CJC-1295
CJC-1295 with DAC (Drug Affinity Complex)
CJC-1295 is a synthetic analog of growth hormone-releasing hormone (GHRH) designed to stimulate natural growth hormone production from the pituitary gland. Its unique Drug Affinity Complex (DAC) modification allows it to bind to albumin, extending its half-life to 6-8 days and enabling sustained pulsatile growth hormone release. Unlike direct growth hormone therapy, CJC-1295 works with the body's natural rhythms to optimize anabolic effects while maintaining physiological hormone patterns.
CJC-1295 Dosing Guide
Primary Benefits
- Increases growth hormone levels by 2-10 fold for over 6 days
- Elevates IGF-1 levels by 1.5-3 fold for 9-11 days with single dose
- Promotes lean muscle mass gain (up to 5% increase in studies)
- Reduces visceral fat mass (up to 8% reduction observed)
- Enhances bone mineral density (up to 7% improvement)
How It Works
CJC-1295 binds with high affinity to the growth hormone-releasing hormone receptor (GHRHR) on somatotroph cells within the anterior pituitary gland, triggering a cascade of intracellular signaling that includes activation of adenylate cyclase, elevation of cyclic AMP (cAMP) levels, and subsequent activation of protein kinase A (PKA). This leads to pulsatile release of growth hormone in a physiologically relevant pattern, mimicking natural GHRH activity. The peptide's prolonged half-life, facilitated by its conjugation with a drug affinity complex (DAC) via a maleimide-linked lysine, enhances albumin binding in serum, extending its bioavailability to approximately 6-8 days. Downstream, it stimulates insulin-like growth factor 1 (IGF-1) production in the liver and peripheral tissues, promoting anabolic effects on muscle, bone, and fat metabolism without significantly upregulating other hormones like cortisol or prolactin.
Quick Reference
Typical Dosage Range
CJC-1295 without DAC dosing follows a structured protocol: Start with 100 mcg once daily for beginners, taken subcutaneously on an empty stomach. Advanced users may progress to 100-300 mcg twice daily (morning after waking and evening before bed). Use for 8-12 week cycles followed by 2-4 week breaks. Reconstitute with bacteriostatic water - example: 1 mL water to 2 mg vial creates 2 mg/mL concentration. For 100 mcg dose, draw 0.05 mL.
Administration Methods
Subcutaneous injection using reconstituted peptide with bacteriostatic water. Injection sites: fatty areas of abdomen, thigh, or upper arm. Technique: pinch skin, insert needle at slight angle, inject slowly. Rotate injection sites to prevent lipodystrophy. Timing: on empty stomach - wait 2-3 hours after eating before injection, avoid eating for 30 minutes post-injection to maximize growth hormone release. Storage: refrigerate reconstituted vial, use within 30 days. Store unmixed vials in cool, dry place away from light.
What It's Used For
CJC-1295 is a growth hormone-releasing peptide that helps stimulate the natural production of growth hormone (GH). This powerful peptide works with your body's natural rhythms to optimize muscle growth, fat loss, and recovery while maintaining healthy hormone patterns.
Muscle Growth & Recovery
Perfect for athletes, bodybuilders, or anyone wanting to enhance muscle repair and growth through natural growth hormone stimulation.
Fat Loss & Body Composition
Helps improve body composition by reducing fat and increasing lean mass through enhanced growth hormone production.
Anti-Aging & Wellness
Supports improved sleep quality, better skin health, and enhanced energy levels through optimized growth hormone patterns.
How Much to Take
Beginner Protocol
100 mcg once daily
Start with this dose for the first 1-2 weeks. Take in the morning on an empty stomach to assess tolerance and response.
Advanced Protocol
100-300 mcg twice daily
Morning after waking and evening before bed. Only progress to this after establishing tolerance with single daily dosing.
Injection Frequency
Once or twice daily depending on experience level and goals
Best Timing
On empty stomach - morning and/or before bed for optimal absorption
Dose Adjustment
Increase gradually based on tolerance and response over 2-4 weeks
How Long to Use It
Recommended Cycle Length
Use CJC-1295 for 8-12 weeks for optimal results and safety.
This duration allows your body to experience the full benefits while preventing potential receptor desensitization or hormonal imbalances from prolonged use.
Mandatory Break Period
Take a 2-4 week break between cycles.
This break allows your natural hormone production to reset and prevents tolerance buildup. Never skip the break period, even if you feel great.
Need-to-Know Information
How CJC-1295 Works
CJC-1295 signals your body to release natural growth hormone in small, frequent pulses. This supports muscle growth, fat loss, and recovery while working with your body's natural hormone rhythms rather than replacing them.
Key Benefits You Can Expect
Who Should Avoid CJC-1295
• Those with active cancer or tumor history
• People with severe heart conditions
• Anyone with uncontrolled diabetes
• Those allergic to any ingredients
Possible Side Effects
• Redness or irritation at injection site
• Slight headache or light-headedness
• Rare: tingling, water retention, nausea
Storage & Injection Guide
Mixing Instructions
Use bacteriostatic water to reconstitute. Example: Add 1 mL of water to a 2 mg vial = 2 mg/mL concentration. For 100 mcg dose, draw 0.05 mL into syringe.
Storage Requirements
Keep reconstituted vial in the refrigerator. Use within 30 days after mixing. Store unmixed vials in cool, dry place away from light.
Injection Sites
Subcutaneous (under skin) in fatty areas like stomach or thigh
Injection Method
Pinch skin, insert needle at slight angle, inject slowly and steadily
Important Tips
Rotate injection sites to avoid irritation or lumps from repeated use
Example Dosing Schedule
Daily Injection Schedule
Morning Injection
100-300 mcg on empty stomach after waking up (wait 2-3 hours after last meal)
Evening Injection (Advanced)
100-300 mcg before bed on empty stomach (only if using twice daily protocol)
If You Miss a Dose
Take it as soon as you remember, but don't double up doses.
If it's close to your next scheduled dose time, skip the missed dose and continue with your regular schedule. Consistency is more important than perfect timing.
Extra Tips for Best Results
Fasting for Best Results
Wait 2-3 hours after eating before injection. Avoid eating for 30 minutes after injecting to maximize growth hormone release.
Support Your Goals
Combine with resistance training for muscle growth. Use a diet rich in lean protein and healthy fats for better results.
Track Your Progress
Stay well-hydrated and log improvements in sleep, energy, muscle recovery, and fat loss to fine-tune your dosing.
Combination Protocol
Often paired with Ipamorelin for synergistic effects. Together, they optimize growth hormone release and support better outcomes.
Expected Results Timeline
Studies show 2-10 fold increase in growth hormone levels within days, with muscle building and fat loss benefits becoming noticeable after 4-6 weeks of consistent use. Peak benefits typically seen after 8-12 weeks.
Research Phase Compound
CJC-1295 is for research purposes only and is not FDA approved for human therapeutic use. Clinical trials were discontinued in 2008, and long-term safety data remains limited.
Medical Disclaimer
CJC-1295 is an investigational research compound not approved by the FDA for human therapeutic use. This information is for educational purposes only and should not be construed as medical advice. Any use should occur only under medical supervision in approved research settings. Long-term effects are not well-studied in humans.