococcus aureus bacteremia

    Named in the study description rather than as the headline intervention — often a drug given alongside the one being tested.

  • NCT07230041Recruiting20 enrolled2025

    In Vivo Antibiotics Removal During Hemoadsorption Cartridges and Continuous Renal Replacement Therapy in the Intensive Care Unit

    Niguarda Hospital

    Septic Shock

    Named in the study description rather than as the headline intervention — often a drug given alongside the one being tested.

  • NCT06637332Phase 4Recruiting300 enrolled2024

    Daptomycin vs. Vancomycin for the Treatment of Methicillin Resistant S. Aureus Bacteremia

    Todd C. Lee MD MPH FIDSA

    Staphylococcus Aureus Septicemia · Staphylococcus Aureus Bacteremia · S. Aureus Bacteremia · S. Aureus Bloodstream Infection

  • NCT06695832Active Not Recruiting369 enrolled2024

    Adjunctive Fosfomycin for Treatment of Staphylococcus Aureus Bacteraemia

    Hospital Universitari de Bellvitge

    Staphylococcus Aureus Bacteremia

    Named in the study description rather than as the headline intervention — often a drug given alongside the one being tested.

  • NCT06423898Phase 4Recruiting284 enrolled2024

    Ampicillin and Ceftriaxone for the Treatment of Enterococcus Faecalis Infective Endocarditis.

    Fundación Pública Andaluza para la gestión de la Investigación en Sevilla

    Endocarditis, Infective

    Named in the study description rather than as the headline intervention — often a drug given alongside the one being tested.

  • NCT06189885Unknown184 enrolled2024

    Preoperative Daptomycin Prophylaxis in Two-Stage Exchange Arthroplasty: A Prospective, Randomized, Double-Blinded Trial

    Chang Gung Memorial Hospital

    Periprosthetic Joint Infection

  • 2023-508456-18-00Temporarily Halted284 enrolled2024

    INTENSE

    Fundacion Publica Andaluza Para La Gestion De La Investigacion En Salud De Sevilla

    Uncomplicated bacteremia caused by E. faecalis or E. faecium.

    Named in the study description rather than as the headline intervention — often a drug given alongside the one being tested.

  • 2023-508442-18-00Ongoing364 enrolled2024

    DURATIOM

    Fundacion Publica Andaluza Para La Gestion De La Investigacion En Salud De Sevilla

    Patients with an infection of the osteosynthesis material implanted after a long bone fracture, who are treated by surgical debridement with retention of the implant plus targeted antimicrobial therapy or by surgical debridement with removal of the material. These patients have the osteosynthesis material implanted to stabilize and help heal the fracture and who meet the criteria for Infections associated with the osteosynthesis material. -arm without/with removal MO: 256/108pac (364pac)

    Named in the study description rather than as the headline intervention — often a drug given alongside the one being tested.

  • 2023-503582-35-00Ongoing2,348 enrolled2023

    Staphylococcus aureus Network Adaptive Platform trial (SNAP)

    University Medical Center Utrecht

    Staphylococcus aureus bacteremia

    Named in the study description rather than as the headline intervention — often a drug given alongside the one being tested.

  • NCT05977868Phase 4Terminated94 enrolled2023

    Comparing Oral Versus Parenteral Antimicrobial Therapy

    West Virginia University

    Endovascular Infection · Bone and Joint Infection · Skin and Soft Tissue Infection · Pulmonary Infection

  • 2024-514952-34-00Ongoing406 enrolled2023

    APHP220763

    Assistance Publique Hopitaux De Paris

    Catheter related bloodstream infections due to Staphylococcus aureus

    Named in the study description rather than as the headline intervention — often a drug given alongside the one being tested.

  • NCT05137119Phase 4Recruiting8,000 enrolled2022

    Staphylococcus Aureus Network Adaptive Platform Trial

    University of Melbourne

    Staphylococcus Aureus Bacteremia

  • 2023-507652-76-00Ongoing50 enrolled2022

    Accelerated treatment of infectious endocarditis

    Region Skane

    Infectious endocarditis

    Named in the study description rather than as the headline intervention — often a drug given alongside the one being tested.

