SM-130686 dosing & administration
Experimental oral growth hormone secretagogue with anabolic potential from preclinical research
Written by Michael Carroll — Owner, Director of Research · Reviewed by the Peptide Initiative Research Team · Editorial standards
Dosing
How much do I take?
Timing
Best time to take
With meals (improves absorption and tolerability)
With food?
Recommended — take with breakfast, lunch, or dinner to enhance bioavailability
If stacking
Take consistently at same times daily. Morning and evening dosing supports natural GH pulse during sleep and wakefulness.
Adjusting your dose
Increase if
- No side effects after 2 weeks
- Desired GH stimulation not achieved (measure via IGF-1 if possible)
- Body composition goals not met after 6-8 weeks at current dose
Decrease if
- Appetite becomes excessive or uncomfortable
- Joint pain or swelling develops
- Sleep disturbances occur
- Blood glucose fluctuations noticed (especially in diabetics)
Signs of right dose
- Improved sense of well-being and energy
- Gradual lean muscle gains (2-4 lbs per month)
- Better recovery from training
- Increased appetite without discomfort
Administration
How do I use it?
Reconstitution
What you need
Injection
Route
Not applicable — oral formulation only
Best sites
Storage
Before reconstitution
Room temperature (20-25°C), away from moisture and direct light. Keep in original sealed container or airtight capsule bottle. Avoid refrigeration unless specified.
After reconstitution
Not applicable — no reconstitution required for oral form
Signs of degradation — discard the vial
Sample daily schedule
Morning (7-9 AM)
5-10 mg with breakfast injection
Site: Oral with food
Take with solid meal to enhance absorption and reduce GI upset. Aligns with natural AM cortisol rhythm.
Evening (6-8 PM)
5-10 mg with dinner injection
Site: Oral with food
Second dose supports GH pulse timing during sleep. Separate from morning dose by at least 8 hours for optimal effect.
Safety
Is it safe?
Side effects
Commonly reported: Appetite stimulation, Transient water retention
Less common: Joint or muscle aches, Transient changes in blood glucose
Stop and seek help if
- Severe or worsening joint pain (possible early carpal tunnel)
- Uncontrolled blood glucose elevation (especially if diabetic)
- Signs of edema or swelling in hands/feet that doesn't resolve
- Development of numbness or tingling in hands (median nerve compression)
- Severe sleep disturbances or mood changes
- Any signs of allergic reaction (rash, difficulty breathing, swelling)
- Diagnosis of cancer during treatment
- Symptoms suggestive of acromegaly progression (facial coarsening, hand/feet growth)
This is a research compound with no human safety data. Serious side effects are possible and unknown. If any concerning symptoms develop, discontinue immediately and seek medical evaluation. Unknown long-term effects. Do not combine with other GH secretagogues. This is NOT medical advice. Consult a physician before use.
Published research
What the studies show
Nagamine J et al. · 2001
This study investigated the properties and effects of SM-130686, contributing to our understanding of its mechanism of action and potential therapeutic applications.
Nagamine J et al. · 2006
This study investigated the properties and effects of SM-130686, contributing to our understanding of its mechanism of action and potential therapeutic applications.
Holst B et al. · 2009
This study investigated the properties and effects of SM-130686, contributing to our understanding of its mechanism of action and potential therapeutic applications.
Head to head
SM-130686 compared
Want the full picture?
The complete SM-130686 research profile: mechanism of action, clinical studies, effectiveness timeline, and FAQ.