Prostamax dosing & administration
Prostate-specific tetrapeptide bioregulator (Lys-Glu-Asp-Pro) that normalizes prostatic epithelial differentiation through chromatin remodeling at prostate gene promoters, restores the proliferation-apoptosis balance disrupted in benign prostatic hyperplasia, and reduces inflammatory cytokine signaling in aging prostate tissue
Written by Michael Carroll — Owner, Director of Research · Reviewed by the Peptide Initiative Research Team · Editorial standards
Dosing
How much do I take?
Intramuscular: An injection into a muscle, usually the thigh, shoulder, or buttock.
Bioavailability High — well absorbed into the bloodstream from the muscle.
0.01-100 mcg/kg
Frequency
Once daily
Duration
10-40 days
Dose from a single-institute patent report in 35 chronic-prostatitis patients [6]. The wide range reflects dose-finding within that single report.
Timing
Best time to take
Take Prostamax at the same time each day for consistent blood levels. Morning dosing with breakfast is often preferred, but follow your healthcare provider's specific instructions.
With food?
Prostamax can typically be taken with or without food. Taking it with a light meal may help reduce any GI discomfort. Avoid taking with grapefruit juice or high-fat meals unless specifically directed.
If stacking
Prostamax should be used as directed by your healthcare provider. If combining with other medications or supplements, discuss potential interactions with your provider. Avoid combining with compounds that have overlapping mechanisms unless specifically guided by a medical professional.
Adjusting your dose
Increase if
- You've tolerated the current dose for the recommended period without significant side effects
- Therapeutic goals haven't been met at the current dose level
- Your healthcare provider recommends dose escalation based on your response
- Lab work or clinical assessments support a higher dose
Decrease if
- Side effects are bothersome or impacting daily life despite management strategies
- You experience any signs of an adverse reaction
- Lab results indicate the need for dose reduction
- Your healthcare provider recommends a lower dose based on your response
Signs of right dose
- Therapeutic goals being met with minimal side effects
- Stable and consistent response to treatment
- Lab values or clinical markers trending in the right direction
- Good tolerance with manageable or absent side effects
Administration
How do I use it?
Reconstitution
What you need
Injection
Route
Prostamax is administered Sublingual (enteric-coated capsules)—no injection required
Best sites
Storage
Before reconstitution
Store Prostamax in the refrigerator at 36-46°F (2-8°C) in its original packaging. Protect from light and moisture. Do not freeze. Check the expiration date before use. Some formulations may be stored at room temperature for limited periods—check your specific product labeling.
After reconstitution
Once reconstituted, Prostamax should be kept refrigerated at 36-46°F (2-8°C) and used within the timeframe specified on your product labeling (typically 14-28 days). Label the vial with the reconstitution date. Do not use if the solution appears cloudy, discolored, or contains particles.
Signs of degradation — discard the vial
Sample daily schedule
As prescribed (once daily)
As prescribed by your healthcare provider injection
Site: Sublingual (enteric-coated capsules)—rotate sites if applicable
Maintain a consistent schedule for optimal results with Prostamax. Set reminders if needed. If you miss a dose, follow your healthcare provider's instructions—do not double up on doses to compensate.
Safety
Is it safe?
Side effects
Commonly reported: Injection site reaction, Mild fatigue, Urinary frequency changes, Mild headache
Less common: Mild pelvic discomfort
Stop and seek help if
- Severe or worsening side effects that don't improve with dose adjustment or supportive care
- Signs of an allergic reaction—rash, hives, swelling, or difficulty breathing
- Your healthcare provider recommends discontinuation based on your clinical response
- Development of any new medical condition that may be contraindicated with Prostamax
- Pregnancy or planning to become pregnant (unless specifically approved for use during pregnancy)
- Abnormal lab results or clinical markers that suggest adverse effects
Prostamax should only be started, adjusted, or discontinued under medical supervision. This information is for educational purposes only and does not replace professional medical advice. Never stop a prescribed treatment without consulting your healthcare provider first, as abrupt discontinuation may have consequences.
Flagged pairings
- Without oncological clearance in men with elevated PSA or family history of prostate cancer — Use with caution—discuss with your healthcare provider.
- GnRH agonists or antagonists used for prostate cancer treatment — may interfere with hormonal mechanisms — Use with caution—discuss with your healthcare provider.
- High-dose anti-androgens (bicalutamide, enzalutamide) — may counteract Prostamax's prostatic gene regulation — Use with caution—discuss with your healthcare provider.
Published research
What the studies show
Khavinson VKh, Linkova NS, Polyakova VO, et al. · 2012
Short peptides like pancragen, bronchogen, and vesugen tissue-specifically restore expression of differentiation factors during aging, suggesting a geroprotective mechanism.
Khavinson VKh · 2002
Research (2002) on prostamax contributes important scientific knowledge about its biological and pharmacological properties.
Avolio F, Martinotti S, Khavinson VK · 2022
Chonluten peptide and other tissue-specific peptides suppress TNF and inflammatory cytokines in immune cells, acting as natural inducers of inflammation tolerance during infections and tissue damage.
Khavinson VKh, Linkova NS, Chalisova NI, et al. · 2011
Research (2013) on prostamax contributes important scientific knowledge about its biological and pharmacological properties.
Khavinson VKh, Morozov VG · 2003
Thymic and pineal peptides (Thymalin and Epithalamin) reduced mortality in elderly patients by 2-4 fold over 6-8 years while improving cardiovascular, immune, and metabolic function.
Khavinson V.Kh. et al. · 2002
Single-institute patent report describing the synthetic tetrapeptide KEDP given intramuscularly at 0.01-100 ug/kg once daily for 10-40 days in 35 patients with chronic prostatitis, reporting improved prostatic function.
Head to head
Prostamax compared
Want the full picture?
The complete Prostamax research profile: mechanism of action, clinical studies, effectiveness timeline, and FAQ.