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Injection Guide
Long-acting amylin analog that supercharges satiety signals, delivering powerful appetite suppression and up to 10-15% weight loss with convenient once-weekly dosing.
Route
Subcutaneous
Sites
4 recommended
Frequency
Once weekly
Preparation
Bacteriostatic water (BAC water)
Insulin syringe (29-31 gauge, 0.5-1mL)
Alcohol swabs
Sterile vial of cagrilintide powder
Sharps container for safe needle disposal
Pro Tip
Prepare all supplies on a clean surface before you begin. Having everything ready makes the process smoother and more sterile.
Mixing
Wash your hands thoroughly with soap and water. Gather all supplies on a clean, flat surface.
Remove the plastic cap from the peptide vial and wipe the rubber stopper with an alcohol swab. Let it air dry.
Draw the appropriate amount of bacteriostatic water into a sterile syringe.
Insert the needle into the vial at an angle, aiming at the inside wall of the vial. Slowly push the plunger to let the water trickle down the glass wall -- do NOT squirt directly onto the powder.
Once all water is added, gently swirl the vial in a slow circular motion. Never shake the vial, as this can damage the peptide bonds.
Continue swirling until the powder is completely dissolved and the solution is clear. If particles remain, let the vial sit for a few minutes and swirl again.
Label the vial with the date of reconstitution, the peptide name, and the concentration (e.g. 250mcg per 0.1mL).
Example Calculation
5mg vial + 1mL BAC water = 5mg/mL concentration. Each 0.1mL (10 units) contains 0.5mg cagrilintide.
Dose Calculation
For 2.4mg dose at 5mg/mL concentration: draw 0.48mL (48 units on insulin syringe). For easier math, many use 2mL water with 5mg vial for 2.5mg/mL.
Pro Tip
Always add the bacteriostatic water slowly, letting it run down the side of the vial. Never shake the vial -- swirl gently to avoid damaging the peptide.
Location
Site 01
Abdomen
Pinch the skin 2 inches from navel. Avoid the area directly around the belly button. Rotate between left and right sides.
Site 02
Outer Thigh
Middle third of the outer thigh. Keep at least 4 inches above the knee and below the hip. Alternate legs each injection.
Site 03
Upper Arm
Back or outer area of the upper arm. This site may require assistance from another person for proper technique.
Site 04
Gluteal
Upper outer quadrant of the buttock. This site is best for intramuscular injections and larger volumes.
Rotate between 4 sites to prevent tissue buildup and ensure consistent absorption.
Pro Tip
Rotate your injection sites with each dose to prevent lipohypertrophy (buildup of fatty tissue). Keep a simple log of where you last injected.
Step by Step
Wash hands thoroughly and clean injection site with alcohol swab
Let the alcohol dry completely - this reduces stinging
Pinch the skin to create a fold for easier injection
Insert needle at a 45-90 degree angle depending on body composition
Inject the medication slowly over 5-10 seconds
Hold for 10 seconds before removing needle, then release skin
Pro Tip
This peptide uses subcutaneous injection once weekly. Inject at a 45-90 degree angle into pinched skin. Aspirate before injecting to ensure you haven't hit a blood vessel.
Timing
Optimal Timing
Best time
Same day each week, any time of day that works for your schedule
With food?
Can be taken with or without food - choose whatever is most convenient
Stacking notes
When combining with semaglutide (CagriSema), both can be injected on the same day. The combination is designed to be taken together for synergistic effects.
Sample Daily Schedule
Weekly (choose a consistent day)
Current dose per titration schedule injection
Site: Rotate between abdomen, thigh, and arm
Set a recurring phone reminder for the same day and time each week. Many people choose weekend mornings.
If combining with semaglutide
Both can be injected same day injection
Site: Use different injection sites for each medication
The CagriSema combination uses 2.4mg of each. Inject at separate sites at least 2 inches apart.
Dosing Tiers
Dose
0.3-0.6 mg
Frequency
Once weekly
Duration
2-4 weeks
Start low to let your body adjust to the new satiety signals. Most people tolerate cagrilintide well, but starting slow helps minimize any GI discomfort.
Dose
1.2-2.4 mg
Frequency
Once weekly
Duration
Ongoing
The sweet spot for most people. This dose range provides meaningful appetite suppression and steady weight loss without overwhelming side effects.
Dose
4.5 mg
Frequency
Once weekly
Duration
Ongoing
Maximum studied dose for those who tolerate lower doses well and want maximum effect. Often used in combination with semaglutide for enhanced results.
Preservation
Before Mixing
Store in refrigerator at 36-46 degrees F (2-8 degrees C). Keep in original packaging to protect from light. Never freeze. Can tolerate brief room temperature exposure during shipping but return to refrigeration promptly.
After Mixing
Refrigerate immediately after mixing with bacteriostatic water. Do not freeze reconstituted solution. Use within 28 days of first puncture. Keep vial upright to minimize contamination risk.
Shelf Life After Mixing
28 days
Signs of Degradation
Discard the vial immediately if you notice any of these:
Cloudy or discolored solution (should be clear)
Visible particles, floaters, or clumps
Solution that has been accidentally frozen
Unusual smell when opening vial
Important
When to Stop
Severe allergic reaction (rash, swelling, difficulty breathing)
Persistent severe nausea or vomiting not improving with dose reduction
Signs of pancreatitis (severe abdominal pain radiating to back)
Planned pregnancy or positive pregnancy test
Inability to maintain adequate nutrition despite dose adjustments
Any concerning symptoms your healthcare provider advises stopping for
Always consult your healthcare provider before stopping or modifying your dose. Do not stop abruptly without medical guidance, especially if you are also on diabetes medications.
Clean Technique Checklist
Wash hands thoroughly with soap and water before handling supplies
Swab vial tops and injection site with alcohol and let dry
Never touch the needle tip or allow it to contact non-sterile surfaces
Use a new syringe and needle for each injection
Dispose of used sharps in a proper sharps container
Store reconstituted peptides according to the storage instructions above