  • NCT05224687Unknown100 enrolled2021

    Utility Assessment of a Pharmacy-to-Dose Daptomycin

    Methodist Health System

    Antibiotics Causing Adverse Effects in Therapeutic Use

  • NCT04983901Phase 2Completed100 enrolled2021

    PHASE II SINGLE-CENTER, RANDOMIZED, OPEN-LABEL, PROSPECTIVE, STUDY TO DETERMINE THE IMPACT OF SERIAL PROCALCITONIN

    M.D. Anderson Cancer Center

    Hematopoietic and Lymphoid Cell Neoplasm · Malignant Solid Neoplasm

  • NCT04933344Unknown1,130 enrolled2021

    Pharmacokinetics and Toxicodynamics of Daptomycin in Bone and Joint Infections

    Hospices Civils de Lyon

    Dactinomycin Adverse Reaction · Bone and Joint Infection

  • NCT04775953Phase 2Completed200 enrolled2021

    DOTS: Dalbavancin as an Option for Treatment of Staphylococcus Aureus Bacteremia

    National Institute of Allergy and Infectious Diseases (NIAID)

    Staphylococcal Bacteraemia

  • NCT04033029Completed20 enrolled2021

    Antibiotic Plasma Concentrations During Continuous Renal Replacement Therapy With a High Adsorption Membrane (oXiris®)

    Hospital Universitari de Bellvitge

    Hemodiafiltration · Sepsis · Acute Kidney Injury

  • NCT04277143Unknown120 enrolled2020

    A Pharmacokinetics Study of Daptomycin in Critically Ill Patients and Effects of Daptomycin on Kidney

    Zhongnan Hospital

    Outcome, Fatal · Infection

  • NCT04434300Phase 1Completed12 enrolled2020

    Subcutaneous Daptomycin in Healthy Volunteers (DAPTOSC)

    University Hospital, Caen

    Antibiotics · Subcutaneous Injection · Daptomycin

  • NCT04546815Unknown2,000 enrolled2020

    The Efficacy and Safety of Daptomycin in the Treatment of Gram-positive Bacterial Infection.

    Jiangsu Hengrui Pharmaceutical Co., Ltd.

    Antibiotic

  • ISRCTN1530950040 enrolled2020

    Study of antimicrobial resistance in patients receiving outpatient parenteral antimicrobial therapy

    Cambridge University Hospitals NHS Foundation Trust

    Antimicrobial resistance (AMR)

  • NCT04132115Unknown104 enrolled2019

    Optimized Antibiotic Therapy in Patients With Subarachnoid Haemorrhage (ES) and Cerebral Haemorrhage (EC)

    Azienda Sanitaria-Universitaria Integrata di Udine

    Therapeutic Drug Monitoring · Subarachnoid Hemorrhage · Intracerebral Hemorrhage

  • NCT04141787Phase 4Unknown310 enrolled2019

    Ceftriaxone as Home IV for Staph Infections

    Vancouver Island Health Authority

    Staphylococcal Infections · Osteomyelitis · CNS Infection · Septic Arthritis

  • NCT04414137Unknown20 enrolled2019

    Description of Eosinophilic Pneumonia in BJI/PJI Treated by Daptomycin

    Hospices Civils de Lyon

    Dactinomycin Adverse Reaction · Bone and Joint Infection

    Named in the study description rather than as the headline intervention — often a drug given alongside the one being tested.

  • NCT03643952Phase 2Completed18 enrolled2018

    Safety, Efficacy, and Pharmacokinetics (PK) of Daptomycin (MK-3009) in Japanese Pediatric Subjects With Complicated Skin and Soft Tissue Infections (cSSTI) and Bacteremia (MK-3009-029)

    Merck Sharp & Dohme LLC

    Bacteremia · Soft Tissue Infections · Skin Diseases, Infectious

  • NCT03138733Phase 3Completed390 enrolled2018

    Ceftobiprole in the Treatment of Patients With Staphylococcus Aureus Bacteremia

    Basilea Pharmaceutica

    Staphylococcus Aureus Bacteremia

  • NCT03480191Phase 2Completed112 enrolled2018

    Adjunction of Daptomycin for the Treatment of Pneumococcal Meningitis

    Centre Hospitalier Universitaire Dijon

    Pneumococcal Meningitis

  • NCT03588637Completed200 enrolled2018

    Real-world Daptomycin Use in Chinese ICUs

    West China Hospital

    Daptomycin · Real-world Study · Intensive Care Unit

    Named in the study description rather than as the headline intervention — often a drug given alongside the one being tested.

