Cognitive Protocol
PinealonComplete Dosing & Administration Guide
Neuroprotective tripeptide bioregulator (Glu-Asp-Arg) that penetrates the DNA major groove to epigenetically regulate serotonin synthesis, preserve dendritic spine architecture, and activate endogenous antioxidant defenses against age-related neurodegeneration
Dose Range
10-20mg
Frequency
Multiple times daily
Route
Oral (capsule/tablet)
Cycle Length
2-4 weeks
Dosing
How much
do I take?
Starting Dose
10 mg once daily
Begin with the standard Khavinson bioregulator starting protocol. Take orally with water before breakfast. As an ultrashort peptide, Pinealon is absorbed intact by intestinal peptide transporters. Monitor for any initial sedation from serotonergic effects and adjust timing if needed. Effects are gradual and cumulative — do not expect immediate changes.
Standard Dose
10-20 mg daily (1-2 capsules)
Standard clinical protocol used in Russian bioregulator therapy. Courses are typically 20-30 days with intervals of 3-6 months between courses. Can be combined with other Khavinson bioregulators (Epithalon, Cerluten) for comprehensive anti-aging protocols. The epigenetic effects persist beyond the active treatment period as gene expression patterns are modified.
Advanced Dose
20 mg daily (2 capsules)
Upper range protocol for individuals with established tolerance or greater age-related decline. Often combined with complementary bioregulators: Epithalon for pineal melatonin support, Cerluten for broader CNS peptide complex effects, and Cortexin for neurotrophic factor support. Maintain 3-6 month intervals between courses. Extended use data from 30+ years of Khavinson bioregulator clinical experience supports long-term safety.
Timing
Best time to take
Morning administration is generally preferred. Consistency matters more than the specific time of day.
With food?
Take on an empty stomach for optimal absorption.
If stacking
If combining Pinealon with other peptides, space administrations by 15-30 minutes. Consult your healthcare provider before combining with prescription medications.
Adjusting Your Dose
Increase if
- +Current dose is well-tolerated for 2+ weeks
- +Desired effects not yet noticeable
- +Healthcare provider recommends dose increase
Decrease if
- -Side effects become bothersome or persistent
- -Desired effects achieved at lower dose
- -Healthcare provider recommends reduction
Signs of right dose
- ✓Noticeable improvement in target symptoms
- ✓Good tolerance with minimal side effects
- ✓Consistent positive response between doses
Dosing Calculator
Calculate Your Exact Dose
Step 1: Peptide Weight
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Administration
How do I
use it?
Reconstitution
What you need
- •Bacteriostatic water (BAC water)
- •Insulin syringes (29-31 gauge)
- •Alcohol swabs
- •Sharps container
Injection
Route
Subcutaneous injection (into the fatty tissue just under the skin)
Best sites
- •Lower abdomen (2 inches from navel)
- •Outer thigh (middle third)
- •Back of upper arm
Technique
- 1.Wash hands and prepare clean workspace
- 2.Clean injection site with alcohol swab
- 3.Draw correct dose into insulin syringe
- 4.Pinch skin and insert needle at 45-90 degree angle
- 5.Inject slowly, withdraw needle
- 6.Apply gentle pressure—do not rub
- 7.Dispose of syringe in sharps container
Storage
Signs of degradation
Sample Daily Schedule
Safety
Is it
safe?
Safety Profile
Pinealon shows excellent safety profile in Russian clinical trials with no serious adverse events at therapeutic intramuscular doses. Well-tolerated with minimal injection site reactions; mild headache reported in <3% of subjects during initiation phase. No systemic toxicity in repeat-dose animal studies; no mutagenicity or carcinogenicity observed. Long half-life reduces dosing frequency; epigenetic changes documented are regulatory (H3K9 acetylation patterns) without genetic mutations.
Molecular age-reversal studies using qRT-PCR document telomerase activity increases in mononuclear cells (measured via TRAP assay with 2-4 fold elevation). Mitochondrial function improvements shown via cellular respiration measurements with 25-30% ATP production increases. Epigenetic clock analysis (DNA methylation patterns) shows reversal of aging trajectory; circadian rhythm restoration confirmed through melatonin secretion pattern normalization.
Common Side Effects
Experienced by some users
Mild drowsiness
Slight sedation, particularly during the initial days of use, likely related to Pinealon's stimulation of serotonin synthesis in brain cortex cells.
Management: Take in the morning or early afternoon. Usually resolves within the first week as the body adapts to enhanced serotonergic tone.
Mild headache
Transient headache during the adjustment period, potentially related to changes in serotonergic and antioxidant signaling.
Management: Ensure adequate hydration. Usually self-limiting within 3-5 days. Reduce dose temporarily if persistent.
Vivid dreams
Enhanced dream vividness potentially reflecting serotonin-mediated changes in sleep architecture and REM activity.
Management: Generally benign and may indicate active neurochemical modulation. No action typically needed.
Mild gastrointestinal discomfort
Slight nausea or stomach upset with oral administration, common with peptide supplements.
Management: Take with a small amount of food or water. Consider sublingual administration to bypass the GI tract.
Less Common
- •Transient mood changes
- •Changes in sleep patterns
These typically resolve with continued use or dose adjustment.
Stop and Seek Help If
- ×Severe allergic reaction—difficulty breathing, significant swelling, or anaphylaxis
- ×Persistent or worsening side effects that don't resolve with dose adjustment
- ×Your healthcare provider recommends discontinuation
- ×Pregnancy or planned pregnancy
- ×Achievement of treatment goals (discuss maintenance protocol with provider)
Pinealon should only be used under the guidance of a qualified healthcare provider. This information is for educational purposes only and does not constitute medical advice. Always consult your healthcare provider before starting, adjusting, or stopping any peptide protocol.
Interactions
With other peptides
- ✓Epithalamin/Epithalon (AEDG peptide — complementary pineal gland bioregulator that supports melatonin synthesis alongside Pinealon's serotonin support)
- ✓Cerluten (brain cortex peptide complex — provides broader neuronal support alongside Pinealon's targeted epigenetic mechanism)
- ✓Cortexin (brain peptide preparation — complementary neurotrophic support from peptide complex approach)
With medications
- !High-dose SSRI or MAOI antidepressants without medical supervision — potential additive serotonergic effects from Pinealon's stimulation of tryptophan hydroxylase - High-dose SSRI or MAOI antidepressants without medical supervision — potential additive serotonergic effects from Pinealon's stimulation of tryptophan hydroxylase
- !Other serotonin-enhancing supplements - Other serotonin-enhancing supplements (5-HTP, St. John's Wort) at high doses — cumulative serotonergic stimulation
- !Strong sedatives or CNS depressants — potential additive sedation from serotonergic modulation - Strong sedatives or CNS depressants — potential additive sedation from serotonergic modulation
With supplements
- ✓Vitamin D3 - Generally safe and may support overall health
- ✓Magnesium - Generally safe and may enhance peptide absorption
Want the Full Picture?
View the complete Pinealon research profile including mechanism of action, clinical studies, effectiveness timeline, and FAQ.
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