Cosmetic Protocol
SYN-AKEComplete Dosing & Administration Guide
Synthetic snake venom-mimetic tripeptide that competitively antagonizes nicotinic acetylcholine receptors for rapid expression wrinkle reduction.
Dose Range
1%-4%%
Frequency
Once daily
Route
Topical
Cycle Length
Ongoing/indefinite
Dosing
How much
do I take?
Timing
Best time to take
Apply SYN-AKE to clean, dry skin. For best results, use consistently at the same time(s) each day. Evening application is often preferred to allow overnight absorption, unless otherwise directed.
With food?
As a topical product, SYN-AKE is not affected by food intake. Apply to clean skin and allow adequate absorption time before covering the area.
If stacking
SYN-AKE should be used as directed by your healthcare provider. If combining with other medications or supplements, discuss potential interactions with your provider. Avoid combining with compounds that have overlapping mechanisms unless specifically guided by a medical professional.
Adjusting Your Dose
Increase if
- +You've tolerated the current dose for the recommended period without significant side effects
- +Therapeutic goals haven't been met at the current dose level
- +Your healthcare provider recommends dose escalation based on your response
- +Lab work or clinical assessments support a higher dose
Decrease if
- -Side effects are bothersome or impacting daily life despite management strategies
- -You experience any signs of an adverse reaction
- -Lab results indicate the need for dose reduction
- -Your healthcare provider recommends a lower dose based on your response
Signs of right dose
- ✓Therapeutic goals being met with minimal side effects
- ✓Stable and consistent response to treatment
- ✓Lab values or clinical markers trending in the right direction
- ✓Good tolerance with manageable or absent side effects
Dosing Calculator
Calculate Your Exact Dose
Step 1: Peptide Weight
Find the weight printed on your peptide vial label
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The peptide weight is printed on the label
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The weight is on the label
Administration
How do I
use it?
Reconstitution
What you need
- •SYN-AKE in its prescribed form
- •Clean, dry storage container
- •Measuring device if applicable (oral syringe, measuring cup)
- •Calendar or reminder app for dosing schedule
Injection
Route
SYN-AKE is administered Topical—no injection required
Best sites
- •Not applicable—this is not an injectable formulation
Technique
- 1.Follow the specific administration instructions for your SYN-AKE formulation
- 2.Take or apply as directed by your healthcare provider
- 3.Store properly between uses according to package instructions
Storage
Signs of degradation
Sample Daily Schedule
Safety
Is it
safe?
Safety Profile
SYN-AKE demonstrates excellent topical tolerability with no serious adverse events reported in cosmetic use spanning 15+ years. Adverse testing including Ames test (genotoxicity) and cytotoxicity assays show negative results at therapeutic concentrations, confirming absence of mutagenic or cellular toxicity potential. Occasional mild tingling or slight dryness represents expected local skin responses rather than true adverse effects; systemic absorption is negligible due to peptide topical application mechanism.
Safety evidence derives from manufacturer (Lipotec/Lubrizol) cosmetic safety dossiers, post-market surveillance across millions of units distributed globally, and in vitro toxicology studies. The peptide works topically without transdermal penetration into systemic circulation, making serious adverse events extremely unlikely. Not FDA-regulated as a drug (cosmetic peptide), though clinical-grade efficacy studies document 26-30% wrinkle reduction without safety signals.
Common Side Effects
Experienced by some users
Mild Tingling Sensation
Slight tingling or cooling upon application, particularly noticeable with first use. Generally benign and transient.
Management: Normal sensory response. Resolves within minutes. No action required.
Temporary Tightening Sensation
Subtle skin tightening feeling as neuromuscular modulation takes effect. Indicates product activity.
Management: Expected pharmacological response. Follow with a hydrating moisturizer if sensation feels uncomfortable.
Mild Skin Dryness
Possible minor dryness in dry skin types, typically related to the glycerin-based vehicle rather than the peptide itself.
Management: Apply a moisturizer over the peptide serum. Choose formulations with built-in humectants.
Transient Redness
Very rare mild erythema at application site in highly reactive skin, resolving within hours.
Management: Reduce application frequency to once daily. If persistent, discontinue and patch test before restarting.
Less Common
- •Contact Irritation (rare)
These typically resolve with continued use or dose adjustment.
Stop and Seek Help If
- ×Severe or worsening side effects that don't improve with dose adjustment or supportive care
- ×Signs of an allergic reaction—rash, hives, swelling, or difficulty breathing
- ×Your healthcare provider recommends discontinuation based on your clinical response
- ×Development of any new medical condition that may be contraindicated with SYN-AKE
- ×Pregnancy or planning to become pregnant (unless specifically approved for use during pregnancy)
- ×Abnormal lab results or clinical markers that suggest adverse effects
SYN-AKE should only be started, adjusted, or discontinued under medical supervision. This information is for educational purposes only and does not replace professional medical advice. Never stop a prescribed treatment without consulting your healthcare provider first, as abrupt discontinuation may have consequences.
Interactions
With other peptides
- ✓May be used together under medical guidance.
- ✓May be used together under medical guidance.
- ✓May be used together under medical guidance.
With medications
- !Products above pH 7.5 - Use with caution—discuss with your healthcare provider.
- !Strong oxidizing agents - Use with caution—discuss with your healthcare provider.
- !Very high-concentration L-ascorbic acid (>20%) - Use with caution—discuss with your healthcare provider.
With supplements
- ✓Multivitamins - Generally safe to take alongside SYN-AKE. Space doses apart if taking oral formulations to ensure optimal absorption.
- ✓Electrolyte supplements - Helpful if experiencing any GI side effects that could lead to dehydration. Safe to combine.
Want the Full Picture?
View the complete SYN-AKE research profile including mechanism of action, clinical studies, effectiveness timeline, and FAQ.
View Full SYN-AKE Profile