  • NCT03426761Phase 4Completed41 enrolled2018

    Dalbavancin For The Treatment of Gram Positive Osteoarticular Infections

    Infectious Diseases Physicians, Inc.

    Bone Infection · Osteomyelitis · Septic Arthritis · Joint Infection

  • NCT02972983Phase 4Completed102 enrolled2016

    Daptomycin as Adjunctive Therapy for Staphylococcus Aureus Bacteremia

    McGill University Health Centre/Research Institute of the McGill University Health Centre

    Methicillin Susceptible Staphylococcus Aureus Septicemia · Bacteremia

  • NCT03004066Completed9 enrolled2016

    Daptomycin Concentration in Drainage Fluid and Blood Samples of ICU Patients

    University Hospital Tuebingen

    Heart Assist Device

  • NCT03961503Completed72 enrolled2016

    Retrospective Analysis of Nephrotoxicity During Daptomycin Versus Vancomycin Treatments in High Risk Patients

    University Hospital, Montpellier

    Infective Endocarditis · Infection Related to Ventricular Assist Device · Infection Related to Vascular Prothesis · Surgical Site Infection

  • NCT02660346Phase 4Completed40 enrolled2015

    IL-10 Stratifying Tool for Towards Antibiotic Selection for MRSaB

    Sharp HealthCare

    Bacteremia

  • NCT02539407Recruiting3,000 enrolled2015

    Population Pharmacokinetics of Anti-infectives in Critically Ill Children

    Assistance Publique - Hôpitaux de Paris

    Pediatric Intensive Care Unit · Pediatric Immuno-hematology Department

    Named in the study description rather than as the headline intervention — often a drug given alongside the one being tested.

  • NCT02508350Unknown12 enrolled2015

    The Pharmacokinetics/Pharmacodynamics of High-dose Daptomycin in Patients With Septic Shock

    Zhongda Hospital

    Septic Shock

  • NCT02208063Phase 3Terminated121 enrolled2014

    A Phase 3 Telavancin Staphylococcus Aureus (S. Aureus) Bacteremia Trial

    Cumberland Pharmaceuticals

    Bacteremia

  • NCT02241941Phase 4Withdrawn2014

    Evaluation of Single-dose Pharmacokinetics of Intravenous Daptomycin in Patients With Thermal Injury

    University of Zurich

    Burn Injury

  • NCT02097953Early Phase 1Completed12 enrolled2014

    Influence of Rifampin Co-Administration on the Pharmacokinetic Profile of Daptomycin

    University of Utah

    Drug Interactions · Pharmacokinetics

  • NCT02168816Phase 2Terminated30 enrolled2014

    Efficacy of Oral Antibiotic Therapy Compared to Intravenous Antibiotic Therapy for Osteomyelitis

    Loyola University

    Osteomyelitis

  • NCT02142075Phase 3Completed2014

    Population Pharmacokinetic (PK) Study of Multiple Doses of Cubicin® (Daptomycin) 10 mg/kg in Critical Care Patients Having Bacteremia, Endocarditis or Skin Soft Tissue Infections Due to Gram Positive Bacteria With Various Degrees of Renal Failure

    Poitiers University Hospital

    Renal Failure · Critical Care · Gram Positive Bacteria

  • NCT02052388Phase 2Completed215 enrolled2014

    Efficacy and Safety Study of Brilacidin to Treat Serious Skin Infections

    Cellceutix Corporation

    Skin Infection · Bacterial Infection

  • NCT01975662Phase 2Terminated14 enrolled2014

    Vancomycin Versus Daptomycin for the Treatment of Methicillin Resistant Staphylococcus Aureus (MRSA) Bacteremia

    Singapore General Hospital

    Bacteremia Due to Staphylococcus Aureus

  • NCT01792804Phase 3Completed215 enrolled2013

    Staphylococcus Aureus Bacteremia Antibiotic Treatment Options

    Heinrich-Heine University, Duesseldorf

    Staphylococcus Aureus Infection

  • NCT01898338Phase 3Completed167 enrolled2013

    Efficacy of Daptomycin Plus Fosfomycin Versus Daptomycin for Treatment of MRSA Bacteremia

