Angiotensin (1-7) vs Thymosin Beta-4
The heart-friendly peptide that balances your blood pressure and protects your cardiovascular system
The body's natural healing peptide that accelerates tissue repair and reduces inflammation
Written by Michael Carroll — Owner, Director of Research · Reviewed by the Peptide Initiative Research Team · Editorial standards
Quick comparison
Dose range
Angiotensin (1-7)
100–100 mcg/kg
Thymosin Beta-4
2–5 mg
Frequency
Angiotensin (1-7)
Once daily
Thymosin Beta-4
Twice weekly
Administration
Angiotensin (1-7)
As directed by healthcare provider
Thymosin Beta-4
Subcutaneous injection
Cycle length
Angiotensin (1-7)
Ongoing/indefinite
Thymosin Beta-4
8-12 weeks
Onset speed
Angiotensin (1-7)
Moderate (1-2 weeks)
Thymosin Beta-4
Moderate (1-2 weeks)
Evidence level
Angiotensin (1-7)
Moderate human trials (Phase 1-2)
Thymosin Beta-4
Moderate human trials (Phase 1-2)
Benefit ratings
Heart Health & Protection
Blood Pressure Balance
Anti-Inflammatory Support
Wound Healing
Inflammation Reduction
Tissue Regeneration
Compound specifications
Angiotensin (1-7)
Molecular formula
C41H62N12O11
Molecular weight
899.02 g/mol
Half-life
Approximately 2-6 hours (varies by route of administration)
Bioavailability
Varies by route of administration
CAS number
25016-41-7
Thymosin Beta-4
Molecular formula
C212H350N56O78S
Molecular weight
4963
Half-life
Dose-dependent (increases with higher doses)
Bioavailability
100% (subcutaneous and intravenous)
CAS number
77591-33-4
Dosing compared
Angiotensin (1-7)
Subcutaneous
100 mcg/kg
Once daily after each chemotherapy session · Up to 6 chemotherapy cycles
In a cancer trial, this dose was injected under the skin after chemo to help protect platelet counts. A higher 300 mcg/kg dose was also tested but did not work better. [4]
Intravenous
0.5 mg/kg
Once daily · Up to 10 days
In a COVID-19 study, the lab-made form (called TXA-127) was given as a daily drip into a vein. No serious drug-related side effects were seen. [5]
Thymosin Beta-4
Subcutaneous injection
2-5 mg (community injectable practice for 'TB-500')
Once or twice weekly · 4-6 week loading phase, then weekly maintenance
Documented community/research-practice injectable dosing for tissue repair; thymosin beta-4 has ~100% bioavailability by the subcutaneous route [1]. Not an FDA-approved use.
Topical ophthalmic (eye drops)
0.1% (1 mg/mL) RGN-259 solution, 1 drop
Several times daily (e.g. up to 5x/day) · 4 weeks
0.1% RGN-259 ophthalmic solution used in phase III neurotrophic keratopathy and dry-eye trials, applied as eye drops several times daily for ~4 weeks [5].
Intravenous injection
450-1200 mg
IV push daily for the first 3 days, then weekly · Total of 7 doses over ~5 weeks
Doses studied in the RGN-352 acute myocardial infarction clinical program, given IV after PCI [6].
Best suited for
Angiotensin (1-7)
Cardiovascular health and heart protection
Angiotensin (1-7) is particularly well-suited for individuals focused on cardiovascular health and heart protection. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Blood pressure management and hypertension
Angiotensin (1-7) is particularly well-suited for individuals focused on blood pressure management and hypertension. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Recovery from heart-related conditions
Angiotensin (1-7) is particularly well-suited for individuals focused on recovery from heart-related conditions. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Anti-inflammatory support
Angiotensin (1-7) is particularly well-suited for individuals focused on anti-inflammatory support. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Thymosin Beta-4
Post-Surgery Recovery
Accelerates healing of surgical wounds and reduces post-operative inflammation and scarring
Chronic Wound Management
Helps pressure ulcers, venous stasis ulcers, and other slow-healing wounds progress faster
Tissue Regeneration
Supports repair of damaged tissues from injury, burns, or degenerative conditions
Side effects
Angiotensin (1-7)
Common
- Hypotension (Low Blood Pressure)
- Dizziness or Lightheadedness
- Injection Site Reactions
- Headache
Serious
- Hyperkalemia (High Potassium)
Thymosin Beta-4
Common
- Injection site redness
- Injection site swelling
Uncommon
- Temporary mild headache
- Mild bruising at injection site
- Transient fatigue
Serious
- Allergic reaction
Safety & evidence
Angiotensin (1-7)
Evidence level
Moderate human trials (Phase 1-2)
FDA status
Research compound
Safety overview
Angiotensin (1-7) is not FDA-approved and has no completed human clinical trials, with all safety data limited to animal studies and in vitro mechanistic work. Animal studies suggest potential benefits in hypertension and cardiac remodeling but also reveal risks of hypotension, particularly with concurrent ACE inhibitor or ARB therapy. The peptide's effects on systemic inflammation and immune function in animal models are not validated in humans. No pharmacokinetic data exists defining safe doses, optimal delivery routes, or organ accumulation patterns in humans.
Contraindications
- Severe hypotension or uncontrolled low blood pressure
- Acute myocardial infarction in early stages
- Concurrent use with certain ACE inhibitors without medical supervision
- Pregnancy and breastfeeding (insufficient safety data)
Thymosin Beta-4
Evidence level
Moderate human trials (Phase 1-2)
FDA status
Research compound
Safety overview
Thymosin Beta-4 is a naturally occurring peptide found in all cells and body fluids in the human body. Clinical trials have demonstrated excellent safety even at very high doses. IV studies showed doses up to 1260 mg were well tolerated with no serious adverse events.
Contraindications
- Active systemic infections
- Severe immunosuppression
- Hypersensitivity to thymosin or any component
- Pregnancy (insufficient safety data)
Which is right for you?
Choose Angiotensin (1-7) if...
- Cardiovascular health and heart protection
- Blood pressure management and hypertension
- Recovery from heart-related conditions
- Anti-inflammatory support
Choose Thymosin Beta-4 if...
- Recovering from injuries or surgery
- Improving wound healing speed
- Reducing inflammation
- Minimizing scar formation