    Miquel Pujol

    Staph Aureus Methicillin Resistant Bacteremia

  • NCT01922011Phase 3Completed149 enrolled2013

    Safety and Efficacy Study of Daptomycin Compared to Active Comparator in Pediatric Participants With Acute Hematogenous Osteomyelitis (AHO) (MK-3009-006)

    Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

    Acute Hematogenous Osteomyelitis

  • NCT02000414Completed8 enrolled2013

    Pharmacokinetics Study of Intraperitoneal Administration of Daptomycin in Peritoneal Infection

    University Hospital, Caen

    Peritoneal Infection

  • NCT01756924Phase 2Terminated14 enrolled2012

    Safety and Efficacy of CEM-102 With Rifampin Compared to Standard Therapy in Patients With Prosthetic Joint Infections or Spacer Infection

    Arrevus Inc.

    Prosthetic Joint Infections of Hip · Prosthetic Joint Infections of Knee · Infected Spacers

  • NCT01728376Phase 4Completed82 enrolled2012

    Safety & Efficacy of Daptomycin Versus Standard of Care (SOC) in 1 - 17 Year Olds With Staphylococcus Aureus Bacteremia (MK-3009-005)

    Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

    Bacteremia

  • NCT01626560Phase 4Completed20 enrolled2012

    The Effects of Daptomycin and Cytokines Production in Comparison With Vancomycin

    Hospital Universitario Evangelico de Curitiba

    Cellulitis

  • NCT01144000Phase 2Unknown60 enrolled2012

    Daptomycin With Rifampin for Treatment of Staphylococcal Prosthetic Joint Infection

    Andrej Trampuz

    Staphylococcal Infections

  • NCT01515020Phase 3Terminated10 enrolled2012

    Daptomycin Versus Vancomycin in the Treatment of Nosocomial or Healthcare-associated MRSA Bacteremia

    Assistance Publique - Hôpitaux de Paris

    Nosocomial Infection · Healthcare-associated Infection

  • NCT01549613Phase 4Completed104 enrolled2012

    Evaluation of Daptomycin for the Emergency Department Treatment of Complicated Skin and Skin Structure Infections

    University of Cincinnati

    Cellulitis · Skin Infections

  • NCT01592032Phase 4Unknown125 enrolled2012

    Concentration of Antimicrobials in Catheter-lock Solutions

    Clinica Universidad de Navarra, Universidad de Navarra

    Catheter-Related Infections · Bacteremia.

  • NCT01522105Phase 1Terminated1 enrolled2012

    Daptomycin in Pediatric Patients With Bacterial Meningitis

    Insel Gruppe AG, University Hospital Bern

    Meningitis

  • NCT01551719Withdrawn2012

    Clinical Usefulness of Mic/Breakpoint Ratio and Penetration in Tissues. A Prospective Study of Clinical Validation

    Federico II University

    Infection of Skin and/or Subcutaneous Tissue

  • NCT01734694Phase 4Terminated100 enrolled2011

    Safety and Efficacy of Strategy to Prevent Drug-Induced Nephrotoxicity in High-Risk Patients

    Henry Ford Health System

    Health Care Associated Pneumonia · Osteomyelitis/Septic Arthritis · Endocarditis · Bacteremia

  • NCT01419184Phase 4Completed250 enrolled2011

    Daptomycin Versus Vancomycin in Participants With Skin Infections Due to MRSA

    Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

    Staphylococcal Skin Infections

  • NCT01199783Phase 3Terminated1 enrolled2011

    Application of Daptomycin in MRSA Infected Diabetic Foot in Comparison to Vancomycin Treatment

    Ruhr University of Bochum

    Diabetic Foot

  • NCT01287832Phase 4Terminated11 enrolled2011

    Vancomycin Versus Daptomycin for the Treatment of Methicillin-resistant Staphylococcus Aureus Bacteremia Due to Isolates With High Vancomycin Minimum Inhibitory Concentrations (MICs)

    St. John Health System, Michigan

    Bacteremia

  • NCT01216241Phase 3Terminated36 enrolled2011

    Daptomycin Versus Placebo in Patients With Neutropenia and Fever

    University of Rochester

    Febrile Neutropenia

  • NCT01191840Phase 2Completed509 enrolled2011

    Treatment Algorithm to Reduce the Use of Vancomycin in Adults With Blood Stream Infection

    Duke University

    Bacteremia

  • ISRCTN1424469843 enrolled2011

    Daptomycin > 6 mg/kg/day in complex bone and joint infection

    Hospices Civils de Lyon

    Complex bone and joint infection

  • NCT01455246Phase 2/3Terminated32 enrolled2010

    Daptomycin + Meropenem Versus Ceftazidime in the Treatment of Nosocomial Spontaneous Bacterial Peritonitis

    University of Padova

    Cirrhosis · Ascites · Nosocomial Spontaneous Bacterial Peritonitis

  • NCT01196169Phase 4Terminated28 enrolled2010

    Daptomycin Use for Antimicrobial Prophylaxis in Methicillin Resistant Staphylococcus Aureus (MRSA) Colonized Adult Patients Undergoing Primary Elective Hip, Knee, or Shoulder Arthroplasty

    Mountain Home Research & Education Corporation

    Staphylococcal Infections · Methicillin-resistant Staphylococcus Aureus

  • NCT01211470Phase 2Completed215 enrolled2010

    Initial Treatment for Acute Bacterial Skin Infections (ABSSSI) Caused by Staphylococcus Aureus

    PolyMedix, Inc.

    Acute Bacterial Skin and Skin-structure Infection(ABSSSI) Due to Staphylococcus Aureus (MSSA) · (Susceptible or Methicillin Resistant)

  • NCT01133600Phase 4Terminated6 enrolled2010

    Outpatient Treatment of Gram Positive Wound Infections in the Diabetic Foot: A Pharmaco-economic Comparison of Daptomycin vs. Vancomycin Based Regimens

    Clinical Alliance for Research & Education - Infectious Diseases, LLC.

    Diabetic Foot

  • NCT01175707Phase 4Terminated80 enrolled2010

    Study Comparing Cubicin With Vancomycin in Treatment of Participants With Complicated Skin and Skin Structure Infections in a Home Infusion Setting

    Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

    Complicated Skin or Skin Structure Infection

  • NCT01025271Terminated2 enrolled2010

    Cerebrospinal Fluid Pharmacokinetics of Daptomycin

    University of Pittsburgh

    Meningitis

  • NCT01104662Phase 4Terminated92 enrolled2010

    Study of Daptomycin Safety and Efficacy for Complicated Skin and Skin Structure Infections (cSSSI) and Bacteremia in Renal Impairment

    Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

    Complicated Skin and Skin Structure Infections · S. Aureus Bacteremia · Renal Impairment

  • NCT01184872Phase 3Completed120 enrolled2010

    Study to Compare Efficacy and Safety of Daptomycin in Elderly Patients With Complicated Skin and Soft Tissue Infections

    Novartis Pharmaceuticals

    Infections

  • NCT01171547Phase 2Unknown15 enrolled2010

    Daptomycin Pharmacokinetics in Continuous Veno-venous Hemodiafiltration

    University of Zurich

    Bacteremia

  • NCT01019395Phase 1Completed23 enrolled2010

    Pharmacokinetics (PK) and Safety Evaluation of Daptomycin in Children Ages 3-24 Months With Proven or Suspected Gram-positive Infections or Peri-Operative Subjects Receiving Prophylactic Antibiotics

    Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

    Gram Positive Bacterial Infection

  • NCT00942149Phase 1Completed20 enrolled2010

    An Open Label Study to Describe the Pharmacokinetics of Daptomycin in Infants

    Duke University

    Sepsis

  • NCT01212432Phase 2Unknown15 enrolled2009

    Daptomycin Pharmacokinetics in Critically Ill Patients Undergoing Continuous Veno-venous Hemodiafiltration, a Dose Finding Study

    University of Zurich

    Gram-Positive Bacterial Infections

  • NCT01012089Completed6 enrolled2009

    Study of the Pharmacokinetics of Daptomycin in Children With Renal Disease

    University of Oklahoma

    Chronic Kidney Disease · Bacterial Infection

  • NCT00882557Phase 1Completed16 enrolled2009

    Study to Evaluate Daptomycin Given During Dialysis and After Dialysis

    Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

    End-stage Renal Disease · Renal Failure Chronic Requiring Hemodialysis

  • NCT00638157Phase 4Terminated24 enrolled2009

    Phase 4 Efficacy and Safety Study of Cubicin® With and Without Combination Therapy in S. Aureus Infective Endocarditis (SAIE)

    Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

    Infective Endocarditis

  • NCT00858325Phase 1Completed24 enrolled2009

    Pharmacokinetic Study of Daptomycin in Healthy Chinese Subjects Living in China

    AstraZeneca

    Healthy

  • NCT01080963Phase 4Completed650 enrolled2008

    Daptomycin as Antibiotic Prophylaxis of Sternal Wound Infections

    Hannover Medical School

    Wound Infection

  • NCT00695903Phase 2Terminated38 enrolled2008

    Phase 2 Study of Safety, Efficacy, and Pharmacokinetics of Higher Doses of Daptomycin and Vancomycin in MRSA Bacteremia

    Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

    Endocarditis, Bacterial · Infective Endocarditis

  • NCT00772447Phase 3Completed265 enrolled2008

    China Registration Study in Patients With Skin Infections

    AstraZeneca

    Skin Diseases · Infectious

  • NCT00770341Phase 3Completed122 enrolled2008

    A Study of MK-3009 in Japanese Patients With Skin or Blood Stream Infections Caused by Methicillin-resistant Staphylococcus Aureus (MK-3009-002)

    Merck Sharp & Dohme LLC

    Staphylococcal Infection

  • NCT00711802Phase 4Completed396 enrolled2008

    Safety and Efficacy Study of Daptomycin in Pediatric Participants (1 to 17 Years-old) With Skin and Skin Structure Infections

    Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

    Skin Diseases, Infectious

  • NCT00701636Phase 3Completed30 enrolled2008

    Pharmacokinetics of Daptomycin During Cardiopulmonary Bypass Surgery

    Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center

    Late Effects of Surgery · Staphylococcus Aureus · Surgical Site Infection

  • NCT00679835Phase 1Completed24 enrolled2008

    PK and Safety Evaluation of Daptomycin in Children Ages 2-6 With Proven or Suspected Gram-positive Infections

    Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

    Gram Positive Infection · Concurrent Antibiotic Treatment

  • NCT00572260Phase 4Terminated11 enrolled2008

    A Pilot Study of Daptomycin for Antimicrobial Prophylaxis

    Duke University

    Antimicrobial Prophylaxis

  • NCT00490737Phase 1Completed12 enrolled2007

    Safety Study to Evaluate Daptomycin in Non-infected Adults Who Are Either on Hemodialysis or Continuous Ambulatory Peritoneal Dialysis (MK-3009-021)

    Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

    End-Stage Renal Disease

  • NCT00428844Phase 2Completed75 enrolled2007

    Study of Daptomycin in Subjects Undergoing Surgery for Osteomyelitis Associated With an Infected Prosthetic Caused by Staphylococci

    Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

    Osteomyelitis

  • NCT00467272Phase 2Completed30 enrolled2007

    Catheter Related - Gram Positive Bloodstream Infections

    M.D. Anderson Cancer Center

    Bloodstream Infection

  • NCT00663403Phase 4Completed8 enrolled2007

    Pharmacokinetics of Daptomycin in Critically Ill Patients Receiving Continuous Venovenous Hemodialysis (CVVHD)

    University of Michigan

    Critically Ill · Hemodialysis

  • NCT00426933Phase 2Completed100 enrolled2007

    Phase 2 Safety and Efficacy Study of Daptomycin in Complicated Skin and Skin Structure Infections

    Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

    Soft Tissue Infections

  • NCT00463801Phase 4Terminated52 enrolled2007

    Safety and Efficacy of Daptomycin for the Treatment of Complicated Skin and Skin-structure Infections

    Novartis

    Staphylococcal Skin Infections

  • NCT00335478Phase 2Completed54 enrolled2006

    Daptomycin in Treating Neutropenia and Fever in Patients With Cancer

    OHSU Knight Cancer Institute

    Fever · Sweating · Hot Flashes · Infection

  • NCT00401960Phase 4Terminated6 enrolled2006

    Daptomycin as an Adjuvant Agent in the Treatment of Enterococcal Native Valve Endocarditis.

    Weill Medical College of Cornell University

    Endocarditis, Bacterial

  • NCT00451373Unknown300 enrolled2006

    Acute Renal Failure in the Surgical Intense Care Units - NTUH-SICU-ARF (NSARF) Study

    National Taiwan University Hospital

    Acute Renal Failure · Sepsis · Postoperative

  • NCT00507247Phase 2Completed11 enrolled2006

    Daptomycin in the Treatment of Catheter-Related Staphylococcus Aureus

    M.D. Anderson Cancer Center

    Staphylococcus Aureus

  • NCT00430937Phase 3Terminated194 enrolled2006

    Efficacy and Safety of Daptomycin Versus Vancomycin or Teicoplanin for Treatment of Complicated Skin and Soft Tissue Infections

    Novartis Pharmaceuticals

    Skin Diseases, Infectious · Soft Tissue Infections

  • NCT00295178Phase 4Completed80 enrolled2006

    Study Comparing CUBICIN® (Daptomycin for Injection) With Vancomycin in Cellulitis or Erysipelas

    Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

    Cellulitis

  • NCT00136292Phase 1Completed33 enrolled2005

    Study of Single Dose Daptomycin in Pediatric Patients With Gram-positive Infection for Which They Are Receiving Standard Antibiotics

    Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

    Gram-positive Bacterial Infections

  • NCT00296049Withdrawn2005

    Daptomycin or Vancomycin in Treating Bacteria in the Blood in Patients With Neutropenia Caused By Chemotherapy

    Wake Forest University Health Sciences

    Infection · Neutropenia · Unspecified Adult Solid Tumor, Protocol Specific · Unspecified Childhood Solid Tumor, Protocol Specific

  • NCT00261807Completed25 enrolled2005

    Daptomycin for the Treatment of Severe Necrotizing Soft-Tissue Infections

    University of Maryland, Baltimore

    Fasciitis, Necrotizing · Severe Necrotizing Skin and Soft Tissue Infections · Fournier's Gangrene

  • NCT00102947Phase 4Terminated72 enrolled2005

    Daptomycin in the Treatment of Patients With Renal Insufficiency and Complicated Skin and Skin Structure Infections

    Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

    Soft Tissue Infections

  • NCT00651131Phase 4Terminated69 enrolled2004

    Cubicin(R) for Complicated Post-surgical Wound Infections

    Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

    Wound Infections

  • NCT00055198Phase 3Terminated75 enrolled2002

    Daptomycin for the Treatment of Infections Due to Gram-Positive Bacteria

    Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

    Gram-Positive Bacterial Infections

  • NCT00093067Phase 3Completed2002

    Daptomycin in the Treatment of Subjects With Infective Endocarditis or Bacteremia Due to S. Aureus

    Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

    Bacterial Endocarditis · Bacteremia

  • NCT00540072Phase 3Completed2001

    Study of Cidecin™ (Daptomycin) to Rocephin® (Ceftriaxone) in the Treatment of Moderate to Severe Community-Acquired Acute Bacterial Pneumonia Due to S. Pneumoniae

    Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

    Pneumonia, Bacterial

  • NCT00538694Phase 3Completed2000

    Comparative Study of Cidecin™ (Daptomycin) to Rocephin® (Ceftriaxone) in the Treatment of Moderate to Severe Community-Acquired Acute Bacterial Pneumonia

    Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

    Pneumonia, Bacterial

  • 2023-504480-17-00Authorised, Not Started384 enrolled

    IIBSP-TDM-2023-28

    Fundacio Institut De Recerca De L Hospital De La Santa Creu I Sant Pau

    Critical Patients admitted to the ICU

    Named in the study description rather than as the headline intervention — often a drug given alongside the one being tested.

  • 2026-526149-91-00Authorised, Not Started166 enrolled

    ZKSJ0165

    Friedrich-Schiller-Universitaet Jena

    Infectious endocarditis caused by Gram-positive cocci (staphylococci, enterococci, streptococci)

    Named in the study description rather than as the headline intervention — often a drug given alongside the one being tested.

Sources: ClinicalTrials.gov, the EU Clinical Trials Information System and ISRCTN, deduplicated so a study registered in more than one registry is counted once. A study is listed when Daptomycin is named as an intervention. A registered trial is a plan, not a result — registration says nothing about whether the peptide worked.